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Type 2 Diabetes and the Lung - Cause and Consequence. 2型糖尿病与肺部——原因和后果。
IF 6.4 2区 医学
Current Diabetes Reports Pub Date : 2026-05-07 DOI: 10.1007/s11892-026-01625-6
Dinah Foer, Tianshi David Wu, Juan C Celedón, M Furkan Burak, Vanita R Aroda
{"title":"Type 2 Diabetes and the Lung - Cause and Consequence.","authors":"Dinah Foer, Tianshi David Wu, Juan C Celedón, M Furkan Burak, Vanita R Aroda","doi":"10.1007/s11892-026-01625-6","DOIUrl":"https://doi.org/10.1007/s11892-026-01625-6","url":null,"abstract":"<p><strong>Purpose of review: </strong>The purpose of this review is to synthesize literature investigating the relationship between type 2 diabetes (T2D) and obstructive airway diseases and to identify implications for clinical care.</p><p><strong>Recent findings: </strong>Type 2 diabetes is a common and challenging comorbidity in patients with asthma and chronic obstructive pulmonary disease (COPD). Basic, translational and clinical studies support a bidirectional association between T2D and the lung. In animal models and human studies, insulin resistance and hyperglycemia are associated with pulmonary inflammation, respiratory exacerbation risk and disease severity. Corticosteroids are a mainstay for respiratory disease control and exacerbation treatment but promote ongoing metabolic dysregulation. Randomized, placebo-controlled trials of glucose-lowering medications for asthma are actively ongoing. Additional studies addressing clinical pathways to co-manage respiratory and metabolic risk are needed. Patients with comorbid T2D and asthma or COPD are at risk for worse outcomes. There are opportunities to improve cross-disciplinary care, potentially reducing risk and multimorbidity associated with both conditions.</p>","PeriodicalId":10898,"journal":{"name":"Current Diabetes Reports","volume":"26 1","pages":""},"PeriodicalIF":6.4,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pharmacologic Treatment of Obesity in the Context of Type 2 Diabetes. 2型糖尿病肥胖的药物治疗
IF 6.4 2区 医学
Current Diabetes Reports Pub Date : 2026-04-13 DOI: 10.1007/s11892-026-01626-5
Caterina Conte, Anastassia Amaro
{"title":"Pharmacologic Treatment of Obesity in the Context of Type 2 Diabetes.","authors":"Caterina Conte, Anastassia Amaro","doi":"10.1007/s11892-026-01626-5","DOIUrl":"https://doi.org/10.1007/s11892-026-01626-5","url":null,"abstract":"<p><strong>Purpose of review: </strong>To examine the role of pharmacologic obesity treatment in people with type 2 diabetes (T2D), with a focus on efficacy, safety, and clinical positioning in the context of T2D-specific metabolic and therapeutic challenges.</p><p><strong>Recent findings: </strong>Contemporary incretin receptor agonists enable clinically meaningful weight loss in people with T2D while improving glycemic control and cardio-renal, hepatic, and functional outcomes, including improvements in physical performance and symptoms in heart failure with preserved ejection fraction (HFpEF). However, weight loss is consistently attenuated compared with obesity without diabetes, reflecting reduced metabolic flexibility (impaired ability to appropriately adjust fuel utilization), background therapies, and social determinants of health rather than treatment failure. Obesity pharmacotherapy should be considered a disease-modifying component of T2D care. Treatment success should be defined by improvements in adiposity-related complications, organ protection, and patient-centered outcomes, not by fixed weight-loss thresholds. A complication-focused, individualized approach is essential to optimize long-term benefit in T2D.