Current pharmaceutical biotechnology最新文献

{"title":"Detailed Comprehensive Review on Advancement of Cubosomes and their Currently Available Applications.","authors":"Raghwendra R Waghmode, Pranay Wal, Seshadri Nalla, Praneeth Ivan Joel Fnu, Virat Kumar Khatri, Pravin Kumar Darji, Binit Patel, Ankita Wal","doi":"10.2174/0113892010347758250122173337","DOIUrl":"https://doi.org/10.2174/0113892010347758250122173337","url":null,"abstract":"<p><p>Cubosomes, nanostructured lipid-based carriers, exhibit a promising potential in drug delivery due to their unique structure, which integrates amphiphilic lipids and polymer-based stabilizers. This review examines the scientific principles of digestion relevant to cubosome function, their structural and compositional aspects, and various processing methods. We also explore potential distribution pathways, drug delivery strategies, and therapeutic applications, including cancer therapy, antimicrobial therapy, vaccine delivery, ocular and dermatological applications, and transdermal delivery. Notably, some challenges still hinder the clinical application of cubosome products, which this review addresses. This paper aims to provide an in-depth discussion on cubosomes, encompassing their composition, theories, processing techniques, and the diverse administration routes that make them a versatile option for targeted drug delivery. A bibliographic review was conducted using major electronic databases (PubMed, ScienceDirect, Scopus, Google Scholar, Springer, and Wiley) along with offline and online academic libraries for comprehensive data collection. Cubosomes, as innovative lipid-based nanotechnology similar to liposomes and niosomes, possess significant potential due to their unique bioadhesive properties, thermodynamic stability, and capability to encapsulate a variety of compounds. Composed typically of glyceryl monooleate and Phytantriol with a stabilizer, cubosomes enable sustained and targeted release, suggesting a broad range of applications. Further advancements are needed to address current limitations in their practical application.</p>","PeriodicalId":10881,"journal":{"name":"Current pharmaceutical biotechnology","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dendrimers-Based Hydrogels and Nanogels for Drug Delivery.","authors":"Deblina D Bhowmik, Juhi S Gupta, Pallavi A Kamandar, Amol D Gholap, Satish Rojekar, Navnath T Hatvate","doi":"10.2174/0113892010347680250209183005","DOIUrl":"https://doi.org/10.2174/0113892010347680250209183005","url":null,"abstract":"<p><p>Current developments in nanotechnology provide an alternative therapy for various diseases by utilizing customized medicine. Among some of the nanoscale superstructures made of the hydrophilic or amphiphilic polymeric matrix are nanogels. At the same time, hydrogels are the first biomaterials created for insertion into the human body and have several biological uses. Owing to the advantages of nanogels and hydrogel, including biocompatibility, hydrophilicity, controlled drug release, and intelligent drug delivery, another macromolecule called dendrimer is incorporated into the nanogel and hydrogel for synergistic effects. In this review, we focus on the applications of dendrimer-based hydrogels and nanogels as carriers for targeted delivery of drugs. We also present the synthetic processes, different characterization methods, and challenges in incorporating the dendrimer and the drug during the preparation of nanogel and hydrogel. In recent years, the most widely used dendrimers for hydrogel formation have been reported to be poly(amidoamine) (PAMAM), phosphorous, peptide, and polyester dendrimers. Dendrimer-based hydrogel and nanogels show various applications in the treatment of a wide range of diseases, such as glaucoma, cancer, and microbial diseases. The self-cleaving mechanism of dendrimer hydrogels (DH) leads to enhanced and sustained delivery of the drugs in the treatment of cancer. Recent studies show the use of doxorubicinconjugated nanogel-based PAMAM dendrimer as a capable nanocarrier for the delivery of drugs in the treatment of cancer.</p>","PeriodicalId":10881,"journal":{"name":"Current pharmaceutical biotechnology","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioactive Phytochemicals: Unlocking the Promise of Natural Remedies for Diabetes Mellitus.","authors":"Diksha Gulati, Ajmer Singh Grewal, Balraj Saini","doi":"10.2174/0113892010371753250324150813","DOIUrl":"https://doi.org/10.2174/0113892010371753250324150813","url":null,"abstract":"<p><strong>Background: </strong>Metabolic syndrome encompasses conditions such as diabetes mellitus (DM), which has become increasingly prevalent. Chemically synthesized medications are commonly used to mitigate the effects of DM and its complications; however, these often result in undesirable side effects, including weight gain, digestive issues, and heart failure.