Open Access Indonesian Journal of Medical Reviews最新文献_第3页

The Role of Natural Physical, Mechanical, and Biochemical Barriers as Innate Immunity: A Narrative Literature Review 自然物理、机械和生化屏障作为先天免疫的作用:叙述性文献综述

Open Access Indonesian Journal of Medical Reviews Pub Date : 2023-05-08 DOI: 10.37275/oaijmr.v3i2.299

Septi Purnamasari, R. Hidayat, Article Info

{"title":"The Role of Natural Physical, Mechanical, and Biochemical Barriers as Innate Immunity: A Narrative Literature Review","authors":"Septi Purnamasari, R. Hidayat, Article Info","doi":"10.37275/oaijmr.v3i2.299","DOIUrl":"https://doi.org/10.37275/oaijmr.v3i2.299","url":null,"abstract":"The specialized epithelial outer layer, including the skin and mucosal surfaces, is relatively resistant to most environmental hazards and resistant to infection by disease-causing microorganisms. This literature review aimed to describe the role of natural physical, mechanical, and biochemical barriers in innate immunity. The physical barrier that protects against damage and infection consists of closely related epithelial cells, including the skin and the sheet membranes that line the digestive tract, genitourinary, and breathing. The epithelial surface also provides a biochemical barrier by synthesizing and secreting substances intended to trap or destroy microorganisms (chemicals derived from the epithelium). Mucus, sweat, saliva, tears, and earwax are examples of biochemical secretions that can trap and kill potential disease-causing microorganisms. Microorganisms in the microbiome do not usually cause disease, although some are opportunistic in that they can cause disease if the integrity of the body surface is compromised or the individual's immune or inflammatory systems are damaged. In conclusion, natural barriers include physical, mechanical, and biochemical on the surface of the body and are present from birth to prevent damage by substances in the environment and prevent infection by pathogenic microorganisms.","PeriodicalId":106715,"journal":{"name":"Open Access Indonesian Journal of Medical Reviews","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121214411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of Pattern Recognition Receptor (PRR) in the Body's Defense System: A Narrative Literature Review 模式识别受体(PRR)在机体防御系统中的作用:叙述性文献综述

Open Access Indonesian Journal of Medical Reviews Pub Date : 2023-05-08 DOI: 10.37275/oaijmr.v3i2.300

Z. Maritska, R. Hidayat, Article Info

{"title":"The Role of Pattern Recognition Receptor (PRR) in the Body's Defense System: A Narrative Literature Review","authors":"Z. Maritska, R. Hidayat, Article Info","doi":"10.37275/oaijmr.v3i2.300","DOIUrl":"https://doi.org/10.37275/oaijmr.v3i2.300","url":null,"abstract":"Each cell has receptors on the cell surface that specifically bind to solutes (ligands) produced during tissue damage or infection. This review aimed to describe the role of PRR in the human body's defense system. The binding of the ligand to its receptor results in the activation of intracellular signaling pathways and cell activation. The B and T lymphocytes of the adaptive immune system have developed surface receptors (that is, the T-cell receptor, or TCR, and the B-cell receptor, or BCR) that bind a broad spectrum of antigens. The cells involved in innate resistance have developed a distinct set of receptors that recognize a much more limited array of specific molecules. These are called pattern recognition receptor (PRR), and they recognize the molecular patterns in infectious agents or their products (pathogen-associated molecular patterns, or PAMP) or products of cellular damage (necrosis or apoptosis; molecular pattern-associated damage, or DAMPs). In conclusion, the pattern recognition receptor (PRR) is a receptor complex that interacts with various molecules, such as PAMP and DAMPs. PRR bonds with these various molecules and play a role in various actions of innate immunity and adaptive immunity.","PeriodicalId":106715,"journal":{"name":"Open Access Indonesian Journal of Medical Reviews","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117263882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanisms of Cellular Adaptation and Change: A Narrative Literature Review 细胞适应和改变的机制:叙述性文献综述

Open Access Indonesian Journal of Medical Reviews Pub Date : 2023-05-03 DOI: 10.37275/oaijmr.v3i2.298

