Current Diabetes Reports最新文献_第2页

Implementation Science and Pediatric Diabetes: A Scoping Review of the State of the Literature and Recommendations for Future Research. 实施科学与儿童糖尿病：文献现状范围综述及未来研究建议》（A Scoping Review of the State of the Literature and Recommendations for Future Research）。

IF 5.2 2区医学

Current Diabetes Reports Pub Date : 2024-10-29 DOI: 10.1007/s11892-024-01561-3

Julia Price, Jaclynn Hawkins, Daniel J Amante, Richard James, Debra Haire-Joshu

{"title":"Implementation Science and Pediatric Diabetes: A Scoping Review of the State of the Literature and Recommendations for Future Research.","authors":"Julia Price, Jaclynn Hawkins, Daniel J Amante, Richard James, Debra Haire-Joshu","doi":"10.1007/s11892-024-01561-3","DOIUrl":"10.1007/s11892-024-01561-3","url":null,"abstract":"Purpose of review: This scoping review aimed to identify implementation science (IS) research in pediatric diabetes, report integration of IS theory and terminology, and offer guidance for future research.Recent findings: Of 23 papers identified, 19 were published since 2017 and 21 focused on type 1 diabetes. Most involved medical evidence-based practices (EBPs; n = 15), whereas fewer focused on psychosocial (n = 7) and diabetes education (n = 2). The majority either identified barriers and facilitators of implementing an EBP (n = 11) or were implementation trials (n = 11). Fewer studies documented gaps in EBP implementation in standard care (n = 7) or development of implementation strategies (n = 1). Five papers employed IS theories and two aimed to improve equity. There is a paucity of IS research in pediatric diabetes care literature. Few papers employed IS theory, used consistent IS terminology, or described IS strategies or outcomes. Guidance for future research to improve IS research in pediatric diabetes is offered.","PeriodicalId":10898,"journal":{"name":"Current Diabetes Reports","volume":"25 1","pages":"2"},"PeriodicalIF":5.2,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11522144/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142544276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Digitally Enabled Peer Support Interventions on Diabetes Distress and Depressive Symptoms in People Living with Type 1 Diabetes: A Systematic Review. 数字化同伴支持干预对 1 型糖尿病患者糖尿病困扰和抑郁症状的影响：系统回顾

IF 5.2 2区医学

Current Diabetes Reports Pub Date : 2024-10-28 DOI: 10.1007/s11892-024-01560-4

Titilola I Yakubu, Samantha Pawer, Nicholas C West, Tricia S Tang, Matthias Görges

{"title":"Impact of Digitally Enabled Peer Support Interventions on Diabetes Distress and Depressive Symptoms in People Living with Type 1 Diabetes: A Systematic Review.","authors":"Titilola I Yakubu, Samantha Pawer, Nicholas C West, Tricia S Tang, Matthias Görges","doi":"10.1007/s11892-024-01560-4","DOIUrl":"10.1007/s11892-024-01560-4","url":null,"abstract":"Purpose of review: To explore the impact of digitally-enabled peer support interventions on diabetes distress and depression for individuals living with Type 1 Diabetes (T1D).Recent findings: We synthesized the results of nine key studies from a review of 3,623 English-language articles published between January 2012 and January 2024. Three studies demonstrated significant reductions in diabetes distress, and two studies reported reductions in depression. Data were analyzed using a narrative approach, including thematic synthesis. This process was structured around the Behavior Change Wheel framework Effective interventions shared several common features such as (1) involved participatory development approaches, (2) included diabetes education, (3) lasted over a longer time, (4) designed with a psychological framework, and (5) utilized peer mentors. Studies showed that digitally-enabled peer support has the potential to improve diabetes distress and depression among people living with T1D despite heterogeneity in intervention approaches. Moreover, designing interventions with certain features may enhance key psychosocial outcomes.","PeriodicalId":10898,"journal":{"name":"Current Diabetes Reports","volume":"25 1","pages":"1"},"PeriodicalIF":5.2,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142544275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Are we Ready for Real-Time Continuous Glucose Monitoring in the Hospital Setting? Benefits, Challenges, and Practical Approaches for Implementation : Case Vignette: Remote Real-Time Continuous Glucose Monitoring for Hospitalized Care in Quincy Koala. 我们准备好在医院环境中进行实时连续血糖监测了吗？实施的优势、挑战和实用方法：案例小故事：昆西考拉住院护理中的远程实时连续血糖监测。

