Current Opinion in Allergy and Clinical Immunology最新文献_第2页

Local allergic rhinitis in Asia: rethinking the allergy landscape. 亚洲局部变应性鼻炎：重新思考过敏景观。

IF 3 4区医学

Current Opinion in Allergy and Clinical Immunology Pub Date : 2025-06-01 Epub Date: 2025-04-01 DOI: 10.1097/ACI.0000000000001069

Aneeza W Hamizan, Salina Husain, Pongsakorn Tantilipikorn

{"title":"Local allergic rhinitis in Asia: rethinking the allergy landscape.","authors":"Aneeza W Hamizan, Salina Husain, Pongsakorn Tantilipikorn","doi":"10.1097/ACI.0000000000001069","DOIUrl":"10.1097/ACI.0000000000001069","url":null,"abstract":"Purpose of review: Local allergic rhinitis (LAR) is increasingly recognized as a distinct phenotype of chronic rhinitis, yet its prevalence and characteristics in Asia remain underexplored. Given the variability in reported LAR prevalence across regions, this review re-evaluates the allergy landscape in Asia, considering environmental and immunological factors, as well as study methodology that may contribute to differences from Western populations.Recent findings: There were more Asian studies which reported lower prevalence (0-20%), in contrast to higher rates in Europe, particularly Mediterranean countries. Urbanization, air pollution, and high dust mite exposure may be important factors of nonatopic rhinitis in Asia. Diagnostic approaches, including nasal-specific IgE and provocation tests, vary across studies, impacting prevalence estimates.Summary: The lower reported LAR prevalence in Asia suggests potential differences in underlying mechanisms or diagnostic limitations. Further research is needed to refine diagnostic criteria, explore environmental triggers, and assess the clinical relevance of LAR in Asian populations. A better understanding of LAR in Asia could guide targeted management strategies and improve recognition of this condition in clinical practice.","PeriodicalId":10956,"journal":{"name":"Current Opinion in Allergy and Clinical Immunology","volume":" ","pages":"135-143"},"PeriodicalIF":3.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Common data elements for food allergy clinical trials: an overview. 食物过敏临床试验的常见数据要素：综述。

IF 3 4区医学

Current Opinion in Allergy and Clinical Immunology Pub Date : 2025-06-01 Epub Date: 2025-04-21 DOI: 10.1097/ACI.0000000000001075

Shruti Sehgal, Justin Starren, Kyle Cattin, Lucy Bilaver, Anupama Gururaj, Alkis Togias, Ruchi S Gupta

{"title":"Common data elements for food allergy clinical trials: an overview.","authors":"Shruti Sehgal, Justin Starren, Kyle Cattin, Lucy Bilaver, Anupama Gururaj, Alkis Togias, Ruchi S Gupta","doi":"10.1097/ACI.0000000000001075","DOIUrl":"https://doi.org/10.1097/ACI.0000000000001075","url":null,"abstract":"Purpose of review: Food allergy represents a major public health issue, affecting about 8% of children and 11% of adults in the United States. Research in the field has rapidly expanded but is limited by a lack of standardized data fields or common data elements (CDEs) to record food allergy data. The present review focuses on the need for developing CDEs for food allergy, and their anticipated impact, as well as describes the central tenets of CDEs.Recent findings: Standardization of data definitions and consistency in data collection within a study and across multiple studies is a fundamental principle of clinical research. Several NIH centers have been collaborating to support the development of CDEs, thereby promoting the FAIR principles for clinical research.Summary: The population health burden of food allergies continues to rise in the absence of a standardized language for documenting food allergy clinical research data. Development and implementation of food allergy CDEs is needed both nationally and globally, to better understand and reduce the burden of this immune-mediated disease. When adopted, these CDEs will not only improve data consistency and interoperability but also speed up and improve the quality of future food allergy clinical trials.","PeriodicalId":10956,"journal":{"name":"Current Opinion in Allergy and Clinical Immunology","volume":"25 3","pages":"194-198"},"PeriodicalIF":3.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12043398/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143967988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Breaking down the tower of babel: common languages in food allergy studies. 打破巴别塔：食物过敏研究中的常用语言。

IF 3 4区医学

Current Opinion in Allergy and Clinical Immunology Pub Date : 2025-06-01 Epub Date: 2025-05-01 DOI: 10.1097/ACI.0000000000001073

Alessandro Fiocchi, Motohiro Ebisawa

引用次数: 0

Re-evaluating treatment success in trials of peanut oral-immunotherapy: impact of different definitions on efficacy outcomes. 重新评估花生口服免疫治疗试验的治疗成功：不同定义对疗效结果的影响。

