The Internet Journal of Alternative Medicine最新文献

{"title":"Effect of Coriandrum sativum, a common herbal medicine, on endocrine and reproductive organ structure and function","authors":"E. A. Suhaimi","doi":"10.5580/3b1","DOIUrl":"https://doi.org/10.5580/3b1","url":null,"abstract":"We investigated the effects of Coriandrum sativum seeds, used to treat hyperglycemia and hyperlipidemia, on endocrine functions and structures. Healthy adult male rabbits (n = 20) were randomly divided into two groups: control group and treatment group (250 mg/kg Coriandrum sativum seed aqueous extract). Fasting blood samples were taken in the morning on day 0 (baseline) and day 4 of the 7-day treatment, and day 1 and day 8 post-treatment. Significant changes in cortisol levels occurred during the treatment period, but they could not be attributed to Coriandrum sativum treatment. Testosterone, glucose, and cholesterol were not significantly altered after treatment compared to control or baseline levels. No histopathological changes were observed in the epididymis, pancreas, testis interstitial tissue, or seminiferous tubules. The traditional herbal medicine, Coriandrum sativum, does not appear to exert negative effects on testosterone or cholesterol levels, nor on the reproductive or endocrine functions. The interrelationship between metabolism and gonad functions is an important concern when medicinal plants are used; therefore, use of Coriander sativum requires further study before it can be recommended for use as a medicinal plant.","PeriodicalId":107168,"journal":{"name":"The Internet Journal of Alternative Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2008-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129840542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Free Radical Scavenging Properties and LC/MS Analysis of Bulgarian Crataegus Oxycantha Fruits Ethanol Extract","authors":"V. Hadjimitova, T. Traykov, P. Hadjieva, P. Traldi","doi":"10.5580/2633","DOIUrl":"https://doi.org/10.5580/2633","url":null,"abstract":"Investigations on procyanidin profile on Bulgarian Crataegus oxycantha fruits extract has been carried out by different analytical approaches based on chromatographic methods. We retained of interest to test the validity of direct infusion of Crataegus extract in ESI conditions to achieve an immediate fingerprinting of the procyanidins therein contained. The results are compared with those obtained by classical HPLC/MS approach. The antioxidant properties of Crataegus extract on iron-dependant lipid peroxidation and on UV irradiation induced deoxyribose oxidation were investigated. On the basis of the experimental data C-50 value was calculated: 0.70 ± 0.02 mg/ml and 0.26 ± 0.01 mg/ml for LP and UV irradiation systems respectively. The LP measured for the same model system but in the presence of six of the main biologically active Crataegus fruits extract components proved by GC/MS analysis. We identified poliphenols in this extract and we proved the antioxidant effect in two biologically relevant systems.","PeriodicalId":107168,"journal":{"name":"The Internet Journal of Alternative Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2008-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132214716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bacteriophage Therapy: A War Against Antibiotic Resistant Bacteria","authors":"M. Abhilash, A. Vidya, T. Jagadevi","doi":"10.5580/2992","DOIUrl":"https://doi.org/10.5580/2992","url":null,"abstract":"Bacteriophages or phages are bacterial viruses that invade bacterial cells and, in the case of lytic phages, disrupt bacterial metabolism and cause the bacterium to lyse.Recent examples of the use of bacteriophages in controlling bacterial infections are presented, some of which show therapeutic promise. The therapeutic use of bacteriophages, possibly in combination with antibiotics, may be a valuable approach. However, it is also quite clear that the safe and controlled use of phage therapy will require detailed information on the properties and behavior of specific phage–bacterium systems, both in vitro and especially in vivo. In vivo susceptibility of bacterial pathogens to bacteriophages is still largely poorly understood and future research on more phage–bacterium systems has to be undertaken to define the requirements for successful phage treatments.","PeriodicalId":107168,"journal":{"name":"The Internet Journal of Alternative Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2008-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115084406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antimicrobial