IF 5.2 2区医学

Current Diabetes Reports Pub Date : 2024-10-01 Epub Date: 2024-08-10 DOI: 10.1007/s11892-024-01549-z

Athena Philis-Tsimikas, Emily Rose N San Diego, Lauren Vincent, Suzanne Lohnes, Cora Singleton

{"title":"Are we Ready for Real-Time Continuous Glucose Monitoring in the Hospital Setting? Benefits, Challenges, and Practical Approaches for Implementation : Case Vignette: Remote Real-Time Continuous Glucose Monitoring for Hospitalized Care in Quincy Koala.","authors":"Athena Philis-Tsimikas, Emily Rose N San Diego, Lauren Vincent, Suzanne Lohnes, Cora Singleton","doi":"10.1007/s11892-024-01549-z","DOIUrl":"10.1007/s11892-024-01549-z","url":null,"abstract":"Purpose of review: While preliminary evidence for use of real-time continuous glucose monitoring (rtCGM) in the hospital setting is encouraging, challenges with currently available devices and technology will need to be overcome as part of real-world integration. This paper reviews the current evidence and guidelines regarding use of rtCGM in the hospital and suggests a practical approach to implementation.Recent findings: There is now a considerable body of real-world evidence on the benefits of reducing dysglycemia in the hospital using both traditional point-of-care (POC) glucose testing and rtCGM. Benefits of rtCGM include decreased frequency of hypo- and hyperglycemia with reduced need of frequent POC checks and it is both feasible and well-accepted by nursing staff and providers. If expansion to additional sites is to be considered, practical solutions will need to be offered. Recommendations for an operational workflow and tools are described to guide implementation in the non-ICU setting. Further testing in randomized controlled trials and real-world dissemination and implementation designs is needed, together with industry and technology collaborations, to further streamline the integration into health systems.","PeriodicalId":10898,"journal":{"name":"Current Diabetes Reports","volume":" ","pages":"217-226"},"PeriodicalIF":5.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141912106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Precision Interventions Targeting the Maternal Metabolic Milieu for Healthy Pregnancies in Obesity. 针对母体代谢环境进行精准干预，促进肥胖孕妇健康怀孕。

IF 5.2 2区医学

Current Diabetes Reports Pub Date : 2024-10-01 Epub Date: 2024-08-20 DOI: 10.1007/s11892-024-01550-6

Alexandra M Niclou, Hannah E Cabre, Emily W Flanagan, Leanne M Redman

{"title":"Precision Interventions Targeting the Maternal Metabolic Milieu for Healthy Pregnancies in Obesity.","authors":"Alexandra M Niclou, Hannah E Cabre, Emily W Flanagan, Leanne M Redman","doi":"10.1007/s11892-024-01550-6","DOIUrl":"10.1007/s11892-024-01550-6","url":null,"abstract":"Purpose of review: Entering pregnancy with obesity increases the risk of adverse health outcomes for parent and child. As such, research interventions are largely focused on limiting excess gestational weight gain during pregnancy, especially in those with obesity. Yet, while many lifestyle interventions are successful in reducing GWG, few affect pregnancy outcomes. Here we review work targeting the metabolic milieu instead of focusing solely on weight.Recent findings: Work done in non-pregnant populations suggests that specifically targeting glucose, triglyceride, and leptin levels or inflammatory makers improves the metabolic milieu and overall health. We posit that precision interventions that include strategies such as time restricted eating, following the 24 h movement guidelines, or reducing sedentary behavior during pregnancy can be successful approaches benefiting the maternal metabolic milieu and minimize the risk of adverse pregnancy outcomes. Personalized tools such as continuous glucose monitors or community-based approaches play an important role in pre-conception health and should be extrapolated to pregnancy interventions to directly benefit the metabolic milieu optimizing health outcomes for both parent and child.","PeriodicalId":10898,"journal":{"name":"Current Diabetes Reports","volume":" ","pages":"227-235"},"PeriodicalIF":5.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142003828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Elusive Nature of ABCC8-related Maturity-Onset Diabetes of the Young (ABCC8-MODY). A Review of the Literature and Case Discussion. ABCC8相关青年成熟期发病糖尿病（ABCC8-MODY）的神秘性。文献综述与病例讨论。

