Current Psychopharmacology最新文献

{"title":"Outpatient Psychotropic Drug Interactions in a Public Psychiatry Hospital in Bahrain: An Audit Study","authors":"Yasin Tayem, Saeed Aljaberi, Ali Alfehaid, Abdulaziz Almekhyal, H. Jahrami, Mazen Ali, S. Hattab","doi":"10.2174/2211556010666210701164436","DOIUrl":"https://doi.org/10.2174/2211556010666210701164436","url":null,"abstract":"\u0000\u0000Psychotropic polypharmacy is particularly common which puts psychiatric patients at high risk for developing drug-drug interactions. \u0000\u0000\u0000\u0000\u0000We aimed to study potential interactions between psychotropic medications prescribed within the outpatient psychiatry setting. \u0000\u0000\u0000\u0000\u0000 This was an audit study, which targeted a sample of outpatient prescriptions ordered within the outpatient clinics of the main psychiatry hospital in Bahrain over 2017. We studied the degree and correlation between psychotropic drugs. \u0000\u0000\u0000\u0000\u0000The total number of prescriptions in our sample was 992 (56.1% males, 43.9% females). Psychotropic polypharmacy was detected in 842 prescriptions (84.9%). Potential interactions between psychotropic drugs were observed in 550 prescriptions (56.4%). The degree of interaction was minor in 43 prescriptions (7.8%), significant in 419 prescriptions (76.2%), and serious in 88 prescriptions (16%). Schizoaffective disorder subjects were the most likely to suffer from interactions (64.6%), whereas prescriptions issued for those who had schizophrenia contained the least number of interactions (51.6%). The total number of interactions was strongly associated with polypharmacy (p < .001), and gender (p < .01), but not with age (p > .05) or diagnosis (p > .05). \u0000\u0000\u0000\u0000\u0000 High prevalence of polypharmacy and interactions between psychotropic medications were observed in our sample, particularly of the significant grade. \u0000\u0000","PeriodicalId":10751,"journal":{"name":"Current Psychopharmacology","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90206428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Captagon use in a patient with iatrogenic opioid use disorder","authors":"M. Hamdan, S. El Hayek, M. Bizri","doi":"10.2174/2211556010666210701163649","DOIUrl":"https://doi.org/10.2174/2211556010666210701163649","url":null,"abstract":"\u0000\u0000Captagon or Fenethylline is a synthetic theophylline derivative of amphetamine that is widely available for recreational use in the Middle East. It has pain-reducing properties and is known to induce restlessness, irritability, and psychotic symptoms. \u0000\u0000\u0000\u0000\u0000 A middle-aged man with iatrogenic opioid use disorder was admitted for acute cholecystitis. A week following cholecystectomy, the patient used Captagon while hospitalized to manage opioid withdrawal pain. He experienced waxing and waning episodes of irritability, aggressiveness, disorganized behaviors, delusions, and hallucinations, all concurrent with his Captagon intake. These episodes were managed similarly to intoxication with other stimulant types. \u0000\u0000\u0000\u0000\u0000 Careful patient counseling and close follow-up are essential when opioids are prescribed. Captagon’s pain-reducing properties make it an attractive and dangerous option for Middle Eastern patients suffering from opioid withdrawal. Captagon intoxication is currently managed similarly to other stimulant types, but more studies are needed to develop management guidelines specific to this substance.\u0000\u0000","PeriodicalId":10751,"journal":{"name":"Current Psychopharmacology","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87931132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meet Our Co-Editor","authors":"M. Gold","doi":"10.2174/221155601002210517123521","DOIUrl":"https://doi.org/10.2174/221155601002210517123521","url":null,"abstract":"<jats:sec>\u0000<jats:title />\u0000<jats:p />\u0000</jats:sec>","PeriodicalId":10751,"journal":{"name":"Current Psychopharmacology","volume":"50 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76695051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploration of Epigenetic State Hyperdopaminergia (Surfeit) and Genetic Trait Hypodopaminergia (Deficit) During Adolescent Brain Development.","authors":"Kenneth Blum, Abdalla Bowirrat, Marjorie C Gondre Lewis, Thomas A Simpatico, Mauro Ceccanti, Bruce Steinberg, Edward J Modestino, Panayotis K Thanos, David Baron, Thomas McLaughlin, Raymond Brewer, Rajendra D Badgaiyan, Jessica Valdez Ponce, Lisa Lott, Mark S Gold","doi":"10.2174/2211556010666210215155509","DOIUrl":"10.2174/2211556010666210215155509","url":null,"abstract":"<p><strong>Background: </strong>The risk for all