Potentials of Yaji-Spices: The Constituents of a Complex Nigerian Suya Meat Sauce Inducing Histological Investigations","authors":"A. Nwaopara, Chilie Anibeze, F. Akpuaka, S. Nwaopara","doi":"10.5580/2184","DOIUrl":"https://doi.org/10.5580/2184","url":null,"abstract":"Spices and herbs have been used for thousands of centuries as preservatives for foods and for medicinal purposes. Some of these spices and herbs possess antimicrobial potentials that may, in combination, be considered as alternatives to conventional antimicrobial agents especially in this era of antimicrobial drug resistance. Our interest however, is on the widely consumed Nigerian suya meat sauce called Yaji. It is a complex mixture of salt, ginger, clove, red pepper and black pepper, all of which, on individual basis, have established antimicrobial properties. This paper therefore highlights these all-in-one antimicrobial potentials of Yaji.","PeriodicalId":107168,"journal":{"name":"The Internet Journal of Alternative Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2008-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125699800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti Pyretic Activity Of Aristolochia Bracteata","authors":"V. Rajamanickam, A. Rajasekaran, M. Jesupillai, S. D. Quine, R. Sabitha","doi":"10.5580/1736","DOIUrl":"https://doi.org/10.5580/1736","url":null,"abstract":"Pet ether and acetone extracts of the plant Aristolochia Bracteata were prepared using Soxlet extraction. phytochemical analysis of Aristolochia Bracteata showed the presence of alkaloids, carbohydrates, flavones, triterpenoids and phytosterols in the crude extracts. In the present study, Pet.ether and acetone extracts of Aristolochia Bracteata was investigated for their anti pyretic activity. Injection of 20 ml/kg (s.c) of 20% aqueous suspension of Brewer’s yeast suspension produced pyrexia in rats. Extracts at 250 mg/kg exhibited significant anti pyretic activity. Aspirin (300mg/kg) was included as standard. Pet. Ether extracts was found to be more effective than acetone extract. INTRODUCTION Aristolochia bracteata Linn. (Aaduthinnapalai – Tamil; Worm killer English; Gadaparku – Telugu; BhringiHindi), is a shrub distributed through out India. It belongs to the family Aristolochiaceae. In the indigenous system of medicine, the plant was used for the treatment of skin diseases, inflammation and purgative1,2. Root extract was reported to have anti bacterial activity 3 and also Toxicity of Aristolochia bracteata was reported 4.The present study was aimed to evaluate antipyretic efficacy of Acetone and Pet.ether extract of Aristolochia bracteata. MATERIALS AND METHODS PLANT COLLECTION AND AUTHENTICATION The plant material was collected in the Tirunelveli district, Tamilnadu, India. It was authenticated by Dr.V.Chelladurai, Govt. Research officer, Botany C.C.R.A.S. Govt. of India, (Retired), Tirunelveli. A voucher specimen has been kept in our laboratory for future reference PREPARATION OF EXTRACT Aristolochia bracteata was collected dried under shade, coarsely powdered and passed through sieve no.22 to get particle of uniform size. Then extracted exhaustively with Pet. Ether and Acetone using Soxhlet apparatus5 . The solvent was removed under reduced pressure to obtain a solid mass. It was then preserved in a desiccators until further use. ANIMALS Male Wister Albino rats (100-150gm) were procured form animal house of our institute, maintained under room temperature (20±10C) and relative humidity 55±10Cwith 12 h light / dark cycle. The animals were provided with standard pellet diet (M/s Hindustan Lever Ltd, Mumbai, India.) with free access to water adlibidum. The present study was approved by institutional animal ethics committee (Approval no. 509/02/C/CPCSEA). ANTIPYRETIC ACTIVITY The antipyretic activity of Pet.etheric and Acetone extracts were screened by using yeast-induced hyperpyrexia method6,7. The selected animals were divided into four groups, each having six animals. They were maintained at constant temperature of 24-25° for 24 h before pyrexia was induced by subcutaneous injection of 1 ml of 15% brewer’s yeast suspension in saline solution10. After 18 h of yeast injection, the extracts at a dose of 250 mg/kg were administered orally to each group as a suspension in tween 80. Paracetamol i.p. (200 mg/kg) was used as standard for comparison","PeriodicalId":107168,"journal":{"name":"The Internet Journal of Alternative Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2008-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123783962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Michelia