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Economic Burden of Fatigue in Inflammatory Bowel Disease. 炎症性肠病患者疲劳的经济负担。
IF 1.8
Crohn's & Colitis 360 Pub Date : 2023-04-20 eCollection Date: 2023-07-01 DOI: 10.1093/crocol/otad020
Ashwin N Ananthakrishnan, Raj Desai, Wan-Ju Lee, Jenny Griffith, Naijun Chen, Edward V Loftus
{"title":"Economic Burden of Fatigue in Inflammatory Bowel Disease.","authors":"Ashwin N Ananthakrishnan, Raj Desai, Wan-Ju Lee, Jenny Griffith, Naijun Chen, Edward V Loftus","doi":"10.1093/crocol/otad020","DOIUrl":"10.1093/crocol/otad020","url":null,"abstract":"<p><strong>Background: </strong>This retrospective study gathered medical/pharmacy claims data on patients with inflammatory bowel disease (IBD) between January 01, 2000 and March 31, 2019 from the IBM MarketScan commercial claims database to assess the real-world impact of fatigue on healthcare costs in patients newly diagnosed with IBD.</p><p><strong>Methods: </strong>Eligible participants were ≥18 years, newly diagnosed with IBD (≥2 separate claims), and had ≥12 months of continuous database enrollment before and after fatigue diagnosis. The date of fatigue diagnosis was the index date; participants were followed for 12 months post-index. Patients with (cases) or without (controls) fatigue were matched 1:1 by propensity score matching. Patients with evidence of prior IBD diagnosis/treatment, or those with a chronic disease other than IBD wherein fatigue is the primary symptom, were excluded. Healthcare resource utilization (HCRU), including hospitalizations, inpatient and outpatient visits, and associated costs were compared between cases and controls.</p><p><strong>Results: </strong>Matched IBD cohorts (21 321 cases/21 321 controls) were identified (42% Crohn's disease [CD] and 58% ulcerative colitis [UC]) with similar baseline characteristics (average age: 46 years; 60% female). Cases versus controls had significantly more all-cause outpatient visits (incidence rate ratio [IRR], 95% confidence intervals [95% CI]: 1.64 [1.61, 1.67], <i>P</i> < .001) and all-cause hospitalizations (IRR [95% CI]: 1.92 [1.81, 2.04], <i>P</i> < .001); as well as significantly higher all-cause total direct healthcare costs (mean: $24 620 vs. $15 324; <i>P</i> < .001). Similar findings were observed for IBD-related outcomes, as well as in CD- and UC-specific subgroups.</p><p><strong>Conclusions: </strong>Presence of fatigue is associated with an increase in HCRU and total medical costs among patients newly diagnosed with IBD.</p>","PeriodicalId":10847,"journal":{"name":"Crohn's & Colitis 360","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2023-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10470665/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10143893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corticosteroids Increase the Risk of Invasive Fungal Infections More Than Tumor Necrosis Factor-Alpha Inhibitors in Patients With Inflammatory Bowel Disease. 在炎症性肠病患者中,皮质类固醇比肿瘤坏死因子- α抑制剂更能增加侵袭性真菌感染的风险。
IF 1.4
Crohn's & Colitis 360 Pub Date : 2023-04-01 DOI: 10.1093/crocol/otad010
Martin H Gregory, Andrej Spec, Dustin Stwalley, Anas Gremida, Carlos Mejia-Chew, Katelin B Nickel, Matthew A Ciorba, Richard P Rood, Margaret A Olsen, Parakkal Deepak
{"title":"Corticosteroids Increase the Risk of Invasive Fungal Infections More Than Tumor Necrosis Factor-Alpha Inhibitors in Patients With Inflammatory Bowel Disease.","authors":"Martin H Gregory,&nbsp;Andrej Spec,&nbsp;Dustin Stwalley,&nbsp;Anas Gremida,&nbsp;Carlos Mejia-Chew,&nbsp;Katelin B Nickel,&nbsp;Matthew A Ciorba,&nbsp;Richard P Rood,&nbsp;Margaret A Olsen,&nbsp;Parakkal Deepak","doi":"10.1093/crocol/otad010","DOIUrl":"https://doi.org/10.1093/crocol/otad010","url":null,"abstract":"<p><strong>Background: </strong>Invasive fungal infections are a devastating complication of inflammatory bowel disease (IBD) treatment. We aimed to determine the incidence of fungal infections in IBD patients and examine the risk with tumor necrosis factor-alpha inhibitors (anti-TNF) compared with corticosteroids.