IF 3 4区医学

Current Opinion in Allergy and Clinical Immunology Pub Date : 2025-06-01 Epub Date: 2025-04-10 DOI: 10.1097/ACI.0000000000001077

Stefanie Berkes, Klara Liddell, Kirsten Beyer, Katharina Blumchen, Antoine Deschildre, Kaarina Kukkonen, Mika J Mäkelä, Nandinee Patel, Paul J Turner

{"title":"Re-evaluating treatment success in trials of peanut oral-immunotherapy: impact of different definitions on efficacy outcomes.","authors":"Stefanie Berkes, Klara Liddell, Kirsten Beyer, Katharina Blumchen, Antoine Deschildre, Kaarina Kukkonen, Mika J Mäkelä, Nandinee Patel, Paul J Turner","doi":"10.1097/ACI.0000000000001077","DOIUrl":"https://doi.org/10.1097/ACI.0000000000001077","url":null,"abstract":"Purpose of review: Allergen immunotherapy (AIT) is increasingly popular as a treatment strategy for food allergy. Unfortunately, there is significant heterogeneity in reported outcomes, specifically in the dose-thresholds selected for evaluation and the symptoms used to define a \"tolerated dose\". These considerations are often investigator-driven and do not consider patient perspectives.Recent findings: A systematic review by the EAACI CO-FAITH taskforce recently flagged the need to better standardize and harmonize outcomes used in clinical trials of food-AIT. Using less objective symptoms to define dose-limiting symptoms can underestimate the reaction threshold determined at baseline food challenge. As a consequence, this can overestimate the efficacy of food-AIT by 15%. In this review, we perform an individual patient data (IPD) meta-analysis using data from three randomized-controlled trials and one real-world registry, to evaluate how the definition of dose \"tolerance\" impacts upon reported desensitization rates.Summary: This analysis provides insight into how clinical efficacy rates for food-AIT are impacted by using different dose thresholds and definitions for when a dose might be consider tolerated. Using more patient-centric outcomes may be a more useful metric to harmonize reporting of outcomes and inform clinical practice, paving the way towards reaching a consensus on outcome reporting in trials of food-AIT.","PeriodicalId":10956,"journal":{"name":"Current Opinion in Allergy and Clinical Immunology","volume":"25 3","pages":"185-193"},"PeriodicalIF":3.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052049/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143985726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Use of the DEFASE score in research trials. 在研究试验中使用DEFASE评分。

IF 3 4区医学

Current Opinion in Allergy and Clinical Immunology Pub Date : 2025-06-01 Epub Date: 2025-04-03 DOI: 10.1097/ACI.0000000000001072

Stefania Arasi, Lucia Lo Scalzo, Maddalena Sciannamea, Ludger Klimek, Alessandro Fiocchi

{"title":"Use of the DEFASE score in research trials.","authors":"Stefania Arasi, Lucia Lo Scalzo, Maddalena Sciannamea, Ludger Klimek, Alessandro Fiocchi","doi":"10.1097/ACI.0000000000001072","DOIUrl":"10.1097/ACI.0000000000001072","url":null,"abstract":"Purpose of review: To explore the potential applicability in clinical trials of the groundbreaking international consensus named DEFASE (DEfinition of Food Allergy SEverity) as the unique grading system for IgE-mediated food allergy (FA) severity embracing the different aspects of the disease in a holistic approach. Herein, we discuss its relevance in clinical trials and potential applications in research and clinical settings through a few clinical scenarios.Recent findings: The DEFASE score has been developed to be used in research settings as a comprehensive scoring system. Researchers are currently focusing on internal and external validation of the scoring system, targeting these models to various food allergenic sources, populations, and settings.Summary: Implementing the DEFASE score in clinical trials could improve patient stratification, guide therapeutic decisions, and support regulatory assessments. Future research will focus on its external validation and integration with biomarker data to refine its predictive accuracy and make this tool applicable in the near future.","PeriodicalId":10956,"journal":{"name":"Current Opinion in Allergy and Clinical Immunology","volume":" ","pages":"199-204"},"PeriodicalIF":3.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hypereosinophilia: clinical and therapeutic approach in 2025. 嗜酸性粒细胞增多症：2025年的临床和治疗方法。

IF 3 4区医学

Current Opinion in Allergy and Clinical Immunology Pub Date : 2025-05-22 DOI: 10.1097/ACI.0000000000001078

Giusi Taurisano, Maria Clara Ruffi, Silvia Canalis, Giulia Anna Maria Luigia Costanzo

