Current issues in pharmacy and medicine: science and practice最新文献

{"title":"Study the polyphenolic compounds composition of Thymus vulgaris L. herb","authors":"O. V. Mazulin, L. Fukleva, G. V. Mazulin","doi":"10.14739/2409-2932.2023.1.265524","DOIUrl":"https://doi.org/10.14739/2409-2932.2023.1.265524","url":null,"abstract":"The Thymus L. genus is extremely widespread on the territory of Ukraine and includes up to 50 main species. Extracts from the official species of the Thymus L. genus are part of effective herbal preparations with pronounced anti-inflammatory, antimicrobial and antioxidant activities. A promising direction of modern phytochemical research is the determination of the accumulation of biologically active polyphenolic compounds in the Thymus vulgaris L. herb, which is widely cultivated in Ukraine and other countries.\u0000The aim of the work is to determine the accumulation of polyphenolic compounds in Thymus vulgaris L. herb at the end of flowering using TLC and HPLC methods.\u0000Materials and methods. For experimental studies, alcohol extracts from Thymus vulgaris L. herb (1:100) were used. The plants were cultivated in Volodymyrivka, Zaporizhzhia region during the period of maximum polyphenolic compounds accumulation (June – August 2022). The substances’ component composition was studied by TLC method Biostep CD 60 densitometer (Germany) and HPLC Agilent 1260 Infinity HPLC System Open LABCDS Software (Japan).\u0000Results. TLC and HPLC methods revealed up to 29 polyphenolic compounds. Experimentally determined flavonoids and hydroxycinnamic acids are known in phytotherapy for their pronounced anti-inflammatory, antimicrobial, and antioxidant activities.\u0000Conclusions. Considering the results obtained by TLC and HPLC methods, it can be concluded that Thymus vulgaris L. is a promising species for further phytochemical research.","PeriodicalId":10800,"journal":{"name":"Current issues in pharmacy and medicine: science and practice","volume":"54 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79640219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The current state and prospects for the development of the Ukrainian market of veterinary drugs for the treatment of skin diseases","authors":"I. V. Bushuieva, M. V. Ohloblina","doi":"10.14739/2409-2932.2023.1.273661","DOIUrl":"https://doi.org/10.14739/2409-2932.2023.1.273661","url":null,"abstract":"The trend of increasing incidence of skin diseases of various etiologies and the frequency of complications caused by them (dermatitis, allergies, secondary infections, eczema, trichophytosis, dermatophytosis, dermatomycosis, etc.) is increasing in Ukraine.\u0000Nowadays the important problem is the development of new domestic effective medicines to combat this pathology. The general market of veterinary drugs, feed additives of finished feed, and premixes was investigated, and the place of drugs used to combat fungal diseases of animal skin was determined to identify the current state and prospects for the development of domestic veterinary drugs (DVD) production. It is established that the studied range of the market saturation structure of veterinary drugs, feed additives, finished feeds, and premixes have significant competition in the pharmaceutical market of Ukraine from foreign manufacturers. The range of effective domestic medicines for the treatment of fungal skin diseases of animals based on domestic substances is very minor, so there are prospects for the introduction into production and further promotion of new effective drugs in this area on the domestic market.\u0000The aim of the work is to determine the current state and prospects for the development of the production of national veterinary medicines for the treatment of fungal diseases of animal skin based on the study of the structure of the general market for veterinary drugs, feed additives, finished feed, premixes and determination of their market share.\u0000Materials and methods. The following methods (synthetic, analytical, information search, descriptive, generalization) were used in the work. The research materials were literary sources that contain information on the structure of the veterinary market of antifungal and antimicrobial drugs and the “List of Registration of Veterinary Drugs, Feed Additives, and Finished Feeds” as of July 21, 2022.\u0000Results. According to the above List, it was found that as of 21.07.2022, 6574 trade names of these products were registered on the Ukrainian market of veterinary medicines, feed additives, finished feed, and premixes. 