{"title":"Food Contamination with Micro-plastics: Occurrences, Bioavailability, Human Vulnerability, and Prevention","authors":"Lakshmayya NSV, Ashoutosh Panday, Rajasri Yadavalli, C Nagenrdanatha Reddy, Sanjeeb Kumar Mandal, Dinesh Chand Agrawal, Bishwambhar Mishra","doi":"10.2174/1573401319666230915164116","DOIUrl":"https://doi.org/10.2174/1573401319666230915164116","url":null,"abstract":"Abstract: Microplastics (MPs) are emergent environmental contaminants that are designated as either primary or secondary dependent on their origins. Formulation, morphology, dimensions, and colour scheme, along with other features, are connected with their propensity to reach the food webs and their dangers. Whilst ecological adversities of MPs have drawn considerable interest, the hazards to individuals from dietary exposure have yet to be determined. The aim of this review is to gauge existing understanding concerning MPs in foodstuffs and to explore the problems and inadequacies for threat assessment. The prevalence of MPs in foodstuffs and sugary drinks has been detected all over the world, but most researchers judged the existing information to be not only inadequate but also of dubious value, owing to the notable lack of agreement on a regulated quantification methods and a consistent appellation. Most published papers have highlighted potable water and condiments such as sugars, salts, and nectar as significant food components of MPs for humans. The threat assessment reveals significant discrepancies in our understanding of MP toxicity for human consumption, which hinders the estimate of risk-based regulations regarding food safety. The lack of comparators for evaluating MPs food consumption prohibits dietary MPs risk description and risk mitigation. Researchers and Food Safety Administrators confer various obstacles along with possibilities linked to the appearance of MPs in foodstuffs. Further investigation on the MPs categorization and exposures is essential considering that any subsequent threat evaluation record can contain a comprehensive dietary viewpoint.","PeriodicalId":10944,"journal":{"name":"Current Nutrition & Food Science","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135437685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fahad Al-Asmari, Pankaj Koirala, Nikheel Bhojraj Rathod, Tareq M. Alnemr, Saeed A Asiri, Mohamed Yousif Babeker, Li LI, Nilesh Prakash Nirmal
{"title":"Antimicrobial Activity of Formulated Origanum and Thyme Essential Oil Nanoemulsions - A comparative study","authors":"Fahad Al-Asmari, Pankaj Koirala, Nikheel Bhojraj Rathod, Tareq M. Alnemr, Saeed A Asiri, Mohamed Yousif Babeker, Li LI, Nilesh Prakash Nirmal","doi":"10.2174/1573401319666230914140953","DOIUrl":"https://doi.org/10.2174/1573401319666230914140953","url":null,"abstract":"INTRODUCTION: This study focused on the formulation processing and antimicrobial activities of Origanum and Thyme essential oils (OEO) (TEO) and their nanoemulsions (OEON) (TEON) on gram-positive and gram-negative bacteria and yeast. Optimal nanoemulsion formulation and stability were achieved through balancing between requisite hydrophilic-lipophilic balance (rHLB) and surfactant concentration (Smix) of nanoemulsions. METHOD: The smallest droplet sizes of OEON: (z -185.1 nm ± 0.85) and TEON (z -130.1 nm ± 0.60), were achieved by using 10 g/100 mL of OEO and TEO with 15 g/100 mL Smix at ultrasonication for 2 min with no phase separation. The size of nanoemulsion droplet and PDI was found to be influenced by HLB value, treatment time, and Smix concentration. Antimicrobial analyses, including a zone of inhibition, minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), and time-kill kinetics assay, were performed against Escherichia coli, Staphylococcus aureus, and Saccharomyces cerevisiae. RESULT: The antimicrobial findings demonstrated that OEO exhibited higher antimicrobial activity compared to TEO (P<0.05). Meanwhile, the OEON and TEON substantially reduced the MIC and MBC values, compared to OEO and TEO against all tested microorganisms (P<0.05). Throughout the time-kill assay, E. coli was reduced by 5 log CFU/ml within 120 minutes, while S. cerevisiae and S. aureus were eradicated after 60 and 120 minutes of incubation with OEON, respectively. CONCLUSION: In turn, TEON reduced E. coli by 5 log CFU/ml and S. cerevisiae by 4 log CFU/ml within 120 minutes, while S. aureus was inhibited within the same time of incubation with TEON. The nanoemulsion formulations of OEO and TEO considerably enhanced the antimicrobial properties, which provides a promising alternative plant-derived antimicrobial for pharmaceuticals and food applications.","PeriodicalId":10944,"journal":{"name":"Current Nutrition & Food Science","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134969908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pankaj Prabhakar, Vijay Marakala, Dhanya Sacheendran, Thomas George, Rhea Katherine D'souza, Princy Louis Palatty, Manjeshwar Shrinath Baliga
