Crohn's & Colitis 360最新文献

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The Comorbidity of Patient-Reported Crohn's Disease Activity and Depression: The Role of Health Behavior Mediators. 患者报告的克罗恩病活动性与抑郁的共存性:健康行为中介因素的作用。
IF 1.4
Crohn's & Colitis 360 Pub Date : 2023-12-23 eCollection Date: 2024-01-01 DOI: 10.1093/crocol/otad080
Lawrence S Gaines, Michael D Kappelman, David A Schwartz, Sara N Horst, Dawn B Beaulieu, Elizabeth S Scoville, Robin L Dalal, Baldeep S Pabla, James C Slaughter
{"title":"The Comorbidity of Patient-Reported Crohn's Disease Activity and Depression: The Role of Health Behavior Mediators.","authors":"Lawrence S Gaines, Michael D Kappelman, David A Schwartz, Sara N Horst, Dawn B Beaulieu, Elizabeth S Scoville, Robin L Dalal, Baldeep S Pabla, James C Slaughter","doi":"10.1093/crocol/otad080","DOIUrl":"10.1093/crocol/otad080","url":null,"abstract":"<p><strong>Background: </strong>Longitudinal research reveals a unidirectional relationship between a nonsomatic symptom of depression, a negative view of the self, and later reported Crohn's disease (CD) activity. We evaluated whether health behaviors mediated this association using a longitudinal design.</p><p><strong>Methods: </strong>We studied 3304 adult volunteers with a self-reported diagnosis of CD who completed a baseline survey that included demographics, CD activity, a symptom-specific index of depression, and measures of physical activity, smoking, and sleep quality. Crohn's disease status and the cognitive index of depression were also measured 6 and 12 months after the baseline evaluation. We specified single-mediator and multiple-mediator models to elucidate the depression-disease activity relationship.</p><p><strong>Results: </strong>Among 2395 females and 909 males, we found a significant mediation effect for activity level (<i>P</i> < .001) after adjusting for age, sex, and body mass index. There was no evidence that sleep quality and smoking are significant single mediators. When we considered multiple mediation models, smoking and less activity partially mediate the depression-CD association.</p><p><strong>Conclusions: </strong>Smoking and lower levels of physical activity are potential mediators of the unidirectional association between a nonsomatic symptom of depression-a negative view of the self-and patient-reported CD activity. Evaluating and treating specific symptoms of depression may reduce the frequency of CD exacerbations.</p>","PeriodicalId":10847,"journal":{"name":"Crohn's & Colitis 360","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2023-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10771267/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139377331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Trial Design in Ulcerative Colitis: Interpreting Evolving Endpoints Based on Post Hoc Analyses of the Vedolizumab Phase 3 Trials GEMINI 1 and VISIBLE 1. 溃疡性结肠炎的临床试验设计:基于韦多珠单抗 GEMINI 1 和 VISIBLE 1 3 期试验的事后分析解读不断变化的终点。
IF 1.4
Crohn's & Colitis 360 Pub Date : 2023-12-18 eCollection Date: 2024-01-01 DOI: 10.1093/crocol/otad076
William J Sandborn, Bruce E Sands, Sharif Uddin, Rana M Qasim Khan, Richa Sagar Mukherjee
{"title":"Clinical Trial Design in Ulcerative Colitis: Interpreting Evolving Endpoints Based on Post Hoc Analyses of the Vedolizumab Phase 3 Trials GEMINI 1 and VISIBLE 1.","authors":"William J Sandborn, Bruce E Sands, Sharif Uddin, Rana M Qasim Khan, Richa Sagar Mukherjee","doi":"10.1093/crocol/otad076","DOIUrl":"10.1093/crocol/otad076","url":null,"abstract":"<p><strong>Background: </strong>The 12-point total Mayo score including a Physician's Global Assessment (PGA) of disease activity has been used to assess outcomes in clinical trials for ulcerative colitis (UC). In 2016, the US Food and Drug Administration (FDA) issued guidance advising the removal of the PGA in future trials. We examined how endpoints in UC trials have evolved and conducted a post hoc analysis of the GEMINI 1 and VISIBLE 1 trials to understand how the use of a 9-point modified Mayo score, excluding PGA, compares with the total Mayo score.