addictive drug and non-drug behaviors, especially, in the unmyelinated Prefrontal Cortex (PFC) of adolescents, is important and complex. Many animal and human studies show the epigenetic impact on the developing brain in adolescents, compared to adults. Some reveal an underlying hyperdopaminergia that seems to set our youth up for risky behaviors by inducing high quanta pre-synaptic dopamine release at reward site neurons. In addition, altered reward gene expression in adolescents caused epigenetically by social defeat, like bullying, can continue into adulthood. In contrast, there is also evidence that epigenetic events can elicit adolescent hypodopaminergia. This complexity suggests that neuroscience cannot make a definitive claim that all adolescents carry a hyperdopaminergia trait.</p><p><strong>Objective: </strong>The primary issue involves the question of whether there exists a mixed hypo or hyper-dopaminergia in this population.</p><p><strong>Method: </strong>Genetic Addiction Risk Score (GARS®) testing was carried out of 24 Caucasians of ages 12-19, derived from families with RDS.</p><p><strong>Results: </strong>We have found that adolescents from this cohort, derived from RDS parents, displayed a high risk for any addictive behavior (a hypodopaminergia), especially, drug-seeking (95%) and alcohol-seeking (64%).</p><p><strong>Conclusion: </strong>The adolescents in our study, although more work is required, show a hypodopaminergic trait, derived from a family with Reward Deficiency Syndrome (RDS). Certainly, in future studies, we will analyze GARS in non-RDS Caucasians between the ages of 12-19. The suggestion is first to identify risk alleles with the GARS test and, then, use well-researched precision, pro-dopamine neutraceutical regulation. This \"two-hit\" approach might prevent tragic fatalities among adolescents, in the face of the American opioid/psychostimulant epidemic.</p>","PeriodicalId":10751,"journal":{"name":"Current Psychopharmacology","volume":"10 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8547282/pdf/nihms-1726360.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39567152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epigenetic Repair of Terrifying Lucid Dreams by Enhanced Brain Reward Functional Connectivity and Induction of Dopaminergic Homeostatic Signaling.","authors":"Kenneth Blum, Thomas McLaughlin, Edward J Modestino, David Baron, Abdalla Bowirrat, Raymond Brewer, Bruce Steinberg, A Kenison Roy, Marcello Febo, Rajendra D Badgaiyan, Marks S Gold","doi":"10.2174/2211556010666210215153513","DOIUrl":"10.2174/2211556010666210215153513","url":null,"abstract":"<p><p>During Lucid Dreams, the dreamer is aware, experiences the dream as if fully awake, and may control the dream content. The dreamer can start, stop, and restart dreaming, depending on the nature and pleasantness of the dream. For patients with Reward Deficiency Syndrome (RDS) behaviors, like Attention Deficit Hyperactivity Disorder (ADHD), Tourette's- Syndrome, and Posttraumatic Stress Disorder (PTSD), the dream content may be pleasant, unpleasant, or terrifying. A sample of psychiatric center patients identified as having RDS reported the effectiveness of a neuronutrient, dopamine agonist, KB200Z, in combating terrifying, lucid dreaming. These reports motivated the study of eight clinical cases with known histories of substance abuse, childhood abuse, and PTSD. The administration of KB200Z, associated with eliminating unpleasant or terrifying lucid dreams in 87.5% of the cases. Subsequently, other published cases have further established the possibility of the long-term elimination of terrifying dreams in PTSD and ADHD patients. Induction of dopamine homeostasis may mitigate the effects of neurogenetic and epigenetic changes in neuroplasticity, identified in the pathogenesis of PTSD and ADHD. The article explores how relief of terrifying lucid dreams may benefit from modulation of dopaminergic signaling activated by the administration of a neuronutrient. Recently, precision formulations of the KB220 neuronutrient guided by Genetic Addiction Risk Score (GARS) test results have been used to repair inheritable deficiencies within the brain reward circuitry. The proposition is that improved dopamine transmodulational signaling may stimulate positive cognitive recall and subsequently attenuate the harmful epigenetic insults from trauma.</p>","PeriodicalId":10751,"journal":{"name":"Current Psychopharmacology","volume":"10 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8547281/pdf/nihms-1726353.