5097 (77.53 %) of which were supplied by foreign manufacturers, the rest – 1497 (22.47 %) were products of domestic manufacturers. The geography of suppliers is represented by 47 countries, including Ukraine. France, Poland, and Germany remain the leaders in terms of the number of registered items of drugs, feed additives, finished feeds, and premixes. Based on the marketing analysis, it was found that in terms of dosage forms, this market is overly heterogeneous and is represented by 31 dosage forms, which are powders, liquid, solid, soft, and gaseous forms by consistency. It has been proved that a small assortment of antifungal DVDs makes it possible to saturate this segment of the pharmaceutical market not only with imported drugs, but also to find opportunities for the creation and introduction of fundamentally new antifungal","PeriodicalId":10800,"journal":{"name":"Current issues in pharmacy and medicine: science and practice","volume":"47 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77113111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative studies of the specific activity of soft dosage forms minoxidil for trichological practice","authors":"V. V. Hladyshev, O. B. Kharaponova, A. Diudiun, I. O. Pukhalska, S. A. Hladysheva, A. V. Kurinnyi, H. P. Lysianska","doi":"10.14739/2409-2932.2023.1.273705","DOIUrl":"https://doi.org/10.14739/2409-2932.2023.1.273705","url":null,"abstract":"The treatment and prevention of hair loss have been a serious aesthetic problem for the population for a long time due to the widespread occurrence of the condition and its undesirable medical and social consequences. The pharmacotherapeutic options for trichological practice are very limited, and the effectiveness of many of these drugs is small or questionable. The peripheral vasodilator minoxidil is one of the few medicinal substances that has been proven to stimulate hair growth. However, the number of minoxidil preparations allowed by the Ministry of Health for use in Ukraine is minimal and mainly represented by rare dosage forms for external use. Considering the above, the employees of the Department of Medicines Technology at Zaporizhzhia State Medical University have proposed rational formulations and technologies for two new soft dosage forms of minoxidil – a 2 % cream for external use based on an emulsion, and a shampoo in gel form – based on complex physical-chemical, pharmaco-technological, rheological, and biopharmaceutical research. These formulations are intended to stabilize hair growth and restore hair coverage in men and women suffering from androgenic alopecia.\u0000The aim of this research is to study the specific activity of the proposed topical dosage forms of minoxidil.\u0000Materials and methods. Experimental cream with 2 % minoxidil on an emulsion carrier and a gel-like shampoo containing 1 % minoxidil combined with phytoextracts of hops and burdock, as well as corresponding placebo compositions, were used as objects of preclinical studies. The compositions of the topical minoxidil pharmacotherapeutic agents are scientifically based, ensuring their optimal pharmacotechnological, biopharmaceutical, and consistent consumer properties. The study of the specific activity of soft medicinal forms of minoxidil for external use was carried out by evaluating their growth-stimulating and follicle-protective activity. “Pilfood Bosnalek” spray for external use (Bosnalijek, Bosnia and Herzegovina), containing 2 % minoxidil, was used as a reference drug when studying the growth-stimulating effect of 2 % cream for external use with minoxidil. The reference drug in the study of the similar activity of the gel-like shampoo “Trichlomine” was the shampoo against hair loss “Dove” (Unilever, Germany).\u0000Results. It has been found that a 2 % minoxidil cream for topical use, when used together with the reference drug “Pilfood Bosnalek” (Bosnalijek, Bosnia and Herzegovina), has a significant hair growth-stimulating effect, which statistically significantly increases hair growth in experimental animals from as early as 3–4 days of use. The shampoo “Trichlomine” also has a significant effect on hair growth in experimental animals, with results observed from 3–4 days of use. Furthermore, the strength of the hair growth-stimulating effect observed from the use of “Trichlomine” shampoo significantly exceeds that of the reference “Dove” shampoo (Unilever, Germany","PeriodicalId":10800,"journal":{"name":"Current issues in pharmacy and medicine: science and practice","volume":"56 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88951165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a spectrophotometric technique for the quantitative determination of ademol","authors":"S. Semenenko, K. Miedviedieva, S. Vasiuk, B. Burlaka","doi":"10.14739/2409-2932.2023.1.267437","DOIUrl":"https://doi.org/10.14739/2409-2932.2023.1.267437","url":null,"abstract":"According to statistics, craniocerebral injuries are often the cause of disability among the population. The choice of medicines for traumatic brain injuries is one of the most difficult problems in the complex treatment of such patients. Ademol (1-adamantylethyloxy-3-morpholino-2-propanol hydrochloride) is a promising medicinal substance that has a huge positive therapeutic effect of a protective act on the damaged brain and can be presented in medicinal preparations in different dosages. Therefore, the urgent task is the development of highly accurate, reliable, affordable, and fast methods of quantitative determination of ademol.\u0000The aim of the work is to study the optimal conditions for the “ademol – bromocresol green” reaction and to develop an express, sensitive and easy-to-implement method for the quantitative determination of ademol.