</p><p><strong>Methods: </strong>In a retrospective cohort study using the IBM MarketScan Commercial Database we identified US patients with IBD and at least 6 months enrollment from 2006 to 2018. The primary outcome was a composite of invasive fungal infections, identified by ICD-9/10-CM codes plus antifungal treatment. Tuberculosis (TB) infections were a secondary outcome, with infections presented as cases/100 000 person-years (PY). A proportional hazards model was used to determine the association of IBD medications (as time-dependent variables) and invasive fungal infections, controlling for comorbidities and IBD severity.</p><p><strong>Results: </strong>Among 652 920 patients with IBD, the rate of invasive fungal infections was 47.9 cases per 100 000 PY (95% CI 44.7-51.4), which was more than double the TB rate (22 cases [CI 20-24], per 100 000 PY). Histoplasmosis was the most common invasive fungal infection (12.0 cases [CI 10.4-13.8] per 100 000 PY). After controlling for comorbidities and IBD severity, corticosteroids (hazard ratio [HR] 5.4; CI 4.6-6.2) and anti-TNFs (HR 1.6; CI 1.3-2.1) were associated with invasive fungal infections.</p><p><strong>Conclusions: </strong>Invasive fungal infections are more common than TB in patients with IBD. The risk of invasive fungal infections with corticosteroids is more than double that of anti-TNFs. Minimizing corticosteroid use in IBD patients may decrease the risk of fungal infections.</p>","PeriodicalId":10847,"journal":{"name":"Crohn's & Colitis 360","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9999356/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9104713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Challenges in the Management of and Biologic Use in Incarcerated Patients With Inflammatory Bowel Disease. 炎症性肠病嵌顿患者的管理和生物用药的挑战。
IF 1.4
Crohn's & Colitis 360 Pub Date : 2023-04-01 DOI: 10.1093/crocol/otad002
Sarah Barbina, John Romano, Erin Forster
{"title":"Challenges in the Management of and Biologic Use in Incarcerated Patients With Inflammatory Bowel Disease.","authors":"Sarah Barbina,&nbsp;John Romano,&nbsp;Erin Forster","doi":"10.1093/crocol/otad002","DOIUrl":"https://doi.org/10.1093/crocol/otad002","url":null,"abstract":"<p><strong>Background: </strong>Therapy and management of inflammatory bowel disease (IBD) require commitment from both the provider and patient to ensure optimal disease management. Prior studies show vulnerable patient populations with chronic medical conditions and compromised access to health care, such as incarcerated patients, suffer as a result. After an extensive literature review, there are no studies outlining the unique challenges associated with managing prisoners with IBD.</p><p><strong>Methods: </strong>A detailed retrospective chart review of 3 incarcerated patients cared for at a tertiary referral center with an integrated patient-centered IBD medical home (PCMH) and a review of literature was performed.</p><p><strong>Results: </strong>All 3 patients were African American males in their 30s with severe disease phenotypes requiring biologic therapy. All patients had challenges with medication adherence and missed appointments related to inconsistent access to clinic. Two of the 3 cases depicted better patient-reported outcomes through frequent engagement with the PCMH.</p><p><strong>Conclusions: </strong>It is evident there are care gaps and opportunities to optimize care delivery for this vulnerable population. It is important to further study optimal care delivery techniques such as medication selection, though interstate variation in correctional services poses challenges. Efforts can be made to focus on regular and reliable access to medical care, especially for those who are chronically ill.</p>","PeriodicalId":10847,"journal":{"name":"Crohn's & Colitis 360","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9994588/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9104714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role and Impact of a Clinical Pharmacy Team at an Inflammatory Bowel Disease Center. 炎症性肠病中心临床药学团队的作用和影响。
IF 1.4
Crohn's & Colitis 360 Pub Date : 2023-04-01 DOI: 10.1093/crocol/otad018
David K Choi, David T Rubin, Archariya Puangampai, Monika Lach