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39570458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meet Our Editor-in-Chief","authors":"K. Blum","doi":"10.2174/221155601001210125124530","DOIUrl":"https://doi.org/10.2174/221155601001210125124530","url":null,"abstract":"","PeriodicalId":10751,"journal":{"name":"Current Psychopharmacology","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91258074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transitioning from Child and Adolescent to Adult Psychiatric Care: Improving Outcomes after University Matriculation","authors":"Giuseppe D’Amelio, J. Gold","doi":"10.2174/2211556009999200616131458","DOIUrl":"https://doi.org/10.2174/2211556009999200616131458","url":null,"abstract":"\u0000\u0000The transition from pediatric to adult psychiatric care is not well coordinated. Transitional\u0000age youths who are going to college for the first time experience a number of concomitant stressors,\u0000which make the transition of psychiatric care even more difficult. Given the burden of psychiatric illness\u0000in college students and the limited resources available, more investigation into feasible means of\u0000coordinating care needs to occur. Particularly as individuals with mental illness are most likely to experience\u0000lapses in care during this transition and have worse outcomes, being more likely to drop out\u0000of college.\u0000","PeriodicalId":10751,"journal":{"name":"Current Psychopharmacology","volume":"74 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77898835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meet Our Editorial Board Member","authors":"P. Illés","doi":"10.2174/221155600903200923144300","DOIUrl":"https://doi.org/10.2174/221155600903200923144300","url":null,"abstract":"<jats:sec>\u0000<jats:title />\u0000<jats:p />\u0000</jats:sec>","PeriodicalId":10751,"journal":{"name":"Current Psychopharmacology","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84640124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Method Validation for the Determination of Carbamazepine in Spiked-saliva Using HPLC-UV for Therapeutic Drug Monitoring Application","authors":"A. Wibowo, V. Ningrum, Rahma N. Ilhamy","doi":"10.2174/2211556009999200727191226","DOIUrl":"https://doi.org/10.2174/2211556009999200727191226","url":null,"abstract":"\u0000\u0000Carbamazepine has been used in the treatment of bipolar disorder,\u0000both in acute mania and maintenance therapy, particularly in developing countries. Not only\u0000its interaction with various drugs and auto-inducer nature, but the narrow therapeutic\u0000range of carbamazepine also makes monitoring necessary to guarantee the adequacy of its\u0000safety and therapeutic concentration. To date, the most common biological specimen used\u0000for therapeutic drug monitoring (TDM) purposes is still plasma, but saliva can become an\u0000alternative biological matrix since its level in saliva strongly correlates with carbamazepine\u0000plasma concentration.\u0000\u0000\u0000\u0000 This study validated the bioanalytical method parameters used for carbamazepine\u0000in spiked-saliva in accordance with the Food and Drug Administration (FDA) criteria\u0000in the Guidance for Industry Bioanalytical Method Validation.\u0000\u0000\u0000\u0000HPLC-UV detector was employed at 285 nm λ with methanol: water: glacial\u0000acetic acid (65:34:1) as the mobile phase and C8 as the stationary phase (4.6x150 mm; 5 μm).\u0000\u0000\u0000\u0000The linearity test in a range of 0.0 - 5 μg/mL carbamazepine concentration resulted\u0000in a correlation coefficient of 0.999 with 0.20 μg/mL LoD, 0.30 μg/mL LLoQ, and 0.61\u0000μg/mL LoQ. The coefficient of variation and 0iff in the selectivity, accuracy, and precision\u0000parameters remained below 20%, indicating fulfillment of the criteria for a bioanalytical\u0000method, while the average % recovery was more than 90%.\u0000\u0000\u0000\u0000The currently-developed bioanalytical method has fulfilled the stipulated validation\u0000criteria to be used for determining carbamazepine concentration in spiked-saliva as\u0000an alternative method for relative bioequivalence studies or TDM application in a clinical\u0000setting.\u0000","PeriodicalId":10751,"journal":{"name":"Current Psychopharmacology","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80938436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meet Our Associate Editorial Board Member","authors":"Karthick Subramanian","doi":"10.2174/221155600902200703094839","DOIUrl":"https://doi.org/10.2174/221155600902200703094839","url":null,"abstract":"<jats:sec>\u0000<jats:title />\u0000<jats:p />\u0000</jats:sec>","PeriodicalId":10751,"journal":{"name":"Current Psychopharmacology","volume":"136 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78182429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}