</p><p><strong>Methods: </strong>Endpoint definitions of clinical remission in phase 3 trials were extracted from published literature and ClinicalTrials.gov. The difference (%Δ) between the proportions of patients in GEMINI 1 and VISIBLE 1 achieving clinical remission with vedolizumab versus placebo at week 52 was measured according to 4 endpoint definitions.</p><p><strong>Results: </strong>Trials completed up to the end of 2019 used the total Mayo score to assess clinical remission. Most trials that were completed or estimated to be completed by June 2020 or later used modified Mayo scores. Post hoc analysis revealed decreasing endpoint stringency was associated with increasing %Δ values. The modified Mayo score definition most like the definition recommended by the FDA produced %Δ values like those reported using the total Mayo score in GEMINI 1 and VISIBLE 1.</p><p><strong>Conclusions: </strong>Endpoint definitions for UC clinical trials have evolved following FDA guidance. The efficacy of vedolizumab, measured using modified Mayo scoring, was comparable to values reported using the total Mayo score.</p>","PeriodicalId":10847,"journal":{"name":"Crohn's & Colitis 360","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2023-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10782208/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139424499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Racial, Ethnic, and Geographic Disparities in Immunization Rates Among Patients With Inflammatory Bowel Disease. 炎症性肠病患者免疫接种率的种族、民族和地域差异。
IF 1.4
Crohn's & Colitis 360 Pub Date : 2023-12-14 eCollection Date: 2023-10-01 DOI: 10.1093/crocol/otad078
Poonam Beniwal-Patel, Gabrielle Waclawik, Keely Browning, Aijan Urmat, Trevor L Schell, Ryan Smith, Antonio Huerta, Lauren Hipp, Sonya Dave, Neemit Shah, Kayla E Dillon, Katelyn Reiter-Schreurs, Rachel K Russ, Miguel A Mailig, Fauzia Osman, Francis A Farraye, Jennifer Weiss, Mary S Hayney, Freddy Caldera
{"title":"Racial, Ethnic, and Geographic Disparities in Immunization Rates Among Patients With Inflammatory Bowel Disease.","authors":"Poonam Beniwal-Patel, Gabrielle Waclawik, Keely Browning, Aijan Urmat, Trevor L Schell, Ryan Smith, Antonio Huerta, Lauren Hipp, Sonya Dave, Neemit Shah, Kayla E Dillon, Katelyn Reiter-Schreurs, Rachel K Russ, Miguel A Mailig, Fauzia Osman, Francis A Farraye, Jennifer Weiss, Mary S Hayney, Freddy Caldera","doi":"10.1093/crocol/otad078","DOIUrl":"10.1093/crocol/otad078","url":null,"abstract":"<p><strong>Background and aims: </strong>Racial and ethnic disparities exist in the treatment of IBD. These disparities exist in adult vaccine uptake among the general population and may extend to patients with IBD. The primary aim of this study was to determine whether racial, ethnic, or geographic disparities existed in influenza vaccine uptake among patients with IBD.</p><p><strong>Methods: </strong>We performed a multicenter, retrospective cohort study evaluating adult vaccine uptake among patients with IBD seen at two tertiary referral centers between September 2019 and February 2020. The primary outcome was to determine if racial/ethnic and geographic disparities existed in influenza vaccine uptake for the two prior seasons. Our secondary outcomes were to determine if disparities existed for pneumococcal, zoster, or hepatitis B vaccines.