IF 5.2 2区医学

Current Diabetes Reports Pub Date : 2024-09-01 Epub Date: 2024-07-09 DOI: 10.1007/s11892-024-01547-1

Marella Marassi, Mario Luca Morieri, Viola Sanga, Giulio Ceolotto, Angelo Avogaro, Gian Paolo Fadini

{"title":"The Elusive Nature of ABCC8-related Maturity-Onset Diabetes of the Young (ABCC8-MODY). A Review of the Literature and Case Discussion.","authors":"Marella Marassi, Mario Luca Morieri, Viola Sanga, Giulio Ceolotto, Angelo Avogaro, Gian Paolo Fadini","doi":"10.1007/s11892-024-01547-1","DOIUrl":"10.1007/s11892-024-01547-1","url":null,"abstract":"Purpose of review: Maturity-onset diabetes of the young (MODY) are monogenic forms of diabetes resulting from genetic defects, usually transmitted in an autosomal dominant fashion, leading to β-cell dysfunction. Due to the lack of homogeneous clinical features and univocal diagnostic criteria, MODY is often misdiagnosed as type 1 or type 2 diabetes, hence its diagnosis relies mostly on genetic testing. Fourteen subtypes of MODY have been described to date. Here, we review ABCC8-MODY pathophysiology, genetic and clinical features, and current therapeutic options.Recent findings: ABCC8-MODY is caused by mutations in the adenosine triphosphate (ATP)-binding cassette transporter subfamily C member 8 (ABCC8) gene, involved in the regulation of insulin secretion. The complexity of ABCC8-MODY genetic picture is mirrored by a variety of clinical manifestations, encompassing a wide spectrum of disease severity. Such inconsistency of genotype-phenotype correlation has not been fully understood. A correct diagnosis is crucial for the choice of adequate treatment and outcome improvement. By targeting the defective gene product, sulfonylureas are the preferred medications in ABCC8-MODY, although efficacy vary substantially. We illustrate three case reports in whom a diagnosis of ABCC8-MODY was suspected after the identification of novel ABCC8 variants that turned out to be of unknown significance. We discuss that careful interpretation of genetic testing is needed even on the background of a suggestive clinical context. We highlight the need for further research to unravel ABCC8-MODY disease mechanisms, as well as to clarify the pathogenicity of identified ABCC8 variants and their influence on clinical presentation and response to therapy.","PeriodicalId":10898,"journal":{"name":"Current Diabetes Reports","volume":" ","pages":"197-206"},"PeriodicalIF":5.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11303576/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141558337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lifestyle Intervention in Reducing Insulin Resistance and Preventing type 2 Diabetes in Asia Pacific Region: A Systematic Review and Meta-Analysis. 亚太地区减少胰岛素抵抗和预防 2 型糖尿病的生活方式干预：系统回顾与元分析》。

IF 5.2 2区医学

Current Diabetes Reports Pub Date : 2024-09-01 Epub Date: 2024-07-31 DOI: 10.1007/s11892-024-01548-0

Yingting Cao, Abha Shrestha, Amy Janiczak, Xia Li, Yang Lu, Tilahun Haregu

{"title":"Lifestyle Intervention in Reducing Insulin Resistance and Preventing type 2 Diabetes in Asia Pacific Region: A Systematic Review and Meta-Analysis.","authors":"Yingting Cao, Abha Shrestha, Amy Janiczak, Xia Li, Yang Lu, Tilahun Haregu","doi":"10.1007/s11892-024-01548-0","DOIUrl":"10.1007/s11892-024-01548-0","url":null,"abstract":"Purpose of review: To update the evidence of lifestyle interventions for the prevention of type 2 diabetes mellites (T2DM) in adults, particularly in the Asia Pacific region. The key questions to ask are: 1) How effective are lifestyle interventions in preventing T2DM among at-risk adults in the Asia Pacific Region? 2)What are the key characteristics of the implementation of lifestyle interventions for diabetes prevention?Recent findings: Lifestyle interventions for the prevention of T2DM have been suggested to be effective. There is evidence of ethnic differences in some glycaemic and anthropometric outcomes. The meta-analysis suggested a significant result in reducing waist circumference (standardised mean difference - 019, 95%CI ( -0.31, -0.06)), and no significant effects in other outcomes. However, the implementation outcomes suggested lifestyle intervention might be a cost-effective and sustainable approach in T2DM particularly in countries in the Asia Pacific Region. The focus of lifestyle intervention in the Asia Pacific Region should not only lie in the effectiveness of the trial but a thorough evaluation of the implementation outcomes, as well as cultural adaptations, with the support of all stakeholders through all stages of the implementation.","PeriodicalId":10898,"journal":{"name":"Current Diabetes Reports","volume":" ","pages":"207-215"},"PeriodicalIF":5.2,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11303493/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141855102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Youth-onset Type 2 Diabetes: An Overview of Pathophysiology, Prognosis, Prevention and Management. 青少年发病的 2 型糖尿病：病理生理学、预后、预防和管理概述。

