J. Brooks, Mateus Reghin Neto, Guilherme L. Silveira, R. A. Oliveira, E. A. G. Nogueira, M. V. D. Queiroz, V. Souza, C. L. S. Oliveira, J. Harding, F. Prosdocimi
{"title":"Spontaneous Intracranial Dural Arteriovenous Fistula in the Differential Diagnosis of Pulsatile Tinnitus","authors":"J. Brooks, Mateus Reghin Neto, Guilherme L. Silveira, R. A. Oliveira, E. A. G. Nogueira, M. V. D. Queiroz, V. Souza, C. L. S. Oliveira, J. Harding, F. Prosdocimi","doi":"10.15406/jnsk.2018.08.00280","DOIUrl":"https://doi.org/10.15406/jnsk.2018.08.00280","url":null,"abstract":"Submit Manuscript | http://medcraveonline.com carotid system. The venous drainage was precocious and towards the left transverse and sigmoid sinus into the internal jugular vein and suboccipital plexus in the same topography. The congenital abnormalities in the vascular anatomy of the cerebral arteriovenous transition are the main etiological cause imputed in this case. The patient underwent endovascular treatment with selective arterial embolization with occlusion of the fistulous path and satisfactory results. Conclusion","PeriodicalId":106839,"journal":{"name":"Journal of Neurology and Stroke","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128335006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Ibrahim, M. S. Magzoub, S. F. Abdalla, H. S. Mohamed, M. Ibrahim
{"title":"The Methylene Tetrahydrofolate Reductase Gene VariantC677T is not Associated with Migraine in Twelve Sudanese Pedigrees with Migraine","authors":"S. Ibrahim, M. S. Magzoub, S. F. Abdalla, H. S. Mohamed, M. Ibrahim","doi":"10.15406/JNSK.2018.ISSUE.00279","DOIUrl":"https://doi.org/10.15406/JNSK.2018.ISSUE.00279","url":null,"abstract":"No definitive pathophysiology exists for migraine yet, nevertheless, many theories were postulated with the most ancient one being the vascular theory which was developed by H. Wolff during the 1940s [1]. According to Lauritzen, Wolff described migraine as a vasospastic disorder that is initiated by vasoconstriction in the cranial vasculature. The vasoconstriction is then followed by dilatation of intracranial or extracranial blood vessels. Dilation of the richly innervated meningeal blood vessels activates the trigeminal sensory nerves that surround these blood vessels, initiating pain. The activated trigeminal nerves release vasoactive neuropeptides that further contribute to dilation and worsening of the pain [2].","PeriodicalId":106839,"journal":{"name":"Journal of Neurology and Stroke","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117078770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Vertebrobasilar Vasospasm after Aneurysmal Subarachnoid Hemorrhage: Review","authors":"G. Britz, G. Sviri","doi":"10.15406/jnsk.2018.08.00278","DOIUrl":"https://doi.org/10.15406/jnsk.2018.08.00278","url":null,"abstract":"Aneurysmal subarachnoid hemorrhage (SAH) affects 5-10 per 100,000 individuals per year1 and is associated with high rates of morbidity and mortality [1-4]. Main contributor to poor outcomes after SAH are the early cerebral injury (ECI) caused by the immediate increase in intracranial pressure, decreased cerebral perfusion pressure and global ischemia [1,5-9] and delayed cerebral ischemia (DCI) which affects 30% of the SAH survivors leading to neurological deficit, cognitive decline [4,6,913], and death [14]. This ischemia is historically though to results from a long-lasting narrowing of the large-capacity cerebral arteries. Kassell et al. [15] published statistics that roughly hold to this day, whereby 40-70% of aSAH patients having survived the acute phase demonstrated angiographic VS, 20-30% manifested delayed neurologic deficits (DID), and 7% having died as a consequence there of. Another seminal study by Broderick et al. [16] have discerned a mortality rate of 45%, attributed 2 of 36 (6%) total deaths to VS, even though 44% of all patients manifested DCI. In 1994, Dorsch & King [17] published a review based on over 30,000 clinical cases that established an incidence of angiographic vasospasm at 43.3% overall and DID occurring at a rate of 32.5%. Of those who experienced DID, 34% sustained permanent neurological deficits and 30% died, such that VS was considered the cause of death in roughly 10% of aSAH patients.","PeriodicalId":106839,"journal":{"name":"Journal of Neurology and Stroke","volume":"64 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116031085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Microsurgical Resection Versus Stereotactic Guided Ommaya Reservoir Drainage of Cystic Craniopharyngioma","authors":"M. Mansour, Samer Serag","doi":"10.15406/jnsk.2018.08.00277","DOIUrl":"https://doi.org/10.15406/jnsk.2018.08.00277","url":null,"abstract":"These tumors are located close to the visual apparatus, hypothalamus, pituitary stalk, 3rd ventricle, and vasculature from the circle of Willis. The proximity of the tumor and its adherence to these critical structures makes complete microsurgical removal without neurological deterioration difficult [2]. Craniopharyngioma is often associated with cystic components [3]. Although these tumors are histologically benign, recurrence rates up to 57% have been reported even after surgical gross total resections, due to their invasiveness [4].","PeriodicalId":106839,"journal":{"name":"Journal of Neurology and Stroke","volume":"96 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124725241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
