The Cardioprotective Effects of Adiponectin in Diabetes.

IF 6.4 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Current Diabetes Reports Pub Date : 2025-10-13 DOI:10.1007/s11892-025-01610-5

Tara Kazemi, Yuanjie Mao, Tina Zhang

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引用次数: 0

Abstract

Purpose of review: Adiponectin, a hormone secreted by adipocytes, plays a crucial role in maintaining metabolic balance and supporting cardiovascular health. Although it is known for its protective effects, such as improving insulin sensitivity, reducing inflammation, and maintaining endothelial function, there are paradoxical associations between high adiponectin levels and increased cardiovascular mortality-referred to as the "adiponectin paradox"-which complicates its clinical interpretation. This review explores the cardioprotective effects of adiponectin in both type 1 and type 2 diabetes, focusing on its potential to regulate glucose metabolism and prevent cardiovascular complications.

Recent findings: By reviewing key studies, the article evaluates adiponectin's diverse roles and compares its effects on cardiovascular outcomes across diabetes subtypes, especially in diabetic cardiomyopathy, with an emphasis on congestive heart failure. The findings underscore the importance of further research into therapeutic strategies aimed at modulating adiponectin levels, particularly for individuals with diabetes and congestive heart failure. Understanding the dual nature of adiponectin's effects is critical for developing target interventions to improve cardiovascular outcomes in diabetic populations.

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脂联素在糖尿病中的心脏保护作用。

综述目的：脂联素是脂肪细胞分泌的一种激素，在维持代谢平衡和支持心血管健康中起着至关重要的作用。尽管人们知道它具有保护作用，如改善胰岛素敏感性、减少炎症和维持内皮功能，但高脂联素水平与心血管死亡率增加之间存在矛盾的联系——被称为“脂联素悖论”——这使其临床解释变得复杂。本综述探讨了脂联素在1型和2型糖尿病中的心脏保护作用，重点关注其调节糖代谢和预防心血管并发症的潜力。最近发现：通过回顾关键研究，本文评估了脂联素的多种作用，并比较了其对糖尿病亚型心血管结局的影响，特别是在糖尿病心肌病中，重点是充血性心力衰竭。这些发现强调了进一步研究旨在调节脂联素水平的治疗策略的重要性，特别是对于糖尿病和充血性心力衰竭患者。了解脂联素作用的双重性质对于制定改善糖尿病人群心血管结局的目标干预措施至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Diabetes Reports 医学 -

CiteScore

9.80

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： The goal of this journal is to publish cutting-edge reviews on subjects pertinent to all aspects of diabetes epidemiology, pathophysiology, and management. We aim to provide incisive, insightful, and balanced contributions from leading experts in each relevant domain that will be of immediate interest to a wide readership of clinicians, basic scientists, and translational investigators. We accomplish this aim by appointing major authorities to serve as Section Editors in key subject areas across the discipline. Section Editors select topics to be reviewed by leading experts who emphasize recent developments and highlight important papers published over the past year on their topics, in a crisp and readable format. We also provide commentaries from well-known figures in the field, and an Editorial Board of internationally diverse members suggests topics of special interest to their country/region and ensures that topics are current and include emerging research.