Contraception最新文献

{"title":"Consensus recommendations for measuring the impact of contraception on the menstrual cycle in contraceptive clinical trials","authors":"Amelia C.L. Mackenzie ,&nbsp;Stephanie Chung ,&nbsp;Emily Hoppes ,&nbsp;Nora Miller ,&nbsp;Anne E. Burke ,&nbsp;Sharon L. Achilles ,&nbsp;C. Leigh Allen ,&nbsp;Luis Bahamondes ,&nbsp;Diana L. Blithe ,&nbsp;Vivian Brache ,&nbsp;Rebecca L. Callahan ,&nbsp;Alice F. Cartwright ,&nbsp;Kathryn B.H. Clancy ,&nbsp;Enrico Colli ,&nbsp;Amanda Cordova-Gomez ,&nbsp;Elizabeth C. Costenbader ,&nbsp;Mitchell D. Creinin ,&nbsp;Hilary O.D. Critchley ,&nbsp;Gustavo F. Doncel ,&nbsp;Laneta J. Dorflinger ,&nbsp;Olivia Vandeputte","doi":"10.1016/j.contraception.2025.110829","DOIUrl":"10.1016/j.contraception.2025.110829","url":null,"abstract":"<div><h3>Objective</h3><div>We sought to develop consensus recommendations for measurement and analysis of data on contraceptive-induced menstrual changes (CIMCs) in contraceptive clinical trials. We built upon previous standardization efforts over the last 50 years and prioritized input from a variety of global experts and current regulatory authority guidance on patient-reported outcomes.</div></div><div><h3>Study design</h3><div>We completed a formal consensus-building process with an interdisciplinary group of 57 experts from 30 organizations and 14 countries in five global regions who work across academia, nonprofit research organizations, the pharmaceutical industry, and funding agencies. Smaller topical working groups drafted and revised recommendations.</div></div><div><h3>Results</h3><div>We developed 44 consensus recommendations, including research approaches to establish the evidence for future improvement in the measurement and analysis of CIMC data and guidance for investigators to implement presently. Priority recommendations call for simplification of terminology to make measurement accessible and patient-centered, accounting for intrinsic and extrinsic factors that may impact outcomes during study design and recruitment, standardized data collection of primary CIMC and acceptability outcomes, and harmonized approaches for analysis of these data, including addressing missing data.</div></div><div><h3>Conclusion</h3><div>By virtually convening a large group of global experts working across disciplines and sectors via a formal methodology, we developed consensus recommendations that will improve the current and future measurement and analysis of CIMC data in contraceptive clinical trials. Using these standardized approaches will permit valid and reliable contraceptive product labeling on CIMC outcomes that matter to users and greater comparability across trials that can inform clinical guidance and contraceptive counseling.</div></div><div><h3>Implications</h3><div>Consensus recommendations on measuring bleeding changes and related outcomes in contraceptive clinical trials can improve reporting of standardized, patient-centered outcomes in future product labeling. These improvements can enable healthcare providers to offer more relevant guidance on contraceptives and users to make more informed decisions about their choice of method.</div></div>","PeriodicalId":10762,"journal":{"name":"Contraception","volume":"146 ","pages":"Article 110829"},"PeriodicalIF":2.8,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143048886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of institutional and state policies in management of pregnancies of unknown location: A 2024 online survey of Ryan Programs in the United States","authors":"Madeline V. Smith ,&nbsp;Jema Turk ,&nbsp;Rebecca Mercier ,&nbsp;Jody Steinauer ,&nbsp;Agatha Berger ,&nbsp;Kavita Vinekar","doi":"10.1016/j.contraception.2025.110832","DOIUrl":"10.1016/j.contraception.2025.110832","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to assess the perceived impact of state and institutional policies on managing pregnancies of unknown location (PULs) at US Ryan residency programs.</div></div><div><h3>Study design</h3><div>We conducted a cross-sectional electronic survey of US Ryan residency programs (<em>n</em> = 113) from March to April 2024. We compared the perceived influence of institutional and state policies on PUL management among Ryan Programs in restrictive vs nonrestrictive abortion climates. Provision of diagnostic uterine aspiration in the workup of PUL was a secondary outcome. We compared proportion of responses between restrictive and nonrestrictive climates with Fisher exact tests.</div></div><div><h3>Results</h3><div>We obtained responses from 75 Ryan Programs in 32 states (66.4% response rate). 29 (38.7%) were from states with restrictive abortion policies. Eight programs (10.7%) changed PUL management after the <em>Dobbs</em> decision. Compared to programs in nonrestrictive states, programs in restrictive states were more likely to report that state policy inhibits their ability to care for patients with PUL (34.5% vs 2.17%, <em>p</em> &lt; 0.001), rarely or never offer diagnostic uterine aspiration (34.5% vs 8.7%, <em>p</em> = 0.01), and identify institutional leadership as a barrier to offering diagnostic uterine aspirations (20.7% vs 2.2 %, <em>p</em> = 0.01). The most common institutional barriers to providing diagnostic uterine aspiration were staffing and faculty comfort/willingness, which did not differ by state abortion climate.