Current Breast Cancer Reports最新文献

Locoregional Considerations for Invasive Lobular Carcinoma. 浸润性小叶癌的局部考虑。

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Current Breast Cancer Reports Pub Date : 2026-01-01 Epub Date: 2025-12-27 DOI: 10.1007/s12609-025-00628-8

Rita A Mukhtar, Meghan R Flanagan

引用次数: 0

Hidden in the Data: Breast Cancer Patterns, Gaps, and Challenges for Native American Women. 隐藏在数据中的：美国土著妇女的乳腺癌模式、差距和挑战。

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Current Breast Cancer Reports Pub Date : 2026-01-01 Epub Date: 2026-01-06 DOI: 10.1007/s12609-025-00629-7

Jennifer Erdrich, Hannah E Woriax, Aaron Thomas, Michelle R Huyser

{"title":"Hidden in the Data: Breast Cancer Patterns, Gaps, and Challenges for Native American Women.","authors":"Jennifer Erdrich, Hannah E Woriax, Aaron Thomas, Michelle R Huyser","doi":"10.1007/s12609-025-00629-7","DOIUrl":"10.1007/s12609-025-00629-7","url":null,"abstract":"Purpose of the review: This paper aims to provide a comprehensive overview of breast cancer screening, clinical characteristics, treatment, and survivorship in American Indian/Alaska Native (AI/AN) women.Recent findings: Breast cancer in AI/AN women is a complex public health issue marked by disparities in incidence, stage, treatment, and survival that vary regionally. Limited screening mammography, workforce shortages, and underfunded healthcare systems contribute to late diagnoses and poorer outcomes. Social and cultural factors, including historical trauma and medical mistrust, further hinder care. Data on breast cancer topics for AI/AN is limited and often compromised by misclassification and underrepresentation. The Indian Health Service (IHS) plays a crucial but underfunded role in providing care, often insufficient to meet the complex needs of AI/AN women, especially those living in urban areas.Summary: As Indigenous surgeons working with AI/AN communities, we applied our perspectives to a comprehensive review of the literature. To reduce disparities, research must prioritize Indigenous leadership, respect tribal sovereignty, improve data accuracy, and foster equitable collaborations that center AI/AN priorities.Definitions: The United States (US) Census Bureau defines American Indian and Alaska Natives (AI/ANs) as persons with origins from the Indigenous peoples of the Americas who maintain tribal affiliation and/or community attachment. Common terms for AI/ANs today include Native, Native American, Indigenous, First Nations, Native Hawaiian, Pacific Islander, among others. The most appropriate phrasing would be to use the specific tribe's self-designated name in that tribe's native language when possible. However, for simplicity and the purposes of this manuscript, we will use the term AI/AN.","PeriodicalId":10769,"journal":{"name":"Current Breast Cancer Reports","volume":"18 1","pages":"4"},"PeriodicalIF":0.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12775055/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145932504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Breast Cancer Surgical Risk Reduction, Fertility and Fertility Preservation for Current Breast Cancer Reports. 乳腺癌手术风险降低，生育能力和生育能力保存当前乳腺癌报告。

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Current Breast Cancer Reports Pub Date : 2026-01-01 Epub Date: 2026-04-28 DOI: 10.1007/s12609-026-00646-0

Hannah G Peifer, Emily Shippee Rockefeller, Lisa Newman

{"title":"Breast Cancer Surgical Risk Reduction, Fertility and Fertility Preservation for Current Breast Cancer Reports.","authors":"Hannah G Peifer, Emily Shippee Rockefeller, Lisa Newman","doi":"10.1007/s12609-026-00646-0","DOIUrl":"https://doi.org/10.1007/s12609-026-00646-0","url":null,"abstract":"Purpose of review: Population-based incidence rates of breast cancer are increasing in young/premenopausal women. Genetic testing panels are expanding and identify larger subsets of women with hereditary susceptibility for breast cancer. Options for primary prevention of breast cancer as well as fertility preservation among newly diagnosed patients are therefore becoming more relevant for young women. This review summarizes advances in these strategies.Recent findings: Primary surgical prevention of breast cancer is feasible via prophylactic mastectomy (at any age) or prophylactic removal of the ovaries (in premenopausal women), with prophylactic mastectomy being the most definitive and effective. Improved breast reconstruction and the nipple-sparing mastectomy approach have increased the acceptability of prophylactic mastectomy. Since microscopic foci of breast tissue remain present in the subcutaneous fat of the mastectomy skin flaps (regardless of whether the nipple has been preserved or not) women choosing prophylactic mastectomy surgery must be informed of their residual lifetime risk of developing breast cancer. A variety of fertility preservation options are available and safe in women that are diagnosed with breast cancer or that have high future risk of breast cancer. Unfortunately, these options often incur substantial out-of-pocket expenses. Completing a pregnancy after a breast cancer diagnosis is also safe.Summary: Young women can choose between several alternatives for reducing breast cancer risk and preserving their fertility/family planning options. Further research is warranted regarding expanded access to these important survivorship options.","PeriodicalId":10769,"journal":{"name":"Current Breast Cancer Reports","volume":"18 1","pages":"25"},"PeriodicalIF":0.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13124912/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147812113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Breast Cancer Disparities in the LGBTQ + Community: How to Move Towards Inclusive Care from Screening to Survivorship. LGBTQ +社区的乳腺癌差异：如何走向从筛查到生存的包容性护理

