Clinical chemistry最新文献_第2页

Niacin and Risk of Cardiovascular Events: Deciphering the Paradox. 烟酸与心血管事件风险：解密悖论

IF 7.1 2区医学

Clinical chemistry Pub Date : 2024-11-04 DOI: 10.1093/clinchem/hvae064

Ravinder Sodi

引用次数: 0

Commentary on Mosaic Copy Number Variation in a Patient with Cerebral and Pulmonary Arteriovenous Malformations and Recurrent Epistaxis. 关于一名脑和肺动静脉畸形及复发性鼻衄患者的马赛克拷贝数变异的评论。

IF 7.1 2区医学

Clinical chemistry Pub Date : 2024-11-04 DOI: 10.1093/clinchem/hvae128

Naif A M Almontashiri

引用次数: 0

Adiponectin and Risk of Psoriasis: Observational and Mendelian Randomization Studies in up to 900 000 Individuals. 脂联素与牛皮癣风险：对多达 900 000 人进行的观察性和孟德尔随机研究。

IF 7.1 2区医学

Clinical chemistry Pub Date : 2024-10-30 DOI: 10.1093/clinchem/hvae160

Maria B Nielsen, Marianne Benn, Børge G Nordestgaard, Lone Skov, Yunus Çolak

{"title":"Adiponectin and Risk of Psoriasis: Observational and Mendelian Randomization Studies in up to 900 000 Individuals.","authors":"Maria B Nielsen, Marianne Benn, Børge G Nordestgaard, Lone Skov, Yunus Çolak","doi":"10.1093/clinchem/hvae160","DOIUrl":"https://doi.org/10.1093/clinchem/hvae160","url":null,"abstract":"Background: Psoriasis is a chronic inflammatory skin disorder often associated with obesity. Adiponectin, an anti-inflammatory protein-hormone secreted by adipose tissue, may be a link between obesity and psoriasis. We hypothesized that low plasma adiponectin is associated with an increased risk of psoriasis in observational and causal genetic studies.Methods: In observational analyses, we used information on plasma adiponectin and psoriasis in 30 045 individuals from the Copenhagen General Population Study (CGPS). In one-sample Mendelian randomization analyses, we used genetic information on adiponectin and psoriasis in 107 308 individuals from the CGPS. In two-sample Mendelian randomization analyses, we used genetic information on adiponectin from the ADIPOGen consortium and genetic information on psoriasis in 373 338 and 462 933 individuals from the FinnGen study and UK Biobank (UKB).Results: In observational analyses, a 1-unit log-transformed higher plasma adiponectin was associated with a hazard ratio (HR) for psoriasis of 0.67 (95% confidence interval: 0.48-0.94) in an age- and sex-adjusted model but not in a multivariable adjusted model including obesity measures with a HR of 0.95 (0.66-1.35). In genetic one-sample Mendelian randomization analysis, a 1-unit log-transformed higher plasma adiponectin was not associated with a causal risk ratio for psoriasis of 1.33 (0.77-2.32) in the CGPS. In two-sample Mendelian randomization analyses, a 1-unit log-transformed higher plasma adiponectin was not associated with causal risk ratios for psoriasis of 0.96 (0.81-1.14) in FinnGen and 1.00 (1.00-1.01) in UKB.Conclusions: Low plasma adiponectin is associated with increased risk of psoriasis in age- and sex-adjusted observational analyses; however, this was not the case after adjustment for obesity measures or in causal genetic analyses.","PeriodicalId":10690,"journal":{"name":"Clinical chemistry","volume":" ","pages":""},"PeriodicalIF":7.1,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142544200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Forever Chemicals, Endless Testing? Expert Advice to Be Prepared for Per- and Polyfluoroalkyl Substances. 永恒的化学品，无休止的测试？专家建议为全氟和多氟烷基物质做好准备。

IF 7.1 2区医学

Clinical chemistry Pub Date : 2024-10-29 DOI: 10.1093/clinchem/hvae165

Frederick G Strathmann, Susan Burden, Jenna Hua, Andrew Patterson, Robert Middleberg

引用次数: 0

Rethinking Albuminuria in Low-Risk Patients and a Call for Urine Albumin Standardization. 反思低风险患者的白蛋白尿，呼吁尿白蛋白标准化。

