Current Biotechnology最新文献_第4页

A Brief Overview of Invasive Fungal Infections in Immunocompromised Individuals 免疫功能低下个体侵袭性真菌感染的简要概述

Current Biotechnology Pub Date : 2022-08-02 DOI: 10.2174/2211550111666220802162126

Deepak K. Pisote, Gowtham M, Rohit L. Choure

引用次数: 0

Treatment with Biostimulants Extracted from Salix babylonica L. Induces Drought Stress Tolerance in Zoysia tenuifolia 从古巴柳中提取的生物刺激素对结缕草抗旱性的影响

Current Biotechnology Pub Date : 2022-06-17 DOI: 10.2174/2211550111666220617125823

Kumchol Ri, J. Ri, Yang Gao

{"title":"Treatment with Biostimulants Extracted from Salix babylonica L. Induces Drought Stress Tolerance in Zoysia tenuifolia","authors":"Kumchol Ri, J. Ri, Yang Gao","doi":"10.2174/2211550111666220617125823","DOIUrl":"https://doi.org/10.2174/2211550111666220617125823","url":null,"abstract":"\u0000\u0000Drought stress limits the growth of plants and even impairs their physiological functions. Under water stress, Zoysia tenuifolia has limited biomass, plant height, and leaf length, decreased protective enzyme activity, while inducing accumulation of large amounts of osmotic regulators. If a plant is in a severely water-deprived environment, its growth is clearly inhibited and may even die.\u0000\u0000\u0000\u0000The purpose of this study was to evaluate the effect of a biostimulant, a willow extract isolated from the bark of S.babylonica, on the drought stress of Z.tenuifolia.\u0000\u0000\u0000\u0000First, the change in the content of salicylic acid was evaluated through the oxidation process by potassium permanganate after acid hydrolysis of the willow extract. Second, through leaf spraying with Z.tenuifolia, the improvement effect on drought stress according to a reasonable concentration of willow extract was observed.\u0000\u0000\u0000\u0000In this paper, it was found that oxidation of potassium permanganate after acid hydrolysis of willow extract significantly increased the content of salicylic acid, a plant growth regulator, and that leaf spray remarkably improved several physiological index of Z.tenuifolia under drought stress conditions.\u0000\u0000\u0000\u0000This study provides important information on the identification and utilization of willow resources as a safe plant protector and growth regulator, and is the first study to report on the use of these willow extracts as a source of liquid extracts as biostimulants in Z.tenuifolia cultivation.\u0000","PeriodicalId":10850,"journal":{"name":"Current Biotechnology","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87164877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microbial Production of Lactic Acid – A Review 微生物生产乳酸的研究进展

Current Biotechnology Pub Date : 2022-06-15 DOI: 10.2174/2211550111666220615110914

Hira Arshad, M. Irfan, H. A. Shakir, Muhammad Khan, Sajid Ali, S. Saeed, Marcelo Franco

引用次数: 0

Preeclampsia : Long Term Prognosis in Mother and Their Children 子痫前期:母亲和孩子的长期预后

Current Biotechnology Pub Date : 2022-06-15 DOI: 10.2174/2211550111666220615112432

Sumel Ashique, Tahamina Khatun, N. Sandhu

引用次数: 0

Role of Functional Food Additives to Regulate the Immune Response to Covid-19 功能性食品添加剂在调节Covid-19免疫应答中的作用

Current Biotechnology Pub Date : 2022-06-13 DOI: 10.2174/2211550111666220613143422

