Current Cardiology Reviews最新文献_第10页

Genetic Determinants of Response to Statins in Cardiovascular Diseases. 心血管疾病患者对他汀类药物反应的遗传决定因素。

IF 2.4

Current Cardiology Reviews Pub Date : 2024-01-01 DOI: 10.2174/011573403X267793231220114042

Ghazaleh Ghorbannezhad, Shima Mehrabadi, Negar Golampour-Shamkani, Amirhossein Barjasteh, Poorya Etesamizadeh, Mohammad Tayyebi, Majid Khazaei, Seyed Mahdi Hassanian, Gordon A Ferns, Amir Avan

{"title":"Genetic Determinants of Response to Statins in Cardiovascular Diseases.","authors":"Ghazaleh Ghorbannezhad, Shima Mehrabadi, Negar Golampour-Shamkani, Amirhossein Barjasteh, Poorya Etesamizadeh, Mohammad Tayyebi, Majid Khazaei, Seyed Mahdi Hassanian, Gordon A Ferns, Amir Avan","doi":"10.2174/011573403X267793231220114042","DOIUrl":"10.2174/011573403X267793231220114042","url":null,"abstract":"Despite extensive efforts to identify patients with cardiovascular disease (CVD) who could most benefit from the treatment approach, patients vary in their benefit from therapy and propensity for adverse drug events. Genetic variability in individual responses to drugs (pharmacogenetics) is considered an essential determinant in responding to a drug. Thus, understanding these pharmacogenomic relationships has led to a substantial focus on mechanisms of disease and drug response. In turn, understanding the genomic and molecular bases of variables that might be involved in drug response is the main step in personalized medicine. There is a growing body of data evaluating drug-gene interactions in recent years, some of which have led to FDA recommendations and detection of markers to predict drug responses (e.g., genetic variant in VKORC1 and CYP2C9 genes for prediction of drug response in warfarin treatment). Also, statins are widely prescribed drugs for the prevention of CVD. Atorvastatin, fluvastatin, rosuvastatin, simvastatin, and lovastatin are the most common statins used to manage dyslipidemia. This review provides an overview of the current knowledge on the pharmacogenetics of statins, which are being used to treat cardiovascular diseases.","PeriodicalId":10832,"journal":{"name":"Current Cardiology Reviews","volume":" ","pages":"20-28"},"PeriodicalIF":2.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11107471/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139416604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emerging Strategies and Effective Prevention Measures for Investigating the Association Between Stroke and Sudden Cardiac Fatality. 调查中风与心脏猝死之间关系的新策略和有效预防措施。

IF 2.4

Current Cardiology Reviews Pub Date : 2024-01-01 DOI: 10.2174/011573403X259676231222053709

H Nithesh Kumar, S Jeevanandham, M Shankar Ganesh, M Ashmi Sabana, P Manivasakam

{"title":"Emerging Strategies and Effective Prevention Measures for Investigating the Association Between Stroke and Sudden Cardiac Fatality.","authors":"H Nithesh Kumar, S Jeevanandham, M Shankar Ganesh, M Ashmi Sabana, P Manivasakam","doi":"10.2174/011573403X259676231222053709","DOIUrl":"10.2174/011573403X259676231222053709","url":null,"abstract":"Stroke-related cardiac death is a significant concern for patients with stroke and their healthcare providers. It is a complex and multifaceted condition that requires careful management of both modifiable and non-modifiable risk factors. This review provides an overview of the pathophysiology, risk factors, and prevention strategies for stroke-related cardiac death. The review highlights the importance of identifying and managing modifiable risk factors such as hypertension, diabetes, and lifestyle factors, as well as non-modifiable risk factors such as age and genetics. Additionally, the review explores emerging strategies for prevention, including the use of wearable devices and genetic testing to identify patients at risk, stem cell therapy and gene therapy for cardiac dysfunction, and precision medicine for personalized treatment plans. Despite some limitations to this review, it provides valuable insights into the current understanding of stroke-related cardiac death and identifies important areas for future research. Ultimately, the implementation of evidence-based prevention strategies and personalized treatment plans has the potential to improve outcomes for patients with stroke and reduce the burden of stroke-related cardiac death in the population.","PeriodicalId":10832,"journal":{"name":"Current Cardiology Reviews","volume":" ","pages":"35-44"},"PeriodicalIF":2.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11284691/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139680764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Timing of Surgery for Asymptomatic Primary Mitral Regurgitation: Possible Value of Early, Serial Measurements of Left Ventricular Sphericity. 无症状原发性二尖瓣反流的手术时机：早期连续测量左心室球形度的可能价值。

