Current pharmaceutical biotechnology最新文献

{"title":"Corrigendum to: Artificial Intelligence in Cancer Diagnosis: A Game-changer in Healthcare.","authors":"Pramit Sahoo, Meghoparna Kundu, Jeenatara Begum","doi":"10.2174/1389201027999261012100148","DOIUrl":"https://doi.org/10.2174/1389201027999261012100148","url":null,"abstract":"<p><p>Following publication of the article entitled \"Artificial Intelligence in Cancer Diagnosis: A Game-changer in Healthcare\" [1], certain phrases and expressions were identified that were unclear or inconsistent with established scientific terminology. To ensure the accuracy and clarity of the published record, these expressions have been corrected using appropriate terminology that more accurately conveys the intended scientific meaning. These corrections are limited to the wording and terminology of the affected passages and do not alter the data, results, scientific interpretations, or conclusions of the article. The specific corrections are provided below: 4.1. Key Concepts and Model Architectures Definition, Paragraph 1, Line 21 Original text: ….Table 1 gives a summary of common supervised learning approaches, covering older decision tree and deep learning (DL) algorithms as well as more recent choice tree and logistic regression (LR) statistical models. Corrected text: ....Table 1 gives a summary of common supervised learning approaches, covering older decision tree and deep learning (DL) algorithms as well as more recent decision tree and logistic regression (LR) statistical models. The original article has been updated accordingly. This corrigendum is published to maintain transparency and accuracy of the scholarly record. The corrected version of the article is available online at: https://www.eurekaselect.com/article/140874 The authors regret these errors and apologise for any inconvenience they may have caused.</p>","PeriodicalId":10881,"journal":{"name":"Current pharmaceutical biotechnology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biotechnological Approaches to Biofilm-Targeted Antifungal Therapy in Recurrent Vulvovaginal Candidiasis.","authors":"Nazia Hassan, Asgar Ali","doi":"10.2174/0113892010514884261005110150","DOIUrl":"https://doi.org/10.2174/0113892010514884261005110150","url":null,"abstract":"<p><p>Recurrent Vulvovaginal Candidiasis (RVVC) is increasing worldwide, with biofilm persistence and antifungal resistance limiting treatment options. The combined use of antifungal treatments with antibiofilm agents has become a promising strategy. This review explores advanced therapeutic approaches, their limitations, and prospects. Overgrowth of vaginal Candida inflames the mucosa, causing itching, dryness, and whitish discharge. Biofilm formation worsens the condition, contributing to treatment failure, resistance, and recurrence. Conventional antifungal modalities are often inadequate against these multidimensional biofilm assemblies. Combining natural and synthetic antifungal agents with antibiofilm adjuncts has shown improved outcomes by targeting Candida cells within biofilms. This review compiles studies on multicomponent approaches to managing vaginal Candida infections, focusing on pan-Candida species to clarify species-specific resistance and persistence. Host factors in non-virgin women, a highly affected population, are examined alongside regional data on recurrence and treatment failure. Together, these insights highlight the microbiology of Candida biofilms, host and regional influences, and the socio-economic burden of RVVC, while emphasising the translational importance of combination therapy and biotechnology-driven innovations such as molecular docking, nanocarriers, CRISPR-based gene modulation, and engineered probiotics.</p>","PeriodicalId":10881,"journal":{"name":"Current pharmaceutical biotechnology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dopamine Homeostasis, Cognitive Testing, and Precision Pain Management: A Narrative Review of Reward Circuitry, Opioid Risk, and Personalized Recovery Metrics.","authors":"Kai-Uwe Lewandrowski, Sergio Schmidt, Rossano Kepler Alvim Fiorelli, Kavya Mohankumar, Albert Pinhasov, Morgan P Lorio, Panayotis K Thanos, Mark S Gold, Eliot L Gardner, Igor Elman, Alireza Sharafshah, Catherine A Dennen, Debasis Bagchi, Alexander P L Lewandrowski, Edward J Modestino, David Baron, Rajendra D Badgaiyan, Abdalla Bowirrat, Keerthy Sunder, Milan Makale, Kenneth Blum","doi":"10.2174/0113892010424007260928171201","DOIUrl":"https://doi.org/10.2174/0113892010424007260928171201","url":null,"abstract":"<p><strong>Introduction/objective: </strong>Chronic pain and opioid-related harm intersect through overlapping biological, behavioral, and clinical pathways. This narrative review presents a framework linking dopamine homeostasis, opioid-risk reduction, and objective cognitive testing in precision pain and addiction medicine.