</p><p><strong>Results: </strong>Among the 2453 patients who met the inclusion criteria, most identified as non-Hispanic White (89.9%), were on immunosuppressive therapy (74.5%), and received the influenza vaccine in both seasons (56.0%). Older age (prevalence ratio (PR) 0.98; 95% confidence interval (95%CI) 0.98-0.99; <i>P</i> < .001) and non-Hispanic White patients (PR 0.76, 95%CI 0.59-0.98, <i>P</i> < 0.03) were significantly more likely to be immunized. Black patients (PR 1.37; 95%CI 1.18-1.59; <i>P</i> < .001) and those living in underserved geographic areas (PR 1.35; 95%CI 1.17-1.56; <i>P</i> < 0.001) were less likely to be immunized. Racial/ethnic and geographic disparities were identified for pneumococcal, zoster, and hepatitis B vaccine uptake.</p><p><strong>Conclusions: </strong>Racial and ethnic vaccination uptake disparities exist among patients with IBD; patients from medically underserved areas are also vulnerable to these disparities Studies identifying patient, provider, and system-level opportunities to address these disparities are needed.</p>","PeriodicalId":10847,"journal":{"name":"Crohn's & Colitis 360","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2023-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10734681/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138828659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unraveling the Place of Small Molecules in the Treatment of Fistulizing Crohn's Disease-A Systematic Review and Network Meta-Analysis. 揭示小分子药物在治疗瘘性克罗恩病中的地位--系统综述和网络荟萃分析。
IF 1.4
Crohn's & Colitis 360 Pub Date : 2023-12-13 eCollection Date: 2023-10-01 DOI: 10.1093/crocol/otad074
Mohamed Attauabi, Ditlev Nytoft Rasmussen, Fredrik Olof Bergenheim, Johan Burisch, Jakob Benedict Seidelin
{"title":"Unraveling the Place of Small Molecules in the Treatment of Fistulizing Crohn's Disease-A Systematic Review and Network Meta-Analysis.","authors":"Mohamed Attauabi, Ditlev Nytoft Rasmussen, Fredrik Olof Bergenheim, Johan Burisch, Jakob Benedict Seidelin","doi":"10.1093/crocol/otad074","DOIUrl":"10.1093/crocol/otad074","url":null,"abstract":"","PeriodicalId":10847,"journal":{"name":"Crohn's & Colitis 360","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2023-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10734679/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138828660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Authors' Reply to Unraveling the Place of Small Molecules in the Treatment of Fistulizing Crohn's Disease-A Systematic Review and Network Meta-analysis. 作者对《揭示小分子药物在治疗瘘性克罗恩病中的地位--系统综述和网络荟萃分析》的回复。
IF 1.4
Crohn's & Colitis 360 Pub Date : 2023-12-13 eCollection Date: 2023-10-01 DOI: 10.1093/crocol/otad075
Arshdeep Singh, Vandana Midha, Gursimran Singh Kochhar, Bo Shen, Ajit Sood
{"title":"Authors' Reply to Unraveling the Place of Small Molecules in the Treatment of Fistulizing Crohn's Disease-A Systematic Review and Network Meta-analysis.","authors":"Arshdeep Singh, Vandana Midha, Gursimran Singh Kochhar, Bo Shen, Ajit Sood","doi":"10.1093/crocol/otad075","DOIUrl":"10.1093/crocol/otad075","url":null,"abstract":"","PeriodicalId":10847,"journal":{"name":"Crohn's & Colitis 360","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2023-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10734682/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138828658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diet and Nutrition in Inflammatory Bowel Disease: A Review of the Literature. 炎症性肠病的饮食与营养:文献综述。
IF 1.4
Crohn's & Colitis 360 Pub Date : 2023-12-09 eCollection Date: 2024-01-01 DOI: 10.1093/crocol/otad077
Scott Manski, Nicholas Noverati, Tatiana Policarpo, Emily Rubin, Raina Shivashankar
