Journal of Neurology and Stroke最新文献_第3页

Childhood arterial ischemic stroke in Egypt 埃及儿童动脉缺血性中风

Journal of Neurology and Stroke Pub Date : 2018-03-23 DOI: 10.15406/jnsk.2018.08.00290

Nabil Kitchener, Magdy Khalaf, Gamal Khairalla, Mohammed Helmy

{"title":"Childhood arterial ischemic stroke in Egypt","authors":"Nabil Kitchener, Magdy Khalaf, Gamal Khairalla, Mohammed Helmy","doi":"10.15406/jnsk.2018.08.00290","DOIUrl":"https://doi.org/10.15406/jnsk.2018.08.00290","url":null,"abstract":"Arterial ischemic stroke (AIS) in neonates and children is a major cause of significant morbidity and mortality.1–4 Although considered rare, estimates place the incidence of AIS at 2.7 per 100 000 children, which is comparable to the incidence of brain tumors in children.5 Unlike brain tumors however, there is no comprehensive, multi-institutional approach to understand the pathophysiology and improve the management of childhood AIS. Our understanding of the epidemiology of childhood AIS in Egypt is limited. Judging by the largest cohort of childhood stroke available, the majority of children with AIS presented in association with a recognized risk factor.6 However, over one third of cases occur in otherwise well children.6 Recent interests have focused on thrombophilia as a cause of AIS in these children.7 Thrombophilic states may lead to a reduced threshold for pathological thrombus formation in cerebral vessels presenting with AIS in children.8 An association between thrombophilia and AIS may warrant development of primary and secondary thromboprophylactic strategies as prevention of childhood AIS. To gain a greater understanding of epidemiology, risk factors including thrombophilic abnormalities, and outcome of childhood AIS in Egypt, we reviewed all cases of AIS admitted to the EL Mataryia Teaching Hospital, Cairo, Egypt 2004–2008.","PeriodicalId":106839,"journal":{"name":"Journal of Neurology and Stroke","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116847620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mitochondria morphopathological changes in human congenital hydrocephalus, Arnold-Chiari malformation and postmeningitis hydrocephalus. An electron microscopic study 人先天性脑积水、Arnold-Chiari畸形和脑膜炎后脑积水的线粒体形态病理改变。电子显微镜研究

Journal of Neurology and Stroke Pub Date : 2018-03-22 DOI: 10.15406/JNSK.2018.08.00289

Orl, O. Castejón

{"title":"Mitochondria morphopathological changes in human congenital hydrocephalus, Arnold-Chiari malformation and postmeningitis hydrocephalus. An electron microscopic study","authors":"Orl, O. Castejón","doi":"10.15406/JNSK.2018.08.00289","DOIUrl":"https://doi.org/10.15406/JNSK.2018.08.00289","url":null,"abstract":"Vuia1 reported two twin brothers diagnosed with congenital spongy degeneration of the brain featured by accumulation of lamellar bodies within the mitochondria, and free in the cellular cytoplasm with tendency to form inclusions of the multilamellar or finger-print type. Watanabe2 described in a 51/2-year-old boy with congenital myopathy associated with communicating hydrocephalus myofibrillar disorganization and Z-band streaming with decrease or absence of mitochondria. These Authors considered that common pathogenetic mechanism may have been involved in the development of both the myopathy and the hydrocephalus. Kaur and Ling3 found swelling and disintegration of mitochondria in ricin-induced hydrocephalus in postnatal rats. Madhavi and Jacob4 carried out a morphometry study of mitochondria in the choroidal ependyma of hydrocephalic guinea pigs, and observed that the inner membrane of the mitochondria including cristae exhibited a significant decrease in the hydrocephalic animals. According to these Authors, this reduction in the surface area could probably be attributed to the reduced activity of choroid ependymal cells in obstructive hydrocephalus. Castejón5 distinguished variable degrees of mitochondrial swelling in human hydrocephalic cerebral cortex. Boillat et al.6 described distorted mitocondria in the deep cortical pyramidal cells of infant rats with inherited hydrocephalus. Castejón et al.7 examined in details the pathological changes of mitochondria in the edematous human cerebral cortex associated to severe and complicated brain trauma, tumors, and in a preliminary way the human hydrocephalus.","PeriodicalId":106839,"journal":{"name":"Journal of Neurology and Stroke","volume":"155 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116965617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Critical revision of the role of surgery for treatment of primary brain b cell lymphoma in an immunocompetent patient: a case report and literature review 对免疫功能正常患者原发性脑b细胞淋巴瘤手术治疗作用的关键性修订:一个病例报告和文献复习