R. Verma, Meenakshi Pal Bagel

{"title":"Role of Functional Food Additives to Regulate the Immune Response to Covid-19","authors":"R. Verma, Meenakshi Pal Bagel","doi":"10.2174/2211550111666220613143422","DOIUrl":"https://doi.org/10.2174/2211550111666220613143422","url":null,"abstract":"\u0000\u0000Food additives act as preventive measures and promote a healthy immune response against pathogenic diseases. There are several functional food additives with antiviral potential that are part of our daily food supplements, which can be exploited to improve the immunity of the human being during the pandemic of Covid-19.\u0000\u0000\u0000\u0000For the development of this literature, an extensive database search using the scientific databases and Google Scholar, as well as commercial search engines such as Google, Google Patent and Patent Scope to search for commercial and patentable applications.\u0000\u0000\u0000\u0000Food additives such as Phyllanthus emblica, Long pepper, Cinnamon, Turmeric, Cardamom, Ginger, Garlic, Holy basil, and liquorice are used in traditional cultures as preventative treatments. The phytocompounds extracted from these food additives are immune modulators against various pathogenic inflammations. Enhancing the immune response and boosting health are the benefits of these food additives.\u0000\u0000\u0000\u0000The phytocompounds extracted from food additives such as Phyllanthus emblica, Long pepper, Cinnamon, Turmeric, Cardamom, Ginger, Garlic, Holy basil, and liquorice are immune modulators against various pathogenic inflammations. The research literature and reputable sources online confirm that functional food additives in a regular diet may help cure Covid-19 disease. It is necessary to conduct scientific research to determine the effectiveness of food additives.\u0000\u0000\u0000\u0000The majority of diseases are caused by metabolic disorders. It is clear that the diet plays a major role in controlling the inflammation associated with diseases and metabolic disorders. There are still a lack of phytochemical screenings and their interaction with metabolism. This effort will help the science community to think outside of the box of medicine.\u0000","PeriodicalId":10850,"journal":{"name":"Current Biotechnology","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87760744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular Modelling and Docking Analysis of Filarial Targets by using New Lead Compounds identified from Psoralea corylifolia and Mimusops elengi 从补骨脂和蜜草中鉴定的新先导化合物对丝虫病靶点的分子建模和对接分析

Current Biotechnology Pub Date : 2022-05-17 DOI: 10.2174/2211550111666220517095527

Shobana A, Priyadharshini Am, Yogalakshmi Manoharan, Gowri Shankar Bagavananthem Andavan

{"title":"Molecular Modelling and Docking Analysis of Filarial Targets by using New Lead Compounds identified from Psoralea corylifolia and Mimusops elengi","authors":"Shobana A, Priyadharshini Am, Yogalakshmi Manoharan, Gowri Shankar Bagavananthem Andavan","doi":"10.2174/2211550111666220517095527","DOIUrl":"https://doi.org/10.2174/2211550111666220517095527","url":null,"abstract":"\u0000\u0000Psoralea corylifolia and Mimusops elengi could be a source for new bioactive compounds for treating filariasis Psoralea corylifolia and Mimusops elengi. These plants are rich in medicinally and phytochemically has been proved. These plants played an important role in ancient medicine for the treatments of various ailments and especially against many helminths.\u0000\u0000\u0000\u0000Psoralea corylifolia and Mimusops elengi could be a source for new bioactive compounds for treating filariasis. 20g of dried powder of Psoralea corylifolia and Mimusops elengi were extracted using a Soxhlet apparatus using various solvents like methanol, chloroform, acetone and water for about 30 cycles and then concentrated using a rotary evaporator and stored at 4 °C in air tight containers. It is effective against Setaria cervi at 100 and 200 µg respectively. In-vitro studies have been done for the respective compounds. Homology models of Glutathione S transferase, Chitinase and Transglutaminase were constructed using MODELLER v9.20 (Accelrys).\u0000\u0000\u0000\u0000The results from the in vitro studies were confirmed by TLC and GC MS analysis of the extracts which showed the presence of different phytochemical compounds in the extracts. Among the compounds identified in GC MS 7,10-Octadecadienoic acid, methyl ester, Pentadecanoic acid, 14-methyl-, methyl ester, 2-Nonadecanone2,4-dinitrophenylhydrazine, Aspidospermidin-17-ol, 1-acetyl-19,21-epoxy-15,16-dimethoxy-, 9- (2’,2’-Dimethylpropanihydrozano)-3,6 dichloro-2,7-bis-[2-(diethylamino)-ethoxy] fluorine, 2,2,4-Trimethyl-3-(3,8,12,16-tetramethyl-heptadeca-3,7,11,15-tetraenyl)-cyclohexanol were docked against crystallised bioactive compounds.\u0000\u0000\u0000\u0000As a result of this study, it was concluded that arresting these proteins will help in arresting the growth and multiplication of parasites, thus leading to the development of a new anti-filarial drug.\u0000","PeriodicalId":10850,"journal":{"name":"Current Biotechnology","volume":"60 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91038879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Outrage: The Mechanism of Antimicrobial Resistance (AMR) in Microorganisms 微生物抗微生物药物耐药性(AMR)的机制