{"title":"Diet and Nutrition in Inflammatory Bowel Disease: A Review of the Literature.","authors":"Scott Manski, Nicholas Noverati, Tatiana Policarpo, Emily Rubin, Raina Shivashankar","doi":"10.1093/crocol/otad077","DOIUrl":"10.1093/crocol/otad077","url":null,"abstract":"<p><p>Diet is thought to contribute to the development of inflammatory bowel disease (IBD) and may act as a mediator of inflammation in patients with IBD. Patients commonly associate their diet with symptoms and inquire about dietary modifications to manage their IBD. Without clinical guidelines and well-established nutritional data, healthcare providers managing patients with IBD may find it difficult to provide recommendations. Strong evidence for enteral nutrition, particularly in the pediatric population, has been established in Crohn's disease (CD) as a therapeutic option. Enteral nutrition may also serve as an adjunct to an exclusion diet. Recent studies such as the randomized trial comparing the Specific Carbohydrate Diet to a Mediterranean Diet in CD patients provide additional insights in forming dietary plans. A low-fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAP) diet in quiescent IBD and an anti-inflammatory diet have also been explored as adjunctive therapies. In this review, we discuss the latest evidence for the role of diet in IBD both as a therapeutic modality and as an opportunity to provide patient-centered care.</p>","PeriodicalId":10847,"journal":{"name":"Crohn's & Colitis 360","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2023-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10782214/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139424500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Accurate Diet Assessment, Patient Selection, and Objective Clinical Outcome Are Critical in Untangling the Role of Diet on Pouchitis. 准确的饮食评估、患者选择和客观的临床结果是了解饮食对胃袋炎影响的关键。
IF 1.4
Crohn's & Colitis 360 Pub Date : 2023-12-09 eCollection Date: 2024-01-01 DOI: 10.1093/crocol/otad079
Dakota Rhys-Jones, Chu K Yao, Zaid S Ardalan
{"title":"Accurate Diet Assessment, Patient Selection, and Objective Clinical Outcome Are Critical in Untangling the Role of Diet on Pouchitis.","authors":"Dakota Rhys-Jones, Chu K Yao, Zaid S Ardalan","doi":"10.1093/crocol/otad079","DOIUrl":"10.1093/crocol/otad079","url":null,"abstract":"","PeriodicalId":10847,"journal":{"name":"Crohn's & Colitis 360","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2023-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10862651/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139729189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence Rates of Pneumococcal Vaccination in IBD and 30-Day Clinical Outcomes in Patients With IBD and Pneumococcal Disease Stratified by Receipt of Pneumococcal Vaccination: A Multi-Network Study. 根据肺炎球菌疫苗接种情况分层的 IBD 和肺炎球菌疾病患者肺炎球菌疫苗接种流行率和 30 天临床结果:一项多网络研究。
IF 1.4
Crohn's & Colitis 360 Pub Date : 2023-12-08 eCollection Date: 2023-10-01 DOI: 10.1093/crocol/otad048
Andrew Ford, Vibhu Chittajallu, Jaime Abraham Perez, Scott Martin, Motasem Alkhayyat, Maneesh Dave, Edith Y Ho, Preetika Sinh, Vu Nguyen, Gregory Cooper, Jeffry Katz, Fabio Cominelli, Miguel Regueiro, Emad Mansoor
{"title":"Prevalence Rates of Pneumococcal Vaccination in IBD and 30-Day Clinical Outcomes in Patients With IBD and Pneumococcal Disease Stratified by Receipt of Pneumococcal Vaccination: A Multi-Network Study.","authors":"Andrew Ford, Vibhu Chittajallu, Jaime Abraham Perez, Scott Martin, Motasem Alkhayyat, Maneesh Dave, Edith Y Ho, Preetika Sinh, Vu Nguyen, Gregory Cooper, Jeffry Katz, Fabio Cominelli, Miguel Regueiro, Emad Mansoor","doi":"10.1093/crocol/otad048","DOIUrl":"10.1093/crocol/otad048","url":null,"abstract":"","PeriodicalId":10847,"journal":{"name":"Crohn's & Colitis 360","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2023-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10708920/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138799739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to: Practical Primer Addressing Real-World Use Scenarios of Subcutaneous Vedolizumab in Ulcerative Colitis and Crohn's Disease: Post Hoc Analyses of VISIBLE Studies. 修正:解决溃疡性结肠炎和克罗恩病中皮下Vedolizumab实际使用场景的实用引物:可见研究的事后分析。