</p><p><strong>Methods: </strong>Literature on chronic pain, opioid exposure, mesocorticolimbic dopamine signaling, reward-circuit vulnerability, pharmacogenomics, dopamine precursor and pro-dopaminergic adjuncts, and Continuous Visual Attention Test (CVAT) metrics was synthesized narratively; this is not a systematic review or clinical guideline.</p><p><strong>Results: </strong>Pain relief, reinforcement, withdrawal, mood, attention, and recovery motivation involve overlapping regulatory systems. Dopamine biology is relevant to these intersections but does not provide a single-cause explanation for pain or addiction. Genetic risk stratification and pharmacogenomic testing may enrich research models and selected counseling but require external validation, ancestry-aware calibration, and ethical safeguards. CVAT reaction time, variability, omissions, and commissions may complement pain and disability scales during treatment.</p><p><strong>Discussion: </strong>The framework distinguishes established opioid-sparing care from investigational dopamine precursor strategies and emphasizes repeated measurement of function, medication exposure, and cognition.</p><p><strong>Conclusion: </strong>Precision pain care should integrate biological risk, opioid stewardship, multimodal analgesia, dopamine-homeostasis hypotheses, and objective cognitive monitoring.</p>","PeriodicalId":10881,"journal":{"name":"Current pharmaceutical biotechnology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149164761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of the Synergistic Effect of Drug Hydrocortisone and Catechin on Wound Healing in a Surgically Excised and Burned Wound Model in Rats.","authors":"Kanika Goyal, Parakh Basist, Gofran Ibrahim Alkhalaf, Ebrahim Ahmed Jaber Al Hatef, Sradhanjali Mohapatra, Vikas Jogpal, Ritu Dahiya","doi":"10.2174/0113892010478136260830112754","DOIUrl":"https://doi.org/10.2174/0113892010478136260830112754","url":null,"abstract":"<p><strong>Introduction: </strong>Wound healing is a complex biological process involving inflammation, cell proliferation, and tissue remodeling. Persistent inflammation and oxidative stress can delay healing, particularly in surgical and burn wounds. This study investigated the synergistic wound-healing potential of a hydrogel containing hydrocortisone and catechin in surgically excised and burn wound models in Wistar albino rats.</p><p><strong>Methods: </strong>A Carbopol-based hydrogel containing hydrocortisone and catechin was formulated after confirming drug compatibility using Fourier Transform Infrared Spectroscopy (FTIR) and Differential Scanning Calorimetry (DSC). Surgically excised and burn wounds were created in Wistar albino rats, which were randomly assigned to five groups: untreated control, standard treatment, hydrocortisone hydrogel, catechin hydrogel, and combination hydrogel. Wound contraction was assessed on days 1, 5, 10, 15, and 21 (or day 19 for burn wounds). Histopathological evaluation was performed using hematoxylin and eosin staining, and statistical analysis was conducted using one-way ANOVA followed by Tukey's post hoc test, with p < 0.05 considered significant.</p><p><strong>Results: </strong>The hydrocortisone-catechin hydrogel significantly accelerated wound healing compared with the control and individual treatment groups (p < 0.05). In the excision wound model, the combination treatment reduced the wound area to 0.0162 ± 0.0050 mm² by day 21, while in the burn wound model the wound area decreased to 0.0162 ± 0.0056 mm² by day 19. Histopathological analysis demonstrated enhanced collagen deposition, fibroblast proliferation, angiogenesis, and complete re-epithelialization, together with reduced inflammatory cell infiltration in the combination-treated group.</p><p><strong>Discussion: </strong>The improved healing response observed with the combination hydrogel suggests a synergistic interaction between hydrocortisone and catechin. Hydrocortisone effectively suppressed excessive inflammation, whereas catechin provided antioxidant protection and promoted collagen synthesis, angiogenesis, and tissue regeneration. Their complementary mechanisms produced faster wound closure and superior tissue repair compared with either agent alone.