</p>","PeriodicalId":10898,"journal":{"name":"Current Diabetes Reports","volume":"26 1","pages":""},"PeriodicalIF":6.4,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147671049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dysregulation of the Gut-Adipose Tissue-Liver Axis: a Possible Mechanism Behind the Relationship Between Metabolic Dysfunction-Associated Steatotic Liver Disease and Type 2 Diabetes. 肠-脂肪组织-肝轴的失调：代谢功能障碍相关的脂肪变性肝病与2型糖尿病之间关系的可能机制
IF 6.4 2区 医学
Current Diabetes Reports Pub Date : 2026-04-11 DOI: 10.1007/s11892-026-01623-8
Susanna Longo, Tommaso Giovanni Rinaldi, Jose Manuel Fernández-Real, Massimo Federici
{"title":"Dysregulation of the Gut-Adipose Tissue-Liver Axis: a Possible Mechanism Behind the Relationship Between Metabolic Dysfunction-Associated Steatotic Liver Disease and Type 2 Diabetes.","authors":"Susanna Longo, Tommaso Giovanni Rinaldi, Jose Manuel Fernández-Real, Massimo Federici","doi":"10.1007/s11892-026-01623-8","DOIUrl":"10.1007/s11892-026-01623-8","url":null,"abstract":"<p><strong>Purpose of review: </strong>Metabolic dysfunction-associated steatotic liver disease (MASLD) is a hepatic manifestation of metabolic syndrome, frequently occurring alongside type 2 diabetes (T2D), and it can present in varied phenotypes. This review provides a critical analysis of gut-adipose tissue-liver axis (GALA) dysregulation in MASLD pathogenesis, contextualizing the discussion within both established and emerging paradigms. The review elucidates how GALA dysregulation shapes the interplay between MASLD and T2D, emphasizing inter-organ crosstalk among the gut, liver, and adipose tissue, and highlighting the role of microbial metabolites, notably bile acids. The review further summarizes recent advances in stratifying MASLD into distinct clusters, examining intricate associations with cardiometabolic comorbidities, and critically evaluates novel therapeutic approaches targeting GALA modulation.</p><p><strong>Recent findings: </strong>MASLD can show heterogeneous phenotypes. It significantly increases the risk of developing new-onset T2D, and both conditions often coexist due to their shared pathophysiological basis in insulin resistance. The gut microbiota influences immune function and modulates host metabolism by regulating glucose tolerance and insulin sensitivity through a specific crosstalk between the gut, liver, and adipose tissue. The dysregulation of the GALA may be a mechanism underlying the interplay between MASLD and T2D, influencing IR and metabolic syndrome. A thorough investigation of GALA's role in the physiopathogenesis of MASLD and T2D highlights its potential to distinguish specific MASLD clusters and to identify personalized therapeutic strategies.</p>","PeriodicalId":10898,"journal":{"name":"Current Diabetes Reports","volume":"26 1","pages":""},"PeriodicalIF":6.4,"publicationDate":"2026-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13070062/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147662529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction: Glucagon-Like Peptide-1 and Dual Incretin Agonists in Type 2 Diabetes with Peripheral Artery Disease: A Systematic Review and Meta-Analysis of Vascular, Cardiovascular, Metabolic, and Mortality Outcomes. 更正：胰高血糖素样肽-1和双重肠促胰岛素激动剂治疗伴有外周动脉疾病的2型糖尿病：血管、心血管、代谢和死亡率结局的系统回顾和荟萃分析。
IF 6.4 2区 医学
Current Diabetes Reports Pub Date : 2026-04-10 DOI: 10.1007/s11892-026-01622-9