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Current Breast Cancer Reports Pub Date : 2025-12-01 Epub Date: 2025-07-11 DOI: 10.1007/s12609-025-00597-y

Lauren N Cohen, Faith Bobholz, Chandler S Cortina

{"title":"Breast Cancer Disparities in the LGBTQ + Community: How to Move Towards Inclusive Care from Screening to Survivorship.","authors":"Lauren N Cohen, Faith Bobholz, Chandler S Cortina","doi":"10.1007/s12609-025-00597-y","DOIUrl":"10.1007/s12609-025-00597-y","url":null,"abstract":"Purpose of review: Breast cancer disparities for LGBTQ + individuals exist from screening to survivorship care and lead to worse breast cancer outcomes compared to cisgender, heterosexual individuals. The intent of this review is to provide information on differences in screening rates, risk profiles, treatment goals, and survivorship care plans in breast cancer care for LGBTQ + individuals, along with recommendations on how to reduce and eliminate these disparities.Recent findings: There has been an expansion in the recognition of LGBTQ + cancer care and preliminary data on the effects of gender-affirming hormone therapy specific to breast cancer development. However, healthcare avoidance of LGBTQ + individuals remains a large barrier to care. Recent studies have found that subgroups within the LGBTQ + community have distinct needs from one another. Specifically, the transgender and gender-diverse population face increased discrimination within the healthcare system with non-uniform breast cancer screening measures.Summary: Current research highlights the ongoing breast cancer disparities that impact the LGBTQ + community. There is a need for increased education on the needs of the LGBTQ + community to mitigate the breast cancer disparities in time to diagnosis and treatment, along with more tailored breast cancer survivorship care plans.","PeriodicalId":10769,"journal":{"name":"Current Breast Cancer Reports","volume":"17 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12320750/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144788475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Survivorship Issues in Older Adults with Breast Cancer. 老年乳腺癌患者的生存问题。

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Current Breast Cancer Reports Pub Date : 2025-12-01 Epub Date: 2025-06-04 DOI: 10.1007/s12609-025-00586-1

Claire R Morton, Eliza H Lorentzen, Christina A Minami

{"title":"Survivorship Issues in Older Adults with Breast Cancer.","authors":"Claire R Morton, Eliza H Lorentzen, Christina A Minami","doi":"10.1007/s12609-025-00586-1","DOIUrl":"10.1007/s12609-025-00586-1","url":null,"abstract":"Purpose of review: The number of older adult breast cancer survivors is increasing. This growing demographic comprises both women diagnosed with breast cancer when they are 65 years or older as well as women diagnosed in younger adulthood who then survive to elderhood. Older adult breast cancer survivors face unique challenges, including possible increased baseline comorbidity, symptom burden and a greater propensity to experience functional and cognitive decline after treatment.Recent findings: This review outlines survivorship concerns affecting older adults with a history of breast cancer, including osteoporosis, increased risks of hip fractures, and worsened survival associated with the development of comorbidity. The review also acknowledges the existing interventions to identify and mitigate survivorship concerns of older adults including comprehensive geriatric assessments.Summary: Highlighting the unique needs of this population may better inform treatment decision-making at the time of diagnosis and identify opportunities for future investigation in this realm.","PeriodicalId":10769,"journal":{"name":"Current Breast Cancer Reports","volume":"17 1","pages":""},"PeriodicalIF":0.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12781956/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145951594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting PARP1: A Promising Approach for Next-Generation Poly (ADP-ribose) Polymerase Inhibitors. 靶向PARP1：下一代聚（adp -核糖）聚合酶抑制剂的一种有希望的方法。

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Current Breast Cancer Reports Pub Date : 2025-01-01 Epub Date: 2025-06-12 DOI: 10.1007/s12609-025-00582-5

