Current Opinion in Allergy and Clinical Immunology最新文献_第7页

The evolution of cyclosporine treatments for treatment of ocular surface diseases. 环孢素治疗眼表疾病的演变。

IF 3 4区医学

Current Opinion in Allergy and Clinical Immunology Pub Date : 2024-10-01 Epub Date: 2024-07-24 DOI: 10.1097/ACI.0000000000001017

Anna Flts, Richard Medina, Esen K Akpek

{"title":"The evolution of cyclosporine treatments for treatment of ocular surface diseases.","authors":"Anna Flts, Richard Medina, Esen K Akpek","doi":"10.1097/ACI.0000000000001017","DOIUrl":"10.1097/ACI.0000000000001017","url":null,"abstract":"Purpose of review: Cyclosporine is a versatile immunomodulatory drug commonly employed in modern medicine. Although cyclosporine was initially used to prevent solid organ transplant rejection, its indications have extended to treat many inflammatory or autoimmune diseases. Cyclosporin is available for use in oral, intravenous, and topical forms, including eye drops to treat corneal and ocular surface conditions. It is naturally advantageous to administer cyclosporin directly into the eye, avoiding potential and dose limiting systemic adverse effects. However, the transition from systemic to topical administration has been a challenging one. This report reviews the evolution of ophthalmic cyclosporine treatment and explores its clinical impacts and future research directions.Recent findings: Latest advancements in formulations - from oil-based solutions to nanomicelle and gel systems and waterless formulations - have improved the therapeutic efficacy and tolerability of topically applied cyclosporine, demonstrating greater effectiveness in treating ocular surface parameters compared to oil-based solution.Summary: Cyclosporine continues to be a safe and effective immunomodulatory drug in the field of ophthalmology to treat various chronic inflammatory ocular surface diseases and dry eye. Currently, there are several commercially available topical preparations available for ophthalmic use each with unique formulation and clinical outcomes.","PeriodicalId":10956,"journal":{"name":"Current Opinion in Allergy and Clinical Immunology","volume":" ","pages":"360-367"},"PeriodicalIF":3.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141855047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ocular surface disorders: office procedures for the allergist/clinical immunologist. 眼表疾病：过敏学家/临床免疫学家的诊疗程序。

IF 3 4区医学

Current Opinion in Allergy and Clinical Immunology Pub Date : 2024-10-01 Epub Date: 2024-08-12 DOI: 10.1097/ACI.0000000000001022

Matthew Ryan Norris, Constance Katelaris, Nelson Rosario, Luis Delgado, Andrea Leonardi, Leonard Bielory

{"title":"Ocular surface disorders: office procedures for the allergist/clinical immunologist.","authors":"Matthew Ryan Norris, Constance Katelaris, Nelson Rosario, Luis Delgado, Andrea Leonardi, Leonard Bielory","doi":"10.1097/ACI.0000000000001022","DOIUrl":"10.1097/ACI.0000000000001022","url":null,"abstract":"Purpose of review: Ocular surface disorders (OSDs) are a prevalent and often debilitating condition encountered in clinical practice, particularly by allergists and clinical immunologists.Recent findings: A comprehensive guide to office procedures for evaluating and managing OSDs, with a specific focus on ocular allergies, would assist in the evaluation process that begins with an initial patient assessment utilizing standardized forms to systematically gather detailed medical history, symptomatology, and environmental exposure data. This structured approach ensures a thorough understanding of the patient's condition and facilitates targeted interventions. In addition to allergy testing, the assessment of the tear film is essential for a comprehensive evaluation of OSDs. The Schirmer test is employed to quantify tear production, providing objective data on tear film adequacy and guiding interventions for tear film deficiencies.Summary: This multifaceted diagnostic approach ensures that all contributing factors to OSDs are identified and appropriately managed. By integrating these office procedures, allergists and clinical immunologists can enhance their diagnostic accuracy and therapeutic efficacy, ultimately improving patient outcomes. This manuscript provides a practical resource, outlining some of the methodologies and clinical applications of each procedure, and highlighting their role in the holistic management of OSDs in allergic patients.","PeriodicalId":10956,"journal":{"name":"Current Opinion in Allergy and Clinical Immunology","volume":" ","pages":"375-379"},"PeriodicalIF":3.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141916335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anaphylaxis: glimpse into the future, attention to the present. 过敏性休克：展望未来，关注现在。