\u0000Materials and methods. Bromocresol green (BCG) grade “chemically pure” and acetone grade “pure for analysis” were used as reagents and solvents. Analytical equipment: spectrophotometer Specord 200, electronic scales AVT-120-5DM, ultrasonic bath Elmasonic E 60H, class A measuring vessels.\u0000Results. A new method of quantitative determination of ademol by the spectrophotometric method was developed. The optimal conditions of the flow between the substance to be determined and the reagent have been studied, the concentration limits have been established, in which subordination to the basic law of light absorption is observed. A forecast of the complete uncertainty of the results of the specified method of quantitative determination was made to assess the correctness of the reproduction of the developed method in other laboratories. The proposed method is relevant according to the requirements of the State Pharmacopoeia of Ukraine.\u0000Conclusions. According to the experimental data, the method of quantitative determination of ademol can be correctly reproduced and suitable for use.","PeriodicalId":10800,"journal":{"name":"Current issues in pharmacy and medicine: science and practice","volume":"83 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90377920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application trends of the systemic paradigm in pharmaceutical research","authors":"T. Mahanova, N. Tkachenko","doi":"10.14739/2409-2932.2023.1.273576","DOIUrl":"https://doi.org/10.14739/2409-2932.2023.1.273576","url":null,"abstract":"Pharmacists use systematic knowledge to study the regularities of complex, multilevel systems with a considerable number of variable, feedback connections between them in order to find or make rational management decisions. However, the level and direction of application of the system paradigm of knowledge in pharmacy remain to the end do not determine.\u0000The aim of our research is to identify trends in the application of a systemic paradigm in modern pharmaceutical research to outline promising directions in pharmaceutical science for raising the level of pharmaceutical assistance to the population.\u0000Materials and methods. The research material was publications of fundamental and applied research of domestic and foreign scientists on the raised issue, scientific and methodical publications, dissertations on the repositions of medical and pharmaceutical universities of Ukraine, and database PubMed for the last 20 years.\u0000Results. The research, analysis, and systematization of 59 scientific works of domestic scientists on the application of system paradigms in pharmaceutical research by different applied values were carried out. Namely this pharmaceutical provision for diseases of different nosology, management of pharmaceutical organizations (including regulation, logistics), assessment of medical technologies, social pharmacy (including patient-centered model), pharmaceutical marketing (including pricing, information support), and systems architecture.\u0000Conclusions. The developed array of information sources showed the significant spread of system methodology, approach, and system method. However, the issue of a coordinated and integral definition of the pharmaceutical system remains open. Perspective has seen the application of system analysis and modeling of pharmaceutical systems with modern computer technologies with the further realization of results in the patient’s health care system to increase the level of pharmaceutical care.","PeriodicalId":10800,"journal":{"name":"Current issues in pharmacy and medicine: science and practice","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78263392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of physical and occupational therapy in palliative and hospice medicine of neurodegenerative diseases","authors":"O. Raznatovska, S. M. Kanyhina, O. S. Shalmin, O. O. Cherepok","doi":"10.14739/2409-2932.2023.1.268289","DOIUrl":"https://doi.org/10.14739/2409-2932.2023.1.268289","url":null,"abstract":"The aim of our research is to review modern literature regarding the relevance and frequency of physical and occupational therapy in palliative and hospice medicine of neurodegenerative diseases.\u0000Results. The role of physical therapy and occupational therapy in palliative-hospice medicine for such neurodegenerative diseases as Parkinson’s disease, cognitive impairment and/or dementia, Alzheimer’s disease, amyotrophic lateral sclerosis, multiple sclerosis has been studied. It has been found, a wide variety of physical and occupational therapy is widely used in palliative hospice medicine despite the disease’s severity. These methods significantly improve the quality of life of both palliative patients and their families ultimately. Physical and occupational therapist specialists are a very important link in the multidisciplinary team of palliative-hospice medicine.