Journal of Neurology and Stroke Pub Date : 2018-03-21 DOI: 10.15406/jnsk.2018.08.00288

Rizzi Gaetano, Berardi Arturo, B. Vincenzo, D. Pasquale, Rauseo Michela, Merlicco Gaetano

{"title":"Critical revision of the role of surgery for treatment of primary brain b cell lymphoma in an immunocompetent patient: a case report and literature review","authors":"Rizzi Gaetano, Berardi Arturo, B. Vincenzo, D. Pasquale, Rauseo Michela, Merlicco Gaetano","doi":"10.15406/jnsk.2018.08.00288","DOIUrl":"https://doi.org/10.15406/jnsk.2018.08.00288","url":null,"abstract":"Primary Central Nervous System Lymphoma (PCNSL) consists in diffuse large B cell non-Hodgkin lymphoma usually confining to the CNS. PCNSL is well known to be a form of extra nodal, highgrade non-Hodgkin B-cell neoplasm. It can originate in the brain, leptomeninges, spinal cord, or eyes; usually it remains confined to the CNS, rarely it spreads outside the nervous system. It was previously considered as a rare tumor accounting for less than 2% of cerebral neoplasms, PCNSL is now being found with increasing frequency in immunocompetent patients. Although the cells of origin are lymphocytes (usually large cell or immunoblastic type), PCNSL should be considered a brain tumor, because its therapeutic challenges resemble those of other brain tumors. In particular, drug delivery is impaired by the blood-brain barrier, and cerebral toxicity limits the use of available treatment strategies. Most PCNSLs (about 90%) are diffuse large B-cell lymphomas (DLBCLs); the remaining 10% are poorly characterized low-grade lymphomas, Burkitt lymphomas, and T-cell lymphomas.1 Primary symptoms may be the sum of local mass effect due to raised intracranial pressure, or ocular involvement, or from focal deposits on cranial or spinal nerve roots. PCNSL incidence has risen steadily since the end of the 20th century. Incidence in immunocompetent patients is approximately 51 cases per 10,000,000 per year. Among immunocompetent patients with PCNSL, males outnumber females by approximately 2:1 The median age of immunocompetent patients with PCNSL is 55 years.2","PeriodicalId":106839,"journal":{"name":"Journal of Neurology and Stroke","volume":"107 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116365866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

FMRI analysis of the motor network functional connections at rest and with motor load in healthy people and patients with STBI 健康人与脑外伤患者静息状态和运动负荷状态下运动网络功能连接的FMRI分析

Journal of Neurology and Stroke Pub Date : 2018-03-16 DOI: 10.15406/JNSK.2018.08.00287

E. Sharova, T. Mukhina, GNBoldyreva, L. Zhavoronkova, MVChelyapina, A. S. Smirnov, Everitt Alex, rova, I. Pronin

引用次数: 1

Positive and negative aspects of cell technologies in cerebral diseases 大脑疾病中细胞技术的积极和消极方面

Journal of Neurology and Stroke Pub Date : 2018-03-15 DOI: 10.15406/JNSK.2018.08.00286

V. Kulchitsky, Alex, ra Zamaro, Y. Shanko, S. Koulchitsky

引用次数: 19

Generalized chorea as the first presentation of systemic lupus erythematosus: case report and review of literature 全身性舞蹈病作为系统性红斑狼疮的首发表现:病例报告及文献复习

Journal of Neurology and Stroke Pub Date : 2018-03-13 DOI: 10.15406/JNSK.2018.08.00285