{"title":"Hypereosinophilia: clinical and therapeutic approach in 2025.","authors":"Giusi Taurisano, Maria Clara Ruffi, Silvia Canalis, Giulia Anna Maria Luigia Costanzo","doi":"10.1097/ACI.0000000000001078","DOIUrl":"https://doi.org/10.1097/ACI.0000000000001078","url":null,"abstract":"Purpose of review: This review addresses the clinical and biological complexities of hypereosinophilia (HE) and hypereosinophilic syndrome (HES), highlighting the need for improved diagnostic frameworks and therapeutic strategies. Due to the increasing recognition of HE and its potential for severe multiorgan involvement, a structured, multidisciplinary approach to diagnosis and management is essential for optimizing patient outcomes.Recent findings: Recent literature categorizes HE into hereditary, reactive, and neoplastic forms, with significant advancements in defining associated conditions and their pathophysiological mechanisms. Clinical manifestations range from asymptomatic eosinophilia to life-threatening complications involving the skin, lungs, gastrointestinal tract, heart, and nervous system. Corticosteroids remain the first-line treatment across most subtypes. Imatinib has shown high efficacy, particularly in patients with FIP1L1::PDGFRA fusion. However, therapeutic resistance and relapse still occur. Biologic therapies targeting interleukin (IL)-5 or its receptor, such as mepolizumab and benralizumab, have demonstrated promise in reducing eosinophils counts and preventing flare-ups. Additional agents under investigation include dupilumab and lirentelimab.Summary: The findings highlight the importance of accurate classification and tailored management of HE and HES, which are crucial for preventing organ damage and improving quality of life. Ongoing clinical trials and research will expand therapeutic options, clarify underlying mechanisms, and address current unmet needs.","PeriodicalId":10956,"journal":{"name":"Current Opinion in Allergy and Clinical Immunology","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New approaches in childhood IgE-mediated food allergy treatment. 儿童ige介导的食物过敏治疗新途径

IF 3 4区医学

Current Opinion in Allergy and Clinical Immunology Pub Date : 2025-04-01 Epub Date: 2025-01-27 DOI: 10.1097/ACI.0000000000001058

Deniz Ilgun Gurel, Aikaterini Anagnostou, Alessandro Fiocchi, Chinthrajah Sharon, Umit Sahiner, Sayantani Sindher, Stefania Arasi

{"title":"New approaches in childhood IgE-mediated food allergy treatment.","authors":"Deniz Ilgun Gurel, Aikaterini Anagnostou, Alessandro Fiocchi, Chinthrajah Sharon, Umit Sahiner, Sayantani Sindher, Stefania Arasi","doi":"10.1097/ACI.0000000000001058","DOIUrl":"10.1097/ACI.0000000000001058","url":null,"abstract":"Purpose of review: This review aims to provide an overview of the current and future treatment options for children with food allergies (FAs), highlighting the latest research findings and the potential impact of these new approaches on improving patients' and caregivers' quality of life.Recent findings: In the last decade, many promising approaches have emerged as an alternative to the standard avoidance of the culprit food with the risk of severe accidental reactions. Desensitization through oral immunotherapy has been introduced in clinical settings as a therapeutic approach, and more recently also omalizumab. In addition, alternative routes of administration for immunotherapy, other biologics, small molecules, probiotics or prebiotics, microbiota transplantation therapy, IGNX001, and PVX108 are being investigated.Summary: The portfolio of available treatment options for food allergies is increasing but several relevant unmet needs remain. This review aims to provide a brief overview of the existing and future treatment options for IgE-mediated food allergies.","PeriodicalId":10956,"journal":{"name":"Current Opinion in Allergy and Clinical Immunology","volume":" ","pages":"115-122"},"PeriodicalIF":3.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143045878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Occupational allergy and climate change. 职业性过敏和气候变化。

IF 3 4区医学

Current Opinion in Allergy and Clinical Immunology Pub Date : 2025-04-01 Epub Date: 2025-01-27 DOI: 10.1097/ACI.0000000000001060