</p><p><strong>Conclusion: </strong>The hydrocortisone-catechin hydrogel demonstrated superior wound-healing efficacy in both surgically excised and burn wound models by accelerating wound contraction, reducing inflammation, and improving tissue regeneration. These findings support the potential of this combination hydrogel as a promising topical therapeutic strategy for wound management and warrant further preclinical and clinical investigations.</p>","PeriodicalId":10881,"journal":{"name":"Current pharmaceutical biotechnology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149105374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Evaluation of an Eudragit-Coated Colon-Targeted Delivery System for Myrica esculenta in Ulcerative Colitis.","authors":"Monika Joshi, Manju Pandey, Prem Shankar Gupta, Akash Ved, Ravi Shankar","doi":"10.2174/0113892010430704260911064141","DOIUrl":"https://doi.org/10.2174/0113892010430704260911064141","url":null,"abstract":"<p><strong>Background: </strong>Ulcerative colitis is a chronic inflammatory disorder of the colon that significantly impacts patients' quality of life. Current therapies often show limited efficacy and cause systemic side effects. Myrica esculenta, with its potent anti-inflammatory and antioxidant properties, presents a promising alternative for targeted treatment.</p><p><strong>Objective: </strong>This study aimed to design and evaluate colon-targeted tablets for Myrica esculenta using Eudragit E100 and Eudragit S100, and to assess various pharmaceutical parameters to enhance therapeutic outcomes while minimizing systemic exposure.</p><p><strong>Methods: </strong>Myrica esculenta extract was prepared via Soxhlet extraction and characterized using FTIR spectroscopy. CODESTM-based tablets were formulated with Eudragit E100 and E100 for pH-sensitive release, and the formulations were optimized using a central composite design (CCD). In vitro dissolution and in vivo roentgenography studies assessed drug release and colonic targeting.</p><p><strong>Results: </strong>The extraction yield of Myrica esculenta was 21.11%, and FTIR confirmed the presence of key bioactive compounds. The drug content across all formulations ranged from 91.59 ± 0.79% to 98.85%. Further in vitro release studies of 13 formulations (D1-D13) showed that the optimized formulation (D5) achieved 96.34% cumulative drug release, with 10% or less drug release in gastric and intestinal conditions. In vivo roentgenography confirmed that the CODESTM-based tablets remained intact through the small intestine and dissolved and released the active at colonic pH, validating the Eudragit-coated delivery system's efficacy.</p><p><strong>Discussion: </strong>The optimized CODESTM-based tablet not only achieved controlled release but also demonstrated high drug content uniformity, indicating the feasibility of reproducible manufacturing. In vivo roentgenography further validated the in vitro findings, confirming the integrity of tablets up to the small intestine and their disintegration in the colon. These results establish the suitability of Eudragit E100 and Eudragit S100 as functional polymers for pH-triggered colonic release.</p><p><strong>Conclusion: </strong>The developed colon-targeted system for Myrica esculenta effectively addresses the challenge of reaching the colon intact and achieving targeted release in the colonic fluid.</p>","PeriodicalId":10881,"journal":{"name":"Current pharmaceutical biotechnology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149105385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prebiotics in Food Fermentation and Bioprocessing: Advances and Applications.","authors":"Sasmita Dash, Sonali Dutta, Priyanka Dash, Jitu Halder, Chandan Das, Goutam Ghosh, Goutam Rath, Biswakanth Kar","doi":"10.2174/0113892010470804260914135550","DOIUrl":"https://doi.org/10.2174/0113892010470804260914135550","url":null,"abstract":"<p><p>Prebiotics are nondigestible food components that selectively stimulate beneficial gut microbiota and have garnered significant attention in food science and biotechnology because of their health-promoting properties. Among them, fructooligosaccharides and galactooligosaccharides are especially important for their positive effects on human health. Functional foods with