Clinical chemistry最新文献_第2页

Commentary on Normal Thyroid-Stimulating Hormone and Elevated Free Thyroxine in a Patient Presenting with Self-Reported Heart Palpitations.

IF 7.1 2区医学

Clinical chemistry Pub Date : 2025-04-03 DOI: 10.1093/clinchem/hvae197

Ann M Gronowski

引用次数: 0

Commentary on Normal Thyroid-Stimulating Hormone and Elevated Free Thyroxine in a Patient Presenting with Self-Reported Heart Palpitations.

IF 7.1 2区医学

Clinical chemistry Pub Date : 2025-04-03 DOI: 10.1093/clinchem/hvae205

Stephen L Atkin

引用次数: 0

Cardiac Biomarkers and Malnutrition Incidence in Community-Dwelling Older Adults without Cardiovascular Disease: The Seniors-ENRICA-2 Cohort.

IF 7.1 2区医学

Clinical chemistry Pub Date : 2025-04-03 DOI: 10.1093/clinchem/hvae221

Blanca Fabre-Estremera, Antonio Buño-Soto, Mercedes Sotos-Prieto, Adrián Carballo-Casla, Samara Palma Milla, Fernando Rodríguez-Artalejo, Rosario Ortolá

{"title":"Cardiac Biomarkers and Malnutrition Incidence in Community-Dwelling Older Adults without Cardiovascular Disease: The Seniors-ENRICA-2 Cohort.","authors":"Blanca Fabre-Estremera, Antonio Buño-Soto, Mercedes Sotos-Prieto, Adrián Carballo-Casla, Samara Palma Milla, Fernando Rodríguez-Artalejo, Rosario Ortolá","doi":"10.1093/clinchem/hvae221","DOIUrl":"10.1093/clinchem/hvae221","url":null,"abstract":"Background: Given the close relationship between cardiovascular disease (CVD) and malnutrition, we examined whether higher concentrations of high-sensitivity cardiac troponin T (hs-cTnT) and N-terminal pro-brain natriuretic peptide (NT-proBNP), which indicate CVD risk in the general population, were prospectively associated with malnutrition incidence in community-dwelling older adults without CVD.Methods: We used data from 1490 individuals ≥65 years from the Seniors-ENRICA-2 cohort followed up for 2.2 years. Malnutrition was evaluated by the screening Mini Nutritional Assessment-Short Form (MNA-SF) score, which consists of a short questionnaire, and a complete nutritional assessment according to the Global Leadership Initiative on Malnutrition (GLIM) criteria. Associations were summarized with odds ratios (OR) and their 95% confidence interval (CI), obtained from logistic regression and adjusted for the main confounders.Results: NT-proBNP was associated with higher malnutrition incidence assessed by the MNA-SF score and the GLIM criteria, with OR (95% CI) of 1.51 (1.09-2.09) and 1.43 (1.04-1.96) per one logarithmic-unit increment, respectively. Malnutrition incidence according to the GLIM criteria was also higher in participants who had elevated NT-proBNP (heart stress age-specific rule-in cutoffs) vs those who did not, with OR (95% CI) of 1.84 (1.05-3.22). hs-cTnT was not associated with higher malnutrition incidence.Conclusions: In this cohort of older adults without CVD, NT-proBNP was associated with higher malnutrition incidence. Further research is needed to validate our findings, uncover the underlying biological mechanisms, and assess whether preventive interventions can reduce NT-proBNP concentrations and, consequently, reduce the risk of malnutrition.","PeriodicalId":10690,"journal":{"name":"Clinical chemistry","volume":" ","pages":"474-483"},"PeriodicalIF":7.1,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143364155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Normal Thyroid-Stimulating Hormone and Elevated Free Thyroxine in a Patient Presenting with Self-Reported Heart Palpitations.

IF 7.1 2区医学

Clinical chemistry Pub Date : 2025-04-03 DOI: 10.1093/clinchem/hvae177

William Butler, Melissa Sawyer Falcon, Daniel S Herman, Ping Wang

引用次数: 0

Determinants of Cardiac Myosin Binding Protein C in the General Population.