{"title":"Ginger (ZingiberofficinaleRoscoe; family:Zingiberaceae) in Non-Alcoholic Fatty Liver Disease: review on the existing scientific evidence and way forward","authors":"Pankaj Prabhakar, Vijay Marakala, Dhanya Sacheendran, Thomas George, Rhea Katherine D'souza, Princy Louis Palatty, Manjeshwar Shrinath Baliga","doi":"10.2174/1573401319666230913122317","DOIUrl":"https://doi.org/10.2174/1573401319666230913122317","url":null,"abstract":"Abstract: Non-alcoholic fatty liver disease (NAFLD) is today the most prevalent hepatic disorder in the world. Although many pharmaceutical agents have been investigated for their potential to prevent or treat NAFLD, currently, there is no standard treatment to manage this ailment. Reports indicate that ginger and its phytochemicals gingerol and zingerone are effective in mitigating NAFLD in experimental study models. Furthermore, randomised control trials have demonstrated that ginger is also effective in preventing NAFLD in both adults and children. Mechanistic studies suggest that ginger mediates these beneficial effects by activating many pathways, such as reducing free radicals, dyslipidemia, and hepatic fat deposition. Concomitantly, ginger also increases antioxidant enzyme levels and insulin-sensitive effects, and all these pharmacological actions provide beneficial outcomes. In this review, the evidence from experimental and clinical trials has been emphasised. In addition, an attempt has been made to identify the gaps for future study to address for the benefit of the medical, pharmaceutical, nutraceutical, and agricultural businesses.","PeriodicalId":10944,"journal":{"name":"Current Nutrition & Food Science","volume":"65 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135783971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Natália Eirão Zulin, Carolina Garcia Martins, Márcia Helena Appel, Débora Salles da Silva Coutinho, Amanda Plaça Bialli, Daiana Milena Bronoski, Stephanie Rubianne Silva Carvalhal, Elisvania Freitas dos Santos, Paulo Sérgio Loubet Filho, Sandro José Ribeiro Bonatto, Luiz Cláudio Fernandes, Lucimara Mach Côrtes Cordeiro, Fabíola Iagher
{"title":"Guavira Fruit Pomace Promotes Immunomodulation and Reduction of Tumor Growth in Walker 256 Tumor-Bearing Rats","authors":"Natália Eirão Zulin, Carolina Garcia Martins, Márcia Helena Appel, Débora Salles da Silva Coutinho, Amanda Plaça Bialli, Daiana Milena Bronoski, Stephanie Rubianne Silva Carvalhal, Elisvania Freitas dos Santos, Paulo Sérgio Loubet Filho, Sandro José Ribeiro Bonatto, Luiz Cláudio Fernandes, Lucimara Mach Côrtes Cordeiro, Fabíola Iagher","doi":"10.2174/1573401319666230912105912","DOIUrl":"https://doi.org/10.2174/1573401319666230912105912","url":null,"abstract":"Background: Guavira fruit is widely used for juice extraction purposes, and this process generates large amounts of pomace (waste). Guavira pomace was dried and milled to produce guavira pomace flour (GPF), which is rich in antioxidants and dietary fibers (polysaccharides). These compounds are known for their immunomodulatory and antitumor effects. Objective: To investigate whether GPF intake promotes immunomodulation and reduces Walker 256 tumor growth in rats. Methods: GPF was provided to Wistar rats in two different models: 1) 15-day Model, according to which, Walker 256 tumor-bearing rats received GPF (63 mg/200 g b.w./day) simultaneously to tumor growth for 15 days; 2) 45-day Model, according to which, tumor-bearing rats received GPF for 30 days before tumor cell implantation, as well as during tumor growth - it totaled 45 days. After animals were euthanized, tumors were collected and weighed, and tumor cells were isolated for proliferation capacity determination ex vivo. Enzymatic/colorimetric methods were used to determine resident peritoneal macrophages’ functionality, whereas blood T and B lymphocytes were assayed for proliferation capacity, ex vivo, under stimuli Results: The 15-day Model did not show tumor mass or cell proliferation reduction in the treated group. GPF stimulated macrophage response in tumor-bearing and non-tumor-bearing rats. However, there was a substantial reduction in tumor mass and tumor cell proliferation under the 45-day Model. Macrophage and lymphocyte response decreased; it suggested that GPF can directly act in the tumor. Conclusion: Based on these findings, GPF has immunomodulatory and antitumor actions, and ingestion time plays a key role in them.","PeriodicalId":10944,"journal":{"name":"Current Nutrition & Food Science","volume":"64 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135885455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Potential of Non-dairy Kefir Products: Their Health Benefits, Physiochemical, Sensory, and Bioactive Properties","authors":"Inas Zahidah, Sibel