{"title":"Role and Impact of a Clinical Pharmacy Team at an Inflammatory Bowel Disease Center.","authors":"David K Choi,&nbsp;David T Rubin,&nbsp;Archariya Puangampai,&nbsp;Monika Lach","doi":"10.1093/crocol/otad018","DOIUrl":"https://doi.org/10.1093/crocol/otad018","url":null,"abstract":"<p><strong>Background: </strong>There is limited literature describing the role of a clinical pharmacy team within a tertiary academic inflammatory bowel disease (IBD) center. The goal of this paper is to describe and showcase the clinical and operational impact of an integrated clinical pharmacy team.</p><p><strong>Methods: </strong>This was a retrospective study evaluating the referral outcomes for all patients referred to University of Chicago Medicine Specialty Pharmacy for self-administered advanced IBD therapies covered by prescription insurance from October 1, 2020 to October 31, 2021.</p><p><strong>Results: </strong>A total of 1800 referrals were received for advanced IBD therapies. Prior authorizations (PAs) were required and submitted for 1700 referrals. Of those 1700 PA submissions, 297 (17%) were denied by insurance. To overturn the denials, 344 appeals, including second-level appeals and external reviews, were submitted. Manufacturer patient assistance programs were obtained for 69 patients. From the 1800 referrals, 98% of patients were successfully started on the intended therapy. Clinically, there were 2141 pharmacist-initiated interventions by 2 IBD pharmacists. The most common interventions were prevention in interruption of therapy and providing patient education.</p><p><strong>Conclusions: </strong>Clinical pharmacy teams are well positioned to streamline care within a tertiary academic IBD center. Their unique skillset and ability to provide high yield medication access supports the use of this model as a best practice in IBD centers.</p>","PeriodicalId":10847,"journal":{"name":"Crohn's & Colitis 360","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10111283/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9739623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Crohn's Disease Patient Experiences and Preferences With Disease Monitoring: An International Qualitative Study. 克罗恩病患者的经验和偏好与疾病监测:一项国际定性研究。
IF 1.4
Crohn's & Colitis 360 Pub Date : 2023-04-01 DOI: 10.1093/crocol/otad012
Noelle Rohatinsky, Sandra Zelinsky, Michael Dolinger, Britt Christensen, Rune Wilkens, Shellie Radford, Marla Dubinsky, Kerri Novak
{"title":"Crohn's Disease Patient Experiences and Preferences With Disease Monitoring: An International Qualitative Study.","authors":"Noelle Rohatinsky,&nbsp;Sandra Zelinsky,&nbsp;Michael Dolinger,&nbsp;Britt Christensen,&nbsp;Rune Wilkens,&nbsp;Shellie Radford,&nbsp;Marla Dubinsky,&nbsp;Kerri Novak","doi":"10.1093/crocol/otad012","DOIUrl":"https://doi.org/10.1093/crocol/otad012","url":null,"abstract":"<p><strong>Background: </strong>Strategies incorporating objective disease monitoring in Crohn's disease (CD), beyond clinical symptoms are important to improve patient outcomes. Little evidence exists to explore patient understanding of CD treatment goals, nor preferences and experiences with monitoring options. This qualitative study aimed to explore patient experiences and preferences of CD monitoring to inform monitoring strategies, improve patient engagement, and optimize a patient-centered approach to care.</p><p><strong>Methods: </strong>This study used a patient-oriented, qualitative descriptive design. Convenience and snowball sampling were used to recruit adult participants diagnosed with CD who had experience with at least 2 types of disease monitoring. Online focus groups were conducted and data were analyzed using thematic analysis.</p><p><strong>Results: </strong>This international study included 37 participants from Australia, Canada, United Kingdom, and the United States. Overall, participants preferred more noninvasive types of monitoring [eg, intestinal ultrasound (IUS)] but were willing to undergo more invasive monitoring (eg, colonoscopy) if required. To improve disease monitoring, participants wanted increased access to IUS, establishment of a patient-centered interdisciplinary team and access to information and self-testing. Participants identified challenges with communication between patients and providers and stressed the importance of participating in shared decision making and being equal team members in their care.</p><p><strong>Conclusions: </strong>It is imperative to incorporate patient-driven preferences into how we can best structure monitoring strategies, to ensure equitable access to those preferred modalities and embrace a shared decision-making approach to disease management in CD.</p>","PeriodicalId":10847,"journal":{"name":"Crohn's & Colitis 360","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ef/e2/otad012.PMC10022708.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9145716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