IF 7.1 2区医学

Clinical chemistry Pub Date : 2025-04-03 DOI: 10.1093/clinchem/hvaf013

Michael F Paus, Magnus N Lyngbakken, Arnljot Tveit, Kjetil Steine, Trygve Berge, Julia B Skranes, Erika N Aagaard, Brede Kvisvik, Jon Brynildsen, Siri L Heck, Thakshani Wimalanathan, Kristin M Aakre, Helge Røsjø, Torbjørn Omland

{"title":"Determinants of Cardiac Myosin Binding Protein C in the General Population.","authors":"Michael F Paus, Magnus N Lyngbakken, Arnljot Tveit, Kjetil Steine, Trygve Berge, Julia B Skranes, Erika N Aagaard, Brede Kvisvik, Jon Brynildsen, Siri L Heck, Thakshani Wimalanathan, Kristin M Aakre, Helge Røsjø, Torbjørn Omland","doi":"10.1093/clinchem/hvaf013","DOIUrl":"10.1093/clinchem/hvaf013","url":null,"abstract":"Background: Cardiac myosin binding protein C (cMyC) is a novel, cardiac-specific biomarker with an early release profile after acute ischemic myocardial injury. Whether cMyC reflects chronic myocardial injury and left ventricular remodelling in the general population is unknown. The aims of the study were to test the hypotheses that cMyC concentrations are associated with cardiovascular risk factors, biomarkers of chronic myocardial injury, and imaging biomarkers of cardiac anatomy, function, and fibrosis.Methods: Circulating cMyC and cardiac troponin I and T concentrations were measured in 3672 individuals from the general population, born in 1950, who underwent echocardiography. One-hundred-ninety-nine participants with measured cMyC completed a cardiovascular magnetic resonance (CMR) examination for assessment of myocardial fibrosis.Results: Circulating cMyC was measurable in 99.6% of study participants and in 99.0% of CMR substudy participants. cMyC was positively associated with left ventricular mass and left atrial volume and inversely associated with renal function and indices of left ventricular systolic and diastolic function. In participants with available late gadolinium enhancement images for the assessment of focal fibrosis (n = 197), cMyC was positively associated with indices of focal myocardial fibrosis.Conclusions: In the general population, circulating cMyC concentrations are associated with cardiovascular risk factors, reflect left ventricular remodelling, including focal myocardial fibrosis, and systolic and diastolic dysfunction independently of traditional risk factors.","PeriodicalId":10690,"journal":{"name":"Clinical chemistry","volume":" ","pages":"484-496"},"PeriodicalIF":7.1,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mannose Phosphate Isomerase Deficiency-Congenital Disorder of Glycosylation (MPI-CDG) Type 1b: Familial Case of Thrombophilia and Liver Disorder.

IF 7.1 2区医学

Clinical chemistry Pub Date : 2025-04-03 DOI: 10.1093/clinchem/hvaf009

Franklin Ducatez, Elisa Minacori, Sandrine Vuillaumier Barrot, Gaëtan Sauvêtre, Ivana Dabaj

引用次数: 0

New Clinical Practice Guidelines for Vitamin D Supplementation and Testing.

IF 7.1 2区医学

Clinical chemistry Pub Date : 2025-04-03 DOI: 10.1093/clinchem/hvae213

Ashley N Ogorek, Vishnu A Samara

引用次数: 0

Correlations Within and Between Highly Multiplexed Proteomic Assays of Human Plasma.

IF 7.1 2区医学

Clinical chemistry Pub Date : 2025-04-02 DOI: 10.1093/clinchem/hvaf030

Mary R Rooney, Jingsha Chen, Christie M Ballantyne, Ron C Hoogeveen, Eric Boerwinkle, Bing Yu, Keenan A Walker, Pascal Schlosser, Elizabeth Selvin, Nilanjan Chatterjee, David Couper, Morgan E Grams, Josef Coresh

