Current Environmental Health Reports最新文献

{"title":"Micronutrients as Mitigators of Endocrine Disrupting Chemical Health Effects: A Scoping Review and Framework for Epidemiologic Studies.","authors":"Heather M Guetterman, Jessie P Buckley, Kasandra Sanidad, Emily Jamo, Rita S Strakovsky","doi":"10.1007/s40572-026-00536-8","DOIUrl":"10.1007/s40572-026-00536-8","url":null,"abstract":"<p><strong>Purpose of review: </strong>Exposure to endocrine disrupting chemicals (EDC) is linked to numerous adverse health outcomes. However, limiting exposure to EDCs remains a significant challenge due to their widespread uses and persistence in the environment. Adequate micronutrient status supports optimal health and may offer actionable strategies for mitigating the adverse health effects of EDCs. This scoping review aimed to summarize the epidemiologic evidence on micronutrients as potential mitigators of EDC-related health outcomes, with the goal of guiding future research and methodologies.</p><p><strong>Recent findings: </strong>We identified 71 epidemiologic studies assessing micronutrients as mitigators of EDC-outcome relations, focused primarily on exposures during pregnancy (n = 34). Most studies examined phthalates and/or environmental phenols (n = 25), per- and polyfluoroalkyl substances (n = 15), polycyclic aromatic hydrocarbons (n = 10), and self-reported pesticide exposure (n = 6). Most studies suggested higher levels of some micronutrients attenuated adverse associations of EDCs with some health outcomes, particularly iodine (thyroid hormones); folic acid (fertility, birth outcomes, neurodevelopment); vitamin D (lung function, neurodevelopment); and antioxidants (birth outcomes, aging, metabolic health). However, included studies assessed a wide range of micronutrients, EDCs, and outcomes, with limited overlap across studies. This scoping review identified few topics with substantial evidence to warrant focused systematic reviews, suggesting that additional prospective research is needed, especially in at-risk populations and sensitive periods outside of pregnancy. Future epidemiologic research should consider the co-occurrence of EDCs and micronutrients in foods and include multiple methods for assessing micronutrients. Finally, to strengthen causal inference, future research should thoughtfully model potential confounding, mediation, effect measure modification, and/or statistical interaction.</p>","PeriodicalId":10775,"journal":{"name":"Current Environmental Health Reports","volume":"13 1","pages":""},"PeriodicalIF":7.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13132905/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147811816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Itching to know: the Microbiome, Allergic Disease, and Antimicrobial Chemicals.","authors":"Hannah E Laue, Elvira S Fleury, Megan E Romano, Anne G Hoen, Joseph M Braun","doi":"10.1007/s40572-025-00519-1","DOIUrl":"10.1007/s40572-025-00519-1","url":null,"abstract":"<p><p>PURPOSE OF REVIEW: Antimicrobial compounds are pervasive consumer product additives that have been linked to allergic disease outcomes. Human-affiliated microbiomes may induce susceptibility or confer resilience to antimicrobials, or may be a mechanistic link between antimicrobials and allergy. In this review we summarize what is known about the connections between antimicrobials, microbiomes, and allergic disease states in children. RECENT FINDINGS: Our review highlights studies on triclosan, a legacy antimicrobial, while pointing to the need for more research on parabens and quaternary ammonium compounds (QACs), which have continued widespread use in the United States. We found evidence that childhood triclosan exposure is linked to eczema, allergic rhinitis, and asthma, and the few studies of parabens and QACs also found associations with allergy outcomes. Microbiomes in the gut and airways, on skin, and potentially in human milk are also linked to allergic outcomes. Together these findings provide evidence that antimicrobials and microbes may interact in their associations with allergy, but most studies have not looked at microbes as mediators or modifiers of these associations. While the existing evidence of associations among antimicrobials, microbiomes, and allergic disease is compelling, additional epidemiologic and mechanistic studies are needed to elucidate the nature and directionality of these associations. </p>","PeriodicalId":10775,"journal":{"name":"Current Environmental Health Reports","volume":"13 