IF 7.1 2区医学

Clinical chemistry Pub Date : 2024-10-28 DOI: 10.1093/clinchem/hvae157

Jesse C Seegmiller, Joachim H Ix

引用次数: 0

Machine Learning-Based Detection of Bladder Cancer by Urine cfDNA Fragmentation Hotspots that Capture Cancer-Associated Molecular Features 通过捕捉癌症相关分子特征的尿液 cfDNA 片段热点进行基于机器学习的膀胱癌检测

IF 9.3 2区医学

Clinical chemistry Pub Date : 2024-10-21 DOI: 10.1093/clinchem/hvae156

Xiang-Yu Meng, Xiong-Hui Zhou, Shuo Li, Ming-Jun Shi, Xuan-Hao Li, Bo-Yu Yang, Min Liu, Ke-Zhen Yi, Yun-Ze Wang, Hong-Yu Zhang, Jian Song, Fu-Bing Wang, Xing-Huan Wang

{"title":"Machine Learning-Based Detection of Bladder Cancer by Urine cfDNA Fragmentation Hotspots that Capture Cancer-Associated Molecular Features","authors":"Xiang-Yu Meng, Xiong-Hui Zhou, Shuo Li, Ming-Jun Shi, Xuan-Hao Li, Bo-Yu Yang, Min Liu, Ke-Zhen Yi, Yun-Ze Wang, Hong-Yu Zhang, Jian Song, Fu-Bing Wang, Xing-Huan Wang","doi":"10.1093/clinchem/hvae156","DOIUrl":"https://doi.org/10.1093/clinchem/hvae156","url":null,"abstract":"Background cfDNA fragmentomics-based liquid biopsy is a potential option for noninvasive bladder cancer (BLCA) detection that remains an unmet clinical need. Methods We assessed the diagnostic performance of cfDNA hotspot-driven machine-learning models in a cohort of 55 BLCA patients, 51 subjects with benign conditions, and 11 healthy volunteers. We further performed functional bioinformatics analysis for biological understanding and interpretation of the tool’s diagnostic capability. Results Urinary cfDNA hotspots-based machine-learning model enabled effective BLCA detection, achieving high performance (area under curve 0.96) and an 87% sensitivity at 100% specificity. It outperformed models using other cfDNA-derived features. In stage-stratified analysis, the sensitivity at 100% specificity of the urine hotspots-based model was 71% and 92% for early (low-grade Ta and T1) and advanced (high-grade T1 and muscle-invasive) disease, respectively. Biologically, cfDNA hotspots effectively retrieved regulatory elements and were correlated with the cell of origin. Urine cfDNA hotspots specifically captured BLCA-related molecular features, including key functional pathways, chromosome loci associated with BLCA risk as identified in genome-wide association studies, or presenting frequent somatic alterations in BLCA tumors, and the transcription factor regulatory landscape. Conclusions Our findings support the applicability of urine cfDNA fragmentation hotspots for noninvasive BLCA diagnosis, as well as for future translational study regarding its molecular pathology and heterogeneity.","PeriodicalId":10690,"journal":{"name":"Clinical chemistry","volume":"20 1","pages":""},"PeriodicalIF":9.3,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142452175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to: Ready, Set, Screen: The Role of the Clinical Laboratory in Eliminating Chronic Hepatitis B Infection. 更正为准备，开始，筛查：临床实验室在消除慢性乙型肝炎感染中的作用》。

IF 9.3 2区医学

Clinical chemistry Pub Date : 2024-10-17 DOI: 10.1093/clinchem/hvae169

引用次数: 0

Mass Spectrometry Meets Free Light Chains: A Path toward Greater Diagnostic Precision. 质谱法与自由光链：实现更高精度诊断的途径。

IF 9.3 2区医学

Clinical chemistry Pub Date : 2024-10-17 DOI: 10.1093/clinchem/hvae155

Maria Alice Vieira Willrich

引用次数: 0

Proteomic Signature of BMI and Risk of Cardiovascular Disease. 体重指数与心血管疾病风险的蛋白质组特征。

