Clinical chemistry最新文献

Inter-Instrument Imprecision Complements Bias in Evaluating LDL-C Method Performance. 仪器间的不精确性补充了评估LDL-C方法性能的偏差。

IF 6.3 2区医学

Clinical chemistry Pub Date : 2026-05-07 DOI: 10.1093/clinchem/hvag042

Kimberly S Huggler, Isaiah K Mensah, Andres D Dajles, Stephen M Roper, Christopher W Farnsworth

引用次数: 0

In Reply to Inter-Instrument Imprecision Complements Bias in Evaluating LDL-C Method Performance. 在评估LDL-C方法性能时，对仪器间不精确补充偏差的答复。

IF 6.3 2区医学

Clinical chemistry Pub Date : 2026-05-07 DOI: 10.1093/clinchem/hvag043

Xin Yi, Bibek Poudel, Alan T Remaley, Jing Cao

引用次数: 0

Commentary on Bullwinkle's Revenge: From Moose Roast to Nocturnal Urticaria. 《波波鹿的复仇：从驼鹿烤肉到夜间荨麻疹》书评。

IF 6.3 2区医学

Clinical chemistry Pub Date : 2026-05-05 DOI: 10.1093/clinchem/hvaf188

Lokinendi V Rao

引用次数: 0

All for One and One for All? The Role of RNA-Based Next-Generation Sequencing in the Molecular Profiling of Tumors. 人人为我，我为人人？基于rna的新一代测序在肿瘤分子图谱中的作用。

IF 6.3 2区医学

Clinical chemistry Pub Date : 2026-05-05 DOI: 10.1093/clinchem/hvag009

Amy Guimaraes-Young, Kurtis D Davies, Dara L Aisner

引用次数: 0

Bullwinkle's Revenge: From Moose Roast to Nocturnal Urticaria. Bullwinkle的复仇：从驼鹿烤肉到夜间荨麻疹。

IF 6.3 2区医学

Clinical chemistry Pub Date : 2026-05-05 DOI: 10.1093/clinchem/hvaf183

Mark A Cervinski, K Aaron Geno, Karen S Hsu Blatman

引用次数: 0

Correction to: Impact of Clinical Variables on cfDNA Fragmentomic Signatures and Their Potential as Confounders in Cancer Detection. 修正：临床变量对cfDNA片段组学特征的影响及其作为癌症检测混杂因素的潜力。

IF 6.3 2区医学

Clinical chemistry Pub Date : 2026-05-05 DOI: 10.1093/clinchem/hvaf185

引用次数: 0

Frameworks of Health Outcomes for Performance Specifications in Laboratory Medicine. 检验医学性能规范的健康结果框架。

IF 6.3 2区医学

Clinical chemistry Pub Date : 2026-05-05 DOI: 10.1093/clinchem/hvag014

Patrick M Bossuyt, Tze Ping Loh, Katy Bell, Sally Lord, Andrea R Horvath

{"title":"Frameworks of Health Outcomes for Performance Specifications in Laboratory Medicine.","authors":"Patrick M Bossuyt, Tze Ping Loh, Katy Bell, Sally Lord, Andrea R Horvath","doi":"10.1093/clinchem/hvag014","DOIUrl":"10.1093/clinchem/hvag014","url":null,"abstract":"Background: Clinical laboratory measurements provide essential results for prediction, screening, diagnosing, treating, monitoring, and prognosis of patients. To ensure patient safety, laboratory professionals must define appropriate analytical requirements for each measurand, including measurement uncertainty, selectivity, traceability, and robustness. Performance specifications should ensure that laboratory measurement results provide valuable information to support medical decisions, which then lead to improved patient outcomes.Content: To facilitate discussions and studies of performance specifications based on outcomes, here we review generic frameworks for health outcomes in healthcare evaluations. Seven frameworks are presented in chronological order, starting from the World Health Organization definition of health. Most frameworks distinguish between physical, mental, and social health and emphasize functional health: a person's ability to conduct the physical, mental, and social activities that are necessary or meaningful in daily life, given their health conditions and context. We then explore the links between laboratory testing and these health outcomes. These are indirect: in most cases testing affects health outcomes through downstream clinical actions, guided by test results.Summary: Most frameworks of outcomes in healthcare evaluations distinguish between physical, mental, and social health. Because of the indirect link between testing and outcomes, developing recommendations based on effects on outcomes is challenging. Nevertheless, explicitly specifying the respective pathways from testing to potential health outcomes through downstream actions will provide the necessary context for such discussions.","PeriodicalId":10690,"journal":{"name":"Clinical chemistry","volume":" ","pages":"546-553"},"PeriodicalIF":6.3,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147303156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Plasmids for the Modern Microbe. 现代微生物的质粒。

IF 6.3 2区医学

Clinical chemistry Pub Date : 2026-05-05 DOI: 10.1093/clinchem/hvag016

Nicole A Loeven, K Aaron Geno

引用次数: 0

Commentary on Bullwinkle's Revenge: From Moose Roast to Nocturnal Urticaria. 《波波鹿的复仇：从驼鹿烤肉到夜间荨麻疹》书评。

IF 6.3 2区医学

Clinical chemistry Pub Date : 2026-05-05 DOI: 10.1093/clinchem/hvag027

Joshua Bornhorst

引用次数: 0

Correction to: Discordance between Cystatin C-Based and Creatinine-Based Estimated Glomerular Filtration Rate and Mortality in the General Population. 修正：在普通人群中基于胱抑素c和基于肌酐的肾小球滤过率和死亡率估计不一致。