Current Medical Science最新文献

{"title":"Toxicities Associated with Sacituzumab Govitecan: Data from Clinical Trials and a Real-World Pharmacovigilance Database.","authors":"Qiao-Yun Tan, Xiang-Ping Mei, Yue Hu, Hong-Ge Wu, Lin-Ka Xie, Jie Xiong, Jing Yao","doi":"10.1007/s11596-025-00030-6","DOIUrl":"10.1007/s11596-025-00030-6","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to analyze the adverse effects (AEs) of sacituzumab govitecan (SG) through multiple sources of data to provide a reference for clinical safety management.</p><p><strong>Methods: </strong>Clinical trials of SG with available safety data were retrieved and included in the pooled analysis. The adverse drug reaction (ADR) signals of SG were collected from the FDA Adverse Event Reporting System (FAERS) database. Drug interactions with SG in the DDInter database were summarized.</p><p><strong>Results: </strong>A total of 6 clinical trials involving 1737 patients were included in the pooled analysis, and the most common AEs of ≥ grade 3 were neutropenia (46%), leukopenia (13%), and anemia (8%). In the pharmacovigilance study, 1024 AE reports were extracted, and the most common toxicities of SG were hematologic and gastrointestinal. AEs not included in the drug instructions also presented high signals, such as meningitis, colitis and lymphedema. A total of 40 drugs identified could induce drug-drug interactions when they were concomitantly administered with SG.</p><p><strong>Conclusions: </strong>This study provides the most comprehensive profile of SG toxicity on the basis of data from clinical trials and the FRAES and DDInter databases. Attention should be given not only to common ADRs but also to ADRs not reported in drug instructions, and potential drugs that can induce drug-drug interactions.</p>","PeriodicalId":10820,"journal":{"name":"Current Medical Science","volume":" ","pages":"301-313"},"PeriodicalIF":2.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143708983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Manifestations of Ocular Toxoplasmosis in Hubei, China: Case Series.","authors":"Mu Li, Xian Zhang, Xiao-Qin Yan, Peng-Cheng Li","doi":"10.1007/s11596-025-00028-0","DOIUrl":"10.1007/s11596-025-00028-0","url":null,"abstract":"<p><strong>Objective: </strong>The clinical features, disease course and visual outcomes of toxoplasmosis are less commonly reported in China than in other countries. To reduce misdiagnosis and improve visual function, the clinical characteristics, management and visual outcomes of 13 cases of ocular toxoplasmosis (OT) were described.</p><p><strong>Methods: </strong>This retrospective study included 14 eyes of 13 patients who were diagnosed with OT in Hubei, China. The clinical characteristics, course of treatment and outcomes are presented. There were 7 males and 6 females.</p><p><strong>Results: </strong>The main form of OT was retinochoroiditis with vitritis or anterior uveitis. Next-generation sequencing was applied to 3 eyes, and positive results were found in those eyes. Thirteen patients were positive for Toxoplasma gondii IgG antibodies, and 3 of them were also positive for IgM T. gondii antibodies. One patient with acquired immune deficiency syndrome was diagnosed with coinfection with OT and cytomegalovirus, as evidenced by an aqueous humor etiological test. Three patients were misdiagnosed with noninfectious uveitis. Recurrence occurred in 3 eyes during the follow-up periods. One patient who received vitreous implantation of Ozurdex therapy at another hospital before referral relapsed. One patient who received sulfadiazine, azithromycin and glucocorticoid therapy relapsed. One patient who received sulfadiazine therapy experienced relapse. Patients who received clindamycin and sulfadiazine or who received clindamycin only did not experience recurrence during the follow-up period. The best corrected visual acuity was improved in 6 eyes after inflammation resolved.