Current Heart Failure Reports最新文献_第3页

Precision Phenotyping of Heart Failure in People with HIV: Early Insights and Challenges. 艾滋病病毒感染者心力衰竭的精准表型分析：早期见解与挑战

IF 3.8

Current Heart Failure Reports Pub Date : 2024-08-01 Epub Date: 2024-06-28 DOI: 10.1007/s11897-024-00674-w

Eli Grunblatt, Matthew J Feinstein

{"title":"Precision Phenotyping of Heart Failure in People with HIV: Early Insights and Challenges.","authors":"Eli Grunblatt, Matthew J Feinstein","doi":"10.1007/s11897-024-00674-w","DOIUrl":"10.1007/s11897-024-00674-w","url":null,"abstract":"Purpose of review: People with HIV have an elevated risk of developing heart failure even with optimally controlled disease. In this review, we outline the various mechanisms through which HIV infection may directly and indirectly contribute to heart failure pathology and highlight the emerging relationship between HIV, chronic inflammation, and cardiometabolic disease.Recent findings: HIV infection leads to chronic inflammation, immune dysregulation, and metabolic imbalances even in those with well controlled disease. These dysregulations occur through several diverse mechanisms which may lead to manifestations of different phenotypes of heart failure in people with HIV. While it has long been known that people with HIV are at risk of developing heart failure, recent studies have suggested numerous complex mechanisms involving chronic inflammation, immune dysregulation, and metabolic derangement through which this may be mediated. Further comprehensive studies are needed to elucidate the precise relationship between these mechanisms and the development of different subtypes of heart failure in people with HIV.","PeriodicalId":10830,"journal":{"name":"Current Heart Failure Reports","volume":" ","pages":"417-427"},"PeriodicalIF":3.8,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141466786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hypertrophic Cardiomyopathy. 肥厚型心肌病。

IF 3.8

Current Heart Failure Reports Pub Date : 2024-08-01 Epub Date: 2024-03-15 DOI: 10.1007/s11897-024-00654-0

Jason N Dungu, Amy Hardy-Wallace, Anthony D Dimarco, Henry O Savage

{"title":"Hypertrophic Cardiomyopathy.","authors":"Jason N Dungu, Amy Hardy-Wallace, Anthony D Dimarco, Henry O Savage","doi":"10.1007/s11897-024-00654-0","DOIUrl":"10.1007/s11897-024-00654-0","url":null,"abstract":"Purpose of review: Hypertrophic cardiomyopathy (HCM) is a common inherited cardiac condition with potential for severe complications including sudden cardiac death. Early diagnosis allows appropriate risk stratification and prompt intervention to minimise the potential for adverse outcomes. The implications of poorly coordinated screening are significant, either missing relatives at high-risk or burdening low-risk individuals with a diagnosis associated with reduced life expectancy. We aim to guide clinicians through the diagnostic pathway through to novel treatment options. Several conditions mimic the condition, and we discuss the phenocopies and how to differentiate from HCM.Recent findings: We summarise the latest developments informing clinical decision making in the modern era of myosin inhibitors and future gene editing therapies. Early identification will enable prompt referral to specialist centres. A diagnostic flowchart is included, to guide the general cardiology and heart failure clinician in important decision making regarding the care of the HCM patient and importantly their relatives at risk. We have highlighted the importance of screening because genotype-positive/phenotype-negative patients are likely to have the most to gain from novel therapies.","PeriodicalId":10830,"journal":{"name":"Current Heart Failure Reports","volume":" ","pages":"428-438"},"PeriodicalIF":3.8,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140136597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex and Gender-related Disparities in Clinical Characteristics and Outcomes in Heart Transplantation. 心脏移植临床特征和结果中与性别相关的差异。

IF 3.8

Current Heart Failure Reports Pub Date : 2024-08-01 Epub Date: 2024-06-11 DOI: 10.1007/s11897-024-00670-0

Andrea Severo Sánchez, Javier González Martín, Javier de Juan Bagudá, Laura Morán Fernández, Christian Muñoz Guijosa, Fernando Arribas Ynsaurriaga, Juan Francisco Delgado, María Dolores García-Cosío Carmena