Larissa Araújo de Lucena, Deivyd V S Cavalcante, Marcela V Montenegro, Larissa C Hespanhol, William S de Oliveira, Juliana Q Muniz, Sruti Prathivadhi-Bhayankaram, Edgardo Kaplinsky, Alejandro Barbagelata, Juliana Giorgi
{"title":"Correction: Glucagon-Like Peptide-1 and Dual Incretin Agonists in Type 2 Diabetes with Peripheral Artery Disease: A Systematic Review and Meta-Analysis of Vascular, Cardiovascular, Metabolic, and Mortality Outcomes.","authors":"Larissa Araújo de Lucena, Deivyd V S Cavalcante, Marcela V Montenegro, Larissa C Hespanhol, William S de Oliveira, Juliana Q Muniz, Sruti Prathivadhi-Bhayankaram, Edgardo Kaplinsky, Alejandro Barbagelata, Juliana Giorgi","doi":"10.1007/s11892-026-01622-9","DOIUrl":"https://doi.org/10.1007/s11892-026-01622-9","url":null,"abstract":"","PeriodicalId":10898,"journal":{"name":"Current Diabetes Reports","volume":"26 1","pages":""},"PeriodicalIF":6.4,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147644457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lipolysis in Health and Disease: Pathways, Regulation, and Metabolic Consequences. 健康和疾病中的脂肪分解：途径、调节和代谢后果。
IF 6.4 2区 医学
Current Diabetes Reports Pub Date : 2026-04-10 DOI: 10.1007/s11892-026-01624-7
Courtney L Bordelon, Jacqueline M Stephens
{"title":"Lipolysis in Health and Disease: Pathways, Regulation, and Metabolic Consequences.","authors":"Courtney L Bordelon, Jacqueline M Stephens","doi":"10.1007/s11892-026-01624-7","DOIUrl":"10.1007/s11892-026-01624-7","url":null,"abstract":"","PeriodicalId":10898,"journal":{"name":"Current Diabetes Reports","volume":"26 1","pages":""},"PeriodicalIF":6.4,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13068693/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147644453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Review of the Fear of Hypoglycemia Literature in Children and Adolescents with Type 1 Diabetes and their Caregivers. 儿童和青少年1型糖尿病患者及其照护者对低血糖的恐惧文献综述
IF 6.4 2区 医学
Current Diabetes Reports Pub Date : 2026-03-23 DOI: 10.1007/s11892-026-01620-x
Kimberly A Driscoll, Paige J Trojanowski, Emily R Shaffer, Hannah Manis, Alicia Pardon, Cheyenne M Reynolds, Sara E Wetter-Wren, Holly K O'Donnell, Susana R Patton
{"title":"A Review of the Fear of Hypoglycemia Literature in Children and Adolescents with Type 1 Diabetes and their Caregivers.","authors":"Kimberly A Driscoll, Paige J Trojanowski, Emily R Shaffer, Hannah Manis, Alicia Pardon, Cheyenne M Reynolds, Sara E Wetter-Wren, Holly K O'Donnell, Susana R Patton","doi":"10.1007/s11892-026-01620-x","DOIUrl":"10.1007/s11892-026-01620-x","url":null,"abstract":"","PeriodicalId":10898,"journal":{"name":"Current Diabetes Reports","volume":"26 1","pages":""},"PeriodicalIF":6.4,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13009079/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147503334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pharmacologic Treatment of Metabolic Dysfunction-Associated Steatotic Liver Disease in the Context of Type 2 Diabetes. 2型糖尿病患者代谢功能障碍相关脂肪变性肝病的药物治疗
IF 6.4 2区 医学
Current Diabetes Reports Pub Date : 2026-03-14 DOI: 10.1007/s11892-026-01621-w
Konstantinos Malandris, Konstantinos Charalampidis, Rohit Loomba, Emmanouil Sinakos