</p><p><strong>Conclusions: </strong>Primary active retinochoroiditis is the main form of OT in Hubei, China. Timely correct diagnosis on the basis of ocular characteristics and aetiological test results and effective treatment should be adopted to prevent poor visual outcomes and recurrence.</p>","PeriodicalId":10820,"journal":{"name":"Current Medical Science","volume":" ","pages":"314-320"},"PeriodicalIF":2.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143572417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construction of a Multimodal 3D Atlas for a Micrometer-Scale Brain-Computer Interface Based on Mixed Reality.","authors":"Hong Zhou, Zi-Neng Yan, Wei-Hang Gao, Xiang-Xin Lv, Rui Luo, Jason Shih Hoellwarth, Lei He, Jia-Ming Yang, Jia-Yao Zhang, Hong-Lin Wang, Yi Xie, Xiao-Liang Chen, Ming-di Xue, Ying Fang, Yu-Yu Duan, Rui-Yuan Li, Xu-Dong Wang, Rui-Lin Wang, Mao Xie, Li Huang, Peng-Ran Liu, Zhe-Wei Ye","doi":"10.1007/s11596-025-00033-3","DOIUrl":"10.1007/s11596-025-00033-3","url":null,"abstract":"<p><strong>Objective: </strong>To develop a multimodal imaging atlas of a rat brain-computer interface (BCI) that incorporates brain, arterial, bone tissue and a BCI device using mixed reality (MR) for three-dimensional (3D) visualization.</p><p><strong>Methods: </strong>An invasive BCI was implanted in the left visual cortex of 4-week-old Sprague-Dawley rats. Multimodal imaging techniques, including micro-CT and 9.0 T MRI, were used to acquire images of the rat cranial bone structure, vascular distribution, brain tissue functional zones, and BCI device before and after implantation. Using 3D-slicer software, the images were fused through spatial transformations, followed by image segmentation and 3D model reconstruction. The HoloLens platform was employed for MR visualization.</p><p><strong>Results: </strong>This study constructed a multimodal imaging atlas for rats that included the skull, brain tissue, arterial tissue, and BCI device coupled with MR technology to create an interactive 3D anatomical model.</p><p><strong>Conclusions: </strong>This multimodal 3D atlas provides an objective and stable reference for exploring complex relationships between brain tissue structure and function, enhancing the understanding of the operational principles of BCIs. This is the first multimodal 3D imaging atlas related to a BCI created using Sprague-Dawley rats.</p>","PeriodicalId":10820,"journal":{"name":"Current Medical Science","volume":" ","pages":"194-205"},"PeriodicalIF":2.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Durational Exposure to Particulate Matter and Changes in Fertility Intentions: A Study of Adults in China.","authors":"Jia-Yu Wang, Xin Yun, Rui Qu, Wei-Qian Zhang, Jia Liang, Yu Guan, Dong-Dong Tang, Yu Chen, Tai-Lang Yin","doi":"10.1007/s11596-025-00046-y","DOIUrl":"https://doi.org/10.1007/s11596-025-00046-y","url":null,"abstract":"<p><strong>Objective: </strong>The effects of prolonged exposure to persistently elevated atmospheric pollutants, commonly termed air pollution waves, on fertility intentions remain inadequately understood. This study aims to investigate the association between particulate matter (PM) exposure and fertility intentions.</p><p><strong>Methods: </strong>In this nationwide cross-sectional study, we analyzed data from 10,747 participants (5496 females and 5251 males). PM waves were defined as periods lasting 3‒6 consecutive days during which the daily average concentrations exceeded China's Ambient Air Quality Standards Grade II thresholds (PM_2.5 > 75 μg/m³ and PM₁₀ > 150 μg/m³). We employed multivariate logistic regression models to assess the association between exposure to PM waves and fertility intentions.