1","pages":""},"PeriodicalIF":7.9,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147764482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Environmental Justice and Pesticides in the Global South-A Scoping Review.","authors":"Meryl Jagarnath, Leslie London, Iman Nuwayhid, Rima R Habib","doi":"10.1007/s40572-026-00535-9","DOIUrl":"10.1007/s40572-026-00535-9","url":null,"abstract":"<p><p>PURPOSE OF REVIEW: Pesticide exposure is an urgent environmental health issue in the Global South, where structural inequalities, weak regulation, and the export of banned chemicals from the Global North create disproportionate risks for marginalized populations. While environmental justice (EJ) frameworks are increasingly applied in environmental health research, their integration in pesticide research and interventions in the Global South has not been reviewed. This scoping review maps how EJ is conceptualized and operationalized in studies on pesticides in the Global South, identifying justice dimensions, methodological approaches, and interventions. RECENT FINDINGS: Fifty-four peer-reviewed and grey literature sources (1995 to 2024, English language) were reviewed using a five-dimensional EJ framework: distributive, procedural, recognition, capabilities-based, and epistemic justice. Distributive justice dominated, procedural and recognition justice were inconsistently addressed, and capabilities-based and epistemic justice were rarely applied. EJ applications varied regionally: Central and South American studies had a pluralistic approach to EJ. Sub-Saharan African (SSA) research emphasized acute exposure disparities but lacked epistemic justice. Southeast Asia focused on gender and caste-based inequities, and the Middle East and North African (MENA) region was notably under-represented, highlighting a significant geographic gap. Interventions included pesticide bans, litigation, advocacy, user training, and household adaptations, yet most reinforced individual responsibility rather than addressing structural drivers of pesticide use. Additional gaps include limited gender-specific analyses, scarce epidemiological evidence, and co-production of knowledge with affected communities. Pesticide-related EJ scholarship in the Global South remains uneven, with major regional, methodological, and epistemological gaps. Advancing EJ requires rights-based, community-led, gender-sensitive and epistemically inclusive approaches, strengthened regulations, and a global ban on prohibited pesticides. </p>","PeriodicalId":10775,"journal":{"name":"Current Environmental Health Reports","volume":"13 1","pages":""},"PeriodicalIF":7.9,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13086650/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147697609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shared Plant-human Biology: Herbicide Effects and New Biomarkers Perspectives.","authors":"Aline de Souza Espindola, Christine Gibson Parks, Josino Costa Moreira","doi":"10.1007/s40572-026-00523-z","DOIUrl":"10.1007/s40572-026-00523-z","url":null,"abstract":"<p><p>PURPOSE OF REVIEW: Herbicide exposure has been associated with acute poisoning and several chronic diseases. Humans and plants share biological processes targeted by herbicides. Investigating these shared pathways can uncover crucial insights into the underlying mechanisms of herbicides in humans, identify potential biomarkers of herbicide-induced effects, and advance our understanding of related biological processes. RECENT FINDINGS: The tubulin and key enzymes of metabolic pathways, such as hydroxyphenylpyruvate dioxygenase (HPPD), acetyl-CoA carboxylase (ACC), glutamine synthetase (GS), and protoporphyrinogen oxidase (PPO), have been identified as molecular targets of herbicides in humans. These molecules exhibit relative selectivity for herbicide exposure and can be quantified using well-established techniques, thereby representing potential effect biomarkers. Some of these enzymes play crucial roles in regulating all aspects of the immune response. Furthermore, these shared enzymes, as well as other enzymes involved in plant-specific metabolic pathways that are not present in humans, are found in bacteria and fungi of the gut microbiota, therefore also representing potential targets of herbicides. This study highlights molecular targets of herbicides in humans, which may serve as early indicators of biological changes preceding adverse effects or disease. Some of these enzymes are involved in key steps of the regulation of immune