Bölek","doi":"10.2174/1573401319666230809141544","DOIUrl":"https://doi.org/10.2174/1573401319666230809141544","url":null,"abstract":"Abstract: The consumption of functional foods increases with the rising healthy lifestyle trends among the public. Kefir is taken into account as a potential functional food as it contains a large variety of beneficial microorganisms and bioactive compounds.. Non-dairy kefir has been developed to meet the needs of consumers with several limitations, such as milk protein allergies and lactose intolerance or vegan consumers. Various ingredients such as plant-based milk, fruits, and vegetable extracts used in non-dairy kefir can provide a variety of bioactive compounds wider than cow’s milk, such as fiber, unsaturated fatty acids, and higher antioxidant properties, as well as probiotic properties. This review presents non-dairy kefir alternatives with potential health benefits as well as the chemical and physical reactions occur during the fermentation process effecting sensory properties.","PeriodicalId":10944,"journal":{"name":"Current Nutrition & Food Science","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135205218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Nutraceuticals: New Perspective and Approach to Prevent Dysmenorrhea","authors":"Ankita Wal, Pranay Wal, Divyanshi Gupta, Nisha Sharma, Shiva Mishra, Kritika Sachan, Jyoti Sharma","doi":"10.2174/1573401319666230727142047","DOIUrl":"https://doi.org/10.2174/1573401319666230727142047","url":null,"abstract":"Background: The words \"nutrition\" and \"pharmaceutical\" are combined to form the phrase \"nutraceutical.\" Nutraceuticals are foods or dietary components that have an important role in regulating and sustaining normal physiological function in humans. For the treatment of dysmenorrhoea, a variety of pharmacological medications are available, however, they all have significant side effects. Dietary supplements and lifestyle management, on the other hand, were found to have a major influence on the occurrence and control of dysmenorrhea. Objective: The objective of this paper is to study a comprehensive review of the dietary and nutritional supplements with special emphasis on dysmenorrhea. This paper focuses on understanding and interpreting the details of menstrual pain and its effective nutritional diet that can be used as a treatment for avoiding menstrual discomfort. Methods: The selection of data has been done by studying a combination of various research and review papers from different databases like PubMed, NCBI, Science Direct, WHO, Cochrane Library, and Web of Science from the year 2000-2022. Results: Based on various papers and literature reviews, we have concluded about various dietary supplements and herbs that can be used to avoid pain during mensuration followed by its all-daily requirement of nutrition on different age groups and efficacy of treatments. Conclusion: According to current evidence, young women should be instructed in the proper use of dietary supplements, nutrition, and vitamins, as well as the inclusion of effective diet and lifestyle changes such as exercise and a well-balanced diet with adequate nutrition, as these are likely to reduce the negative effects of dysmenorrhea.","PeriodicalId":10944,"journal":{"name":"Current Nutrition & Food Science","volume":"59 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135755448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hamid Reza Sayevand, Farzaneh Bakhtiary, Neda Mollakhalili-Meybodi, Amir M. Mortazavian
{"title":"Industrial Doogh: Technological and Health Aspects","authors":"Hamid Reza Sayevand, Farzaneh Bakhtiary, Neda Mollakhalili-Meybodi, Amir M. Mortazavian","doi":"10.2174/1573401318666220426102043","DOIUrl":"https://doi.org/10.2174/1573401318666220426102043","url":null,"abstract":"Abstract: As a typical and ancient Iranian drink based on fermented milk, Doogh is normally produced from yogurt, drinking water, salt, and flavoring agents on both traditional and industrial scales. Referring to the large production and consumption of Doogh in many countries and the adoption of its Codex standard (2018), considering its technological and health (nutritional and safety) aspects is of special importance. There is versatility and variety in ingredients, production methods, and packaging of Doogh that can affect the physicochemical (i.e., physical, chemical, and rheological) sensory, nutritional, and safety characteristics of the product. On the other hand, its shelf life is regularly an extended shelf life (>2 months) which can be challenging from a technological point of view. This article comprehensively reviews the technological and health aspects of industrial Doogh.","PeriodicalId":10944,"journal":{"name":"Current Nutrition & Food Science","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135702910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}