</p><p><strong>Results: </strong>Significant inverse associations were detected between exposure to PM_2.5 wave events (characterized by concentrations exceeding 75 μg/m³ for durations of 4‒6 days, P < 0.05) and PM₁₀ wave events (defined as concentrations exceeding 150 μg/m³ for 6 consecutive days, P < 0.05) and fertility intentions among females. In contrast, neither the PM_2.5 wave nor the PM₁₀ wave events demonstrated statistically significant correlations with fertility intentions in males (P > 0.05 for all comparisons). The potentially susceptible subgroup was identified as females aged 20-30 years.</p><p><strong>Conclusions: </strong>Our results provide the first evidence that PM_2.5 and PM₁₀ waves are associated with a reduction in female fertility intentions, offering critical insights for the development of public health policies and strategies aimed at individual protection.</p>","PeriodicalId":10820,"journal":{"name":"Current Medical Science","volume":"45 2","pages":"363-372"},"PeriodicalIF":2.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143965269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Silencing NCAPD3 Inhibits Tumor Growth and Metastasis in Hepatocellular Carcinoma by Suppressing PI3K-AKT Signalling Pathway.","authors":"Jun Lv, Fu-Yuan Gan, Ming-Hao Li, Qing-Jun Yin","doi":"10.1007/s11596-025-00026-2","DOIUrl":"10.1007/s11596-025-00026-2","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the expression pattern of non-SMC condensin II complex subunit D3 (NCAPD3) in hepatocellular carcinoma (HCC) tissues, assess its association with clinical characteristics, and explore the effects of NCAPD3 on HCC cells and the potential underlying mechanisms.</p><p><strong>Methods: </strong>NCAPD3 expression in HCC tumors and adjacent noncancerous tissues was quantified via quantitative PCR. Patients were divided into high- and low-expression groups on the basis of NCAPD3 levels, and associations with clinical parameters were assessed. The effects of NCAPD3 knockdown and the phosphatidylinositol-3-kinase (PI3K) agonist Y-P 740 on cell functions were examined via cell proliferation, Transwell migration, and invasion assays. Differentially expressed genes following NCAPD3 knockdown in SMMC-7721 cells were identified via mRNA sequencing. Western blotting was performed to measure NCAPD3, AKT serine/threonine kinase 1 (AKT1), and phosphorylated AKT1 levels.</p><p><strong>Results: </strong>NCAPD3 mRNA expression was notably upregulated in HCC tissues as compared with that in adjacent noncancer tissues. A positive correlation was observed between NCAPD3 expression and both lymphatic and distant metastases in patients with HCC. NCAPD3 knockdown reduced the proliferation and metastasis of SMMC-7721 and Huh-7 cells. mRNA sequencing revealed 140 downregulated genes and 125 upregulated genes. Further validation experiments confirmed that NCAPD3 modulated the PI3K-AKT signalling pathway and that the PI3K agonist Y-P 740 counteracted the effects of NCAPD3 knockdown.</p><p><strong>Conclusions: </strong>Elevated NCAPD3 expression was strongly correlated with HCC metastasis. NCAPD3 inhibition impedes HCC cell growth and metastatic potential by suppressing the PI3K-AKT signalling pathway.</p>","PeriodicalId":10820,"journal":{"name":"Current Medical Science","volume":" ","pages":"253-263"},"PeriodicalIF":2.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal Links Between Gut Microbiota and Vitamin Deficiencies: Evidence from Mendelian Randomization Analysis.","authors":"Zi-Xuan Hou, Wen-Jing Li, Rong Pi, Han-Wen-Xi Wang, Meng-Na Dai, Yan Ouyang, Su-Yun Li","doi":"10.1007/s11596-025-00038-y","DOIUrl":"10.1007/s11596-025-00038-y","url":null,"abstract":"<p><strong>Objective: </strong>Vitamin deficiencies, particularly in vitamins A, B12, and D, are prevalent across populations and contribute significantly to a range of health issues. While these deficiencies are well documented, the underlying etiology remains complex. Recent studies suggest a close link between the gut microbiota and the synthesis, absorption, and metabolism of these vitamins. However, the specific causal relationships between the gut microbiota composition and vitamin deficiencies remain poorly understood. Identifying key bacterial species and understanding their role in vitamin metabolism could provide critical insights for targeted interventions.