</p><p><strong>Objective: </strong>This review highlights the therapeutic potential of bioactive compounds and antidiabetic plants that possess proven anti-diabetic properties. Focusing on phytomedicines also explores their possible mechanisms of action and positions this work relative to current reviews in the field.</p><p><strong>Methods: </strong>A comprehensive literature analysis was conducted, emphasizing the therapeutic potential of bioactive compounds in anti-diabetic plants. Databases such as PubMed, Scopus, and Google Scholar were thoroughly searched to identify studies investigating the anti-diabetic properties and mechanisms of action of plant-derived bioactive compounds. Inclusion criteria focused on studies evaluating the pharmacological effects of herbal medicines, plant extracts, and isolated bioactive compounds on diabetes management.</p><p><strong>Results: </strong>Therapeutic plants, as sources of anti-diabetic compounds, offer significant advantages. They are affordable, exhibit minimal or no adverse effects, and do not necessitate strict dietary restrictions or intense exercise regimens. The integrated insights underscore the potential of phytomedicines to address limitations in current diabetes management strategies.</p><p><strong>Conclusion: </strong>The unique focus on phytomedicines positions this review as a valuable resource for researchers and clinicians. Detailing mechanisms and evidence supporting the efficacy of these compounds, guides the development of innovative strategies for identifying and utilizing bioactive compounds in effective diabetes management.</p>","PeriodicalId":10881,"journal":{"name":"Current pharmaceutical biotechnology","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling the Mechanism of Tangmaikang Granules in Treating Diabetic Kidney Disease Based On UPLC-MS/MS, Network Pharmacology, Molecular Docking, Molecular Dynamics Simulations, and Experimental Validation.","authors":"Zhixin Wang, Shuqin Liu, Ying Zhang, Huaming Xian, Xinzhu Yuan, Changwei Lin, Xisheng Xie","doi":"10.2174/0113892010369197250321083806","DOIUrl":"https://doi.org/10.2174/0113892010369197250321083806","url":null,"abstract":"<p><strong>Background: </strong>Diabetic Kidney Disease (DKD) is a major cause of End-Stage Renal Disease (ESRD) and lacks effective treatments. Tangmaikang Granules (TMK), a multi-herb traditional Chinese medicine formulation, have shown potential in managing DKD. However, the precise active components, molecular mechanisms, and therapeutic advantages of TMK remain unclear.</p><p><strong>Objective: </strong>This study tests the hypothesis that TMK granules exert protective effects on DKD by targeting multiple pathways involved in oxidative stress, inflammation, and apoptosis in podocytes through a multi-targeted approach. The aim was to identify TMK's bioactive components, evaluate its therapeutic potential, and uncover its molecular mechanisms in DKD.</p><p><strong>Methods: </strong>The bioactive constituents in TMK were determined through ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). Drug targets were identified using SwissTargetPrediction and SuperPred, whereas DKD-associated targets were obtained from the GeneCards, DisGeNET, OMIM, and TTD databases. A Protein-Protein Interaction (PPI) network was constructed, and key targets were identified via topological analysis. Molecular docking and dynamics simulations were performed to evaluate stable binding interactions. GO and KEGG pathway enrichment analyses were conducted to uncover relevant signaling pathways. TMK's effects on oxidative stress, inflammation, and apoptosis in podocytes were assessed using CCK-8, flow cytometry, RT-qPCR, ELISA, and Western blot assays.</p><p><strong>Results: </strong>Thirty active compounds and 384 potential therapeutic targets were identified, with eight key targets. Pathway enrichment analysis revealed TMK's involvement in AGE-RAGE, EGFR, HIF-1, and apoptosis pathways, affecting inflammatory cytokine responses and oxidative stress. In vitro experiments demonstrated that TMK significantly reduced oxidative stress, inflammation, and apoptosis in podocytes by inhibiting the MAPK and NF-κB pathways.</p><p><strong>Conclusion: </strong>TMK granules target DKD through a multi-component, multi-target strategy, effectively mitigating oxidative stress and suppressing inflammatory and apoptotic pathways. This study integrates advanced computational and experimental methods, demonstrating TMK's unique therapeutic potential and providing a robust foundation for its clinical application in DKD management.