{"title":"Sex and Gender-related Disparities in Clinical Characteristics and Outcomes in Heart Transplantation.","authors":"Andrea Severo Sánchez, Javier González Martín, Javier de Juan Bagudá, Laura Morán Fernández, Christian Muñoz Guijosa, Fernando Arribas Ynsaurriaga, Juan Francisco Delgado, María Dolores García-Cosío Carmena","doi":"10.1007/s11897-024-00670-0","DOIUrl":"10.1007/s11897-024-00670-0","url":null,"abstract":"Purpose of review: Limited research has been conducted on sex disparities in heart transplant (HT). The aim of this review is to analyse the available evidence on the influence of sex and gender-related determinants in the entire HT process, as well as to identify areas for further investigation.Recent findings: Although women make up half of the population affected by heart failure and related mortality, they account for less than a third of HT recipients. Reasons for this inequality include differences in disease course, psychosocial factors, concerns about allosensitisation, and selection or referral bias in female patients. Women are more often listed for HT due to non-ischaemic cardiomyopathy and have a lower burden of cardiovascular risk factors. Although long-term prognosis appears to be similar for both sexes, there are significant disparities in post-HT morbidity and causes of mortality (noting a higher incidence of rejection in women and of malignancy and cardiac allograft vasculopathy in men). Additional research is required to gain a better understanding of the reasons behind gender disparities in eligibility and outcomes following HT. This would enable the fair allocation of resources and enhance patient care.","PeriodicalId":10830,"journal":{"name":"Current Heart Failure Reports","volume":" ","pages":"367-378"},"PeriodicalIF":3.8,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141300214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of Coagulation in Heart Failure: A Literature Review. 凝血在心力衰竭中的作用：文献综述。

IF 3.8

Current Heart Failure Reports Pub Date : 2024-08-01 Epub Date: 2024-06-13 DOI: 10.1007/s11897-024-00671-z

Farhan Anjum, Mahrukh Gilani, Maryam Latif, Aqsa Sattar, Habiba Ashraf, Saira Rafaqat

{"title":"The Role of Coagulation in Heart Failure: A Literature Review.","authors":"Farhan Anjum, Mahrukh Gilani, Maryam Latif, Aqsa Sattar, Habiba Ashraf, Saira Rafaqat","doi":"10.1007/s11897-024-00671-z","DOIUrl":"10.1007/s11897-024-00671-z","url":null,"abstract":"Purpose of review: This article summarizes the role of coagulation factors in the pathophysiology of heart failure including D-dimer, fibrinogen and fibrin, prothrombin, p-selectin, tissue factor, tissue plasminogen activator, von Willebrand factor, β-thromboglobulin, Factor XI, tissue thromboplastin, plasminogen activator inhibitor-1 (PAI-1), thrombomodulin, soluble urokinase-type plasminogen activator receptor (suPAR) and stuart-prower factor.Recent findings: The D-dimer, P-selectin, prothrombin, von Willebrand factor, tissue plasminogen activator, fibrinogen, suPAR, tissue factor, thrombomodulin and Factor XI play significant roles the pathophysiology of heart failure. However, no associations were found between β-thromboglobulin, tissue thromboplastin, PAI-1 and stuart-prower factor in the context of heart failure. Coagulation factors play significant role in the pathophysiology of heart failure. Consequently, the underlying pathophysiological mechanisms that explain changes in the cascade are closely related to the diagnostic, prognostic and therapeutic roles of coagulation cascade factors, which help physicians identify and treat heart failure.","PeriodicalId":10830,"journal":{"name":"Current Heart Failure Reports","volume":" ","pages":"277-291"},"PeriodicalIF":3.8,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141310252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Sex in the Incidence of Heart Failure in Patients with Chronic Coronary Syndrome. 性别对慢性冠状动脉综合征患者心衰发生率的影响

IF 3.8

Current Heart Failure Reports Pub Date : 2024-08-01 Epub Date: 2024-05-04 DOI: 10.1007/s11897-024-00663-z