{"title":"Correlations Within and Between Highly Multiplexed Proteomic Assays of Human Plasma.","authors":"Mary R Rooney, Jingsha Chen, Christie M Ballantyne, Ron C Hoogeveen, Eric Boerwinkle, Bing Yu, Keenan A Walker, Pascal Schlosser, Elizabeth Selvin, Nilanjan Chatterjee, David Couper, Morgan E Grams, Josef Coresh","doi":"10.1093/clinchem/hvaf030","DOIUrl":"https://doi.org/10.1093/clinchem/hvaf030","url":null,"abstract":"Introduction: The number of assays on proteomic platforms has grown rapidly. The leading platforms, SomaScan and Olink, have strengths and limitations. Comparisons of precision on the latest platforms-SomaScan 11k and Olink Explore HT-have not yet been established.Methods: Among 102 participants in the Atherosclerosis Risk in Communities Study (mean age 74 years, 53% women, 47% Black), we used split plasma samples to measure platform precision. CV and Spearman correlations were calculated for each assay. Cross-platform agreement was assessed for overlapping proteins.Results: SomaScan 11k demonstrated a median correlation of 0.85 for the 10 778 assays and a median CV of 6.8%, similar precision to earlier versions. The 5420 assays on Olink Explore HT exhibited a median correlation of 0.65 and median CV of 35.7%, which was higher than observed in its predecessors (e.g., 19.8% for Olink Explore 3072). Precision of Olink assays was inversely correlated with the percentage of samples above the limit of detection (LOD) (r = -0.77). Upon replacing Olink values below the LOD with values half the LOD, the median correlation for Olink assays measured in duplicate increased to 0.79; the median CV decreased to 13.3%. The distribution of between-platform correlations for the 4443 overlapping proteins had peaks at r approximately 0 and at r approximately 0.8. One-tenth of the protein pairs had cross-platform correlations r ≥ 0.8.Conclusions: Precision of these 2 proteomics platforms in human plasma has diverged as the coverage has increased. These results highlight the need for careful consideration in platform selection based on specific research requirements.","PeriodicalId":10690,"journal":{"name":"Clinical chemistry","volume":" ","pages":""},"PeriodicalIF":7.1,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimizing Estimation: Perspective on Drug Dosing Using New CKD-EPI Equations.

IF 7.1 2区医学

Clinical chemistry Pub Date : 2025-03-29 DOI: 10.1093/clinchem/hvaf031

Edward J Filippone, Walter K Kraft

引用次数: 0

A Meta-Analysis and Systematic Review of Cardiac Troponin I vs T in Community Dwelling Adults: Is Specificity at Risk?

IF 7.1 2区医学

Clinical chemistry Pub Date : 2025-03-27 DOI: 10.1093/clinchem/hvaf023

Yashika Parashar, Aya Awwad, Soahum Bagchi, Brian Claggett, Saman Asad Siddiqui, Ajari Winifred Ogheneochuko, Christie M Ballantyne, Christopher deFilippi

{"title":"A Meta-Analysis and Systematic Review of Cardiac Troponin I vs T in Community Dwelling Adults: Is Specificity at Risk?","authors":"Yashika Parashar, Aya Awwad, Soahum Bagchi, Brian Claggett, Saman Asad Siddiqui, Ajari Winifred Ogheneochuko, Christie M Ballantyne, Christopher deFilippi","doi":"10.1093/clinchem/hvaf023","DOIUrl":"https://doi.org/10.1093/clinchem/hvaf023","url":null,"abstract":"Background: Cardiac troponin I and T measured by high-sensitivity assays (hs-cTn) are detectable in most ambulatory adults. Hs-cTnI and T may perform differently for prediction of cardiovascular (CV) events. In adults with myopathies and advanced age, hs-cTnT can lose CV specificity. We undertook a meta-analysis of ambulatory studies measuring hs-cTn to determine whether hs-cTnI is a superior predictor of CV outcomes.Methods: Articles evaluating hs-cTnI or T for incident heart failure (HF), myocardial infarction (MI), CV, and all-cause death in ambulatory adults were screened. Adjusted HRs were extracted standardized as hs-cTn tertile 3 vs 1. Pooled effects were calculated, and heterogeneity assessed. Predefined subgroup analyses for hs-cTnI vs T included age and prevalent CV disease.Results: A total of 5499 studies were screened and 54 met inclusion criteria with up to 277 498 participants followed for 8.1 ± 4.5 years. Pooled estimates for HF, MI, CV, and all-cause death were reported as 2.30 [95% confidence interval (CI) 2.04, 2.60], 1.64 (95%CI 1.47, 1.86), 2.07 (95%CI 1.82, 2.35), and 1.66 (95%CI 1.51, 1.83). No differences in HRs for subgroups based on hs-cTnI vs hs-cTnT (except all-cause death), age, or prevalent CV disease were observed. Heterogeneity between studies was high with an I2 > 60% for all endpoints for both hs-cTn assays. In a sensitivity analysis of studies measuring both hs-cTnI and T there was also no differences for the prediction of any CV endpoint.Conclusions: Hs-cTnI and T prediction of multiple CV endpoints are not significantly different irrespective of age and pre-existing CV disease in ambulatory adults.","PeriodicalId":10690,"journal":{"name":"Clinical chemistry","volume":" ","pages":""},"PeriodicalIF":7.1,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143729229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0