患者报告的克罗恩病活动性与抑郁的共存性:健康行为中介因素的作用。

IF 1.8 Q3 GASTROENTEROLOGY & HEPATOLOGY
Crohn's & Colitis 360 Pub Date : 2023-12-23 eCollection Date: 2024-01-01 DOI:10.1093/crocol/otad080
Lawrence S Gaines, Michael D Kappelman, David A Schwartz, Sara N Horst, Dawn B Beaulieu, Elizabeth S Scoville, Robin L Dalal, Baldeep S Pabla, James C Slaughter
{"title":"患者报告的克罗恩病活动性与抑郁的共存性:健康行为中介因素的作用。","authors":"Lawrence S Gaines, Michael D Kappelman, David A Schwartz, Sara N Horst, Dawn B Beaulieu, Elizabeth S Scoville, Robin L Dalal, Baldeep S Pabla, James C Slaughter","doi":"10.1093/crocol/otad080","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Longitudinal research reveals a unidirectional relationship between a nonsomatic symptom of depression, a negative view of the self, and later reported Crohn's disease (CD) activity. We evaluated whether health behaviors mediated this association using a longitudinal design.</p><p><strong>Methods: </strong>We studied 3304 adult volunteers with a self-reported diagnosis of CD who completed a baseline survey that included demographics, CD activity, a symptom-specific index of depression, and measures of physical activity, smoking, and sleep quality. Crohn's disease status and the cognitive index of depression were also measured 6 and 12 months after the baseline evaluation. We specified single-mediator and multiple-mediator models to elucidate the depression-disease activity relationship.</p><p><strong>Results: </strong>Among 2395 females and 909 males, we found a significant mediation effect for activity level (<i>P</i> < .001) after adjusting for age, sex, and body mass index. There was no evidence that sleep quality and smoking are significant single mediators. When we considered multiple mediation models, smoking and less activity partially mediate the depression-CD association.</p><p><strong>Conclusions: </strong>Smoking and lower levels of physical activity are potential mediators of the unidirectional association between a nonsomatic symptom of depression-a negative view of the self-and patient-reported CD activity. Evaluating and treating specific symptoms of depression may reduce the frequency of CD exacerbations.</p>","PeriodicalId":10847,"journal":{"name":"Crohn's & Colitis 360","volume":null,"pages":null},"PeriodicalIF":1.8000,"publicationDate":"2023-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10771267/pdf/","citationCount":"0","resultStr":"{\"title\":\"The Comorbidity of Patient-Reported Crohn's Disease Activity and Depression: The Role of Health Behavior Mediators.\",\"authors\":\"Lawrence S Gaines, Michael D Kappelman, David A Schwartz, Sara N Horst, Dawn B Beaulieu, Elizabeth S Scoville, Robin L Dalal, Baldeep S Pabla, James C Slaughter\",\"doi\":\"10.1093/crocol/otad080\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Longitudinal research reveals a unidirectional relationship between a nonsomatic symptom of depression, a negative view of the self, and later reported Crohn's disease (CD) activity. We evaluated whether health behaviors mediated this association using a longitudinal design.</p><p><strong>Methods: </strong>We studied 3304 adult volunteers with a self-reported diagnosis of CD who completed a baseline survey that included demographics, CD activity, a symptom-specific index of depression, and measures of physical activity, smoking, and sleep quality. Crohn's disease status and the cognitive index of depression were also measured 6 and 12 months after the baseline evaluation. We specified single-mediator and multiple-mediator models to elucidate the depression-disease activity relationship.</p><p><strong>Results: </strong>Among 2395 females and 909 males, we found a significant mediation effect for activity level (<i>P</i> < .001) after adjusting for age, sex, and body mass index. There was no evidence that sleep quality and smoking are significant single mediators. When we considered multiple mediation models, smoking and less activity partially mediate the depression-CD association.</p><p><strong>Conclusions: </strong>Smoking and lower levels of physical activity are potential mediators of the unidirectional association between a nonsomatic symptom of depression-a negative view of the self-and patient-reported CD activity. Evaluating and treating specific symptoms of depression may reduce the frequency of CD exacerbations.</p>\",\"PeriodicalId\":10847,\"journal\":{\"name\":\"Crohn's & Colitis 360\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.8000,\"publicationDate\":\"2023-12-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10771267/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Crohn's & Colitis 360\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1093/crocol/otad080\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q3\",\"JCRName\":\"GASTROENTEROLOGY & HEPATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Crohn's & Colitis 360","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1093/crocol/otad080","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

背景:纵向研究显示,非症状性抑郁症状、对自我的消极看法与后来报告的克罗恩病(CD)活动之间存在单向关系。我们采用纵向设计评估了健康行为是否对这种关联起中介作用:我们对 3304 名自我报告诊断为克罗恩病的成年志愿者进行了研究,他们完成了一项基线调查,调查内容包括人口统计学、克罗恩病活动、抑郁症症状特异性指数以及体育锻炼、吸烟和睡眠质量测量。基线评估结束 6 个月和 12 个月后,还对克罗恩病状况和抑郁认知指数进行了测量。我们建立了单中介和多中介模型来阐明抑郁与疾病活动的关系:结果:在 2395 名女性和 909 名男性中,我们发现在对年龄、性别和体重指数进行调整后,活动水平具有显著的中介效应(P < .001)。没有证据表明睡眠质量和吸烟是重要的单一中介因素。当我们考虑多重中介模型时,吸烟和活动量较少部分中介了抑郁与慢性阻塞性肺病的关系:结论:吸烟和较少的体力活动是抑郁症的非症状性症状--对自我的负面看法--与患者报告的CD活动之间单向关联的潜在中介因素。对特定抑郁症状进行评估和治疗可能会降低慢性阻塞性肺病的恶化频率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Comorbidity of Patient-Reported Crohn's Disease Activity and Depression: The Role of Health Behavior Mediators.

Background: Longitudinal research reveals a unidirectional relationship between a nonsomatic symptom of depression, a negative view of the self, and later reported Crohn's disease (CD) activity. We evaluated whether health behaviors mediated this association using a longitudinal design.

Methods: We studied 3304 adult volunteers with a self-reported diagnosis of CD who completed a baseline survey that included demographics, CD activity, a symptom-specific index of depression, and measures of physical activity, smoking, and sleep quality. Crohn's disease status and the cognitive index of depression were also measured 6 and 12 months after the baseline evaluation. We specified single-mediator and multiple-mediator models to elucidate the depression-disease activity relationship.

Results: Among 2395 females and 909 males, we found a significant mediation effect for activity level (P < .001) after adjusting for age, sex, and body mass index. There was no evidence that sleep quality and smoking are significant single mediators. When we considered multiple mediation models, smoking and less activity partially mediate the depression-CD association.

Conclusions: Smoking and lower levels of physical activity are potential mediators of the unidirectional association between a nonsomatic symptom of depression-a negative view of the self-and patient-reported CD activity. Evaluating and treating specific symptoms of depression may reduce the frequency of CD exacerbations.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Crohn's & Colitis 360
Crohn's & Colitis 360 Medicine-Gastroenterology
CiteScore
2.50
自引率
0.00%
发文量
41
审稿时长
12 weeks
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信