</p>","PeriodicalId":10881,"journal":{"name":"Current pharmaceutical biotechnology","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143729205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic Effects of Lactobacillus acidophilus and Balanites aegyptiaca in Managing Hyperglycemia, Oxidative Stress, and Inflammation in Diabetic Rats.","authors":"Dalia Elebeedy, Nada Elgendy, Aml Ghanem, Aya Salem, Muhammad Alaa Eldeen, Mohamed A Ali, Dalal Sulaiman Alshaya, Maha A Aljumaa, Hanadi A Katouah, Eman Fayad, Ghadi Alsharif, Ahmed I Abd El Maksoud","doi":"10.2174/0113892010362400250121075011","DOIUrl":"https://doi.org/10.2174/0113892010362400250121075011","url":null,"abstract":"<p><strong>Background: </strong>Diabetes mellitus is a chronic condition characterized by persistent hyperglycemia, which can lead to serious complications if not managed effectively. Recent interest has grown in exploring the potential of probiotics and prebiotics as complementary therapies. This study investigates the combined effects of the probiotic Lactobacillus acidophilus and the prebiotic Balanites aegyptiaca on blood glucose levels, oxidative stress, and inflammatory markers in an alloxan-induced diabetic rat model.</p><p><strong>Methods: </strong>A total of 40 male rats (100-110 g; 8-10 weeks) were randomly divided into five groups: a normal control group, a diabetic control group, and diabetic groups treated with Lactobacillus acidophilus, Balanites aegyptiaca, or their combination. The mice in the diabetic groups were orally treated with 28.5 mg/kg of Lactobacillus acidophilus, Balanites aegyptiaca, or both twice daily for 30 days. Blood glucose levels were measured before and after treatment. Antioxidant enzyme activities, including glutathione peroxidase, glutathione reductase, glutathione Stransferase, catalase, and superoxide dismutase, were assessed. Inflammatory cytokines (TNF-α and IL-6) and lipid profiles (cholesterol and triglycerides) were also evaluated.</p><p><strong>Results: </strong>The combination of Lactobacillus acidophilus and Balanites aegyptiaca significantly reduced blood glucose levels in diabetic rats from 295 mg/dl to 114 mg/dl, outperforming the effects of either treatment alone. Antioxidant enzyme activities were markedly enhanced in the combined treatment group, indicating reduced oxidative stress. The combined therapy also significantly decreased pro-inflammatory cytokines TNF-α and IL-6 compared to the diabetic control group. Furthermore, lipid profiles showed improved cholesterol and triglyceride levels in the combined treatment group, even in a high-lipid diet.</p><p><strong>Conclusion: </strong>The combination of Lactobacillus acidophilus and Balanites aegyptiaca reduced hyperglycemia, oxidative stress, and inflammation in diabetic rats, suggesting potential as a complementary diabetes therapy.</p>","PeriodicalId":10881,"journal":{"name":"Current pharmaceutical biotechnology","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143729191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fufanglongxujie Capsules Protect against Aspirin-induced Gastric Mucosal Lesions in Rats with Myocardial Ischemia-reperfusion Injury.","authors":"Jiahui Zhou, Min Wang, Lingxu Li, Ruiying Wang, Shan Lu, Lanfang Li, Lifang He, Guibo Sun, Xiaobo Sun","doi":"10.2174/0113892010330899241203115921","DOIUrl":"https://doi.org/10.2174/0113892010330899241203115921","url":null,"abstract":"<p><strong>Background: </strong>Aspirin is frequently employed for the prevention of cardiovascular events, but its clinical utility is hindered by the risk of severe gastrointestinal injury when taken orally. Fufanglongxuejie capsules (FFLXJ), a Chinese patent medicine known for promoting wound healing and alleviating congestion and pain, may offer a promising solution to this clinical challenge.</p><p><strong>Methods: </strong>Using network pharmacology, candidate targets of FFLXJ, gastrointestinal disorders, intersection targets, and associated signaling pathways were examined. Prior to the creation of myocardial ischemia-reperfusion (MI/R) models, male Sprague-Dawley (SD) rats were orally administered FFLXJ and/or aspirin for a consecutive month. Subsequently, serum motilin (MTL), gastrin (GAS), HE staining, transmission electron microscopy analysis, and western blot analysis were performed on the blood samples or gastric tissues. Molecular docking analysis on core targets and relative compounds was conducted using Discovery Studio software. The expressions of core targets were verified by Western blot.</p><p><strong>Results: </strong>Compared with aspirin-treated MI/R rats, FFLXJ restored downregulated serum MTL and GAS levels and lessened aspirin-induced gastrointestinal lesions. Network pharmacology research revealed that the top 4 core targets were TNF, IL-10, PTGS2, and VEGFA. In MI/R rats, aspirin treatment markedly increased the level of stomach IL-10, while FFLXJ administration decreased the expression of PTGS2 and IL-10 compared with aspirin-treated group.