</div></div><div><h3>Conclusions</h3><div>State abortion policy and institutional policy may impact the options available to patients with PULs.</div></div><div><h3>Implications</h3><div>Programs in all legislative climates should address institutional barriers to providing diagnostic uterine aspiration. Legislative advocacy in restrictive states is needed to ensure access to expedient PUL management.</div></div>","PeriodicalId":10762,"journal":{"name":"Contraception","volume":"145 ","pages":"Article 110832"},"PeriodicalIF":2.8,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a transdermal gel for reversible male contraception","authors":"Regine Sitruk-Ware ,&nbsp;Diana L. Blithe ,&nbsp;Stephanie T. Page ,&nbsp;Christina Wang","doi":"10.1016/j.contraception.2025.110830","DOIUrl":"10.1016/j.contraception.2025.110830","url":null,"abstract":"<div><div>While there are several easy-to-use reversible female contraceptives, little is available for men. Introduction of novel, cost-effective male contraceptives could have important downstream global health and economic benefits. Currently, nearly half of all pregnancies globally are unintended, with many resulting in unsafe abortions, a significant burden for women and families in many countries.</div><div>Available reversible options for male contraception include male condoms or withdrawal, both with high typical use failure rates, and vasectomy, which is not easily reversible. Advanced methods of male hormonal contraception include combinations of progestin and androgen, generally testosterone itself. Administration of these steroids results in the suppression of gonadotropins leading to the suppression of sperm production with full reversibility within a few months. Importantly, the exogenous androgen replaces the suppressed endogenous testosterone, minimizing side effects for the user. Using the skin to deliver steroids in the systemic circulation is a well-accepted concept both for the treatment of hypogonadism and contraception. A transdermal gel delivering Nestorone (segesterone acetate) and testosterone is under development and is leading the way in advancing novel, self-delivered methods of male hormonal contraception.</div></div>","PeriodicalId":10762,"journal":{"name":"Contraception","volume":"145 ","pages":"Article 110830"},"PeriodicalIF":2.8,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143043505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of willingness to use hormonal contraception with knowledge: A national survey","authors":"Kathleen M. Beardsworth ,&nbsp;Bharti Garg ,&nbsp;Blair G. Darney ,&nbsp;Leo Han","doi":"10.1016/j.contraception.2025.110816","DOIUrl":"10.1016/j.contraception.2025.110816","url":null,"abstract":"<div><h3>Objective</h3><div>To determine if willingness to use and concern with using hormonal contraception (HC) is associated with knowledge about HC.</div></div><div><h3>Study design</h3><div>We conducted an online cross-sectional survey of self-identified women, US residents 18 and older using Amazon Mechanical Turk and <span><span>ResearchMatch.org</span><svg><path></path></svg></span>. Primary outcome was HC knowledge level, with participants categorized into binary knowledge level variable based on accuracy of responses to seven statements about HC (e.g. HC causes infertility, HC decreases acne). We assessed participant willingness and concern with using HC, including the primary type of concern with HC (physical, emotional, complications, other). We used bivariate tests and a multivariable logistic regression model to test the association of willingness and concern about HC to knowledge level.</div></div><div><h3>Results</h3><div>Of 1041 respondents ages 18–81, 18% had no concerns and were willing to use HC, 64% had some concerns but were willing to use HC, and 18% had concerns and were not willing to use HC. Respondents who had concerns but were still willing to use HC were less likely to be concerned about complications than those who were unwilling (31.0% vs. 43.7%; <em>p</em> &lt; 0.001). The median number of correct responses to knowledge statements was three (IQR 2–5) and 94.8% of participants answered at least one statement incorrectly. After controlling for age, current form of contraception, education, rurality, census region, political, and religious beliefs, participants who were willing to use HC without concerns (aOR<!--> <!-->=<!--> <!-->4.32; 95% CI: 2.45–7.62) and those who were willing but had concerns (aOR<!--> <!-->=<!--> <!-->2.11; 95% CI: 1.35–3.30) was associated with being more knowledgeable as compared to those not willing to use HC (reference).