E. Klimov, K. Skorobogatykh, O. Rudko, Elena A Naumova, N. Kondratieva, J. Azimova, A. Sergeev, Z. Kokaeva, G. Tabeeva
{"title":"The Influence of Dopamine Beta-Hydroxylase Gene Polymorphism C.-979T>C (Rs1611115) on the Clinical Manifestations of Migraine","authors":"E. Klimov, K. Skorobogatykh, O. Rudko, Elena A Naumova, N. Kondratieva, J. Azimova, A. Sergeev, Z. Kokaeva, G. Tabeeva","doi":"10.15406/JNSK.2018.08.00276","DOIUrl":"https://doi.org/10.15406/JNSK.2018.08.00276","url":null,"abstract":"Submit Manuscript | http://medcraveonline.com the development of various forms of familial hemiplegic migraine have been identified [2]. A number of others studies have been conducted to better define genetic predisposition to dopamine metabolism disorders. The first study in this field was published in 1997, revealing the DRD2 (D2 dopamine receptor) gene polymorphism, which was found to be significantly more common in patients suffering from migraine with aura [3]. Subsequent studies broadened the scope of searching for potential research targets. All five receptor types were examined, and the next series of experiments failed to confirm changes in the D2DR gene; conflicting data were obtained on the D4 receptor. A study conducted by Todt in 2009 demonstrated that certain alleles of the gene encoding the dopamine transporter SLC6A3 were reliably associated with migraine with aura [4]. This transporter is responsible for reuptake of dopamine from the synaptic cleft, thus acting as a key regulator of dopaminergic activity. Most completed genetic studies have confirmed the role of polymorphism of the gene encoding the enzyme dopamine beta-hydroxylase (DBH), which stimulates the conversion of dopamine to norepinephrine [5-8].","PeriodicalId":106839,"journal":{"name":"Journal of Neurology and Stroke","volume":"45 5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125831773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Muhammad Ishaq Khan, J. I. Khan, S. Ahmed, U. U. Haq
{"title":"The Epidemiology of Stroke in a Developing Country (Pakistan)","authors":"Muhammad Ishaq Khan, J. I. Khan, S. Ahmed, U. U. Haq","doi":"10.15406/jnsk.2018.08.00275","DOIUrl":"https://doi.org/10.15406/jnsk.2018.08.00275","url":null,"abstract":"A brain stroke is the main cause of neurological morbidity and mortality. In a developing country such as Pakistan, the socioeconomic burden of stroke is tremendous due to insufficient funds availability and inefficient health care providing staff. Further that, to cope with this grave problem, still a complete epidemiological data is not available. In order to address this problem, extensive research work has been undertaken to find out the prevalence of risk factors and their interplay in rural populations. A detailed study of literature has also been undertaken to rationalize stroke incidence in Pakistan with developed countries. As of Today, hypertension has been labeled as the most important cause of stroke having a relatively higher incidence in urban than rural populations. As from research, Germany has a higher stroke incidence that Pakistan.]","PeriodicalId":106839,"journal":{"name":"Journal of Neurology and Stroke","volume":"598 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131573168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Infliximab Induced Leukoencephalopathy and Peripheral Neuropathy: A Case Report and a Review of Literature","authors":"H. Isa, Maryam Ashoor, A. Ali, H. Mohamed","doi":"10.15406/JNSK.2018.08.00274","DOIUrl":"https://doi.org/10.15406/JNSK.2018.08.00274","url":null,"abstract":"Inflammatory bowel disease (IBD) is an idiopathic, chronic condition in which tumor necrosis factor alpha (TNF-α) is thought to play a role [1]. Infliximab (IFX) is a chimeric anti-tumor necrosis factor monoclonal antibody that has a potent anti-inflammatory effect [2]. IFX is currently used as a treatment for severe active cases of IBD in both Crohn’s disease (CD) and ulcerative colitis (UC) that are unresponsive to conventional therapy [2]. The most common side effects of IFX are the increased risks of