enhanced nutritional and medicinal value have been made possible by the recent use of prebiotics in food fermentation and bioprocessing. This review summarizes recent developments in prebiotic production and application, with emphasis on biotechnological approaches such as microbial fermentation, enzymatic synthesis, and strain improvement techniques, based on literature retrieved from PubMed, Scopus, and Web of Science up to July 2025. Advances in fermentation technologies, including solid-state fermentation and co-culture systems, are also discussed for optimizing production processes. In addition, the review highlights the health-promoting effects of prebiotics, including modulation of gut microbiota, immunological regulation, and involvement in the gut-brain axis. Lastly, we highlighted current challenges and prospects, emphasizing their application to transform fermented foods and bioprocessing techniques.</p>","PeriodicalId":10881,"journal":{"name":"Current pharmaceutical biotechnology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149036904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"OX-LDL Drives Excessive Autophagy and Apoptosis of Trophoblasts by the ROS/mTOR/NLRP3 Pathway.","authors":"Fengping He, Chuanyin Xiong, Lujing Chen, Jiwu Lou, Lin Meng, Xueqing Jiang, Linhe Song, Yongmei Zhang, Tizhen Yan","doi":"10.2174/0113892010467400260909083254","DOIUrl":"https://doi.org/10.2174/0113892010467400260909083254","url":null,"abstract":"<p><strong>Introduction: </strong>Unexplained recurrent spontaneous abortion (uRSA) is a devastating clinical condition that affects 2-6% of pregnancies, and more than 50% of cases remain without an identified cause despite comprehensive evaluation, resulting in a significant emotional and reproductive burden for patients. This study clarifies a novel molecular mechanism linking oxidized low-density lipoprotein (OX-LDL)-induced oxidative stress to trophoblast dysfunction through the ROS/mTOR/NLRP3 signaling pathway and identifies miRNA-146 as a key negative regulator with therapeutic potential.</p><p><strong>Methods: </strong>The human trophoblast cell line HTR8/SVneo and decidual tissues from patients with uRSA and controls were analyzed using MTT assays, TUNEL staining, ROS detection, Western blotting, qRT-PCR, and immunohistochemistry. miRNA-146 mimics and inhibitors were applied to investigate the regulatory mechanisms.</p><p><strong>Results: </strong>Exposure to OX-LDL significantly increased ROS production and upregulated mTOR and NLRP3 expression, leading to excessive autophagy and apoptosis in trophoblast cells. miRNA- 146 negatively regulated this pathway, restoring cell viability and migration. Clinical samples from uRSA patients showed decreased miRNA-146 expression and increased mTOR and NLRP3 expression in decidual tissues.</p><p><strong>Discussion: </strong>These findings demonstrate a mechanistic link between OX-LDL-induced oxidative stress and trophoblast dysfunction in uRSA. miRNA-146 counteracts these effects by inhibiting the ROS/mTOR/NLRP3 signaling axis.</p><p><strong>Conclusion: </strong>miRNA-146 mitigates OX-LDL-induced trophoblast autophagy and apoptosis and may represent a potential therapeutic target for uRSA.</p>","PeriodicalId":10881,"journal":{"name":"Current pharmaceutical biotechnology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149036899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protein Phosphatase 2A Modulates AKT-Mediated Macrophage Polarization in Adipocyte-Induced Inflammation.","authors":"Vinoth Kannan K, Kothai T, Lakshmi B S","doi":"10.2174/0113892010477166260824074846","DOIUrl":"https://doi.org/10.2174/0113892010477166260824074846","url":null,"abstract":"<p><p>Obesity and type 2 diabetes mellitus (T2DM) are associated with chronic low-grade inflammation that sustains insulin resistance and metabolic dysfunction. Adipose tissue, through the secretion of adipokines and cytokines, plays a central role in shaping macrophage polarization and maintenance of an inflammatory microenvironment. While kinase-mediated signaling such as PI3K-AKT has been extensively studied, the contribution of phosphatases, particularly protein phosphatase 2A (PP2A), to macrophage polarization remains poorly defined. In this study, RAW264.7 macrophages exposed to inflammatory adipocyte-conditioned medium exhibited altered AKT isoform expression, including upregulation of AKT2 and downregulation of AKT1, along with activation of the PI3K, mTORC1/S6K