{"title":"Pharmacologic Treatment of Metabolic Dysfunction-Associated Steatotic Liver Disease in the Context of Type 2 Diabetes.","authors":"Konstantinos Malandris, Konstantinos Charalampidis, Rohit Loomba, Emmanouil Sinakos","doi":"10.1007/s11892-026-01621-w","DOIUrl":"10.1007/s11892-026-01621-w","url":null,"abstract":"","PeriodicalId":10898,"journal":{"name":"Current Diabetes Reports","volume":"26 1","pages":""},"PeriodicalIF":6.4,"publicationDate":"2026-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12989002/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147456277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Glucagon-Like Peptide-1 and Dual Incretin Agonists in Type 2 Diabetes with Peripheral Artery Disease: A Systematic Review and Meta-Analysis of Vascular, Cardiovascular, Metabolic, and Mortality Outcomes : Incretin Therapy in T2DM and PAD. 胰高血糖素样肽-1和双重肠促胰岛素激动剂治疗伴有外周动脉疾病的2型糖尿病：血管、心血管、代谢和死亡率结局的系统回顾和荟萃分析：肠促胰岛素治疗T2DM和PAD
IF 6.4 2区 医学
Current Diabetes Reports Pub Date : 2026-03-10 DOI: 10.1007/s11892-026-01619-4
Larissa Araújo de Lucena, Deivyd V S Cavalcante, Marcela V Montenegro, Larissa C Hespanhol, William S de Oliveira, Juliana Q Muniz, Sruti Prathivadhi-Bhayankaram, Edgardo Kaplinsky, Alejandro Barbagelata, Juliana Giorgi
{"title":"Glucagon-Like Peptide-1 and Dual Incretin Agonists in Type 2 Diabetes with Peripheral Artery Disease: A Systematic Review and Meta-Analysis of Vascular, Cardiovascular, Metabolic, and Mortality Outcomes : Incretin Therapy in T2DM and PAD.","authors":"Larissa Araújo de Lucena, Deivyd V S Cavalcante, Marcela V Montenegro, Larissa C Hespanhol, William S de Oliveira, Juliana Q Muniz, Sruti Prathivadhi-Bhayankaram, Edgardo Kaplinsky, Alejandro Barbagelata, Juliana Giorgi","doi":"10.1007/s11892-026-01619-4","DOIUrl":"10.1007/s11892-026-01619-4","url":null,"abstract":"","PeriodicalId":10898,"journal":{"name":"Current Diabetes Reports","volume":"26 1","pages":""},"PeriodicalIF":6.4,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147431421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ecological Momentary Assessment of Person-Reported Outcomes in Diabetes: Unlocking Insights with Continuous Glucose Monitoring and the Potential for Precision Medicine. 糖尿病患者报告结果的生态瞬时评估：通过持续血糖监测和精准医学潜力解锁见解。
IF 6.4 2区 医学
Current Diabetes Reports Pub Date : 2026-03-10 DOI: 10.1007/s11892-026-01618-5
Dominic Ehrmann, Norbert Hermanns, Andreas Schmitt, Laura Y Klinker, Bernhard Kulzer
{"title":"Ecological Momentary Assessment of Person-Reported Outcomes in Diabetes: Unlocking Insights with Continuous Glucose Monitoring and the Potential for Precision Medicine.","authors":"Dominic Ehrmann, Norbert Hermanns, Andreas Schmitt, Laura Y Klinker, Bernhard Kulzer","doi":"10.1007/s11892-026-01618-5","DOIUrl":"10.1007/s11892-026-01618-5","url":null,"abstract":"","PeriodicalId":10898,"journal":{"name":"Current Diabetes Reports","volume":"26 1","pages":""},"PeriodicalIF":6.4,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12975859/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147431390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of GERD with Sleeve Gastrectomy: An Unintended Consequence. 胃反流与袖式胃切除术的关联：一个意想不到的后果。
IF 6.4 2区 医学
Current Diabetes Reports Pub Date : 2026-01-29 DOI: 10.1007/s11892-025-01617-y
Jonanne Talebloo, Kishore M Gadde, Ravinder K Mittal, Ninh T Nguyen
{"title":"Association of GERD with Sleeve Gastrectomy: An Unintended Consequence.","authors":"Jonanne Talebloo, Kishore M Gadde, Ravinder K Mittal, Ninh T Nguyen","doi":"10.1007/s11892-025-01617-y","DOIUrl":"10.1007/s11892-025-01617-y","url":null,"abstract":"","PeriodicalId":10898,"journal":{"name":"Current Diabetes Reports","volume":"26 1","pages":"3"},"PeriodicalIF":6.4,"publicationDate":"2026-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12852246/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146092425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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