</p><p><strong>Methods: </strong>We conducted a two-sample Mendelian randomization (MR) study to assess the causal relationship between the gut microbiota and vitamin deficiencies (A, B12, D). The genome-wide association study data for vitamin deficiencies were sourced from the FinnGen biobank, and the gut microbiota data were from the MiBioGen consortium. MR analyses included inverse variance-weighted (IVW), MR‒Egger, weighted median, and weighted mode approaches. Sensitivity analyses and reverse causality assessments were performed to ensure robustness and validate the findings.</p><p><strong>Results: </strong>After FDR adjustment, vitamin B12 deficiency was associated with the class Verrucomicrobiae, order Verrucomicrobiales, family Verrucomicrobiaceae, and genus Akkermansia. Vitamin A deficiency was associated with the phylum Firmicutes and the genera Fusicatenibacter and Ruminiclostridium 6. Additional associations for vitamin B12 deficiency included the Enterobacteriaceae and Rhodospirillaceae and the genera Coprococcus 2, Lactococcus, and Ruminococcaceae UCG002. Vitamin D deficiency was associated with the genera Allisonella, Eubacterium, and Tyzzerella 3. Lachnospiraceae and Lactococcus were common risk factors for both B12 and D deficiency. Sensitivity analyses confirmed the robustness of the findings against heterogeneity and horizontal pleiotropy, and reverse MR tests indicated no evidence of reverse causality.</p><p><strong>Conclusions: </strong>Our findings reveal a possible causal relationship between specific gut microbiota characteristics and vitamin A, B12 and D deficiencies, providing a theoretical basis for addressing these nutritional deficiencies through the modulation of the gut microbiota in the future and laying the groundwork for related interventions.</p>","PeriodicalId":10820,"journal":{"name":"Current Medical Science","volume":" ","pages":"321-330"},"PeriodicalIF":2.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12053135/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to: Naringin and Naringenin: Potential Multi-Target Agents for Alzheimer's Disease.","authors":"Jing Lu, Jie Chen, Shu-Yue Li, Guang-Jie Pan, Yi Ou, Li-Fu Yuan, Jian-Ping Jiang, Ling-Hui Zeng, Jie Zhao","doi":"10.1007/s11596-025-00039-x","DOIUrl":"10.1007/s11596-025-00039-x","url":null,"abstract":"","PeriodicalId":10820,"journal":{"name":"Current Medical Science","volume":" ","pages":"393"},"PeriodicalIF":2.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Histone Demethylase Inhibitor GSK-J4 Attenuates Periodontal Bone Loss and Inflammation in a Rat Model of Periodontitis.","authors":"Jian Kang, Huan Yu, Xu Xiang, Yong-Qiang Ma, Le Zhang, Yuan Zhang, Zhi-Tao Wang, Jing Yang, Zheng Zhang, Hui-Ru Zou, Yue Wang","doi":"10.1007/s11596-025-00018-2","DOIUrl":"10.1007/s11596-025-00018-2","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the treatment effect of the histone demethylase inhibitor GSK-J4, a small molecule that inhibits the demethylase activity of Jumonji domain-containing protein 3 (JMJD3), in the treatment of periodontitis.</p><p><strong>Methods: </strong>Gingival tissues from patients with moderate to severe chronic periodontitis and healthy controls were collected to evaluate JMJD3 expression via real-time quantitative reverse transcription PCR (RT-qPCR) and immunohistochemistry (IHC). Next, Sprague-Dawley (SD) rats were used to investigate the effect of GSK-J4 in vivo. The experimental periodontitis model was induced by upper first molar ligation and gingival sulcus injection of Porphyromonas gingivalis. The rats were divided into a healthy group, a periodontitis group, periodontitis plus GSK-J4 treatment groups (P + GSK-J4 15 mg/kg or 25 mg/kg), and a periodontitis plus dimethyl sulfoxide (DMSO) group (P + DMSO). After 4 weeks, maxillary molar segments were assessed via micro-computed tomography (CT) and hematoxylin and eosin (HE) staining. Serum tumor necrosis factor-α (TNF-α) levels were measured by enzyme-linked immunosorbent assay (ELISA).