Clinical chemistry最新文献

Improved 1H Nuclear Magnetic Resonance Spectroscopy Quantification of Plasma Creatinine.

IF 7.1 2区医学

Clinical chemistry Pub Date : 2025-02-10 DOI: 10.1093/clinchem/hvaf005

Karen Friederike Gauß, Nele Friedrich, Ann-Kristin Henning, Marc Fenzlaff, Stephanie Könemann, Daniel Rosenkranz, Astrid Petersmann, Matthias Nauck

引用次数: 0

The Slow Progress in Developing Better Long-Term Cardiovascular Risk Assessment in Women Continues.

IF 7.1 2区医学

Clinical chemistry Pub Date : 2025-02-10 DOI: 10.1093/clinchem/hvaf003

Leslie J Donato, Kyla M Lara-Breitinger, Allan S Jaffe

引用次数: 0

Laboratory Monitoring in Transgender and Gender-Diverse Individuals.

IF 7.1 2区医学

Clinical chemistry Pub Date : 2025-02-10 DOI: 10.1093/clinchem/hvaf001

Brendan J Nolan, Ada S Cheung

{"title":"Laboratory Monitoring in Transgender and Gender-Diverse Individuals.","authors":"Brendan J Nolan, Ada S Cheung","doi":"10.1093/clinchem/hvaf001","DOIUrl":"https://doi.org/10.1093/clinchem/hvaf001","url":null,"abstract":"Background: Increasing numbers of transgender and gender-diverse individuals are seeking initiation of gender-affirming hormone therapy. This aligns an individual's physical characteristics with their gender identity and improves psychological outcomes. Physical changes, including changes to muscle mass and body fat redistribution, can alter sex-specific laboratory reference ranges.Content: We review the impact of gender-affirming hormone therapy on laboratory parameters with sex-specific reference ranges, with a focus on hemoglobin/hematocrit, renal function, cardiac biomarkers, and prostate-specific antigen.Summary: Gender-affirming hormone therapy results in changes in laboratory parameters with sex-specific reference ranges. For individuals established on gender-affirming hormone therapy, reference ranges that align with an individual's gender identity should be used for hemoglobin/hematocrit, serum creatinine, and high-sensitivity cardiac troponin and N-terminal brain natriuretic peptide. Clinicians should interpret these biomarkers according to the reference range that aligns with one's affirmed gender.","PeriodicalId":10690,"journal":{"name":"Clinical chemistry","volume":" ","pages":""},"PeriodicalIF":7.1,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardiac Biomarkers and Malnutrition Incidence in Community-Dwelling Older Adults without Cardiovascular Disease: The Seniors-ENRICA-2 Cohort.

IF 7.1 2区医学

Clinical chemistry Pub Date : 2025-02-07 DOI: 10.1093/clinchem/hvae221

Blanca Fabre-Estremera, Antonio Buño-Soto, Mercedes Sotos-Prieto, Adrián Carballo-Casla, Samara Palma Milla, Fernando Rodríguez-Artalejo, Rosario Ortolá

