Hong Zhou, Zi-Neng Yan, Wei-Hang Gao, Xiang-Xin Lv, Rui Luo, Jason Shih Hoellwarth, Lei He, Jia-Ming Yang, Jia-Yao Zhang, Hong-Lin Wang, Yi Xie, Xiao-Liang Chen, Ming-di Xue, Ying Fang, Yu-Yu Duan, Rui-Yuan Li, Xu-Dong Wang, Rui-Lin Wang, Mao Xie, Li Huang, Peng-Ran Liu, Zhe-Wei Ye
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引用次数: 0
摘要
目的：利用混合现实（MR）技术建立大鼠脑机接口（BCI）的多模态成像图谱，该图谱包含脑、动脉、骨组织和BCI设备，用于三维（3D）可视化。方法：在4周龄Sprague-Dawley大鼠左视皮层植入侵入性脑机接口。采用micro-CT、9.0 T MRI等多模态成像技术获取植入前后大鼠颅骨结构、血管分布、脑组织功能区、脑机接口装置等图像。利用3D-slicer软件，通过空间变换对图像进行融合，然后进行图像分割和三维模型重建。采用HoloLens平台进行MR可视化。结果：本研究构建了包括颅骨、脑组织、动脉组织、脑机接口装置在内的大鼠多模态成像图谱，结合MR技术建立交互式三维解剖模型。结论：该多模态三维图谱为探索脑组织结构与功能之间的复杂关系提供了客观、稳定的参考，增强了对脑机接口工作原理的认识。这是第一个与使用Sprague-Dawley大鼠创建的脑机接口相关的多模态3D成像图谱。
Construction of a Multimodal 3D Atlas for a Micrometer-Scale Brain-Computer Interface Based on Mixed Reality.
Objective: To develop a multimodal imaging atlas of a rat brain-computer interface (BCI) that incorporates brain, arterial, bone tissue and a BCI device using mixed reality (MR) for three-dimensional (3D) visualization.
Methods: An invasive BCI was implanted in the left visual cortex of 4-week-old Sprague-Dawley rats. Multimodal imaging techniques, including micro-CT and 9.0 T MRI, were used to acquire images of the rat cranial bone structure, vascular distribution, brain tissue functional zones, and BCI device before and after implantation. Using 3D-slicer software, the images were fused through spatial transformations, followed by image segmentation and 3D model reconstruction. The HoloLens platform was employed for MR visualization.
Results: This study constructed a multimodal imaging atlas for rats that included the skull, brain tissue, arterial tissue, and BCI device coupled with MR technology to create an interactive 3D anatomical model.
Conclusions: This multimodal 3D atlas provides an objective and stable reference for exploring complex relationships between brain tissue structure and function, enhancing the understanding of the operational principles of BCIs. This is the first multimodal 3D imaging atlas related to a BCI created using Sprague-Dawley rats.
期刊介绍：
Current Medical Science provides a forum for peer-reviewed papers in the medical sciences, to promote academic exchange between Chinese researchers and doctors and their foreign counterparts. The journal covers the subjects of biomedicine such as physiology, biochemistry, molecular biology, pharmacology, pathology and pathophysiology, etc., and clinical research, such as surgery, internal medicine, obstetrics and gynecology, pediatrics and otorhinolaryngology etc. The articles appearing in Current Medical Science are mainly in English, with a very small number of its papers in German, to pay tribute to its German founder. This journal is the only medical periodical in Western languages sponsored by an educational institution located in the central part of China.
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