Champaca: Wound Healing Activity In Immunosuppressed Rats","authors":"S. Dwajani, T. Shanbhag","doi":"10.5580/1b0d","DOIUrl":"https://doi.org/10.5580/1b0d","url":null,"abstract":"Objectives: To evaluate wound healing profile of alcoholic extract of Michelia champaca in different wound models in rats and to study its effect on Dexamethasone suppressed wound healing.Materials and methods: For assessment of wound healing activity, excision, incision and dead space wound models were used. Group I was assigned as control, Group II received alcoholic extract of M. champaca orally. Group III received Dexamethasone intra muscularly (i.m) and Group IV was given Dexamethasone i.m and alcoholic extract of M.champaca orally. Parameters observed were breaking strength of incision wound; epithelization and wound contraction in excision model and breaking strength, dry weight and hydroxyproline content in dead space wound model.Results: In incision model, it was noted that on co-administration of Dexamethasone and M.champaca the breaking strength was significantly increased. In dead space wound model, the hydroxyproline content was significantly increased in Dexamethasone + M.champaca treated group.Conclusion: It is concluded that M.champaca is an effective agent for healing of wounds in immunocompromised patients.","PeriodicalId":107168,"journal":{"name":"The Internet Journal of Alternative Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2008-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124088007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of cardiovascular risk factors in normolipidemic acute myocardial infarct patients on admission based on aging - A case controlled study from South Asia","authors":"Arun Kumar, S. Nagtilak, R. Sivakanesan","doi":"10.5580/2138","DOIUrl":"https://doi.org/10.5580/2138","url":null,"abstract":"The goal of the present study was to address the various risk factors associated in normolipidemic acute myocardial infarction (AMI) patients admitted to the intensive coronary care unit (ICCU). The study compared serum lipid profiles, lipid peroxidation markers, antioxidants and inflammatory markers in acute myocardial infarction (AMI) patients and age/sex-matched controls. The risk variables were analysed age wise with patients 60 years of age.A lipid profile, lipid peroxidation, enzyme antioxidants, endogenous antioxidants, ischemia modified-albumin (IscMA), ceruloplasmin, C-reactive protein (CRP), fibrinogen, lipoprotein (a) and paraoxonase-1 activities were analyzed in 165 acute myocardial infarction (AMI) patients of which 45 patients were 60 years age of acute myocardial infarction patients. Higher levels of C-reactive protein (p=0.003) were observed among the >60 years age patients compared to <60 years. Other biochemical findings were not statistically significant.During the process of aging the risk factors vary as lowering of antioxidants is due to decreased free radical scavenging properties.","PeriodicalId":107168,"journal":{"name":"The Internet Journal of Alternative Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2008-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132476012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Free Radical Scavenging and Antibacterial Activities of Amrycard Powder (A Ayurvedic Formulation)","authors":"B. Kumar, K. Lakshman, V. Swamy, Saleemulla Khan, Manu S.N. Tripathi, L. Deepa","doi":"10.5580/44d","DOIUrl":"https://doi.org/10.5580/44d","url":null,"abstract":"Free radicals are implicated for more than eighty diseases including diabetes mellitus, arthri- tis, cancer, ageing, etc. in treatment of theses dis- eases; antioxidant therapy has gained an utmost importance. Current research is now directed to- wards finding naturally occurring antioxidant of herbal drugs. Antioxidant activity of methanol e-xtract of Amrycard powder was evaluated by using Phosphomolybdenum assay, DPPH radical sca- venging assay, superoxide radical scavenging as-say and ABTS assay. The total phenolic, total tan-nins, and total flavonoids content were determined. \u0000Antibacterial activity was also studied against Ba-cillus subtilis, Escherichia coli, Streptococcus au-reus and staphylococcus by using cup-plate me-thod. Erythromycin was used as standard antibac-terial agent 1.The methanol extract was diluted into different concentration (1,2, 4, 6, 8, 10 mg/l00 μl)with DMSO. The results of the study revealed that,the Amrycard powder exhibited significant antibac-terial activity.","PeriodicalId":107168,"journal":{"name":"The Internet Journal of