Current Biotechnology Pub Date : 2022-04-28 DOI: 10.2174/2211550111666220428105504

Soamyaa Srivastava

引用次数: 1

Role of Phytoremediation in Enhancing Heavy Metals Tolerance: A Novel Biotechnological Approach 植物修复在提高重金属耐受性中的作用:一种新的生物技术途径

Current Biotechnology Pub Date : 2022-04-28 DOI: 10.2174/2211550111666220428113114

L. M. Behera, Saubhagya Subhadarsini Sahoo, Somanath Baral, Rabindra Nayak, Abhishek Sahu, Rutumbara Dash, Ankit Srivastava, B. P. Jit, Biswajita Pradhan

{"title":"Role of Phytoremediation in Enhancing Heavy Metals Tolerance: A Novel Biotechnological Approach","authors":"L. M. Behera, Saubhagya Subhadarsini Sahoo, Somanath Baral, Rabindra Nayak, Abhishek Sahu, Rutumbara Dash, Ankit Srivastava, B. P. Jit, Biswajita Pradhan","doi":"10.2174/2211550111666220428113114","DOIUrl":"https://doi.org/10.2174/2211550111666220428113114","url":null,"abstract":"\u0000\u0000Rapid global modernization, urbanization, industrialization, and frequent natural processes release toxic heavy metals into the environment such as mercury (Hg), lead (Pb), cadmium (Cd), arsenic (As) and selenium (Se). In the present scenario, soil and water ecosystems are the main environmental alarms. The remediation of contaminated soils and water ecosystems with appropriate approaches is urgently needed. Physical remediation strategies are conventional, expensive, and nonspecific. Phytoremediation is an eco-friendly and fast-growing approach that are accomplished because of uptake of large quantities of toxic heavy metals from the environment. Since, plants are slow-growing and have low biomass that urgently needs to be bioengineered for high biomass. On the other hand, biotechnology helps to identify and isolate the specific gene coding for heavy metal resistance tolerance in plants. Moreover, molecular cloning and the manifestation of heavy metal accumulator genes and degrading enzyme coding genes displayed enhanced remediation rates, which will make the process for large-scale application to remediate faster contamination soils and water. This review has prominence on biotechnological methods and strategies for remediation of heavy metals and metalloid containment from environments. Furthermore, it focuses on the improvements and implications of phytoremediation as well as their operations and applications to clean up toxic pollutants from environments and to improve phytoremediation efficiency to tolerate different heavy metal pollutants highlights future challenges.\u0000","PeriodicalId":10850,"journal":{"name":"Current Biotechnology","volume":"157 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79521729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Chemical Characterization, Antioxidant and Antibacterial Activity of Essential oil of Cymbopogon winterianus Jowitt (Citronella) from Western Nepal 尼泊尔西部香茅属冬香草挥发油的化学性质及抗氧化抗菌活性

Current Biotechnology Pub Date : 2022-04-05 DOI: 10.2174/2211550111666220405133558