Alo Ray, Mateusz Opyrchal

{"title":"Targeting PARP1: A Promising Approach for Next-Generation Poly (ADP-ribose) Polymerase Inhibitors.","authors":"Alo Ray, Mateusz Opyrchal","doi":"10.1007/s12609-025-00582-5","DOIUrl":"10.1007/s12609-025-00582-5","url":null,"abstract":"Limitations of poly adp‒ribose polymerase parp inhibitors: PARPis have demonstrated efficacy in BRCA-mutated cancers deficient in homologous recombination repair. Furthermore, PARPis have shown efficacy in BRCA-wild-type cancers with a homologous recombination deficiency phenotype known as BRCAness. Current clinically approved PARPis inhibit both PARP1 and PARP2, and their clinical promise is limited by toxicity, resistance, and a lack of combination partners.Recent findings: PARP2 inhibition is associated with hematological toxicity, affecting the tolerability and efficacy of monotherapy and combination therapies. Furthermore, synthetic lethality in BRCA-mutated cancers depends mostly on PARP1, whereas PARP2 is not essential. These findings promoted the development of next-generation PARPis with greater selectivity for PARP1 than for PARP2.Summary: In this review, we discuss the next-generation PARPis that target PARP1 and show promise in terms of improved safety, tolerability, pharmacological profiles, and efficacy compared to existing clinically approved PARPis. These next-generation PARP1-selective inhibitors hold significant promises for improving the survival and outcomes of cancer patients.","PeriodicalId":10769,"journal":{"name":"Current Breast Cancer Reports","volume":"17 1","pages":"22"},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12162764/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144301308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Brief History and the Current State of Robotic Mastectomy: a Review. 机器人乳房切除术的简史和现状：综述。

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Current Breast Cancer Reports Pub Date : 2025-01-01 Epub Date: 2025-07-11 DOI: 10.1007/s12609-025-00587-0

Nicole Rademacher, Lauren A Curwick, Catherine C Parker

引用次数: 0

Contemporary Considerations for Breast Cancer Risk and Screening in Transgender, Nonbinary, and Gender-Diverse Populations. 当代对跨性别、非二元和性别多样化人群乳腺癌风险和筛查的考虑。

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Current Breast Cancer Reports Pub Date : 2025-01-01 Epub Date: 2025-02-13 DOI: 10.1007/s12609-025-00573-6

Victoria Huynh, Meghan Conroy, Evelyn F Carroll, Chandler S Cortina

{"title":"Contemporary Considerations for Breast Cancer Risk and Screening in Transgender, Nonbinary, and Gender-Diverse Populations.","authors":"Victoria Huynh, Meghan Conroy, Evelyn F Carroll, Chandler S Cortina","doi":"10.1007/s12609-025-00573-6","DOIUrl":"10.1007/s12609-025-00573-6","url":null,"abstract":"Purpose of review: Breast cancer incidence, risk factors, and risk-reducing strategies are relatively well established for cisgender persons, but this information is limited in the transgender and gender-diverse (TGD) community. TGD persons have unique considerations that may affect risk, such as the need for gender-affirming hormone therapy or gender-affirming operations. This review outlines key literature informing our knowledge of breast cancer risk and summarizes screening recommendations for TGD persons.Recent findings: Studies informing breast cancer risk in TGD persons have significant limitations. Generally, they suggest that transgender women have a higher incidence of developing breast cancer compared to cisgender men, but a much lower incidence compared to cisgender women; and that transgender men have higher rates of breast cancer compared to cisgender men, but lower rates compared to cisgender women. Screening guidelines put forth by professional societies are based on these retrospective cohort studies, expert consensus, and extrapolation from cisgender populations. The United States Preventive Services Task Force and American Cancer Society have not yet published guidelines.Summary: Prospective data are needed to further define risk and best practices for breast cancer screening in the TGD community, an already marginalized population susceptible to worse oncologic outcomes.","PeriodicalId":10769,"journal":{"name":"Current Breast Cancer Reports","volume":"17 ","pages":""},"PeriodicalIF":0.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12234010/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144590630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Relevance of Radial Scars: A Review of the Current Literature 桡骨疤痕的临床意义：当前文献综述

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Current Breast Cancer Reports Pub Date : 2024-01-08 DOI: 10.1007/s12609-023-00519-w

Andrew Seto, Pabel Miah, Preeti Kodavanti Farmah, Kathryn Duckworth, Yassmen Hammam, S. Ghanta

引用次数: 0

Minimally Invasive Breast Cancer: How to Find Early Breast Cancers 微创乳腺癌：如何发现早期乳腺癌

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Current Breast Cancer Reports Pub Date : 2024-01-06 DOI: 10.1007/s12609-023-00518-x

Harnoor Singh, Nilan Bhakta

引用次数: 0