Alternative Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2008-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132661066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New Dimensions in the Treatment of Autism with Homeopathy","authors":"M. Rajalakshmi","doi":"10.5580/168f","DOIUrl":"https://doi.org/10.5580/168f","url":null,"abstract":"Disorders such as autism and mental retardation are developmental disabilities that occur in children. Of these, autism is much more enigmatic than mental retardation. This is because unlike mental retardation where there is global delay in development and reduced I.Q., autism is a developmental neurological disorder which affects brain functioning in specific areas of social and emotional skills and communication abilities with some behavioral stereotypes. This leads to impairments in speech, language and communication skills, impaired social skills and severe inconsistencies in their development. Training and remedial teaching in special schools along with behavior management are the conventional interventions. Using the homeopathic model, I hope to elaborate through this article that homeopathic treatment can help in restoring the internal functional integrity in order to get the best possible results by enhancing and shortening the response to remedial education. This study is an effort to demonstrate the unique modality of homeopathy in the treatment of autism. The study antedates another outcome study of homeopathy in autism conducted by me and published elsewhere (Rajalakshmi, M.A., 2008). Using this study and drawing on the conclusions of my other study along with some recent interesting research findings, I propose that homeopathy is a novel treatment dimension with significant implication in the approach to the management of autism. Six children with a confirmed diagnosis of autism were chosen for the study. Of this three were verbal and three were non-verbal. Two of the children had associated mental retardation. These children were receiving remedial teaching for four hours a day, six days in a week. The criteria used to map the progress of each child were the Autism Behavior Composite Checklist and Profile (ABCCP) along with clinical assessment.","PeriodicalId":107168,"journal":{"name":"The Internet Journal of Alternative Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2008-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132058956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antimicrobial efficacies of methanol extract of Asteracantha longifolia, Ipomoea aquatica and Enhydra fluctuans against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Micrococcus luteus","authors":"J. Bhakta, P. Majumdar, Y. Munekage","doi":"10.5580/95a","DOIUrl":"https://doi.org/10.5580/95a","url":null,"abstract":"Present experiment was executed to investigate the antimicrobial efficacy of Asteracantha longifolia, Ipomoea aquatica and Enhydra fluctuans leaf extracts on four pathogenic bacterial strains, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Micrococcus luteus. Methanol extract of herbs were used at four different concentrations for examining the antibacterial efficacy on bacterial strains using agar-cup-diffusion assay and measuring the diameter (mm) of the clear zone around the cup. The mean values of the clear zone in S. aureus were 1.17 to 3.85, 1.02 to 1.45 and 1.14 to 2.58 times greater in A. longifolia, I. aquatica and E. fluctuans, respectively compared to that of the remaining bacteria. This results obviously implied that the methanol extract of three types of herbs have a highest antimicrobial efficacy against the S. aureus over P. aeruginosa, E. coli and M. luteus. Though, no clear zone was found in the methanol extract of the A. longifolia and E. fluctuans againstP. aeruginosa, but the mean values of the clear zone of the I. aquatica extract exhibited 7.4 mm in P. aeruginosa and showed 28 to 118%, 12 to 96% and 200 to 250% higher than that of the remaining two herb extracts. Therefore, it may be concluded that A. longifolia andE. fluctuans herbs have no activity against the P. aeruginosa, whereas I. aquatica exerted a higher magnitude of antimicrobial activity against the tested four types of bacterial species than that of the rest two herb extracts due to compositional variation in the active biomolecules of three herbs.","PeriodicalId":107168,"journal":{"name":"The Internet Journal of Alternative Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2008-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128624300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}