IF 7.1 2区医学

Clinical chemistry Pub Date : 2024-10-11 DOI: 10.1093/clinchem/hvae149

Hao Ma, Xuan Wang, Yoriko Heianza, JoAnn E Manson, Lu Qi

{"title":"Proteomic Signature of BMI and Risk of Cardiovascular Disease.","authors":"Hao Ma, Xuan Wang, Yoriko Heianza, JoAnn E Manson, Lu Qi","doi":"10.1093/clinchem/hvae149","DOIUrl":"https://doi.org/10.1093/clinchem/hvae149","url":null,"abstract":"Background: Obesity, defined by body mass index (BMI) alone, is a metabolically heterogeneous disorder with distinct cardiovascular manifestations across individuals. This study aimed to investigate the associations of a proteomic signature of BMI with risk of major subtypes of cardiovascular disease (CVD).Methods: A total of 40 089 participants from UK Biobank, free of CVD at baseline, had complete data on proteomic data measured by the Olink assay. A BMI-proteomic score (pro-BMI score) was calculated from 67 pre-identified plasma proteins associated with BMI.Results: A higher pro-BMI score was significantly associated with higher risks of ischemic heart disease (IHD) and heart failure (HF), but not with risk of stroke. Comparing the highest with the lowest quartiles, the adjusted hazard ratio (HR) for IHD was 1.49 (95% CI, 1.32-1.67) (P-trend < 0.001), and the adjusted HR for HF was 1.52 (95% CI, 1.25-1.85) (P-trend < 0.001). Further analyses showed that the association of pro-BMI score with HF risk was largely driven by the actual BMI, whereas the association of the pro-BMI score with IHD risk was independent of actual BMI and waist-to-hip ratio (WHR). The association between pro-BMI score and IHD risk appeared to be stronger in the normal BMI group than other BMI groups (P-interaction = 0.004) and stronger in the normal WHR group than the high WHR group (P-interaction = 0.049).Conclusions: Higher pro-BMI score is significantly associated with higher IHD risk, independent of actual BMI levels. Our findings suggest that plasma proteins hold promise as complementary markers for diagnosing obesity and may facilitate personalized interventions.","PeriodicalId":10690,"journal":{"name":"Clinical chemistry","volume":" ","pages":""},"PeriodicalIF":7.1,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142399651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clonality Determination by Detecting Unmodified Monoclonal Serum Free Light Chains Using On-Probe Extraction Coupled with Liquid Chromatography-High-Resolution Mass Spectrometry. 利用探针萃取与液相色谱-高分辨质谱联用技术检测未修饰的单克隆血清游离光链以确定克隆性

IF 7.1 2区医学

Clinical chemistry Pub Date : 2024-10-08 DOI: 10.1093/clinchem/hvae130

Priscilla S W Yeung, Yajing Liu, Samuel Yang, Ashley Ruan, Christina R Kerr, Carolyn V Wong, Run-Zhang Shi, David J Iberri, Ruben Y Luo

{"title":"Clonality Determination by Detecting Unmodified Monoclonal Serum Free Light Chains Using On-Probe Extraction Coupled with Liquid Chromatography-High-Resolution Mass Spectrometry.","authors":"Priscilla S W Yeung, Yajing Liu, Samuel Yang, Ashley Ruan, Christina R Kerr, Carolyn V Wong, Run-Zhang Shi, David J Iberri, Ruben Y Luo","doi":"10.1093/clinchem/hvae130","DOIUrl":"10.1093/clinchem/hvae130","url":null,"abstract":"Background: Serum free light chains (FLCs) are an essential clinical biomarker for the diagnosis and monitoring of patients with plasma cell neoplasms. The current widely used immunoassay methods quantify total serum FLCs, which include monoclonal FLCs as well as FLCs in the polyclonal background. Patients with chronic diseases, inflammatory disorders, or renal dysfunction can have elevated total FLCs that lead to ambiguous results. These patients may benefit from a direct measurement of monoclonal FLCs. The purpose of this study was to develop a method that couples on-probe extraction (OPEX) with liquid chromatography-high-resolution mass spectrometry (LC-HR-MS), abbreviated to OPEX-MS, to directly determine the clonality of FLCs.Methods: OPEX immunocapture was performed using microprobes loaded with anti-kappa or anti-lambda light chain antibodies. Captured proteins were separated by reversed-phase LC and analyzed by HR-MS.Results: Four cohorts of samples from unique patients were tested based on immunoassay FLC results. The LC-HR-MS analysis in the OPEX-MS method provides both a unique retention time along with deconvoluted masses of FLC monomers and dimers for each clone. The study found that 16 out of 49 (33%) kappa FLC elevated samples as well as 83 out of 100 (83%) dual kappa and lambda FLC elevated samples did not have monoclonal FLCs, which is consistent with the knowledge that there is often no clonal population in samples with mildly elevated FLC immunoassay results.Conclusions: The OPEX-MS method can serve as a complementary approach to directly determine clonality in patients with difficult-to-interpret FLC immunoassay results.","PeriodicalId":10690,"journal":{"name":"Clinical chemistry","volume":" ","pages":""},"PeriodicalIF":7.1,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142388717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0