D. Shrestha, Prabha Sharma, Anisha Pandey, K. Dhakal, Rameswor Baral, A. Adhikari

{"title":"Chemical Characterization, Antioxidant and Antibacterial Activity of Essential oil of Cymbopogon winterianus Jowitt (Citronella) from Western Nepal","authors":"D. Shrestha, Prabha Sharma, Anisha Pandey, K. Dhakal, Rameswor Baral, A. Adhikari","doi":"10.2174/2211550111666220405133558","DOIUrl":"https://doi.org/10.2174/2211550111666220405133558","url":null,"abstract":"\u0000\u0000Essential oils (EOs) are a mixture of volatile compounds of plant origin, which possess substantial biological activities such as antioxidant, antimicrobial, and antifungal activity.\u0000\u0000\u0000\u0000This study aimed to determine the chemical composition, antioxidant, and antibacterial activity of essential oil isolated from Cymbopogon winterianusJowitt.\u0000\u0000\u0000\u0000The hydro-distillation method was used for the isolation of essential oil. The chemical composition of the isolated essential oil was analyzed using the gas chromatography/mass spectrometry (GC-MS) technique. Antioxidant activity was determined using2,2-Diphenyl-1-picrylhydrazyl(DPPH) free radical scavenging assay, and the IC50 value was calculated. The well-diffusion method was applied for the antibacterial activity, and the zone of inhibition (ZOI) was measured.\u0000\u0000\u0000\u0000The essential oil from Cymbopogon winterianusJowitt was isolated with a 0.5% yield. Gas Chromatography-Mass Spectrometry(GC-MS) analysis reported 19 different compounds, out of which, Geraniol (28.87%), Citronellal (11.85%), Citronellol (10.88%), Geranial (9.19%), trans-Geranyl acetate (9.11%), and Neral (8.02%) were found to be the major constituents. The essential oil was a promising antioxidant with an IC50 value of 0.458±0.39µg/mL compared to the standard Quercetin 1.187±0.22µg/mL.In addition, the isolated essential oil revealed antibacterial activity against Staphylococcus aureus (ZOI=13.2mm), Bacillus subtilis (ZOI=9.9mm), and Enterococcus faecalis (ZOI=8.4mm).\u0000\u0000\u0000\u0000The essential oil isolated from Cymbopogon winterianusJowittexhibits antioxidant and antibacterial activity, implying that it could find use in modern medicine.\u0000","PeriodicalId":10850,"journal":{"name":"Current Biotechnology","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81618515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Current Review of Systemic Lupus Erythematosus Treatment Using Monoclonal Antibodies 单克隆抗体治疗系统性红斑狼疮的研究进展

Current Biotechnology Pub Date : 2022-03-29 DOI: 10.2174/2211550111666220329183309

R. G. Shinde, V. P. Patel, S. D. Gundgole, S. Dhumale, S. D. Dhole

{"title":"A Current Review of Systemic Lupus Erythematosus Treatment Using Monoclonal Antibodies","authors":"R. G. Shinde, V. P. Patel, S. D. Gundgole, S. Dhumale, S. D. Dhole","doi":"10.2174/2211550111666220329183309","DOIUrl":"https://doi.org/10.2174/2211550111666220329183309","url":null,"abstract":"\u0000\u0000Lupus erythematosus (SLE) is an autoimmune disease that affects the body's immune system, heterogeneous, and inflammatory autoimmune diseases. These diseases, affect multiple tissues and organs. The most frequent kind of lupus is systemic lupus erythematosus (SLE). SLE is an autoimmune illness in which the immune system targets the body's own tissues, resulting in extensive inflammation and tissue destruction in the organs involved. Joints, skin, brain, lungs, kidneys, and blood vessels can all be affected. It examines to be B-cell disease in which autoantibodies attack the cells themselves. Systemic lupus erythematosus autoimmune diseases involve different treatment methods. These abnormalities are due to the presence of autoantibodies, and these autoantibodies contribute to the degeneration of our immune system. In this review, we will focus on various therapies including SLE treatments, such as B-cell therapy, cytokine therapy, interferon targets, and anticomplementary therapies, all of which have become challenging. We will also discuss post-marketing use and ongoing clinical trials, as well as safety and effective doses.\u0000","PeriodicalId":10850,"journal":{"name":"Current Biotechnology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83116870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1