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Current Breast Cancer Reports最新文献

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Targeting PARP1: A Promising Approach for Next-Generation Poly (ADP-ribose) Polymerase Inhibitors. 靶向PARP1：下一代聚（adp -核糖）聚合酶抑制剂的一种有希望的方法。
IF 1
Current Breast Cancer Reports Pub Date : 2025-01-01 Epub Date: 2025-06-12 DOI: 10.1007/s12609-025-00582-5
Alo Ray, Mateusz Opyrchal
{"title":"Targeting PARP1: A Promising Approach for Next-Generation Poly (ADP-ribose) Polymerase Inhibitors.","authors":"Alo Ray, Mateusz Opyrchal","doi":"10.1007/s12609-025-00582-5","DOIUrl":"10.1007/s12609-025-00582-5","url":null,"abstract":"<p><strong>Limitations of poly adp‒ribose polymerase parp inhibitors: </strong>PARPis have demonstrated efficacy in BRCA-mutated cancers deficient in homologous recombination repair. Furthermore, PARPis have shown efficacy in BRCA-wild-type cancers with a homologous recombination deficiency phenotype known as BRCAness. Current clinically approved PARPis inhibit both PARP1 and PARP2, and their clinical promise is limited by toxicity, resistance, and a lack of combination partners.</p><p><strong>Recent findings: </strong>PARP2 inhibition is associated with hematological toxicity, affecting the tolerability and efficacy of monotherapy and combination therapies. Furthermore, synthetic lethality in BRCA-mutated cancers depends mostly on PARP1, whereas PARP2 is not essential. These findings promoted the development of next-generation PARPis with greater selectivity for PARP1 than for PARP2.</p><p><strong>Summary: </strong>In this review, we discuss the next-generation PARPis that target PARP1 and show promise in terms of improved safety, tolerability, pharmacological profiles, and efficacy compared to existing clinically approved PARPis. These next-generation PARP1-selective inhibitors hold significant promises for improving the survival and outcomes of cancer patients.</p>","PeriodicalId":10769,"journal":{"name":"Current Breast Cancer Reports","volume":"17 1","pages":"22"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12162764/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144301308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Brief History and the Current State of Robotic Mastectomy: a Review. 机器人乳房切除术的简史和现状：综述。
IF 1
Current Breast Cancer Reports Pub Date : 2025-01-01 Epub Date: 2025-07-11 DOI: 10.1007/s12609-025-00587-0
Nicole Rademacher, Lauren A Curwick, Catherine C Parker
{"title":"A Brief History and the Current State of Robotic Mastectomy: a Review.","authors":"Nicole Rademacher, Lauren A Curwick, Catherine C Parker","doi":"10.1007/s12609-025-00587-0","DOIUrl":"10.1007/s12609-025-00587-0","url":null,"abstract":"<p><strong>Purpose of review: </strong>To evaluate and describe the current indications, implementation, operative techniques, and patient outcomes for robotic nipple sparing mastectomy (RNSM).</p><p><strong>Recent findings: </strong>The robotic approach to nipple-sparing mastectomies (NSM) has been shown to be feasible. The learning curve required by surgical teams can be overcome, but barriers to implementation exist, including higher cost and longer operative time compared to conventional nipple sparing mastectomies (CNSM). When performed, RNSM have been found to confer greater patient satisfaction and similar if not improved perioperative outcomes. However, the most critical current concern is the lack of long-term oncologic outcomes. The current available literature suggests short-term oncologic outcomes are not significantly different between RNSM and CNSM.</p><p><strong>Summary: </strong>Randomized control trials with longer follow up are needed to determine the oncologic safety of RNSM and drive the future direction of this procedure.</p>","PeriodicalId":10769,"journal":{"name":"Current Breast Cancer Reports","volume":"17 1","pages":"31"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12254071/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144625541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Contemporary Considerations for Breast Cancer Risk and Screening in Transgender, Nonbinary, and Gender-Diverse Populations. 当代对跨性别、非二元和性别多样化人群乳腺癌风险和筛查的考虑。
IF 1
Current Breast Cancer Reports Pub Date : 2025-01-01 Epub Date: 2025-02-13 DOI: 10.1007/s12609-025-00573-6
Victoria Huynh, Meghan Conroy, Evelyn F Carroll, Chandler S Cortina
{"title":"Contemporary Considerations for Breast Cancer Risk and Screening in Transgender, Nonbinary, and Gender-Diverse Populations.","authors":"Victoria Huynh, Meghan Conroy, Evelyn F Carroll, Chandler S Cortina","doi":"10.1007/s12609-025-00573-6","DOIUrl":"10.1007/s12609-025-00573-6","url":null,"abstract":"<p><strong>Purpose of review: </strong>Breast cancer incidence, risk factors, and risk-reducing strategies are relatively well established for cisgender persons, but this information is limited in the transgender and gender-diverse (TGD) community. TGD persons have unique considerations that may affect risk, such as the need for gender-affirming hormone therapy or gender-affirming operations. This review outlines key literature informing our knowledge of breast cancer risk and summarizes screening recommendations for TGD persons.</p><p><strong>Recent findings: </strong>Studies informing breast cancer risk in TGD persons have significant limitations. Generally, they suggest that transgender women have a higher incidence of developing breast cancer compared to cisgender men, but a much lower incidence compared to cisgender women; and that transgender men have higher rates of breast cancer compared to cisgender men, but lower rates compared to cisgender women. Screening guidelines put forth by professional societies are based on these retrospective cohort studies, expert consensus, and extrapolation from cisgender populations. The United States Preventive Services Task Force and American Cancer Society have not yet published guidelines.