</div></div><div><h3>Conclusion</h3><div>Women willing to use HC are more likely to be more knowledgeable about HC. More than 80% of women report concerns with HC.</div></div><div><h3>Implications</h3><div>Patients unwilling to use HC are more likely to have knowledge gaps in their understanding of HC side effects and risk of complications. For shared decision-making, providers should specifically address the facts and myths surrounding HC to ensure patients are making informed decisions about their reproductive health.</div></div>","PeriodicalId":10762,"journal":{"name":"Contraception","volume":"145 ","pages":"Article 110816"},"PeriodicalIF":2.8,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143043504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in contraceptive method use, access, and experiences of care during a statewide contraceptive initiative","authors":"Taehyun Kim ,&nbsp;Julia R. Steinberg ,&nbsp;Michel Boudreaux","doi":"10.1016/j.contraception.2025.110814","DOIUrl":"10.1016/j.contraception.2025.110814","url":null,"abstract":"<div><h3>Objective</h3><div>To examine changes in contraceptive use, access, and care experiences during a statewide contraceptive access initiative, Delaware Contraceptive Access Now.</div></div><div><h3>Study design</h3><div>We used responses from the Delaware/Maryland Survey of Women at the early wave (November, 2016–March, 2017) and late wave (February, 2021–October, 2021). Our cross-sectional sample included 6467 respondents at risk of unintended pregnancy. We used logistic regression to examine changes in contraceptive outcomes, controlling for age, race/ethnicity, income, education, marital status, and employment. Using interaction terms between state and survey wave, we compared population-level changes in outcomes in Delaware to changes in Maryland, which did not implement a similar contraceptive initiative.</div></div><div><h3>Results</h3><div>The change in long-acting reversible contraceptive (LARC) use in Delaware compared to Maryland was estimated as a 2.8% point increase, but was not statistically significant (95% CI: −2.8, 8.3). Knowing where to get free LARC increased by 6.2% points (95% CI: 0.4, 12.1; <em>p</em> &lt; 0.05) in Delaware compared to Maryland. Both Delaware and Maryland indicated substantial within-state decreases in reporting their doctor asked about plans for pregnancy (Delaware: −8.9% points; Maryland: −15.1% points), but the decrease in Delaware was significantly smaller: 5.6% points (95% CI: −0.9, 12.1; <em>p</em> &lt; 0.1). Delaware also had a net decrease of 4.7% points (95% CI: −9.9, 0.5; <em>p</em> &lt; 0.1), compared to Maryland, among those very or somewhat satisfied with their current method.</div></div><div><h3>Conclusions</h3><div>We observed a mixed picture of changes in contraceptive use, access, and care experiences during the program. Our findings will be useful to Delaware program administrators and others, including the federal government, as they adopt similar reforms.</div></div><div><h3>Implications</h3><div>We found that the Delaware contraceptive access initiative substantially increased knowledge of free LARC access and led to a relative increase in respondents reporting they had been asked about their pregnancy plans, compared to Maryland, but was not associated with other outcomes.</div></div>","PeriodicalId":10762,"journal":{"name":"Contraception","volume":"144 ","pages":"Article 110814"},"PeriodicalIF":2.8,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143018280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Navigating “regulatory fog”: Challenges to rigorous abortion research after the Dobbs v. Jackson decision","authors":"Elizabeth A. Mosley ,&nbsp;Lucrecia Mena-Meléndez ,&nbsp;Heather Gould ,&nbsp;Lee Hasselbacher ,&nbsp;Melissa Madera ,&nbsp;Heidi Moseson ,&nbsp;Jane W. Seymour","doi":"10.1016/j.contraception.2025.110815","DOIUrl":"10.1016/j.contraception.2025.110815","url":null,"abstract":"<div><div>In 2022, the United States Supreme Court ruling in <em>Dobbs v. Jackson Women’s Health Organization</em> overturned <em>Roe v. Wade</em> and federal protections for abortion. Two years later, 22 states now ban or severely restrict abortion. Sexual and reproductive health scholars aim to document the impacts of these restrictions and bans on individuals, communities, and populations. In this context, human subjects’ protections are more important than ever, as legal risks to abortion providers, seekers, and supporters have increased. However, in this commentary, we discuss how regulatory systems designed to protect human subjects, including Institutional Review Boards and the National Institutes of Health’s Certificates of Confidentiality program, present challenges that create a “regulatory fog,” which stymies abortion scholarship. Research studies have always required a balance of scientific rigor with human subjects’ protections. We argue that, in the current environment, new regulatory constraints make it impossible for some researchers to conduct rigorous abortion research and protect participant confidentiality to the extent that they could before. We offer lessons learned for working in this environment and call for clear guidance and specific protections from federal and institutional leaders to improve research quality and participant safety.