responses, which may thereby be disrupted by herbicide exposure. These targets, along with other plant-specific molecules, are also present in gut microbiota microorganisms, where herbicide exposure may disrupt their function and provide a mechanistic link to intestinal dysbiosis, a condition increasingly associated with chronic diseases. </p>","PeriodicalId":10775,"journal":{"name":"Current Environmental Health Reports","volume":"13 1","pages":""},"PeriodicalIF":7.9,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13046696/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147590523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Epidemiologic Review of Endocrine-disrupting Chemicals and Understudied Gynecologic Health Conditions Affecting Quality of Life.","authors":"Samantha Schildroth, Kristen Upson, Julia Bond","doi":"10.1007/s40572-026-00534-w","DOIUrl":"10.1007/s40572-026-00534-w","url":null,"abstract":"<p><p>PURPOSE OF REVIEW: Endocrine-disrupting chemicals (EDCs) are exogenous compounds that can deleteriously affect gynecologic health through interference with hormonal systems. Research on EDC exposure and gynecologic health has generally focused on outcomes important for reproduction, particularly fertility. Less attention has been given to gynecologic conditions that substantially affect morbidity and quality of life. In this narrative review, we describe the current epidemiologic literature on EDCs and understudied gynecologic conditions that can be life-altering – adenomyosis, dysmenorrhea, heavy menstrual bleeding (HMB), sexual function, persistent vulvar pain, bacterial vaginosis (BV), and pelvic inflammatory disease (PID). RECENT FINDINGS: We identified only a handful of studies on EDCs and adenomyosis (n = 2), dysmenorrhea (n = 5), HMB (n = 4), sexual function (n = 5), persistent vulvar pain (n = 2), BV (n = 2), and PID (n = 2). The EDCs investigated varied by condition and included phthalates, per- and polyfluoroalkyl substances, polychlorinated biphenyls, polybrominated diphenyl ethers, pesticides, and heavy metals. For each condition, discrepant results were observed across studies, likely due to limitations in study design, small sample size, lack of adjustment for important confounders, and issues with EDC exposure and outcome assessment. Studies of EDCs and several gynecologic conditions affecting morbidity and quality of life are scarce. We provide recommendations for improving methodological rigor in future studies, focusing on epidemiological study design principles, exposure timing, exposure to chemical mixtures, and leveraging interdisciplinary expertise. Expanding environmental epidemiologic research on these understudied gynecologic conditions is vital for supporting the gynecologic health and well-being of women. </p>","PeriodicalId":10775,"journal":{"name":"Current Environmental Health Reports","volume":"13 1","pages":""},"PeriodicalIF":7.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147590535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Air Pollution and Brain Tumors in Children. A Systematic Review.","authors":"Damian Pietrzak, Mateusz Zaręba, Agata Stolecka, Roberta Zupo, Fabio Stefano Castellana, Tim S Nawrot, Luisa Lampignano, Ilaria Bortone, Rodolfo Saradone, Jarosław Madowicz, Katarzyna Musioł, Agnieszka Gruszecka-Kosowska","doi":"10.1007/s40572-026-00533-x","DOIUrl":"10.1007/s40572-026-00533-x","url":null,"abstract":"<p><p>PURPOSE OF REVIEW: Prenatal and early-life exposures to environmental pollutants may significantly influence the risk of childhood brain tumors. This systematic review critically appraised and synthesized existing epidemiological evidence on the association between air pollution exposure and childhood brain tumor risk. RECENT FINDINGS: Following PRISMA guidelines and registered with PROSPERO (CRD420251071700), four databases were searched without date restrictions, yielding 14 eligible studies from the USA, Europe, and Australia. Study designs included case-control, cross-sectional, and cohort approaches. Pollutants examined encompassed particulate matter (PM10, PM2.5), nitrogen dioxide (NO2), black carbon (BC), BTEX compounds, 1,3-butadiene, formaldehyde, chloroform, acetaldehyde, styrene, PAHs, heavy metals, and parental passive smoking. Evidence from the reviewed studies indicates that prenatal and early-life exposure to polycyclic aromatic hydrocarbons (PAHs) was most consistently associated with an increased risk of childhood brain tumors, particularly primitive neuroectodermal