\u0000Conclusions. Physical and occupational therapy play a very important role in neurodegenerative diseases patients requiring palliative-hospice care in today’s world. Palliative physical and occupational therapy of patients with neurodegenerative diseases has many benefits that help maintain or improve various bodily functions. This contributes to the quality of life improving for not only patients but also for their family members who care for them.","PeriodicalId":10800,"journal":{"name":"Current issues in pharmacy and medicine: science and practice","volume":"519 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77193328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study of the chemical composition of the freon extract of the Damask rose (Rosa damascena Mill.)","authors":"O. Panasenko, V. Odyntsova, O. Denysenko, T. Shkopynska, V. I. Mozul, V. V. Holovkin","doi":"10.14739/2409-2932.2023.1.269905","DOIUrl":"https://doi.org/10.14739/2409-2932.2023.1.269905","url":null,"abstract":"Rosa damascena Mill. a rather popular variety of roses has anti-inflammatory, wound-healing, and antiseptic effects.\u0000The aim of this study was to establish the component composition of the freon extract of Damask rose grown in vitro and to substantiate the advantages of this method and the prospects for the use of phytosubstances in medical practice.\u0000Materials and methods. The object of the study was the freon extract of Damask rose, grown by the method of clonal micropropagation in vitro. The qualitative and quantitative determination of the components of the freon extract was determined using the chromato-mass spectrometric method.\u0000Results. According to the results of the chromato-mass-spectrometric study, 60 compounds were identified, 6 of which were in the isomeric state.\u0000The following components prevailed by percentage: рhenylethyl alcohol – 64.070 %, citronellol – 6.090 %, nonadecane – 4.636 %, heneicosane – 2.590 %, geraniol – 1.749 %.\u0000Conclusions. The chemical composition of the freon extract of Rosa damascena Mill., grown in vitro, was investigated for the first time using the chromato-mass-spectrometric method.\u0000The main components of rose petals: рhenylethyl alcohol – 64.070 %, citronellol – 6.090 %, nonadecane – 4.636 %, heneicosane – 2.590 %, geraniol – 1.749 %.","PeriodicalId":10800,"journal":{"name":"Current issues in pharmacy and medicine: science and practice","volume":"201 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76977605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disorder of purine metabolism in the etiopathogenesis of urate nephrolithiasis","authors":"S. Vorotyntsev, A. I. Bilai, I. Bilai","doi":"10.14739/2409-2932.2023.1.273835","DOIUrl":"https://doi.org/10.14739/2409-2932.2023.1.273835","url":null,"abstract":"Urinary stone disease (USD) is a polyetiological urological disease caused by both exogenous and endogenous factors, including hereditary ones. It is characterized by the appearance of stones in the kidneys and urinary tract, and a tendency to relapse, often with a severe course. Almost 25 % of stones consist of uric acid (UA). The leading role in the pathogenesis of urate nephrolithiasis (UN) is played by disorders of purine metabolism, which are characterized by the development of hyperuricemia (HU) and hyperuricuria.\u0000The aim of the work is to review modern literary sources on the role of purine metabolism disorders in the etiopathogenesis of UN.\u0000Results. The development of UN depends on the constancy of the acidic urine pH, as well as on a decrease in diuresis, HU and hyperuricuria. UA is the final metabolite of purine metabolism and the main stone-forming substance in patients with UN. HU develops both due to uncompensated disorders of purine metabolism with a decrease in renal secretion and intestinal uricolysis (excretion pathway) and excessive intake of purine bases in the body and their increased synthesis in vivo (metabolic pathway).\u0000Citric acid, as one of the main metabolites of the tricarboxylic acid (TCA) cycle, is connected through the corresponding substrates to the formation of purines and the metabolite of amino acid metabolism, glutamine. TCA is connected to the cycles of urea, glyoxylate and purine bases through α-ketaglutaric acid. It is a substrate of citric acid, and it affects the synthesis of glutamate, which combines with ammonia to form glutamine, used in the cycle of purine synthesis.\u0000Conclusions. The role and diagnostic value of purine metabolism upsets, disorders of the TCA (citric acid), amino acid metabolism (glutamine), the activity of xanthine oxidase is a key enzyme in purine synthesis which passes through TCA with the participation of its metabolite α-ketaglutarate, have been established. TCA is bound to glutamine, rich in nitrogen, which is necessary for the synthesis of purine bases.","PeriodicalId":10800,"journal":{"name":"Current issues in pharmacy and medicine: science and practice","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78830881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the activity of c-kit immunopositive alpha-cells of the pancreas in exogenous infusions and endogenously formed pathology","authors":"T. Ivanenko","doi":"10.14739/2409-2932.2023.1.273223","DOIUrl":"https://doi.org/10.14739/2409-2932.2023.1.273223","url":null,"abstract":"There are a number of factors and agents that change the population of endocrinocytes and their secretory activity depending on various conditions and experimentally formed pathologies. These include the impact of intermittent hypoxic hypoxia; experimentally formed pathology (diabetes); genetically formed pathology (arterial hypertension), direct effect on endocrinocytes of the pancreas with their own pathophysiological mechanism. In this context, it is interesting to analyze the state of the progenitor potential of alpha cells depending on the living conditions of the organism, its effects, and developing pathological conditions in it.