IF 3 4区医学

Current Opinion in Allergy and Clinical Immunology Pub Date : 2024-10-01 Epub Date: 2024-08-29 DOI: 10.1097/ACI.0000000000001023

Bianca Olivieri, Gianenrico Senna, Mariana Castells

引用次数: 0

Allergen immunotherapy and eosinophilic esophagitis: friends or foes? 过敏原免疫疗法和嗜酸性粒细胞食管炎：是敌还是友？

IF 2.8 4区医学

Current Opinion in Allergy and Clinical Immunology Pub Date : 2024-09-16 DOI: 10.1097/aci.0000000000001029

Constantinos Pitsios,Carlo Maria Rossi

{"title":"Allergen immunotherapy and eosinophilic esophagitis: friends or foes?","authors":"Constantinos Pitsios,Carlo Maria Rossi","doi":"10.1097/aci.0000000000001029","DOIUrl":"https://doi.org/10.1097/aci.0000000000001029","url":null,"abstract":"PURPOSE OF REVIEWThe connection between eosinophilic esophagitis (EoE) and food and airborne allergens is complex. Exposure to allergens (mainly food) is often the trigger for EoE flares. The development of EoE has been described as a side effect of allergen immunotherapy, especially oral immunotherapy (OIT, with food allergens), while isolated cases of EoE have been reported during sublingual immunotherapy (SLIT, with extracts of aeroallergens).RECENT FINDINGSEoE is currently recognized as a common side effect of OIT, while a solid correlation between SLIT and EoE is missing. Animal models have been developed to study the pathophysiological link between sensitization to aeroallergens and the induction of EoE and will probably provide an interpretation of why there are cases of EoE developed during SLIT. Recent findings in animal models suggest a genetic connection to EoE development after sensitization and re-exposure to airborne allergens. Subcutaneous allergen immunotherapy does not have a causative effect on EoE; on the contrary, a beneficial effect on EoE has been reported. Moreover, epicutaneous immunotherapy with a vector containing milk has also been used to treat children with milk-induced EoE.SUMMARYDiscovering the immune links between allergens and EoE will further guide the proper use of allergen immunotherapy and help define future strategies for the management of EoE.","PeriodicalId":10956,"journal":{"name":"Current Opinion in Allergy and Clinical Immunology","volume":"34 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142258275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

State of the art: the treatment of systemic lupus erythematosus. 最新技术：系统性红斑狼疮的治疗。

IF 3 4区医学

Current Opinion in Allergy and Clinical Immunology Pub Date : 2024-08-01 Epub Date: 2024-05-20 DOI: 10.1097/ACI.0000000000000996

Giulia Costanzo, Andrea Giovanni Ledda, Giada Sambugaro

引用次数: 0

New evidence in food allergies treatment. 治疗食物过敏的新证据

IF 3 4区医学

Current Opinion in Allergy and Clinical Immunology Pub Date : 2024-08-01 Epub Date: 2024-05-30 DOI: 10.1097/ACI.0000000000000999

Chiara Ghelli, Giovanni Costanzo, Giorgio Walter Canonica, Enrico Heffler, Giovanni Paoletti