</p><p><strong>Conclusion: </strong>Oral aspirin harmed the gastrointestinal mucosa in MI/R rats; however, FFLXJ was able to mitigate the damage. The protective property of FFLXJ was related to the regulation of inflammation.</p>","PeriodicalId":10881,"journal":{"name":"Current pharmaceutical biotechnology","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tumor Image Segmentation: A Bibliometric Analysis from 2003 to Now.","authors":"Zhenghao Chen, Zhongqing Wang, He Ma","doi":"10.2174/0113892010325620250312082433","DOIUrl":"https://doi.org/10.2174/0113892010325620250312082433","url":null,"abstract":"<p><strong>Background: </strong>Bibliometrics has been applied to the study of tumor image segmentation, which can indicate the current research hotspots and trends.</p><p><strong>Method: </strong>In this study, bibliometric analyses were performed on data retrieved from the Web of Science database. A total of 3377 articles on the application of tumor image segmentation from January 1, 2003, to October 9, 2024, were analyzed for the characteristics of the articles, including the number of yearly publications, country/region, institution, journal, author, keywords, and references. Visualising co-authorship, co-citation, and co-occurrence analysis with VOSviewer.</p><p><strong>Results: </strong>The annual publication volume of tumor image segmentation literature shows that from the first time of more than 100 articles in 2016, the publication volume of literature in this field has surged, reaching 576 articles by 2023. Mainland China is ranked first in terms of publication volume (n=1356). Saudi Arabia ranks first in average publication year (n=2021.96). IEEE Transactions on Medical Imaging was the journal with the highest average number of citations. The Chinese Academy of Sciences (n=78) was the most prolific institution, while Harvard University was the most prestigious, with a total number of citations and an average number of citations of 3190 and 213, respectively. In terms of keywords, co-occurrence analysis of 107 keywords with a frequency of more than 30 times produced four clusters: (1) methods of image segmentation, (2) applications of image segmentation, (3) image segmentation modelled on CT, (4) image segmentation modelled on MRI. Transformer, Attention Mechanism, and U-Net are the latest keywords. The analysis of keywords helps scholars understand and identify the current research hotspots and research directions.</p><p><strong>Conclusion: </strong>Within the last 20 years, the number of articles on the application of tumor image segmentation has increased steadily. From U-Net to MAMBA, many methods for tumor image segmentation have been proposed, and the limitations of models and algorithms are becoming increasingly smaller, which demonstrates the importance of advances in tumor image segmentation technology for disease prevention and monitoring. It presents a strong connection between countries/regions and authors, which reflects the global interest and support for the development of this field. This study shows global trends, research hotspots, and emerging topics in this field and reviews some of the knowledge about tumor image segmentation applications from past studies. And it will provide good research guidelines for researchers in this field.</p>","PeriodicalId":10881,"journal":{"name":"Current pharmaceutical biotechnology","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pisum sativum L. Peel Extract Based Biogenic Silver Nanoparticles as Antibiotic Adjuvants to Reverse Multidrug Resistance in Bacteria.","authors":"Salma Batool, Izzah Shahid, Moaiza Iftikhar, Burhan Haider, Farah Deeba, Rahman Shah Zaib Saleem","doi":"10.2174/0113892010331837241011060611","DOIUrl":"https://doi.org/10.2174/0113892010331837241011060611","url":null,"abstract":"<p><strong>Introduction: </strong>Rapid spread of antimicrobial drug resistance is alarming and demands a sustainable solution. Green synthesis of silver nanoparticles can pave the way for the development of adjuvants that can help overcome bacterial drug resistance.</p><p><strong>Methods: </strong>In the current study, green synthesis of silver nanoparticles utilizing pea (Pisum sativum) peels and their evaluation against multidrug-resistant (MDR) bacterial pathogens has been proposed. Pea peels were extracted and analyzed for antioxidant potential by non-enzymatic DPPH assay. The extract was used to prepare silver nanoparticles (gAgNPs) characterized using UV-VIS spectroscopy, SEM, FTIR, and zeta sizer, and evaluated for antibacterial activity.</p><p><strong>Results: </strong>The SEM showed that the gAgNPs were spherical with a size of 59.24 nm ± 0.3, and the zeta sizer gave a PDI of 0.2. As adjuvants, these gAgNPs in combination with vancomycin showed a superior antibacterial activity against vancomycin-resistant E. faecalis (zone of inhibition= 66 mm ± 0.41) and vancomycin-resistant P. aeruginosa (35 mm ± 1.41) as compared to vancomycin. Hemolysis was IC50= 998.44 μg/mL, creating a therapeutic window for IC50 =5 μg/mL, effective against human pathogens.