Ramón López-Palop, Pilar Carrillo, Íñigo Lozano

{"title":"Impact of Sex in the Incidence of Heart Failure in Patients with Chronic Coronary Syndrome.","authors":"Ramón López-Palop, Pilar Carrillo, Íñigo Lozano","doi":"10.1007/s11897-024-00663-z","DOIUrl":"10.1007/s11897-024-00663-z","url":null,"abstract":"Purpose of review: This review examines the available evidence concerning the incidence of heart failure in patients with chronic coronary syndrome, with a focus on gender differences.Recent findings: The incidence of heart failure in the context of chronic coronary syndrome presents conflicting data. Most of the available information stems from studies involving stable patients' post-acute coronary syndrome, revealing a wide range of incidence rates, from less than 3% to over 20%, observed over 5 years of follow-up. Regarding the gender differences in heart failure incidence, there is no consensus about whether women exhibit a higher incidence, particularly in the presence of evidence of obstructive coronary artery disease. However, in cases where obstructive coronary artery disease is absent, women may face a more unfavourable prognosis due to a higher prevalence of microvascular disease and heart failure with preserved ventricular function. The different profile of ischaemic heart disease in women difficult to establish differences in prognosis independently associated with female sex. Targeted investigations are essential to discern the incidence of heart failure in chronic coronary syndrome and explore potential gender-specific associations.","PeriodicalId":10830,"journal":{"name":"Current Heart Failure Reports","volume":" ","pages":"354-366"},"PeriodicalIF":3.8,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140854551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Is There a Mitochondrial Protection via Remote Ischemic Conditioning in Settings of Anticancer Therapy Cardiotoxicity? 在抗癌治疗心脏毒性的情况下，远程缺血调节对线粒体有保护作用吗？

IF 3.8

Current Heart Failure Reports Pub Date : 2024-08-01 Epub Date: 2024-03-21 DOI: 10.1007/s11897-024-00658-w

Petra Kleinbongard, Ioanna Andreadou

引用次数: 0

Sex-based Differences in Heart Failure Biomarkers. 心力衰竭生物标志物的性别差异

IF 3.8

Current Heart Failure Reports Pub Date : 2024-08-01 Epub Date: 2024-05-20 DOI: 10.1007/s11897-024-00665-x

Ainhoa Robles-Mezcua, Nelsa González Aguado, Antonia Pilar Martin de la Rosa, Concepción Cruzado-Álvarez, Clara Jiménez Rubio, Alejandro IPérez Cabeza, Juan José Gómez-Doblas, Manuel F Jiménez-Navarro, Mora Murri Pierri, José M García-Pinilla

{"title":"Sex-based Differences in Heart Failure Biomarkers.","authors":"Ainhoa Robles-Mezcua, Nelsa González Aguado, Antonia Pilar Martin de la Rosa, Concepción Cruzado-Álvarez, Clara Jiménez Rubio, Alejandro IPérez Cabeza, Juan José Gómez-Doblas, Manuel F Jiménez-Navarro, Mora Murri Pierri, José M García-Pinilla","doi":"10.1007/s11897-024-00665-x","DOIUrl":"10.1007/s11897-024-00665-x","url":null,"abstract":"Purpose of review: Differences in HF biomarker levels by sex may be due to hormonal, genetic, and fat distribution differences. Knowledge of these differences is scarce, and it is not well established whether they may affect their usefulness in the management of HF.Recent findings: The different biomarker profiles in women and men have been confirmed in recent studies: in women, markers of cardiac stretch and fibrosis (NP and galectin-3) are higher, whereas in men, higher levels of markers of cardiac injury and inflammation (cTn and sST2) are found. The use of new biomarkers, together with growing evidence that a multimarker approach can provide better risk stratification, raises the question of building models that incorporate sex-specific diagnostic criteria. More and more research are being devoted to understanding sex-related differences in HF. The aim of this review is to review the dynamics of HF biomarkers according to sex and in different situations, to learn whether these sex differences may affect their use in the diagnosis and follow-up of HF patients.","PeriodicalId":10830,"journal":{"name":"Current Heart Failure Reports","volume":" ","pages":"379-388"},"PeriodicalIF":3.8,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141065285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Estimated Glomerular Filtration Rate Slope as an Endpoint in Cardiovascular Trials. 将估计肾小球滤过率斜率作为心血管试验的终点。