\u0000The aim of the work is to determine the activity of the proliferative factor c-kit in alpha cells under exogenous factors – intermittent hypoxic hypoxia and endogenously formed pathology – arterial hypertension and diabetes.\u0000Materials and methods. The study was conducted on the pancreas of SHR and Wistar rats. Glucagon and c-kit in pancreatic islets were determined by the immunofluorescence method. The immunofluorescence reaction was studied with an AxioImager-M2 fluorescence microscope.\u0000Results. Analysis of the c-kit positive alpha-cell index in rats with diabetes showed a 5-fold increase. This was explained by the fact, that the development of hyperglycemia in diabetes mellitus was characterized not only by an increased level of glucose in the blood due to insufficient insulin production but also due to an increase in the number of alpha cells, their active proliferation and possible transdifferentiation from beta cells. The number of c-kit positive alpha cells in SHR rats decreased. This may indicate that these changes were not so related to a violation of the modulation of the transcription factor, but to the participation of neurogenic mechanisms. The decrease in c-kit positive alpha cells in animals with hypoxic hypoxia can be explained by transdifferentiation (remodeling) changes, aimed at suppressing proliferative processes in alpha endocrinocytes.\u0000Conclusions. The increase in the number of c-kit positive alpha cells in rats with diabetes is explained by the fact, that the development of hyperglycemia in diabetes is characterized not only by an increased level of glucose in the blood due to insufficient insulin production but also by an increase in the number of alpha cells, their active proliferation and possible transdifferentiation from beta cells. A decrease in the number of c-kit positive alpha cells in SHR rats may indicate that these changes are not so much related to a violation of the modulation of the transcription factor, but to the participation of neurogenic mechanisms. The decrease in c-kit positive alpha cells in animals with hypoxic hypoxia can be explained by transdifferentiation (remodeling) changes, aimed at suppressing proliferative processes in alpha endocrinocytes.","PeriodicalId":10800,"journal":{"name":"Current issues in pharmacy and medicine: science and practice","volume":"55 27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81162924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of industrial technology of tablets with cardioprotective action based on cultivated parsnip herb thick extract","authors":"N. А. Symonenko, O. Shpychak, Ye. A. Bezrukavyi","doi":"10.14739/2409-2932.2023.1.264981","DOIUrl":"https://doi.org/10.14739/2409-2932.2023.1.264981","url":null,"abstract":"The aim of the work is to develop the industrial technology of tablets with cardioprotective action based on the domestic raw material of cultivated parsnip herb thick extract (CPHTE).\u0000Materials and methods. Experimental samples of mixtures of the plant substance CPHTE (Pastinacae sativae herbae extracti spissi) with excipients approved for medical application were used as objects of the study.\u0000Results. The results of experimental studies were used during the development of a block diagram of the technological process to produce tablets with cardioprotective action based on the plant raw material CPHTE and an apparatus scheme was tested in the industrial conditions of LLC “Pharmaceutical Company “Zdorovye” (Kharkiv); the control technological parameters for each stage of the technological process of medicine preparation were established.\u0000Conclusions. The technology to produce cardioprotective tablets based on the domestic raw material CPHTE was theoretically substantiated and experimentally developed, as well as a block diagram of the technological process of their production and an apparatus scheme tested in industrial conditions by the LLC “Pharmaceutical Company “Zdorovye” (Kharkiv). The results of the experiment were used while development of projects of quality control methods and technological regulations for the developed medicine in the form of tablets under the conventional name “Pastinocard”.","PeriodicalId":10800,"journal":{"name":"Current issues in pharmacy and medicine: science and practice","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75268824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}