</div></div>","PeriodicalId":10762,"journal":{"name":"Contraception","volume":"144 ","pages":"Article 110815"},"PeriodicalIF":2.8,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143018285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of the contraception-focused Preference-aligned Fertility Management Index in Uganda and Nigeria","authors":"Kelsey Holt ,&nbsp;Rouselinne Gomez ,&nbsp;Dinah Amongin ,&nbsp;Elizabeth Omoluabi ,&nbsp;Stephanie Chung ,&nbsp;Catherine Birabwa ,&nbsp;Shakede Dimowo ,&nbsp;Sneha Challa ,&nbsp;Peter Waiswa ,&nbsp;Ivan Idiodi ,&nbsp;Beth Phillips ,&nbsp;Sylvia Nanono ,&nbsp;Ayobambo Jegede ,&nbsp;Jenny Liu ,&nbsp;Ronald Wasswa ,&nbsp;Grace Nmadu ,&nbsp;Chioma Okoli ,&nbsp;Aminat Tijani ,&nbsp;Christine Galavotti","doi":"10.1016/j.contraception.2025.110813","DOIUrl":"10.1016/j.contraception.2025.110813","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aimed to evaluate construct validity of the contraception-focused “Preference-aligned Fertility Management” (PFM) Index, a new person-centered and rights-based outcome measure, in Nigeria and Uganda.</div></div><div><h3>Study design</h3><div>We analyzed survey data from convenience samples of new users of contraception and nonusers of contraception in Uganda and users of contraception in Nigeria. PFM Index scores were calculated by combining two indicators: indicator 1 assessing alignment between desire to use contraception and actual use; indicator 2 evaluating whether users’ current methods are desired. We developed a nomological network of related constructs and conducted bivariable logistic regressions, predicting the odds of PFM associated with each variable.</div></div><div><h3>Results</h3><div>A total of 71.3% of contraception users in Nigeria, 99.2% of new users in Uganda, and 42.9% of nonusers in Uganda were practicing contraception-focused PFM. In Nigeria, high Women’s and Girls’ Empowerment in Sexual and Reproductive Health Index scores and permission to visit a health center were significantly associated with higher odds of contraception-focused PFM (odds ratio [OR] = 2.72; 95% CI = 1.01–7.31; OR = 2.64; 95% CI = 1.04–6.73, respectively). In Uganda, women’s and partner’s secondary school education were significantly associated with higher odds of contraception-focused PFM (OR = 2.58, 95% CI = 1.58–4.24; OR = 2.01; 95% CI = 1.54–2.62, respectively); as were concordance with partner’s desired number of children, recent experience of gender-based violence, and satisfaction with what (if anything) one is doing to prevent pregnancy (OR = 1.48, 95% CI = 1.30–1.69; OR = 2.33; 95% CI = 1.52–3.56; OR = 4.44, 95% CI = 2.77–7.12, respectively).</div></div><div><h3>Conclusions</h3><div>The contraception-focused PFM Index demonstrated construct validity in Nigeria and Uganda. PFM and other new measures of self-defined need contribute to the paradigm shift underway to align contraception indicators with human rights principles.</div></div><div><h3>Implications</h3><div>The contraception-focused PFM Index is a novel person-centered, rights-based measure that can be used to gauge whether individuals’ self-defined needs related to contraception are met by programs and policies. Our study finds evidence for construct validity of the index among contraceptive users in Nigeria and Uganda and nonusers in Uganda.</div></div>","PeriodicalId":10762,"journal":{"name":"Contraception","volume":"144 ","pages":"Article 110813"},"PeriodicalIF":2.8,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142973568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Building the capacity of young professionals in family planning to publish: Insights from the ICFP2022 WHO scientific writing, mentoring and coaching course","authors":"Jane E. Hirst ,&nbsp;Raqibat Idris ,&nbsp;Jean C. Rusatira ,&nbsp;Kellie Welborn ,&nbsp;Jordan Freeman ,&nbsp;Fionna Poon ,&nbsp;James Kiarie ,&nbsp;Rita Kabra","doi":"10.1016/j.contraception.2025.110810","DOIUrl":"10.1016/j.contraception.2025.110810","url":null,"abstract":"<div><h3>Objectives</h3><div>We describe the development, delivery, and evaluation of a program to support junior professionals to publish their work in a scientific journal.</div></div><div><h3>Study design</h3><div>Conference delegates with an accepted abstract at the International Conference on Family Planning (ICFP), self-identifying as junior professionals and from a low- or middle-income country (LMIC) or working predominantly in LMIC settings, were eligible for the program. The program involved: (1) Four face-to-face workshops at ICFP from the 14th to 17th of November 2022; (2) mentoring meetings at ICFP; (3) a six-month post-conference online coaching program; and (4) post-conference learning webinars from December 2022 to May 2023. We used online surveys to assess the participants' reactions, learning, and behaviour changes to the workshops and the online coaching program. We present participants' self-reported progress towards achieving a scientific publication.