IF 5.2 2区医学

Current Diabetes Reports Pub Date : 2024-08-01 Epub Date: 2024-07-03 DOI: 10.1007/s11892-024-01546-2

Angela Titmuss, Sophy Korula, Brandy Wicklow, Kristen J Nadeau

{"title":"Youth-onset Type 2 Diabetes: An Overview of Pathophysiology, Prognosis, Prevention and Management.","authors":"Angela Titmuss, Sophy Korula, Brandy Wicklow, Kristen J Nadeau","doi":"10.1007/s11892-024-01546-2","DOIUrl":"10.1007/s11892-024-01546-2","url":null,"abstract":"Purpose of review: This review explores the emerging evidence regarding pathogenesis, future trajectories, treatment options, and phenotypes of youth-onset type 2 diabetes (T2D).Recent findings: Youth-onset T2D is increasing in incidence and prevalence worldwide, disproportionately affecting First Nations communities, socioeconomically disadvantaged youth, and people of colour. Youth-onset T2D differs in pathogenesis to later-onset T2D and progresses more rapidly. It is associated with more complications, and these occur earlier. While there are limited licensed treatment options available, the available medications also appear to have a poorer response in youth with T2D. Multiple interacting factors likely contribute to this rising prevalence, as well as the increased severity of the condition, including structural inequities, increasing obesity and sedentary lifestyles, and intergenerational transmission from in-utero exposure to maternal hyperglycemia and obesity. Youth-onset T2D is also associated with stigma and poorer mental health, and these impact clinical management. There is an urgent need to develop effective interventions to prevent youth-onset T2D and enhance engagement of affected youth. It is also critical to better understand the differing phenotypes of youth-onset T2D, to effectively target treatments, and to address intergenerational transmission in high-risk populations.","PeriodicalId":10898,"journal":{"name":"Current Diabetes Reports","volume":" ","pages":"183-195"},"PeriodicalIF":5.2,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11269415/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141491207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Review Article - Diabetes Technology in the Hospital: An Update. 评论文章--医院中的糖尿病技术：最新进展。

IF 5.2 2区医学

Current Diabetes Reports Pub Date : 2024-08-01 Epub Date: 2024-06-06 DOI: 10.1007/s11892-024-01545-3

Margaretha M Visser, Roman Vangoitsenhoven, Pieter Gillard, Chantal Mathieu

{"title":"Review Article - Diabetes Technology in the Hospital: An Update.","authors":"Margaretha M Visser, Roman Vangoitsenhoven, Pieter Gillard, Chantal Mathieu","doi":"10.1007/s11892-024-01545-3","DOIUrl":"10.1007/s11892-024-01545-3","url":null,"abstract":"Purpose of review: There have been many developments in diabetes technology in recent years, with continuous glucose monitoring (CGM), insulin pump therapy (CSII) and automated insulin delivery (AID) becoming progressively accepted in outpatient diabetes care. However, the use of such advanced diabetes technology in the inpatient setting is still limited for several reasons, including logistical challenges and staff training needs. On the other hand, hospital settings with altered diet and stress-induced hyperglycemia often pose challenges to tight glycemic control using conventional treatment tools. Integrating smarter glucose monitoring and insulin delivery devices into the increasingly technical hospital environment could reduce diabetes-related morbidity and mortality. This narrative review describes the most recent literature on the use of diabetes technology in the hospital and suggests avenues for further research.Recent findings: Advanced diabetes technology has the potential to improve glycemic control in hospitalized people with and without diabetes, and could add particular value in certain conditions, such as nutrition therapy or perioperative management. Taken together, CGM allows for more accurate and patient-friendly follow-up and ad hoc titration of therapy. AID may also provide benefits, including improved glycemic control and reduced nursing workload. Before advanced diabetes technology can be used on a large scale in the hospital, further research is needed on efficacy, accuracy and safety, while implementation factors such as cost and staff training must also be overcome.","PeriodicalId":10898,"journal":{"name":"Current Diabetes Reports","volume":" ","pages":"173-182"},"PeriodicalIF":5.2,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141260444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metabolic dysfunction-associated steatotic liver disease and atherosclerosis. 代谢功能障碍与脂肪肝和动脉粥样硬化有关。