{"title":"New evidence in food allergies treatment.","authors":"Chiara Ghelli, Giovanni Costanzo, Giorgio Walter Canonica, Enrico Heffler, Giovanni Paoletti","doi":"10.1097/ACI.0000000000000999","DOIUrl":"10.1097/ACI.0000000000000999","url":null,"abstract":"Purpose of review: To acknowledge, the newly available treatments for food allergy described in the latest scientific literature, such as oral immunotherapy (OIT), biologics and the combination of them in managing patients with IgE-mediated food allergies.Recent findings: Recent studies suggest that OIT and biologics, alone or together, can have a role as disease-modifying treatments for food allergies. The FDA has recently approved omalizumab as a treatment for food allergy. Other biologics are currently under evaluation and further studies are needed to assess the efficacy and safety of these therapies.Summary: The allergology scenario is rapidly evolving, the recent introduction and approval of new therapeutic strategies such as biotechnological drugs and allergen immunotherapy is changing the therapeutic paradigm: we are witnessing a shift from a strategy based on avoiding the trigger and reversing an allergic reaction already in progress, to one that aims to modify the natural history of the disease by acting on the immunological mechanisms that determine it. This approach is consistent with the modern perspective of a personalized patient-tailored medicine. In this opinion review, we will provide a brief analysis of current and future therapeutic options for IgE-mediated food allergy, focusing on OIT, biologics and their combination.","PeriodicalId":10956,"journal":{"name":"Current Opinion in Allergy and Clinical Immunology","volume":" ","pages":"251-256"},"PeriodicalIF":3.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141179154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Editorial: pharmacotherapy and evidence-based medicine. 社论：药物疗法和循证医学。

IF 3 4区医学

Current Opinion in Allergy and Clinical Immunology Pub Date : 2024-08-01 Epub Date: 2024-06-27 DOI: 10.1097/ACI.0000000000000995

Giovanni Paoletti, Federica Buta, Danilo Di Bona

引用次数: 0

Imaging of chronic rhinosinusitis with nasal polyps in the era of biological therapies. 生物疗法时代伴有鼻息肉的慢性鼻窦炎的成像。

IF 3 4区医学

Current Opinion in Allergy and Clinical Immunology Pub Date : 2024-08-01 Epub Date: 2024-02-12 DOI: 10.1097/ACI.0000000000000964

Remo Poto, Corrado Pelaia, Antonio di Salvatore, Hesham Saleh, Guy W Scadding, Gilda Varricchi

{"title":"Imaging of chronic rhinosinusitis with nasal polyps in the era of biological therapies.","authors":"Remo Poto, Corrado Pelaia, Antonio di Salvatore, Hesham Saleh, Guy W Scadding, Gilda Varricchi","doi":"10.1097/ACI.0000000000000964","DOIUrl":"10.1097/ACI.0000000000000964","url":null,"abstract":"Purpose of review: Chronic rhinosinusitis (CRS) is a chronic inflammatory disorder of the sinonasal cavities classified into two major phenotypes: CRS with nasal polyps (CRSwNP) and without nasal polyps (CRSsNP). The diagnosis of CRS is based on clinical symptoms associated with imaging and/or nasal endoscopy findings of mucosal inflammation.Recent findings: Recently, novel biological therapies have emerged as therapeutic options for CRSwNP. Imaging is helpful in deciding whether surgery is likely to be beneficial and in guiding surgery. It can also help demonstrate a clinical response to medical therapy. However, specific guidelines concerning the role of imaging in CRwNP are lacking.Summary: This article provides a comprehensive and critical multidisciplinary review of the role of conventional radiology, computed tomography (CT), and magnetic resonance imaging (MRI) in the diagnosis and characterization of CRSwNP. Since the complete characterization of nasal polyps on CT or MR images is very challenging, we provide a critical review of the best imaging methods and essential reporting elements used to assess nasal polyps.","PeriodicalId":10956,"journal":{"name":"Current Opinion in Allergy and Clinical Immunology","volume":" ","pages":"243-250"},"PeriodicalIF":3.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11213496/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139416613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hereditary angioedema: current therapeutic management and future approaches. 遗传性血管性水肿：当前的治疗管理和未来的方法。

IF 3 4区医学

Current Opinion in Allergy and Clinical Immunology Pub Date : 2024-08-01 Epub Date: 2024-05-13 DOI: 10.1097/ACI.0000000000000992

