Locoregional Considerations for Invasive Lobular Carcinoma.

IF 1 Q4 ONCOLOGY

Current Breast Cancer Reports Pub Date : 2026-01-01 Epub Date: 2025-12-27 DOI:10.1007/s12609-025-00628-8

Rita A Mukhtar, Meghan R Flanagan

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Abstract

Purpose of review: This article summarizes recent literature on locoregional management of patients with invasive lobular carcinoma (ILC), including approaches to breast surgery, axillary management, and neoadjuvant therapy.

Recent findings: Breast conservation therapy is safe in ILC, but has comparatively high rates of positive margins, which can be reduced by routine use of shave margins and oncoplastic surgery. Studies demonstrating the safety of de-escalation of axillary surgery have not included enough patients with ILC to draw strong conclusions; current guidelines do not support omission of sentinel node surgery in most patients with ILC. Neoadjuvant chemotherapy may improve breast conservation and increase nodal pathologic complete response in molecularly selected patients using genomic assays.

Summary: The locoregional management of patients with ILC requires special considerations based on its unique features. ILC specific studies are needed to address knowledge gaps for patients diagnosed with this common tumor type.

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浸润性小叶癌的局部考虑。

综述目的：本文综述了浸润性小叶癌（ILC）局部治疗的最新文献，包括乳房手术、腋窝治疗和新辅助治疗的方法。最近的研究发现：乳房保护治疗在ILC中是安全的，但有相对较高的阳性边缘率，可以通过常规使用刮刀边缘和肿瘤整形手术来降低。证明腋窝手术降级安全性的研究没有包括足够多的ILC患者来得出强有力的结论；目前的指南不支持在大多数ILC患者中省略前哨淋巴结手术。新辅助化疗可能改善乳房保护和增加淋巴结病理完全反应在分子选择患者使用基因组分析。总结：ILC患者的局部管理需要根据其独特的特点进行特殊的考虑。需要进行ILC特异性研究，以解决诊断为这种常见肿瘤类型的患者的知识空白。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Breast Cancer Reports ONCOLOGY-

CiteScore

1.60

自引率

0.00%

发文量

期刊介绍： This journal aims to review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of breast cancer. By providing clear, insightful, balanced contributions by international experts, the journal intends to serve all those involved in the care of those with the disease. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as prevention, systemic therapy, and translational research. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.