Troponin Elevation in Asymptomatic Cancer Patients: Unveiling Connections and Clinical Implications.

IF 3.8 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Current Heart Failure Reports Pub Date : 2024-12-01 Epub Date: 2024-09-10 DOI:10.1007/s11897-024-00681-x

Sebastian W Romann, Evangelos Giannitsis, Norbert Frey, Lorenz H Lehmann

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引用次数: 0

Abstract

Purpose of the review: Elevated troponin levels are well established e.g., for the diagnosis of suspected acute coronary syndrome in symptomatic patients. In contrast, troponin elevations in asymptomatic cancer patients emerge as a complex phenomenon, challenging traditional perceptions of its association solely with cardiac events.

Recent findings: Recent data support the predictive value of cardiac biomarker for all-cause mortality and cardiotoxicity in cancer patients. This review gives an overview about the current literature about cardiac troponins in prediction and identification of high-risk cancer patients. The overview is focusing on diagnostic challenges, biomarker significance, and gaps of knowledge. Latest publications highlight the relevance of cardiac troponin in risk analysis before cancer treatment as well as a potential diagnostic gatekeeper for further cardiological diagnostics and therapy.

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无症状癌症患者肌钙蛋白升高：揭示联系与临床意义

审查目的：肌钙蛋白水平升高已得到公认，如用于诊断有症状患者的疑似急性冠脉综合征。相比之下，无症状癌症患者的肌钙蛋白升高则是一个复杂的现象，它挑战了传统观念，即肌钙蛋白升高仅与心脏事件有关：最新研究结果：最新数据支持心脏生物标志物对癌症患者全因死亡率和心脏毒性的预测价值。本综述概述了目前有关心肌肌钙蛋白在预测和识别高危癌症患者方面的文献。综述的重点是诊断方面的挑战、生物标志物的意义和知识空白。最新出版物强调了心肌肌钙蛋白在癌症治疗前风险分析中的相关性，以及作为进一步心脏病诊断和治疗的潜在诊断守门员的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Heart Failure Reports Medicine-Emergency Medicine

CiteScore

5.30

自引率

0.00%

发文量

期刊介绍： This journal intends to provide clear, insightful, balanced contributions by international experts that review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of heart failure. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as investigative, pharmacologic, and nonpharmacologic therapies, pathophysiology, and prevention. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.