developing severe infections, hypersensitivity reactions and malignancies.3 Rare cases of neurological complications secondary to IFX use have been reported including Guillain-Barre syndrome, chronic inflammatory demyelinating poly-radiculo-neuropathy and neuropathy [3]. Here, we describe a rare case of demyelinating leukoencephalopathy in a patient with UC managed with IFX.","PeriodicalId":106839,"journal":{"name":"Journal of Neurology and Stroke","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115334851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Clinical Neurology: Patients’ Laterality Audit","authors":"R. S. Siddiqui, Khurram A Siddiqui, D. Nicholl","doi":"10.15406/JNSK.2018.08.00273","DOIUrl":"https://doi.org/10.15406/JNSK.2018.08.00273","url":null,"abstract":"Most people tend to have left hemispheric dominance for speech [1], as the left side of the brain controls the right side of the body supported by the overall higher proportion of right handers to left handers [2]. However studies have shown that some left handed neurologic patients may have bilateral hemispheric control or solely right hemispheric control of speech [3]. Hence, due to the relationship between handedness and language lateralization [1], it is essential doctors ask neurologic patients of their handedness in order to predict which side of the brain is more likely dominant for speech. We also observed whether patient’s were asked if they were forced to become right handed or was it natural, as some studies show that the proportion of left handers may be less due to forced dexterity [4,5]. Some studies have also shown that footedness might actually be preferred over handedness in determining lateralization especially in left handed people [6]. This audit was carried out in order to test a potential shortfall of inquiring patients’ laterality during neurology consults. It was developed in order to find out the proportion of doctors asking patients of their laterality i.e. handedness and/or footedness i.e. right or left.","PeriodicalId":106839,"journal":{"name":"Journal of Neurology and Stroke","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130778425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Commentary: A Huge Ependymoma of the Cervical Spinal Cord with Subtle Atypical Manifestations and Hyperhidrosis","authors":"Kaveh Haddadi","doi":"10.15406/JNSK.2018.08.00272","DOIUrl":"https://doi.org/10.15406/JNSK.2018.08.00272","url":null,"abstract":"Submit Manuscript | http://medcraveonline.com The most public initial symptom in patients with cervical spine tumors is neck pain. The pain might start progressively and develop more prominent over a prolonged period of time. Patients may also have shoulder, arm, or leg pain as the tumor mass extends beyond the confines of the bone or spinal canal to involve the spinal cord or nerve roots. As the tumor remains to grow, numbness, tingling, in the arms or legs might be observed. Through additional growth, weakness in the arms or legs can progress, as well as a reduced capability to normal walk. There can even be with bladder and bowel function problems.","PeriodicalId":106839,"journal":{"name":"Journal of Neurology and Stroke","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127905953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Which is Superior in Diagnosing Focal Brain Lesions: CT, MRI, MRS or Histopathology?","authors":"M. Mansour","doi":"10.15406/JNSK.2018.08.00271","DOIUrl":"https://doi.org/10.15406/JNSK.2018.08.00271","url":null,"abstract":"Diagnosis is the key for treatment plan. Some fundamental tasks for accurate diagnosis include: (1) Anatomic localization of the lesion and its relation to surrounding structures which could be determined by CT and /or MRI brain. (2) Evaluation of the activity of this lesion (hyperactive, normal, or silent) by magnetic resonance spectroscopy (MRS). (3) Determining cell of origin of the lesion through tissue sampling which is the gold standard for diagnosing the type of cellular elements of the lesions but taking in consideration that partial excision of tumor tissue may change the behavior of the tumor. Other fundamental tasks like the clinical condition either local or general cannot be neglected. When a patient comes for the evaluation of a focal brain lesion, it is often difficult to differentiate between tumoral and non-tumoral brain lesions and frequently creates a dilemma for physicians and surgeons for further management. The current gold standard characterization of a brain tumor is by histopathological analysis [1].","PeriodicalId":106839,"journal":{"name":"Journal of Neurology and Stroke","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125301605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}