The Impact of Confounders on Symptom-Endoscopic Discordances in Crohn's Disease. 混杂因素对克罗恩病症状-内窥镜不一致的影响
IF 1.4
Crohn's & Colitis 360 Pub Date : 2023-04-01 DOI: 10.1093/crocol/otad017
Anjana Rajan, Yushan Pan, Prerna Mahtani, Rachel Niec, Randy Longman, Juliette Gerber, Dana Lukin, Ellen Scherl, Robert Battat
{"title":"The Impact of Confounders on Symptom-Endoscopic Discordances in Crohn's Disease.","authors":"Anjana Rajan,&nbsp;Yushan Pan,&nbsp;Prerna Mahtani,&nbsp;Rachel Niec,&nbsp;Randy Longman,&nbsp;Juliette Gerber,&nbsp;Dana Lukin,&nbsp;Ellen Scherl,&nbsp;Robert Battat","doi":"10.1093/crocol/otad017","DOIUrl":"https://doi.org/10.1093/crocol/otad017","url":null,"abstract":"<p><strong>Background: </strong>Discordances between clinical and endoscopic Crohn's disease (CD) activity indices negatively impact the utility of clinic visits and efficacy assessments in clinical trials. Bile acid diarrhea (BAD) and small intestinal bacterial overgrowth (SIBO) mimic CD symptoms. This study quantified the impact of BAD and SIBO on the relationship between clinical and endoscopic disease activity indices.</p><p><strong>Methods: </strong>CD patients with 7α-hydroxy-4-cholesten-3-one (7C4) serum measurements and/or SIBO breath tests and matched clinical and endoscopic scores were included. Clinical remission (stool frequency [SF] ≤ 1 and abdominal pain score ≤ 1) rates were compared between those with and without (1) endoscopic remission, (2) BAD (7C4 > 55 ng/mL), and (3) SIBO.</p><p><strong>Results: </strong>Of 295 CD patients, 219 had SIBO testing and 87 had 7C4 testing. Patients with elevated 7C4 had lower proportions with clinical remission (14% vs 40%, <i>P</i> = .007) and SF ≤ 1 (14% vs 42%, <i>P</i> = .004) compared to those with normal 7C4. In patients with normal 7C4, higher rates of clinical remission (65% vs 27%, <i>P</i> = .01) and SF ≤ 1 (71% vs 27%, <i>P</i> = .003) existed in patients with endoscopic remission compared to those without endoscopic remission. Conversely, among the entire 295 patient cohorts, nearly identical clinical remission rates existed between those with and without endoscopic remission (25% vs 24%, <i>P</i> = .8), and the Crohn's Disease Patient-Reported Outcome-2 score was not accurate for predicting endoscopic remission (Area Under the Curve (AUC): 0.48; 95% CI, 0.42-0.55). SIBO status did not impact clinical remission rates (<i>P</i> = 1.0).</p><p><strong>Conclusions: </strong>BAD, but not SIBO, contributed to symptom scores. A relationship between endoscopic inflammation and clinical remission rates only existed in patients without 7C4 elevations.</p>","PeriodicalId":10847,"journal":{"name":"Crohn's & Colitis 360","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10066840/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9251914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Far From Home: The Role of Travel Distance and Care Fragmentation in Surgical Outcomes for Inflammatory Bowel Disease. 远离家乡:旅行距离和护理碎片在炎症性肠病手术结果中的作用。
IF 1.4
Crohn's & Colitis 360 Pub Date : 2023-04-01 DOI: 10.1093/crocol/otad015
Alexander Booth, Henry Colorado, Gayenell Magwood, Erin Forster, Robert N Axon, Thomas Curran
{"title":"Far From Home: The Role of Travel Distance and Care Fragmentation in Surgical Outcomes for Inflammatory Bowel Disease.","authors":"Alexander Booth,&nbsp;Henry Colorado,&nbsp;Gayenell Magwood,&nbsp;Erin Forster,&nbsp;Robert N Axon,&nbsp;Thomas Curran","doi":"10.1093/crocol/otad015","DOIUrl":"https://doi.org/10.1093/crocol/otad015","url":null,"abstract":"<p><strong>Background: </strong>Fragmented care for inflammatory bowel disease (IBD) is known to correlate negatively with outcomes, but it is unclear which aspects of care fragmentation are relevant and potentially modifiable. Furthermore, there is little data on the relationship between travel distance and the benefits of integrated care models. Hypothesizing care coordination in the preoperative period may have a significant impact on surgical outcomes, we explored associations between integrated care, travel distance, and surgical outcomes.