IF 2.4

Current Cardiology Reviews Pub Date : 2024-01-01 DOI: 10.2174/011573403X277223240206062319

Alfred Stanley, Constantine Athanasuleas

引用次数: 0

Cardiovascular Reflexes - Vagus as the Key Player. 心血管反射--迷走神经是关键角色。

IF 2.4

Current Cardiology Reviews Pub Date : 2024-01-01 DOI: 10.2174/011573403X284831240408053528

Shantala S Herlekar, Ashwini R Doyizode, Savitri P Siddangoudra, V Anupama

引用次数: 0

The Association between Serum Follistatin-like Proteins and Cardiovascular Diseases: A Systematic Review and Meta-analysis. 血清花粉素样蛋白与心血管疾病的关系：系统回顾与元分析》。

IF 2.4

Current Cardiology Reviews Pub Date : 2024-01-01 DOI: 10.2174/011573403X304195240715103930

Amir Mahmoud Ahmadzadeh, Rozita Khodashahi, Mahmoud Mohamadzadeh Shabestari, Mohsen Aliakbarian, Amirhossein Sahebkar, Mohammad-Hassan Arjmand

{"title":"The Association between Serum Follistatin-like Proteins and Cardiovascular Diseases: A Systematic Review and Meta-analysis.","authors":"Amir Mahmoud Ahmadzadeh, Rozita Khodashahi, Mahmoud Mohamadzadeh Shabestari, Mohsen Aliakbarian, Amirhossein Sahebkar, Mohammad-Hassan Arjmand","doi":"10.2174/011573403X304195240715103930","DOIUrl":"10.2174/011573403X304195240715103930","url":null,"abstract":"Background: Follistatin-like proteins (FSTLs) are adipomyokines secreted by adipocytes and myocytes. Previous studies have reported an increase in circulating FSTL1 levels in response to cardiovascular injuries. In this study, we conducted a systematic review and metaanalysis to assess the association between circulating FSTLs and Cardiovascular Diseases (CVDs).Methods: We performed a comprehensive literature search using PubMed, Web of Science, Scopus, and Embase databases. After screening the articles, we selected eligible studies, extracted relevant data, and calculated the pooled Standardized Mean Difference (SMD). We also conducted a sensitivity analysis to identify sources of heterogeneity and assessed publication bias.Results: Among the 577 articles initially retrieved, we included 5 studies comprising a total of 941 cases with CVDs and 446 controls. All included studies measured FSTL1 levels. The pooled SMD analysis revealed a significant difference in circulating FSTL1 levels between subjects with CVDs and control groups (SMD = 0.853, 95% CI = 0.158-1.548, P = 0.016). Heterogeneity was primarily attributed to a single study that measured FSTL1 levels in heart failure patients with preserved ejection fraction. No publication bias was observed.Conclusion: Our findings demonstrate significantly higher levels of FSTL1 in patients with CVD compared to control subjects. This suggests that FSTL1 may have potential as a diagnostic and prognostic biomarker in CVDs. However, further well-designed studies are needed to validate its clinical utility.","PeriodicalId":10832,"journal":{"name":"Current Cardiology Reviews","volume":" ","pages":"e180724231994"},"PeriodicalIF":2.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11440331/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141733741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Medicinal Plants in the Treatment of Myocardial Infarction Disease: A Systematic Review. 治疗心肌梗塞疾病的药用植物：系统综述。

IF 2.4

Current Cardiology Reviews Pub Date : 2024-01-01 DOI: 10.2174/011573403X278881240405044328