IF 1.4
Crohn's & Colitis 360 Pub Date : 2023-11-24 eCollection Date: 2023-10-01 DOI: 10.1093/crocol/otad071
{"title":"Correction to: Practical Primer Addressing Real-World Use Scenarios of Subcutaneous Vedolizumab in Ulcerative Colitis and Crohn's Disease: Post Hoc Analyses of VISIBLE Studies.","authors":"","doi":"10.1093/crocol/otad071","DOIUrl":"https://doi.org/10.1093/crocol/otad071","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1093/crocol/otad034.].</p>","PeriodicalId":10847,"journal":{"name":"Crohn's & Colitis 360","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2023-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10668916/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138458457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Questionnaire Survey for Inflammatory Bowel Disease Patients in Japan; A Web-Based Japan, Crohn's Disease, Ulcerative Colitis, Patients Survey. 日本炎症性肠病患者问卷调查一个基于网络的日本,克罗恩病,溃疡性结肠炎,患者调查。
IF 1.4
Crohn's & Colitis 360 Pub Date : 2023-11-17 eCollection Date: 2023-10-01 DOI: 10.1093/crocol/otad069
Takayuki Matsumoto, Keita Imai, Yuki Goda, Yuki Fujimitsu, Toshifumi Kajioka, Hideaki Kihara, Yuji Funaki, Shigeru Imaki, Masato Ueno
{"title":"Questionnaire Survey for Inflammatory Bowel Disease Patients in Japan; A Web-Based Japan, Crohn's Disease, Ulcerative Colitis, Patients Survey.","authors":"Takayuki Matsumoto, Keita Imai, Yuki Goda, Yuki Fujimitsu, Toshifumi Kajioka, Hideaki Kihara, Yuji Funaki, Shigeru Imaki, Masato Ueno","doi":"10.1093/crocol/otad069","DOIUrl":"https://doi.org/10.1093/crocol/otad069","url":null,"abstract":"<p><strong>Background/aims: </strong>The prevalence of inflammatory bowel disease (IBD) in Japan has been increasing. We aimed to clarify the symptoms of patients with IBD in Japan using an internet-based questionnaire survey.</p><p><strong>Methods: </strong>Overall, 805 patients with IBD were asked to complete an internet-based questionnaire addressing their history of disturbances in daily activities, prevalence of fecal urgency, incontinence, and treatment preferences.</p><p><strong>Results: </strong>Responses were obtained from 447 patients with IBD (mean age: 54 years; 70% were men), comprising 363 patients with ulcerative colitis (UC), and 84 with Crohn's disease (CD). Notably, 16% of patients with UC and 35% with CD took over 1 year until the diagnosis of IBD, and 5% of patients with CD visited more than 5 medical institutions. Patients with CD were more likely to experience disturbances in their diet, work, travel, and outings than those with UC. Fecal urgency and incontinence were significantly more frequent in patients with CD than in those with UC (72% vs. 44%, and 50% vs. 26%, respectively). In contrast, 26% of the men and 37% of women with IBD had constipation. Acid reflux, sleep disorders, and depressive symptoms were present in approximately 30% of the patients. Oral administration was preferred.</p><p><strong>Conclusions: </strong>Patients with IBD in Japan experience more severe disturbances in their daily activities, and these are more severe in those with CD than those with UC. In addition to fecal urgency and incontinence, care is required for constipation, acid reflux, sleep disorders, and depressive symptoms.</p>","PeriodicalId":10847,"journal":{"name":"Crohn's & Colitis 360","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2023-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10676197/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138458460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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