</p><p><strong>Methods: </strong>A single-center retrospective cohort study of patients undergoing index abdominal surgery was done to compare the rate of surgical complications with and without long travel distance and nonintegrated preoperative care. Multivariable logistic regression was used to identify factors independently associated with complications.</p><p><strong>Results: </strong>One hundred and fifty-seven patients were included. Complications were more common among patients with travel distance >75 miles (47.6% vs 27.4%, <i>P</i> = .012). Integrated preoperative care was not significant on bivariate (<i>P</i> = .381) or multivariable analysis but had a stronger association among patients with travel distance <75 miles (20.9% integrated vs 36.7%, <i>P</i> = .138). After adjustment, new ileostomy, open surgical approach, and distance >75 miles were independently associated with complications.</p><p><strong>Conclusions: </strong>Patients with longer travel distances to the hospital were twice as likely to have a surgical complication after adjusting for other risk factors. Without significant accommodations for remote patients, potential benefits of an integrated model for IBD care may be limited to patients who live close to the medical center. Future efforts addressing continuity of care should consider tactics to mitigate the impact of travel distance on outcomes.</p>","PeriodicalId":10847,"journal":{"name":"Crohn's & Colitis 360","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/bb/5f/otad015.PMC10066839.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9251915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High Burden of Obesity and Low Rates of Weight Loss Pharmacotherapy in Inflammatory Bowel Disease: 10-Year Trend. 炎症性肠病的高肥胖负担和低减肥药物治疗率:10年趋势
IF 1.4
Crohn's & Colitis 360 Pub Date : 2023-04-01 DOI: 10.1093/crocol/otad007
Abbinaya Elangovan, Raj Shah, Sajjadh M J Ali, Jeffry Katz, Gregory S Cooper
{"title":"High Burden of Obesity and Low Rates of Weight Loss Pharmacotherapy in Inflammatory Bowel Disease: 10-Year Trend.","authors":"Abbinaya Elangovan,&nbsp;Raj Shah,&nbsp;Sajjadh M J Ali,&nbsp;Jeffry Katz,&nbsp;Gregory S Cooper","doi":"10.1093/crocol/otad007","DOIUrl":"https://doi.org/10.1093/crocol/otad007","url":null,"abstract":"<p><strong>Background: </strong>The prevalence of obesity and inflammatory bowel disease (IBD) has increased in the last decade. There is a paucity of data on the recent trend of obesity and the utilization of anti-obesity pharmacotherapy in IBD. We aimed to use a population-level database to analyze their trends.</p><p><strong>Methods: </strong>A retrospective analysis of population-level data from 2010 to 2019 was performed among individuals ≥18 years of age using a commercial database, IBM Explorys. The prevalence and trends of obesity, diabetes mellitus type 2 (DM2), essential hypertension, dyslipidemia and/or hyperlipidemia, sleep apnea, and anti-obesity pharmacotherapy were studied. Univariate analysis using chi-square test and trend analysis using the Cochrane Armitage test were performed.</p><p><strong>Results: </strong>Among 39 717 520 adults, 37.3% of IBD patients have a diagnosis of obesity (Crohn's disease 36.9% vs ulcerative colitis 38.5%, <i>P</i> < .0001). The proportion of IBD adults with obesity and metabolic comorbidities increased from 2010 to 2019: obesity (19.7%-30.1%), DM2 (8.3%-12.5%), hypertension (25.1%-33.9%), hyperlipidemia (22.1%-32.2%), and sleep apnea (4.1%-10.8%). All comparisons were statistically significant (<i>P</i> < .0001). Only 2.8% of eligible adults with obesity were prescribed anti-obesity pharmacotherapy in the last 10 years, with trends increasing from 1.4% to 3.6%, 2010-2019.</p><p><strong>Conclusions: </strong>With obesity being a harbinger for metabolic syndrome, the increase in obesity in IBD patients was accompanied by a concomitant increase in the diseases associated with obesity in the past decade. However, this alarming rise in obesity was accompanied by a disproportionately small increase in anti-obesity pharmacotherapy similar to general population.</p>","PeriodicalId":10847,"journal":{"name":"Crohn's & Colitis 360","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/1f/93/otad007.PMC10022715.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9145715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Exercise Perceptions and Experiences in Adults With Crohn's Disease Following a Combined Impact and Resistance Training Program: A Qualitative Study. 成人克罗恩病患者在联合冲击和阻力训练计划后的运动感知和经验:一项定性研究。