Anamika Rathore, Anuj Kumar Sharma, Yogesh Murti, Sonal Bansal, Vibha Kumari, Varsha Snehi, Mayank Kulshreshtha

{"title":"Medicinal Plants in the Treatment of Myocardial Infarction Disease: A Systematic Review.","authors":"Anamika Rathore, Anuj Kumar Sharma, Yogesh Murti, Sonal Bansal, Vibha Kumari, Varsha Snehi, Mayank Kulshreshtha","doi":"10.2174/011573403X278881240405044328","DOIUrl":"10.2174/011573403X278881240405044328","url":null,"abstract":"Background: Myocardial infarction (MI), also referred to as a \"heart attack,\" is brought on by a partial or total interruption of blood supply to the myocardium. Myocardial infarction can be \"silent,\" go undiagnosed, or it can be a catastrophic occurrence that results in hemodynamic decline and untimely death. In recent years, herbal remedies for MI have become effective, secure, and readily accessible.Objective: The purpose of this review was to examine the medicinal plants and phytochemicals that have been used to treat MI in order to assess the potential contribution of natural substances to the development of herbal MI treatments.Methodology: A literature search was employed to find information utilizing electronic databases, such as Web of Science, Google Scholar, PubMed, Sci Finder, Reaxys, and Cochrane.Results: The identification of 140 plants from 12 families led to the abstraction of data on the plant families, parts of the plant employed, chemical contents, extracts, model used, and dose.Conclusion: The majority of the MI plants, according to the data, belonged to the Fabaceae (11%) and Asteraceae (9%) families, and the most prevalent natural components in plants with MI were flavonoids (43%), glucosides (25%), alkaloids (23%), phenolic acid (19%), saponins (15%), and tannins (12%).","PeriodicalId":10832,"journal":{"name":"Current Cardiology Reviews","volume":" ","pages":"e290424229484"},"PeriodicalIF":2.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11327834/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140848180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nuchal Translucency and Congenital Heart Defects. 颈部透明带与先天性心脏缺陷

IF 2.4

Current Cardiology Reviews Pub Date : 2024-01-01 DOI: 10.2174/011573403X264963231128045500

A Sofia-Gonçalves, L Guedes-Martins

{"title":"Nuchal Translucency and Congenital Heart Defects.","authors":"A Sofia-Gonçalves, L Guedes-Martins","doi":"10.2174/011573403X264963231128045500","DOIUrl":"10.2174/011573403X264963231128045500","url":null,"abstract":"Nuchal translucency comprises a temporary accumulation of fluid in the subcutaneous tissue on the back of a fetus's neck, which accompanies the crown-rump length and is observed through an ultrasound performed between 11 and 13 weeks + 6 days gestation. Nuchal translucency is considered to be above normal when values are higher than the 95th/99th percentile or equal to or higher than 2.5/3.5 mm. The first connection between increased nuchal translucency and the presence of congenital heart defects is described in the study of Hyett et al., who observed that they are directly proportional. Since that time, several studies have been conducted to understand if nuchal translucency measurements can be used for congenital heart defect screening in euploid fetuses. However, there is great variability in the estimated nuchal translucency cutoff values for congenital heart defect detection. The purpose of this review was to understand how increased nuchal translucency values and congenital heart defects are related and to identify which of these defects are more frequently associated with an increase in these values.","PeriodicalId":10832,"journal":{"name":"Current Cardiology Reviews","volume":" ","pages":"1-13"},"PeriodicalIF":2.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11107467/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139564013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dietary Effects of Fasting on the Lipid Panel. 禁食对血脂组合的饮食影响

IF 2.4

Current Cardiology Reviews Pub Date : 2024-01-01 DOI: 10.2174/011573403X257173231222042846