IF 5.2 2区医学

Current Diabetes Reports Pub Date : 2024-07-01 Epub Date: 2024-05-03 DOI: 10.1007/s11892-024-01542-6

Yulino Castillo-Núñez, Paloma Almeda-Valdes, Guillermo González-Gálvez, María Del Rosario Arechavaleta-Granell

{"title":"Metabolic dysfunction-associated steatotic liver disease and atherosclerosis.","authors":"Yulino Castillo-Núñez, Paloma Almeda-Valdes, Guillermo González-Gálvez, María Del Rosario Arechavaleta-Granell","doi":"10.1007/s11892-024-01542-6","DOIUrl":"10.1007/s11892-024-01542-6","url":null,"abstract":"Purpose of review: To update information about the relationship between metabolic dysfunction-associated steatotic liver disease (MASLD) and atherosclerosis. This review emphasizes the potential mechanisms linking MASLD with atherosclerosis and the possible causal relationships between these conditions.Recent findings: An increased risk of cardiovascular disease is related to MASLD. Several molecular, cellular, and metabolic mechanisms have been described to explain the development of atherothrombosis in MASLD patients. These include atherogenic dyslipidemia, low-grade vascular inflammation, endothelial dysfunction, foam cell formation, proliferation of vascular smooth muscle cells, insulin resistance, gut microbiota dysbiosis, activation of renin-angiotensin and sympathetic nervous systems, hypercoagulability, and decreased fibrinolysis. Also, there is recent evidence suggesting an association between genetically driven liver fat and coronary heart disease mediated by the causal effect of apoB-containing lipoproteins. Several meta-analyses and systematic reviews have reported a strong association between MASLD and cardiovascular outcomes. MASLD is an important and independent risk factor for atherosclerosis development. Multiple mechanisms may be involved in this association. Further research is required to establish a causal association between MASLD and atherosclerosis.","PeriodicalId":10898,"journal":{"name":"Current Diabetes Reports","volume":" ","pages":"158-166"},"PeriodicalIF":5.2,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140854628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the Interplay between Diabetes and Lp(a): Implications for Cardiovascular Risk. 探索糖尿病与脂蛋白（a）之间的相互作用：对心血管风险的影响。

IF 5.2 2区医学

Current Diabetes Reports Pub Date : 2024-07-01 Epub Date: 2024-05-28 DOI: 10.1007/s11892-024-01543-5

Corral Pablo, Arrupe Matías, Augusto Lavalle Cobo, Gimenez Sergio, Renna Nicolás Federico

{"title":"Exploring the Interplay between Diabetes and Lp(a): Implications for Cardiovascular Risk.","authors":"Corral Pablo, Arrupe Matías, Augusto Lavalle Cobo, Gimenez Sergio, Renna Nicolás Federico","doi":"10.1007/s11892-024-01543-5","DOIUrl":"10.1007/s11892-024-01543-5","url":null,"abstract":"Purpose of review: The objective of this manuscript is to review and describe the relationship between Lp(a) and diabetes, exploring both their association and synergy as cardiovascular risk factors, while also describing the current evidence regarding the potential connection between low levels of Lp(a) and the presence of diabetes.Recent findings: Epidemiological studies suggest a potential relationship between low to very low levels of Lp(a) and diabetes. Lipoprotein(a), or Lp(a), is an intriguing lipoprotein of genetic origin, yet its biological function remains unknown. Elevated levels of Lp(a) are associated with an increased risk of cardiovascular atherosclerosis, and coexisting diabetes status confers an even higher risk. On the other hand, epidemiological and genetic studies have paradoxically suggested a potential relationship between low to very low levels of Lp(a) and diabetes. While new pharmacological strategies are being developed to reduce Lp(a) levels, the dual aspects of this lipoprotein's behavior need to be elucidated in the near future.","PeriodicalId":10898,"journal":{"name":"Current Diabetes Reports","volume":" ","pages":"167-172"},"PeriodicalIF":5.2,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141158108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0