M. Abdalla, Ahmad O Ahmad, Husam Altahan, Ibrahim A AlOraini, Abdulrahman Altahan

{"title":"Generalized chorea as the first presentation of systemic lupus erythematosus: case report and review of literature","authors":"M. Abdalla, Ahmad O Ahmad, Husam Altahan, Ibrahim A AlOraini, Abdulrahman Altahan","doi":"10.15406/JNSK.2018.08.00285","DOIUrl":"https://doi.org/10.15406/JNSK.2018.08.00285","url":null,"abstract":"Submit Manuscript | http://medcraveonline.com with mobility. Otherwise she did not have any systemic complaints. Had no history of a recent infectious illness and did not use any medication. Her past and family history was unremarkable. On examination, she was alert, fully oriented with intact cognitive functions. The movements were noted as involuntary, rapid and purposeless generalized movements. She could not control it and had difficulty stabilizing her head. Auscultation revealed pansystolic murmur over the apex. She had no skin lesion, joint tenderness or swelling. Blood investigations showed normochromic normocytic anemia with thrombocytopenia (Hb: 8g/dl, MCV: 80 fl, WBCs: 4.5×109 Platelets: 84×109). Had normal renal and liver functions. Coombs test was positive, ANA and anti-dsDNA Abs were positive. Furthermore her cardiolipin IgG was positive (36.9 U/ml) and urine analysis shows hematuria (20-30/HPF) and proteinuria (100 mg/dl). Brain MRI demonstrated multiple bilateral old and recent ischemic lesions (Figure 1). Echocardiography show mildly thickened mitral valve with prolapsed of anterior segments of mitral leaflet & moderate mitral regurgitation.","PeriodicalId":106839,"journal":{"name":"Journal of Neurology and Stroke","volume":"56 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116795161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Type I complex regional pain syndrome (reflex sympathetic dystrophy) developing on the background of carpal tunnel syndrome 在腕管综合征的基础上发展的I型复杂区域性疼痛综合征(反射性交感神经营养不良)

Journal of Neurology and Stroke Pub Date : 2018-03-09 DOI: 10.15406/JNSK.2018.08.00284

M. Senol, T. Kendirli, E. Toğrol, M. Saraçoǧlu

引用次数: 0

Clinical spectrum of callosum corpus splenium lesions: subdiagnostics of a common entity 胼胝体脾病变的临床谱:一种常见实体的亚诊断

Journal of Neurology and Stroke Pub Date : 2018-03-06 DOI: 10.15406/JNSK.2018.08.00283

A. Cañas, R. Torrealba, Nicolas Rebolledo Villar

引用次数: 2

Letter to editor: Dysgeusia as an initial manifestation of Miller-Fisher syndrome 致编辑的信:诵读困难是米勒-费雪综合征的最初表现

Journal of Neurology and Stroke Pub Date : 2018-03-05 DOI: 10.15406/JNSK.2018.08.00282

R. Joao, Aless, R. Colombi, F. A. Rocha, Bruna Pinotti Ferreira Leite, R. V. D. Azevedo, Marcelo Lucci Mussi, J. E. Ferri-de-Barros

引用次数: 0

Radiosurgical Treatment of Recurrent Esthesioneuroblastoma: Case Report 复发性感觉神经母细胞瘤的放射外科治疗1例

Journal of Neurology and Stroke Pub Date : 2018-02-21 DOI: 10.15406/jnsk.2018.08.00281

A. Tokarev, V. Rak, V. Stepanov, V. Krylov

{"title":"Radiosurgical Treatment of Recurrent Esthesioneuroblastoma: Case Report","authors":"A. Tokarev, V. Rak, V. Stepanov, V. Krylov","doi":"10.15406/jnsk.2018.08.00281","DOIUrl":"https://doi.org/10.15406/jnsk.2018.08.00281","url":null,"abstract":"Esthesioneuroblastoma is an uncommon neuroectodermal tumor occurring with an incidence of 0.4 per 1 million and constitutes approximately 2-3% of sinonasal malignancies with no gender predilection [1,2]. ENB was first described by Berger et al. [3] in 1924 and since then approximately 1200 cases have been reported [3,4]. The tumor arises from basal stem cells of sensory olfactory epithelium locating on superior nasal structures, cribriform plate and anterior skull base [4,5]. The most common symptoms are nasal congestion and epistaxis, anosmia, rhinorrhea or lacrimation [6]. Late clinical manifestation resulting from asymptomatic behavior of the tumor on early stages leads to high rate skull base involvement. Therefore the primary treatment modality is often a craniofacial resection, adjuvant external beam radiotherapy and chemotherapy [7]. Despite combined treatment the risk of local recurrence is about 20-50% [4-7]. Appliance of stereotactic radiosurgery (SRS) as a non-invasive treatment modality can be safe and effective in group of patients with local recurrence of ENB after surgery, especially in cases of deep located lesions. Here we present our experience of Gamma Knife SRS for an aggressive Kadish stage C (‘spread beyond nasal and paranasal cavities’) esthesioneuroblastoma involving right orbit, anterior cranial fossa and sphenopetroclival region.","PeriodicalId":106839,"journal":{"name":"Journal of Neurology and Stroke","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133379466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0