</p><p><strong>Results: </strong>Higher expression of the Jmjd3 gene and JMJD3 protein was detected in human inflamed gingiva than in healthy gingiva (P < 0.05). GSK-J4 administration reversed alveolar bone absorption [i.e., reduced alveolar bone crest (ABC)-cementoenamel junction (CEJ) distance], reduced inflammatory cell accumulation at the crest of the alveolar bone, and alleviated serum TNF-α levels in rats with periodontitis. Moreover, the number of H3K27me3-positive nuclei was greater in model rats treated with GSK J4 than in model rats.</p><p><strong>Conclusions: </strong>The histone demethylase inhibitor GSK-J4 attenuated periodontal bone loss and inflammation in a rat periodontitis model by targeting JMJD3.</p>","PeriodicalId":10820,"journal":{"name":"Current Medical Science","volume":" ","pages":"382-390"},"PeriodicalIF":2.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143566436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to: Early Aerobic Exercise Promotes Neurological Function Recovery of Rats after Cerebral Ischemia/Reperfusion by Upregulating the Expression of Heat Shock Protein A5.","authors":"Zhi-Feng Peng, Nai-Bao Zhang, Jian Meng, Ji-Hong Zhang","doi":"10.1007/s11596-025-00029-z","DOIUrl":"10.1007/s11596-025-00029-z","url":null,"abstract":"","PeriodicalId":10820,"journal":{"name":"Current Medical Science","volume":" ","pages":"391-392"},"PeriodicalIF":2.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143604054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NOX4 Suppresses Ferroptosis Through Regulation of the Pentose Phosphate Pathway in Colorectal Cancer.","authors":"Jing Zhu, Chao Jiang, Fan Wang, Ming-Yue Tao, Hai-Xiao Wang, Yuan Sun, Hong-Xia Hui","doi":"10.1007/s11596-025-00013-7","DOIUrl":"10.1007/s11596-025-00013-7","url":null,"abstract":"<p><strong>Objective: </strong>Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (NOXs) are known as major sources of reactive oxygen species (ROS), yet their role in regulating cellular antioxidative metabolism and ferroptosis is unclear. This study assessed the expression and clinical relevance of NOXs across pan-cancer and investigated the role of NOX4 in colorectal cancer progression METHODS: We analyzed transcriptomic and survival data from The Cancer Genome Atlas (TCGA) for NOXs across 22 types of solid tumors. A CRISPR library targeting NOXs was developed for potential therapeutic target screening in colorectal cancer cells (CRCs). Techniques such as CRISPR-knockout cell lines, 1,2-¹³C-glucose tracing, PI staining, BrdU assays, and coimmunoprecipitation were employed to elucidate the function of NOX4 in CRCs.</p><p><strong>Results: </strong>NOX4 emerged as a key therapeutic target for colorectal cancer from TCGA data. CRISPR screening highlighted its essential role in CRC survival, with functional experiments confirming that NOX4 upregulation promotes cell survival and proliferation. The interaction of NOX4 with glucose‑6‑phosphate dehydrogenase (G6PD) was found to enhance the pentose phosphate pathway (PPP), facilitating ROS clearance and protecting CRCs against ferroptosis.</p><p><strong>Conclusions: </strong>This study identified NOX4 as a novel ferroptosis suppressor and a therapeutic target for the treatment of colorectal cancer. The findings suggest that a coupling between NADPH oxidase enzyme NOX4 and the PPP regulates ferroptosis and reveal an accompanying metabolic vulnerability for therapeutic targeting in colorectal cancer.</p>","PeriodicalId":10820,"journal":{"name":"Current Medical Science","volume":" ","pages":"264-279"},"PeriodicalIF":2.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}