{"title":"Cardiac Biomarkers and Malnutrition Incidence in Community-Dwelling Older Adults without Cardiovascular Disease: The Seniors-ENRICA-2 Cohort.","authors":"Blanca Fabre-Estremera, Antonio Buño-Soto, Mercedes Sotos-Prieto, Adrián Carballo-Casla, Samara Palma Milla, Fernando Rodríguez-Artalejo, Rosario Ortolá","doi":"10.1093/clinchem/hvae221","DOIUrl":"https://doi.org/10.1093/clinchem/hvae221","url":null,"abstract":"Background: Given the close relationship between cardiovascular disease (CVD) and malnutrition, we examined whether higher concentrations of high-sensitivity cardiac troponin T (hs-cTnT) and N-terminal pro-brain natriuretic peptide (NT-proBNP), which indicate CVD risk in the general population, were prospectively associated with malnutrition incidence in community-dwelling older adults without CVD.Methods: We used data from 1490 individuals ≥65 years from the Seniors-ENRICA-2 cohort followed up for 2.2 years. Malnutrition was evaluated by the screening Mini Nutritional Assessment-Short Form (MNA-SF) score, which consists of a short questionnaire, and a complete nutritional assessment according to the Global Leadership Initiative on Malnutrition (GLIM) criteria. Associations were summarized with odds ratios (OR) and their 95% confidence interval (CI), obtained from logistic regression and adjusted for the main confounders.Results: NT-proBNP was associated with higher malnutrition incidence assessed by the MNA-SF score and the GLIM criteria, with OR (95% CI) of 1.51 (1.09-2.09) and 1.43 (1.04-1.96) per one logarithmic-unit increment, respectively. Malnutrition incidence according to the GLIM criteria was also higher in participants who had elevated NT-proBNP (heart stress age-specific rule-in cutoffs) vs those who did not, with OR (95% CI) of 1.84 (1.05-3.22). hs-cTnT was not associated with higher malnutrition incidence.Conclusions: In this cohort of older adults without CVD, NT-proBNP was associated with higher malnutrition incidence. Further research is needed to validate our findings, uncover the underlying biological mechanisms, and assess whether preventive interventions can reduce NT-proBNP concentrations and, consequently, reduce the risk of malnutrition.","PeriodicalId":10690,"journal":{"name":"Clinical chemistry","volume":" ","pages":""},"PeriodicalIF":7.1,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143364155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glomerular Filtration Rate (GFR) Estimation with Cystatin C—Past, Present, and Future

IF 9.3 2区医学

Clinical chemistry Pub Date : 2025-02-04 DOI: 10.1093/clinchem/hvae226

Amy B Karger, Michael G Shlipak

{"title":"Glomerular Filtration Rate (GFR) Estimation with Cystatin C—Past, Present, and Future","authors":"Amy B Karger, Michael G Shlipak","doi":"10.1093/clinchem/hvae226","DOIUrl":"https://doi.org/10.1093/clinchem/hvae226","url":null,"abstract":"Background Cystatin C is a long-established filtration marker which can be used to assess kidney function, but it has been sparingly used for clinical care due to creatinine’s role as the primary biomarker for kidney function assessment based on estimated glomerular filtration rate (eGFR). Content This review summarizes the evolution of cystatin C’s role in kidney disease assessment and highlights new guidelines promoting more widespread use. Specifically, the 2021 National Kidney Foundation and American Society of Nephrology Task Force on Reassessing the Inclusion of Race in Diagnosing Kidney Disease report, and the 2024 Kidney Disease Improving Global Outcomes (KDIGO) Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease (CKD), recommend increased use of cystatin C as an alternative and complementary biomarker for kidney function assessment, since it does not differ by race like creatinine, correlates better with adverse outcomes compared to creatinine, and provides a more accurate eGFR when used in combination with creatinine. Summary While robust literature demonstrates improved accuracy with cystatin C-based eGFR (eGFRcys) in certain clinical subpopulations, future research is needed to better understand its performance relative to creatinine-based eGFR (eGFRcr) and measured glomerular filtration rate (mGFR) in additional diverse cohorts, and to achieve assay standardization to match the performance of creatinine assays. Additionally, cystatin C testing availability will need to be broadened from primarily reference laboratories to local laboratories, and partnerships will need to be developed between clinical stakeholders and the laboratory to promote cystatin C’s clinical use, to achieve widespread adoption of guideline-recommended eGFR equations.","PeriodicalId":10690,"journal":{"name":"Clinical chemistry","volume":"39 1","pages":""},"PeriodicalIF":9.3,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143125104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Commentary on An Unexpectedly High IgE Level during Allergic Exploration.

IF 7.1 2区医学

Clinical chemistry Pub Date : 2025-02-03 DOI: 10.1093/clinchem/hvae175

Louis Nevejan, Xavier Bossuyt

引用次数: 0

Commentary on Hiding in Plain Sight: Protein Electrophoresis Profile Inconsistent with Patient's Diagnosis.

IF 7.1 2区医学

Clinical chemistry Pub Date : 2025-02-03 DOI: 10.1093/clinchem/hvae162

Melissa R Snyder

引用次数: 0

An Unexpectedly High IgE Level during Allergic Exploration.