Donatella Lamacchia, Emanuele Nappi, Valentina Marzio, Francesca Locatelli, Maria Rita Messina, Enrico Heffler

{"title":"Hereditary angioedema: current therapeutic management and future approaches.","authors":"Donatella Lamacchia, Emanuele Nappi, Valentina Marzio, Francesca Locatelli, Maria Rita Messina, Enrico Heffler","doi":"10.1097/ACI.0000000000000992","DOIUrl":"10.1097/ACI.0000000000000992","url":null,"abstract":"Purpose of review: The aim of this review is to provide an account of the focus of therapeutic strategies for hereditary angioedema (HAE), give a brief overview of those used in the past and set aside and toughly discuss those currently available as first line. Further research is ongoing and the future therapeutic approaches that are still in different phases of study will be reviewed as well.Recent findings: In the last two decades, major research advancements on HAE pathophysiology and management were made and numerous novel therapeutic options are now available. Compared to the past, drugs available nowadays are more effective, well tolerated, and possibly have a more convenient administration route. Moreover, numerous other drugs with innovative mechanisms of action are under development.Summary: HAE is a rare genetic disease that if not promptly treated, it can lead to death from asphyxiation. Furthermore, due to its disfiguring and painful manifestations, HAE implies an important burden on the quality of life. Recently, following great research progresses on HAE therapy, evidence-based guidelines on HAE management were released. The therapeutic landscape of HAE is still under florid development, and it is possible novel treatments will remarkably revolutionize HAE management in the future.","PeriodicalId":10956,"journal":{"name":"Current Opinion in Allergy and Clinical Immunology","volume":" ","pages":"257-265"},"PeriodicalIF":3.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140920793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Perioperative anaphylaxis: updates on pathophysiology. 围手术期过敏性休克：病理生理学的最新进展。

IF 3 4区医学

Current Opinion in Allergy and Clinical Immunology Pub Date : 2024-08-01 Epub Date: 2024-05-13 DOI: 10.1097/ACI.0000000000000994

Justin Jordan, Jerrold H Levy, Alexei Gonzalez-Estrada

{"title":"Perioperative anaphylaxis: updates on pathophysiology.","authors":"Justin Jordan, Jerrold H Levy, Alexei Gonzalez-Estrada","doi":"10.1097/ACI.0000000000000994","DOIUrl":"10.1097/ACI.0000000000000994","url":null,"abstract":"Purpose of review: Perioperative anaphylaxis has historically been attributed to IgE/FcεRI-mediated reactions; there is now recognition of allergic and nonallergic triggers encompassing various reactions beyond IgE-mediated responses. This review aims to present recent advancements in knowledge regarding the mechanisms and pathophysiology of perioperative anaphylaxis.Recent findings: Emerging evidence highlights the role of the mast-cell related G-coupled protein receptor X2 pathway in direct mast cell degranulation, shedding light on previously unknown mechanisms. This pathway, alongside traditional IgE/FcεRI-mediated reactions, contributes to the complex nature of anaphylactic reactions. Investigations into the microbiota-anaphylaxis connection are ongoing, with potential implications for future treatment strategies. While serum tryptase levels serve as mast cell activation indicators, identifying triggers remains challenging. A range of mediators have been associated with anaphylaxis, including vasoactive peptides, proteases, lipid molecules, cytokines, chemokines, interleukins, complement components, and coagulation factors.Summary: Further understanding of clinical endotypes and the microenvironment where anaphylactic reactions unfold is essential for standardizing mediator testing and characterization in perioperative anaphylaxis. Ongoing research aims to elucidate the mechanisms, pathways, and mediators involved across multiple organ systems, including the cardiovascular, respiratory, and integumentary systems, which will be crucial for improving patient outcomes.","PeriodicalId":10956,"journal":{"name":"Current Opinion in Allergy and Clinical Immunology","volume":" ","pages":"183-188"},"PeriodicalIF":3.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140920796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0