pathway and suppression of protein phosphatase 2A (PP2A) activity, collectively promoting M1 pro-inflammatory polarization. To further elucidate the molecular mechanism, we performed molecular docking and 100 ns molecular dynamics simulations of both unphosphorylated AKT and ATP-bound (phosphorylated) AKT interacting with PP2A. The simulations revealed that phosphorylated AKT has higher binding affinity and greater structural stability with PP2A, facilitated by persistent hydrogen bonds with the regulatory and scaffolding subunits, suggesting a natural self-limiting mechanism that maintains the phosphorylation-dephosphorylation balance. We hypothesise that the experimentally observed reduction in PP2A levels in macrophages exposed to inflammatory adipocyte signals may impair this regulatory loop, favouring sustained pro-inflammatory signaling. These integrated experimental and computational findings highlight PP2A as a critical negative regulator of AKT-driven macrophage activation and suggest that therapeutic strategies aimed at restoring PP2A activity could prevent chronic inflammation in obesity and T2DM and could serve as a potential molecular target for mitigating metabolic inflammation.</p>","PeriodicalId":10881,"journal":{"name":"Current pharmaceutical biotechnology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148967044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Celebrating 25 Years of Current Pharmaceutical Biotechnology.","authors":"Nikolaos E Labrou","doi":"10.2174/0113892010537469260831074645","DOIUrl":"https://doi.org/10.2174/0113892010537469260831074645","url":null,"abstract":"","PeriodicalId":10881,"journal":{"name":"Current pharmaceutical biotechnology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148944216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modeling M. tuberculosis Response to Antibiotics: A Comparison of Logarithmic, Logistic, and Michaelis-Menten Models.","authors":"Manaf AlMatar, Muna Jalal Ali, Gulfer Yakici, Khaoula Balgouthi, Eihab Basheir, Walid Wannes","doi":"10.2174/0113892010499218260826064037","DOIUrl":"https://doi.org/10.2174/0113892010499218260826064037","url":null,"abstract":"<p><strong>Background: </strong>Antimicrobial resistance (AMR) poses a serious threat to global public health and requires truthful measurement to assess bacterial susceptibility to antibiotics. Mathematical modeling is a useful tool for quantifying and predicting antimicrobial susceptibility and its relationship to other features.</p><p><strong>Method: </strong>This study aimed to identify the most appropriate mathematical model for the relationship between Minimum Inhibitory Concentration (MIC) and bacterial susceptibility. The models assessed were the Michaelis-Menten model, the logistic growth model and the logarithmic regression model. To ensure objective and comprehensive comparisons, various statistical indicators were used, including coefficient of determination (R²), Mean Squared Error (MSE), Root Mean Squared Error (RMSE), and the Akaike Information Criterion (AIC).</p><p><strong>Result: </strong>The logarithmic regression model provided the best fit to the data. It yielded the highest R² value and the lowest MSE, RMSE and AIC values compared to Michaelis-Menten and logistic growth models. On the other hand, the logistic growth model provided the poorest fit, with the lowest R² and the largest prediction errors. Although the Michaelis-Menten model outperformed the logistic growth model, the logarithmic regression model consistently achieved lower error metrics and provided a more accurate and informative representation of the relationship between MIC and bacterial susceptibility.</p><p><strong>Discussion: </strong>The logarithmic regression model performed best; thus, this model is appropriate for modeling antimicrobial susceptibility data. The findings indicate that mathematical modeling is important in AST and has the potential to become a powerful predictive tool in the fight against antibiotic resistance.</p><p><strong>Conclusion: </strong>The logarithmic regression is the strongest and most valid model for describing the relationship between MIC and bacterial susceptibility, and it can be useful for interpreting and predicting antimicrobial susceptibility data.</p>","PeriodicalId":10881,"journal":{"name":"Current pharmaceutical biotechnology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148905253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}