Monika Raulf, Isabella Annesi-Maesano

{"title":"Occupational allergy and climate change.","authors":"Monika Raulf, Isabella Annesi-Maesano","doi":"10.1097/ACI.0000000000001060","DOIUrl":"10.1097/ACI.0000000000001060","url":null,"abstract":"Purpose of review: Climate change influences working conditions in various ways, affecting employee health and safety across different sectors. Climatic factors like rising temperatures, increased UV radiation, and more frequent extreme weather events pose risks to in both indoor and outdoor workers. Allergic diseases of the respiratory tract and the skin may emerge due to climate change. This review summarizes current aspects of both direct and indirect consequences of climate change and associated exposures in diverse work environments, focusing on occupational allergies.Recent findings: Outdoor workers, in particular, are increasing susceptible to ubiquitous pollen allergens. Additionally, they may experience climate-related increases in allergens typically associated with specific workplaces, such as Cryptostroma corticale . Changes in production processes, along with altered workplaces exposures, can lead to new sensitizations and trigger allergies, representing indirect consequences of climate change. Furthermore, lifestyle changes aimed to promoting climate protection and sustainability (e.g. the introduction of insects as a protein source or using enzymes), may also contribute to the emergence of new allergens.Summary: The emergence of new occupational sensitization sources from novel or modified allergen exposures must be addressed within the framework of workplace safety and health, necessitating proactive measures to safeguard workers and mitigate risks.","PeriodicalId":10956,"journal":{"name":"Current Opinion in Allergy and Clinical Immunology","volume":" ","pages":"83-87"},"PeriodicalIF":3.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143051918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of climate change in pollen food allergy syndrome. 气候变化对花粉食物过敏综合征的影响。

IF 3 4区医学

Current Opinion in Allergy and Clinical Immunology Pub Date : 2025-04-01 Epub Date: 2025-02-04 DOI: 10.1097/ACI.0000000000001064

Isabel J Skypala

{"title":"The impact of climate change in pollen food allergy syndrome.","authors":"Isabel J Skypala","doi":"10.1097/ACI.0000000000001064","DOIUrl":"10.1097/ACI.0000000000001064","url":null,"abstract":"Purpose of review: To evaluate the effect of climate change on pollen allergenicity, lengthening of the pollen season, and the spread of invasive species such as ragweed. To assess evidence to determine whether these effects are impacting the prevalence of pollen food syndrome (PFS).Recent findings: There is good evidence to demonstrate that markers of climate change, including rising temperatures and to some extent greenhouse gases, are responsible for a rise in the allergenicity of pollen and an increase in the duration of the pollen season, especially for trees. These changes are likely to be linked to the increase in the prevalence of seasonal allergic rhinitis (SAR), especially in children. Sensitization to pollen, especially tree pollen, is also a risk factor for the development of PFS. Thought to mainly affect adults, recent evidence suggests that there is a rise in the prevalence of PFS in children, linked to an increase in SAR.Summary: Increasing SAR due to climate change could lead to a greater number of children and adults developing PFS. Although PFS is generally considered to be a mild condition, severe reactions can occur and there might be numerous plant food triggers, which can adversely affect dietary choice and nutritional intake.","PeriodicalId":10956,"journal":{"name":"Current Opinion in Allergy and Clinical Immunology","volume":" ","pages":"129-133"},"PeriodicalIF":3.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143188523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current risks of byssinosis and chronic obstructive pulmonary disease in textile workers. 纺织工人肺脓毒症和慢性阻塞性肺病的现状

IF 3 4区医学

Current Opinion in Allergy and Clinical Immunology Pub Date : 2025-04-01 Epub Date: 2024-12-04 DOI: 10.1097/ACI.0000000000001053

Asaad Ahmed Nafees, Paul Cullinan

{"title":"Current risks of byssinosis and chronic obstructive pulmonary disease in textile workers.","authors":"Asaad Ahmed Nafees, Paul Cullinan","doi":"10.1097/ACI.0000000000001053","DOIUrl":"10.1097/ACI.0000000000001053","url":null,"abstract":"Purpose of review: The textile manufacturing sector is a major contributor to the economies of several emergent economies in the global South. Respiratory disease, including byssinosis and chronic obstructive pulmonary disease (COPD), among textile workers appears to be common in this setting.Recent findings: Notably, little or no contemporary research has been published from countries, which are major global producers of textiles. Most recent epidemiological studies are of a cross-sectional design, with deficiencies that repeat those of research in this area over the past 20 years and do little to advance the cause of prevention. Their estimates of disease prevalence vary wildly for reasons that are unclear. An important exception was the publication of a successful, randomized trial of a low-cost intervention, the first in this field.Summary: Research into the respiratory problems of textile work needs to embrace modern approaches to the understanding of (occupational) COPD and move beyond the estimation of disease prevalence. There is an important need for cheaper and simpler techniques for workplace dust measurement. Occupational health researchers should pool their skills, resources and protocols towards the prevention of a problem that is common to many low- and middle-income economies.","PeriodicalId":10956,"journal":{"name":"Current Opinion in Allergy and Clinical Immunology","volume":" ","pages":"88-94"},"PeriodicalIF":3.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142784433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0