tumors (PNET) and medulloblastoma. Associations with other pollutants, particularly BTEX, 1,3-butadiene, formaldehyde, chloroform, acetaldehyde, styrene, cobalt (Co), and selenium (Se), as well as general PM, NO2, and BC, were limited, inconsistent, or based on single studies. Key limitations included exposure misclassification, small sample sizes, and residual confounding, limiting causal inference. These findings emphasize the heightened vulnerability of developing children and the urgent need for public health interventions, including stricter air-quality standards, reduced traffic and industrial emissions, systematic exposure monitoring, and protection of pregnant women and children. </p>","PeriodicalId":10775,"journal":{"name":"Current Environmental Health Reports","volume":"13 1","pages":""},"PeriodicalIF":7.9,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147479945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tracking Microplastics From Source to Impact: A Review of Environmental Presence, Exposure, Remediation, and Health Risks.","authors":"Imari Walker-Franklin, Anna Villalobos Santeli, Natalia Neal-Walthall","doi":"10.1007/s40572-026-00531-z","DOIUrl":"10.1007/s40572-026-00531-z","url":null,"abstract":"<p><p>PURPOSE OF REVIEW: Plastics are widely used for their affordability and versatility, but their accumulation in the environment raises growing concerns. Microplastics (MPs), formed intentionally or through degradation of larger plastics, are persistent and pervasive. This review explores recent findings on environmental occurrence, human exposure, health effects, and strategies for MP removal. Information on nanoplastics (NPs) was included when available. RECENT FINDINGS: MPs from major plastic types are increasingly found in environmental compartments and in human fluids, tissues, and organs. Emerging evidence links MP exposure to adverse digestive and respiratory health effects. While some remediation strategies show potential in reducing environmental MP release, research is still limited on effectively minimizing human exposure. Future research should emphasize using well-characterized reference MP materials in human health and remediation studies. These materials must be relevant in size, shape, and polymer type to those identified in environmental and exposure studies, improving the accuracy and applicability of findings. </p>","PeriodicalId":10775,"journal":{"name":"Current Environmental Health Reports","volume":"13 1","pages":""},"PeriodicalIF":7.9,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12995963/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147473033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Review of R Packages for Bayesian Model-based Clustering of High-dimensional Multivariate Environmental Exposures.","authors":"Briana J K Stephenson, Yiran Fu","doi":"10.1007/s40572-026-00532-y","DOIUrl":"10.1007/s40572-026-00532-y","url":null,"abstract":"<p><p>PURPOSE OF REVIEW: The analysis of a collective set of environmental health exposures in large populations can be complex due to its dimensionality, correlation between exposures, and skewed data structures. Bayesian model-based clustering has gained traction for its computational advantages and model flexibility for the analysis of big data. This review aims to highlight R packages available to derive environmental exposure patterns in heterogeneous populations using a Bayesian mixture model framework. RECENT FINDINGS: Twenty-one packages have been developed since 2006 with the capability of analyzing multivariate exposures, with more than half being released in the last ten years. Packages are available to identify both cross-sectional and longitudinal exposure patterns from a joint set of continuous, binary, categorical, directional, and ranked data types. Bayesian nonparametric priors are available to determine the appropriate number of latent clusters to fit. Variable selection is also available in some packages to focus primarily on exposures that may drive underlying patterns present. Bayesian mixture models are an attractive solution to analyze joint environmental exposures and its subsequent impact on population health. While software packages have been developed to provide researchers with advanced tools and models suitable for data complexities seen in environmental exposure data, their applications in the literature is significantly low. Further awareness of software packages and their capabilities could increase utilization and improve analysis of