</p><p><strong>Summary: </strong>Prospective data are needed to further define risk and best practices for breast cancer screening in the TGD community, an already marginalized population susceptible to worse oncologic outcomes.</p>","PeriodicalId":10769,"journal":{"name":"Current Breast Cancer Reports","volume":"17 ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12234010/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144590630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Relevance of Radial Scars: A Review of the Current Literature 桡骨疤痕的临床意义：当前文献综述
IF 0.9
Current Breast Cancer Reports Pub Date : 2024-01-08 DOI: 10.1007/s12609-023-00519-w
Andrew Seto, Pabel Miah, Preeti Kodavanti Farmah, Kathryn Duckworth, Yassmen Hammam, S. Ghanta
{"title":"Clinical Relevance of Radial Scars: A Review of the Current Literature","authors":"Andrew Seto, Pabel Miah, Preeti Kodavanti Farmah, Kathryn Duckworth, Yassmen Hammam, S. Ghanta","doi":"10.1007/s12609-023-00519-w","DOIUrl":"https://doi.org/10.1007/s12609-023-00519-w","url":null,"abstract":"","PeriodicalId":10769,"journal":{"name":"Current Breast Cancer Reports","volume":"41 13","pages":""},"PeriodicalIF":0.9,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139447577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Minimally Invasive Breast Cancer: How to Find Early Breast Cancers 微创乳腺癌：如何发现早期乳腺癌
IF 0.9
Current Breast Cancer Reports Pub Date : 2024-01-06 DOI: 10.1007/s12609-023-00518-x
Harnoor Singh, Nilan Bhakta
{"title":"Minimally Invasive Breast Cancer: How to Find Early Breast Cancers","authors":"Harnoor Singh, Nilan Bhakta","doi":"10.1007/s12609-023-00518-x","DOIUrl":"https://doi.org/10.1007/s12609-023-00518-x","url":null,"abstract":"","PeriodicalId":10769,"journal":{"name":"Current Breast Cancer Reports","volume":"7 1","pages":"1-9"},"PeriodicalIF":0.9,"publicationDate":"2024-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139380598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of Systemic Therapy on Fertility in Women with Early-Stage Breast Cancer 系统疗法对早期乳腺癌妇女生育能力的影响
IF 0.9
Current Breast Cancer Reports Pub Date : 2024-01-03 DOI: 10.1007/s12609-023-00516-z
Kelsey H. Natsuhara, A. J. Chien
{"title":"Impact of Systemic Therapy on Fertility in Women with Early-Stage Breast Cancer","authors":"Kelsey H. Natsuhara, A. J. Chien","doi":"10.1007/s12609-023-00516-z","DOIUrl":"https://doi.org/10.1007/s12609-023-00516-z","url":null,"abstract":"","PeriodicalId":10769,"journal":{"name":"Current Breast Cancer Reports","volume":"118 45","pages":"1-8"},"PeriodicalIF":0.9,"publicationDate":"2024-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139387831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chemoprevention—Historical Perspectives and Current Trends 化学预防--历史视角和当前趋势
IF 0.9
Current Breast Cancer Reports Pub Date : 2024-01-03 DOI: 10.1007/s12609-023-00517-y
Chelsea Marin, Anna Weiss, Jessica C. Gooch
{"title":"Chemoprevention—Historical Perspectives and Current Trends","authors":"Chelsea Marin, Anna Weiss, Jessica C. Gooch","doi":"10.1007/s12609-023-00517-y","DOIUrl":"https://doi.org/10.1007/s12609-023-00517-y","url":null,"abstract":"","PeriodicalId":10769,"journal":{"name":"Current Breast Cancer Reports","volume":"30 27","pages":"1-10"},"PeriodicalIF":0.9,"publicationDate":"2024-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139388688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hereditary Breast Cancer, Genetics, and Fertility Preservation 遗传性乳腺癌、遗传学和生育力保护
IF 0.9
Current Breast Cancer Reports Pub Date : 2023-12-20 DOI: 10.1007/s12609-023-00515-0
Kathryn J. Huber-Keener
{"title":"Hereditary Breast Cancer, Genetics, and Fertility Preservation","authors":"Kathryn J. Huber-Keener","doi":"10.1007/s12609-023-00515-0","DOIUrl":"https://doi.org/10.1007/s12609-023-00515-0","url":null,"abstract":"","PeriodicalId":10769,"journal":{"name":"Current Breast Cancer Reports","volume":"83 22","pages":""},"PeriodicalIF":0.9,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138956758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Breast Cancer in Pakistan: Screening and Detection 巴基斯坦的乳腺癌：筛查和检测
IF 0.9
Current Breast Cancer Reports Pub Date : 2023-12-05 DOI: 10.1007/s12609-023-00514-1
Sashah Shariff, F. Amersi
{"title":"Breast Cancer in Pakistan: Screening and Detection","authors":"Sashah Shariff, F. Amersi","doi":"10.1007/s12609-023-00514-1","DOIUrl":"https://doi.org/10.1007/s12609-023-00514-1","url":null,"abstract":"","PeriodicalId":10769,"journal":{"name":"Current Breast Cancer Reports","volume":"140 16","pages":""},"PeriodicalIF":0.9,"publicationDate":"2023-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138598740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Breast Cancer Stigma in Iraq 伊拉克的乳腺癌耻辱
Current Breast Cancer Reports Pub Date : 2023-10-25 DOI: 10.1007/s12609-023-00513-2
Hamdia Mirkhan Ahmed, Kaveh Khoshnood
{"title":"Breast Cancer Stigma in Iraq","authors":"Hamdia Mirkhan Ahmed, Kaveh Khoshnood","doi":"10.1007/s12609-023-00513-2","DOIUrl":"https://doi.org/10.1007/s12609-023-00513-2","url":null,"abstract":"","PeriodicalId":10769,"journal":{"name":"Current Breast Cancer Reports","volume":"69 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135170811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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