Jason Hourizadeh, Rezwan Munshi, Roman Zeltser, Amgad N Makaryus

{"title":"Dietary Effects of Fasting on the Lipid Panel.","authors":"Jason Hourizadeh, Rezwan Munshi, Roman Zeltser, Amgad N Makaryus","doi":"10.2174/011573403X257173231222042846","DOIUrl":"10.2174/011573403X257173231222042846","url":null,"abstract":"Introduction: Dietary habits, such as the Mediterranean diet and the Dietary Approaches to Stop Hypertension (DASH), have been shown to improve cardiac health. Another more recent popular form of dieting incorporates periods of fasting known as intermittent fasting. The two main forms are alternate-day fasting and time-restricted eating.Methods: PubMed search and literature review was undertaken. This review evaluates the current literature regarding the effects of the fasting dietary model and other types of fasting upon the lipid panel.Results: There have been studies that have shown that intermittent fasting does provide a benefit in cardiovascular health, weight loss, and hypertension. However, the effect on cholesterol and triglyceride levels during intermittent fasting is in question.Conclusion: The effect that fasting has on one's lipid panel is unclear, there are studies that show that different forms of fasting affect the lipid panel in various ways. There are studies that show that intermittent fasting does improve one's lipid profile and provides health benefits. Randomized controlled clinical trials with a large sample size are needed to evaluate the effects that intermittent fasting has based on race, ethnicity, gender, obesity, dyslipidemia, diabetic and healthy patients, and will lead to definitive evidence of lipid panel outcomes beyond current evidence based solely upon observational cohorts with numerous and multifactorial confounding factors and biases.","PeriodicalId":10832,"journal":{"name":"Current Cardiology Reviews","volume":" ","pages":"82-92"},"PeriodicalIF":2.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11107469/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139680763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Revisiting Waist Circumference: A Hypertension Risk Factor that Requires a More In-depth Understanding. 重新审视腰围：需要更深入了解的高血压风险因素。

IF 2.4

Current Cardiology Reviews Pub Date : 2024-01-01 DOI: 10.2174/011573403X290574240322041356

Yue Su, Jin-Yu Sun, Zhen-Yang Su, Wei Sun

{"title":"Revisiting Waist Circumference: A Hypertension Risk Factor that Requires a More In-depth Understanding.","authors":"Yue Su, Jin-Yu Sun, Zhen-Yang Su, Wei Sun","doi":"10.2174/011573403X290574240322041356","DOIUrl":"10.2174/011573403X290574240322041356","url":null,"abstract":"As a major cause of various cardiovascular diseases, the prevalence of hypertension has been increasing in the past 30 years, leading to significant socioeconomic and health burdens. Obesity is one of the major risk factors for hypertension. Body mass index (BMI) is the most used anthropometric index to measure obesity in clinical practice and to assess the risk of obesity-related diseases. However, obesity is a heterogeneous disease, and the accumulation of fat in different body regions leads to differences in cardiovascular and metabolic risks. BMI only reflects the overall obesity but does not consider the distribution of fat and muscle mass. The limitation of BMI makes it insufficient to assess the risk of hypertension attributed to obesity. In addition, waist circumference is an easily obtainable anthropometric index to evaluate abdominal fat distribution. High waist circumference is an independent risk factor for various cardiovascular diseases and all-cause mortality regardless of BMI. Preliminary data indicate that waist circumference is significantly associated with the risk of hypertension at different BMI levels. However, routine measurement of waist circumference is currently not required in current clinical guidelines or is only recommended for obese populations, indicating an insufficient understanding of waist circumference. In this review, we summarize the measurement methods and diagnostic thresholds of waist circumference for abdominal obesity, the trend of central obesity prevalence, the superiority of waist circumference over other anthropometric indices, and recent cross-sectional and longitudinal studies on the association between obesity and hypertension.","PeriodicalId":10832,"journal":{"name":"Current Cardiology Reviews","volume":" ","pages":"e270324228382"},"PeriodicalIF":2.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11327828/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140305176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cross Talks between CNS and CVS Diseases: An Alliance to Annihilate. 中枢神经系统疾病与慢性阻塞性肺疾病之间的交叉对话：消灭联盟

IF 2.4

Current Cardiology Reviews Pub Date : 2024-01-01 DOI: 10.2174/011573403X278550240221112636

Shivani Chib, Sushma Devi, Rishabh Chalotra, Neeraj Mittal, Thakur Gurjeet Singh, Puneet Kumar, Randhir Singh

引用次数: 0