environmental exposures and population health. </p>","PeriodicalId":10775,"journal":{"name":"Current Environmental Health Reports","volume":"13 1","pages":""},"PeriodicalIF":7.9,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12999741/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147479953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health Effects of Living Near Petroleum and Biofuel Refineries: A Systematic Evidence Map and Scoping Review.","authors":"Marinelle Villanueva, Qi Meng, Jenni A Shearston, Rachel Morello-Frosch, Lara J Cushing","doi":"10.1007/s40572-026-00530-0","DOIUrl":"10.1007/s40572-026-00530-0","url":null,"abstract":"<p><p>PURPOSE OF REVIEW : Petroleum refineries are significant sources of toxic contaminant emissions globally that threaten the health of refinery workers and nearby populations. We conducted a scoping review of the epidemiological evidence concerning acute and chronic health impacts of petroleum and biofuel refineries on surrounding communities. We evaluated the evidence using risk-of-bias assessments and catalogued findings into an evidence map to identify gaps in the literature. We systematically searched studies published by August 2024 on PubMed, Embase, and Web of Science. RECENT FINDINGS : Our review includes 54 studies published between 1977 and 2024 in 15 international regions. Most studies focused on cancer, respiratory effects, biomarkers of effect, acute symptoms, and cardiovascular effects; fewer studies examined other chronic diseases, reproductive or birth outcomes. Multiple studies find evidence that residential proximity to refineries is associated with higher risks of leukemia, asthma, bronchitis, respiratory symptoms, and healthcare utilization. 13 studies found evidence of dose-response relationships between proximity or duration of residence near a refinery and severity of risk. Common study limitations included imprecise exposure measures, limited control for confounding, and cross-sectional designs. Recent developments have improved causal inferences, including air pollutant dispersion modeling, quasi-experimental designs, and individual-level exposure measures. The literature suggests a range of acute and chronic health effects among adults and children living near refineries. Additional longitudinal studies and studies of biorefineries are needed, especially as the energy transition from petroleum to bio-based transportation fuels accelerates. Our review underscores the need for additional measures to protect the health of refinery communities. </p>","PeriodicalId":10775,"journal":{"name":"Current Environmental Health Reports","volume":"13 1","pages":""},"PeriodicalIF":7.9,"publicationDate":"2026-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12988906/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147456247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oil and Gas Development and Adverse Birth Outcomes: A Qualitative and Quantitative Bias Analysis of the Epidemiologic Literature.","authors":"Cassandra J Clark, Julia C Bond, Kaylin A Vrkljan, Marijke Rowse, Erin Polka, Erin J Campbell, Amelia K Wesselink, Amira Aker, Mary D Willis","doi":"10.1007/s40572-026-00526-w","DOIUrl":"10.1007/s40572-026-00526-w","url":null,"abstract":"<p><p>PURPOSE OF REVIEW: A growing body of literature examines links between oil and gas development and adverse pregnancy outcomes. However, these studies may be vulnerable to common sources of bias in perinatal epidemiology. We extend a prior systematic review with a joint qualitative and quantitative bias analysis. RECENT FINDINGS: Across 18 studies, the most commonly evaluated outcomes were low birth weight (78%), preterm birth (72%), and small-for-gestational-age (56%). Qualitative bias analysis showed that the vast majority of studies had evidence of fixed cohort and live birth biases, respectively. Quantitative bias analysis estimating the potential magnitude and direction of bias due to unmeasured confounding by socioeconomic status suggested little influence under our assumptions. This review highlights important sources of bias that should be considered when interpreting findings related to the relationship between oil and gas development and birth outcomes. We provide recommendations for future research. </p>","PeriodicalId":10775,"journal":{"name":"Current Environmental Health Reports","volume":"13 1","pages":""},"PeriodicalIF":7.9,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147431296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}