IF 3.8

Current Heart Failure Reports Pub Date : 2024-08-01 Epub Date: 2024-05-25 DOI: 10.1007/s11897-024-00668-8

Arsalan Hamid, Stephen J Greene, Ankit Mehta, Javed Butler, Muhammad Shahzeb Khan

引用次数: 0

Exergaming to Increase Physical Activity in Older Adults: Feasibility and Practical Implications. Exergaming to Increase Physical Activity in Older Adults：可行性和实际意义。

IF 3.8

Current Heart Failure Reports Pub Date : 2024-08-01 Epub Date: 2024-07-18 DOI: 10.1007/s11897-024-00675-9

Patrik Rytterström, Anna Strömberg, Tiny Jaarsma, Leonie Klompstra

{"title":"Exergaming to Increase Physical Activity in Older Adults: Feasibility and Practical Implications.","authors":"Patrik Rytterström, Anna Strömberg, Tiny Jaarsma, Leonie Klompstra","doi":"10.1007/s11897-024-00675-9","DOIUrl":"10.1007/s11897-024-00675-9","url":null,"abstract":"Purpose of review: To evaluate the feasibility of exergaming among older adults, focusing on acceptability, demand, implementation, and practicality. Additionally, to offer practical implications based on the review's findings.Recent findings: Exergaming is a safe for older adults, potentially increasing physical activity, balance, cognition, and mood. Despite these possible benefits, barriers such as unfamiliarity with equipment, complex controls, and unclear instructions may challenge older adults in exergaming. Based on the experience of older adults, they found exergaming enjoyable, particularly the social interactions. Exergaming was perceived as physically and cognitively demanding, with technical and safety challenges. Introducing exergaming requires thorough familiarization, including written and video instructions, follow-up support, and home accessibility. To be able to follow improvements during exergaming as well as age-appropriate challenges are important for successful integration into daily life. Based on these findings, an ExerGameFlow model for older adults was developed which provides practical implications for future design of exergames and interventions.","PeriodicalId":10830,"journal":{"name":"Current Heart Failure Reports","volume":" ","pages":"439-459"},"PeriodicalIF":3.8,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11333506/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141632925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cellular Alterations in Immune Checkpoint Inhibitor Therapy-Related Cardiac Dysfunction. 免疫检查点抑制剂疗法导致的心功能障碍中的细胞变化

Current Heart Failure Reports Pub Date : 2024-06-01 Epub Date: 2024-03-02 DOI: 10.1007/s11897-024-00652-2

Lars Michel, Peter Ferdinandy, Tienush Rassaf

{"title":"Cellular Alterations in Immune Checkpoint Inhibitor Therapy-Related Cardiac Dysfunction.","authors":"Lars Michel, Peter Ferdinandy, Tienush Rassaf","doi":"10.1007/s11897-024-00652-2","DOIUrl":"10.1007/s11897-024-00652-2","url":null,"abstract":"Purpose of review: Immune checkpoint inhibitor (ICI) therapy has emerged as a pivotal advancement in cancer treatment, but the widespread adoption has given rise to a growing number of reports detailing significant cardiovascular toxicity. This review concentrates on elucidating the mechanisms behind ICI-related cardiovascular complications, emphasizing preclinical and mechanistic data.Recent findings: Accumulating evidence indicates a more significant role of immune checkpoints in maintaining cardiac integrity than previously understood, and new key scientific data are available to improve our understanding of ICI-related cardiovascular toxicity, including hidden cardiotoxicity. New avenues for innovative concepts are hypothesized, and opportunities to leverage the knowledge from ICI-therapy for pioneering approaches in related scientific domains can be derived from the latest scientific projects. Cardiotoxicity from ICI therapy is a paramount challenge for cardio-oncology. Understanding the underlying effects builds the foundation for tailored cardioprotective approaches in the growing collective at risk for severe cardiovascular complications.","PeriodicalId":10830,"journal":{"name":"Current Heart Failure Reports","volume":" ","pages":"214-223"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11090976/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140012412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0