</p><p><strong>Conclusion: </strong>This study suggests these gAgNPs could be a good lead to work as adjuvants with vancomycin against vancomycin-resistant Gram-positive and Gram-negative clinical bacteria and thus warrants further studies.</p>","PeriodicalId":10881,"journal":{"name":"Current pharmaceutical biotechnology","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construction and Validation of T-cell Exhaustion-related Gene Signature for Predicting Prognosis in Diffuse Large B-cell Lymphoma.","authors":"Lixin Lv, Jie Zhou, Aibin Liang","doi":"10.2174/0113892010355990250310064916","DOIUrl":"https://doi.org/10.2174/0113892010355990250310064916","url":null,"abstract":"<p><strong>Background: </strong>T-cell exhaustion (TEX) is one reason for immunotherapy resistance among cancers, but the specific mechanism and influencing factors of TEX in diffuse large Bcell lymphoma (DLBCL) are not fully understood. This study aimed to establish a TEX signature for predicting the prognosis of DLBCL and investigate the immune characteristics related to the TEX signature.</p><p><strong>Methods: </strong>The gene expression data of DLBCL were obtained from The Cancer Genome Atlas and Gene Expression Omnibus databases. Prognostic TEX related genes were selected by Cox regression analysis for prognostic signature (TEX score) construction. The correlation of risk grouping with immune cell infiltration was analyzed by CIBERSORT and ssGSEA. Molecular mechanisms between high and low TEX score groups were explored by gene set enrichment analysis (GSEA).</p><p><strong>Results: </strong>A total of 115 differentially expressed TEX-related genes were selected, and 12 were prognosis-related after Cox regression. Following Ninesignature genes, including TRIM6, BIRC3, CTSC, GBP3, IRF3, TRIM22, IFI30, TRIM25 and BAG4 were identified to construct a TEX score. The receiver operator characteristic curve curves suggested that the model presented high predictive precision. A nomogram was established, which also had good prediction performance in survival prognosis. The composition of immune cells in the two risk groups was significantly different. GSEA identified 33 hallmarks between two risk groups, which were associated with immune cells infiltration and inflammation.</p><p><strong>Conclusion: </strong>The TEX score has prognosis-predicting value for DLBCL and might be a valuable biomarker to guide clinical decision-making for patients with DLBCL.</p>","PeriodicalId":10881,"journal":{"name":"Current pharmaceutical biotechnology","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent Advancements in Nanoparticles-Based Approaches for the Theranostics of Glioblastoma Multiforme.","authors":"Jugal Mandan, Dr Abhishek Kanugo","doi":"10.2174/0113892010352026250213055117","DOIUrl":"https://doi.org/10.2174/0113892010352026250213055117","url":null,"abstract":"<p><p>One of the deadliest and most challenging tumors in the body is Glioblastoma Multiforme (GBM). The Most aggressive kinds of brain tumors pose multiple challenges in their treatment due to several barriers (BBB and BCSF). Conventional treatments show poor efficacy in the treatment owing to poor penetrability through the blood-brain barrier and extreme toxicity in the brain. Moreover, the prognosis and diagnosis of GBM are critical, as they can lead to a fatal outcome.The current state-of-the-art review emphasizes the novel theranostic nanoparticles, which are significantly effective in treating the GBM. The most effective nanocarriers are lipid-based (Liposomes, Solid lipid nanoparticles, nanostructured lipid carrier, nanoemulsion), polymeric (polymeric micelles, dendrimers, quantum dots, exosomes, and hydrogels), metallic (Gold, Silver, Platinum), inorganic (iron oxide, mesoporous silica, copper oxide, boron oxide, Gadolinium, Selenium, and Zinc oxide NPs), carbon-based (Carbon nanotubes and graphene oxide) and others (protein-based NPs, Cubosomes, Polymersosomes). These nanoparticle-loaded antitumor agents show good penetration across the barriers and improve survival rates compared to conventional ones. Lipid-based nanoparticles are preferred for providing high biocompatibility, biodegradability, and sustained release action. Polymeric nanocarriers are preferred for facilitating long-acting therapy, and patient comfort, mostly for their biosensing features. Carbon-based nanomaterials are gaining interest for their theranostic action. The most promising outcomes in clinical practices are shown in Liposomes, PLGAbased NPs, Gold NPs, hydrogels, iron oxide NPs, albumin-based NPs, etc.</p>","PeriodicalId":10881,"journal":{"name":"Current pharmaceutical biotechnology","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}