IF 1.4
Crohn's & Colitis 360 Pub Date : 2023-04-01 DOI: 10.1093/crocol/otad019
Katherine Jones, Jenni Naisby, Katherine Baker, Garry A Tew
{"title":"Exercise Perceptions and Experiences in Adults With Crohn's Disease Following a Combined Impact and Resistance Training Program: A Qualitative Study.","authors":"Katherine Jones,&nbsp;Jenni Naisby,&nbsp;Katherine Baker,&nbsp;Garry A Tew","doi":"10.1093/crocol/otad019","DOIUrl":"https://doi.org/10.1093/crocol/otad019","url":null,"abstract":"<p><strong>Background: </strong>Exercise is increasingly being recognized to counteract specific complications of Crohn's disease (CD). The aim of this study was to explore exercise experiences and perceptions after engaging in a combined impact and resistance training program, involving both intervention and control group viewpoints.</p><p><strong>Methods: </strong>Semistructured telephone interviews, involving a convenience sample of participants with CD (<i>n</i> = 41; aged 49.1 ± 12 years) were undertaken up to 6 weeks following completion of the program. Data were analyzed using thematic analysis.</p><p><strong>Results: </strong>Four overarching themes emerged, along with 11 subthemes: (1) Lack of confidence and knowledge, fears surrounding physical ability and symptoms, coupled with issues not addressed as part of the healthcare pathway played a part in transitioning to inactivity; (2) Improvements in strength, mental well-being, physical fitness, fatigue, abdominal and joint pain, comorbidities, and self-management strategies were among the reported benefits of exercise participation; (3) Seeing progress, goal setting, enjoyment, and a peer-led program receiving support and advice increased motivation. Whereas work-related tiredness, other commitments, and self-directed exercise were reported as exercise barriers; (4) The intervention design was well received and the journey from start to finish was positively discussed, important considerations for future interventions and implementation strategies.</p><p><strong>Conclusions: </strong>The study yielded novel perceptions on the transition to inactivity following receiving a diagnosis, physical and psychological benefits accruing from the intervention, and views on program design. Information that will provide an essential step in the development of implementing exercise guidelines into the clinical pathway and supporting individuals with self-management options.</p>","PeriodicalId":10847,"journal":{"name":"Crohn's & Colitis 360","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10071982/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9363578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Will an International Qualitative Study of Crohn's Disease Patient Experiences and Preferences Evolve the Future of Disease Monitoring? 克罗恩病患者经历和偏好的国际定性研究将演变疾病监测的未来吗?
IF 1.4
Crohn's & Colitis 360 Pub Date : 2023-04-01 DOI: 10.1093/crocol/otad013
Rocio Castrillon
{"title":"Will an International Qualitative Study of Crohn's Disease Patient Experiences and Preferences Evolve the Future of Disease Monitoring?","authors":"Rocio Castrillon","doi":"10.1093/crocol/otad013","DOIUrl":"https://doi.org/10.1093/crocol/otad013","url":null,"abstract":"The international qualitative study of Crohn’s disease patient experiences and disease monitoring preferences resulted in key findings, which if utilized by clinicians, will optimize individualized patient care and disease monitoring strategies.","PeriodicalId":10847,"journal":{"name":"Crohn's & Colitis 360","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10022719/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9145717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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