</div></div><div><h3>Results</h3><div>Sixty-seven participants from 29 countries participated in the workshops, and 40 attended the post-conference program. Workshops were rated positively, though the in-conference mentoring program faced challenges, including low attendance. The post-conference program was highly rated, with most participants engaging well with coaching and the webinars. At the end of the six-month program, 31 (46%) participants reported some progress in manuscript writing, with five completed manuscripts submitted.</div></div><div><h3>Conclusions</h3><div>Scientific writing is a complex skill, and whilst our program had several positive elements, our participants faced many challenges completing their manuscripts within six months. The post-conference coaching and webinar program was rated highly, emphasising the need for ongoing support.</div></div><div><h3>Implications</h3><div>Future programs should address this and other difficulties we highlight.</div></div>","PeriodicalId":10762,"journal":{"name":"Contraception","volume":"144 ","pages":"Article 110810"},"PeriodicalIF":2.8,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142967509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of male contraception on global sexual and reproductive health and rights","authors":"Nancy Kidula ,&nbsp;Brian T. Nguyen ,&nbsp;Ndema Habib ,&nbsp;James Kiarie","doi":"10.1016/j.contraception.2025.110811","DOIUrl":"10.1016/j.contraception.2025.110811","url":null,"abstract":"<div><div>The right to health and other health-related human rights are legally binding commitments enshrined in international human rights instruments. While these positions are known and ratified by policy makers, little has been done to actualize men’s sexual and reproductive health (SRH) as an integral part of attaining these important global goals. Not addressing men’s SRH over and above supporting their female partners sustains the sexual and reproductive risks and burdens that women must bear. Advances in contraceptive technology with several male contraceptive candidates in advanced clinical trials bolsters expectations for a broader contraceptive method mix including greater choice of male contraceptives. This would potentially increase awareness and investments in the men’s SRH and promote health systems strengthening and gender equity including shared responsibility for prevention of pregnancy, sexually transmitted infections, and HIV. This paper is a review and synthesis of published literature including research publications, reports, global policies and commitments and technical documents available online and in organizational repositories such as the World Health Organization (WHO) Institutional repository for information sharing (IRIS) on male contraception and men’s SRH. We provide insights on the impact of male contraception including novel methods and the spillover effects on global SRH. We call on all stakeholders to invest in men’s SRH since the attainment of the Sustainable Development Goal (SDG) target 3.7 on Universal access to SRH cannot be met without addressing this neglected topic.</div></div>","PeriodicalId":10762,"journal":{"name":"Contraception","volume":"145 ","pages":"Article 110811"},"PeriodicalIF":2.8,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142960279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of the retinoic acid receptor alpha-specific antagonist YCT-529 for male contraception: A brief review","authors":"Rui Shi ,&nbsp;Debra J. Wolgemuth ,&nbsp;Gunda I. Georg","doi":"10.1016/j.contraception.2024.110809","DOIUrl":"10.1016/j.contraception.2024.110809","url":null,"abstract":"<div><div>Genetic studies in mice have demonstrated that retinoic acid receptor alpha (RARα) deficiency leads to male infertility without affecting overall viability, suggesting that pharmacological inhibition of this receptor could be a viable contraceptive strategy. This review describes the use of experimental approaches to develop RARα-selective antagonists for male contraception. Initial studies with BMS-189453, a pan-RAR antagonist, showed significant testicular degeneration and reversible infertility in mice. The search for RARα-specific antagonists led to the development of YCT-529, a potent and selective RARα antagonist with favorable pharmacokinetics. YCT-529 demonstrated excellent <em>in vivo</em> efficacy in inhibiting spermatogenesis and inducing infertility in mice, with fertility recovery following drug discontinuation. YCT-529 is now in clinical development as a candidate for male contraception.</div></div>","PeriodicalId":10762,"journal":{"name":"Contraception","volume":"145 ","pages":"Article 110809"},"PeriodicalIF":2.8,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142934051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}