R. Hidayat, Catherine

{"title":"Mechanisms of Cellular Adaptation and Change: A Narrative Literature Review","authors":"R. Hidayat, Catherine","doi":"10.37275/oaijmr.v3i2.298","DOIUrl":"https://doi.org/10.37275/oaijmr.v3i2.298","url":null,"abstract":"Injury to cells and the surrounding environment, called the extracellular matrix, triggers injury to tissues and organs. Although a normal cell is limited by narrow boundaries of structure and function, it is capable of adapting to biological demands or stress to maintain a steady state called homeostasis. Adaptation is a reversible, structural, or functional response to normal or physiological conditions and adverse or pathological conditions. This review aimed to describe the mechanism of cellular adaptation in the human body. Cells adapt to the environment to escape and protect against injury. Adaptation of the cell, be it normal or injured, this condition lies somewhere between these two conditions. The most significant adaptive changes in cells include atrophy (decreased cell size), hypertrophy (increased cell size), hyperplasia (increased cell number), and metaplasia (reversible replacement of one mature cell for another less mature cell or change in phenotype). Dysplasia (a disorder of cellular growth) is not considered a true cellular adaptation but rather an atypical hyperplasia. In conclusion, cellular adaptation is a central and common part of many disease conditions.","PeriodicalId":106715,"journal":{"name":"Open Access Indonesian Journal of Medical Reviews","volume":"150 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115554356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phytochemicals; Targeted-Based Therapeutic Approaches for Pigmentation Disorders 植物化学物质;色素沉着障碍的靶向治疗方法

Open Access Indonesian Journal of Medical Reviews Pub Date : 2023-04-05 DOI: 10.37275/oaijmr.v3i2.287

Sana Ullah, Rabbia Shoaib, Siyar Khan, Aalia Masood

{"title":"Phytochemicals; Targeted-Based Therapeutic Approaches for Pigmentation Disorders","authors":"Sana Ullah, Rabbia Shoaib, Siyar Khan, Aalia Masood","doi":"10.37275/oaijmr.v3i2.287","DOIUrl":"https://doi.org/10.37275/oaijmr.v3i2.287","url":null,"abstract":"Skin pigmentation disorders refer to conditions that affect the color of the skin due to alterations in the production or distribution of melanin, the pigment responsible for skin color. The development of skin pigmentation is a complex process involving various signaling pathways, including the melanin synthesis pathway, the cyclic AMP pathway, and the Wnt signaling pathway. Dysregulation of these pathways can lead to the development of skin pigmentation disorders. Phytotherapeutic approaches have been increasingly studied as a potential treatment for skin pigmentation disorders. This literature review aimed to describe the basic mechanism of melanogenesis, various pathways involved in melanin formation, and certain diseases and their treatment through plant extracts. Plant extracts containing bioactive compounds such as flavonoids, phenolic acids, and tannins have been shown to have anti-pigmentary effects through various mechanisms, including inhibition of tyrosinase activity, reduction of melanin synthesis, and modulation of melanogenesis-related signaling pathways. Skin pigmentation disorders are complex and multifactorial conditions that can significantly impact a person's quality of life. Targeting the signaling pathways involved in pigmentation regulation, particularly through phytotherapeutic approaches, represents a promising avenue for the development of new therapies for these disorders.","PeriodicalId":106715,"journal":{"name":"Open Access Indonesian Journal of Medical Reviews","volume":"310 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123329243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Antioxidant Activity of Leucaena leucocephala Lmk.de Wit. N-Hexane Fraction 白头翁的抗氧化活性研究。正己烷分数

Open Access Indonesian Journal of Medical Reviews Pub Date : 2023-03-28 DOI: 10.37275/oaijmr.v3i1.286

Ricka Islamiyati, Yanulia Handayani, Kadar Ismah, Gendis Purno Yudanti, Heni Setyoningsih, Sri Fitrianingsih

引用次数: 0

Vitamin D and Its Role in Modulating Immune System: A Narrative Literature Review 维生素D及其在免疫系统调节中的作用:叙述性文献综述

Open Access Indonesian Journal of Medical Reviews Pub Date : 2023-03-02 DOI: 10.37275/oaijmr.v3i1.282

Chaula Putri Rizkia

引用次数: 0

Risk Factors for Progressive Chronic Kidney Disease in Children with Idiopathic Nephrotic Syndrome at Dr. Mohammad Hoesin General Hospital Palembang Mohammad Hoesin博士综合医院巨港特发性肾病综合征儿童进行性慢性肾病的危险因素

Open Access Indonesian Journal of Medical Reviews Pub Date : 2023-01-02 DOI: 10.37275/oaijmr.v3i1.274

Mirza Gifari Maulana, Eka Intan Fitriana, Phey Liana, Hertanti Indah Lestari, Dalilah

{"title":"Risk Factors for Progressive Chronic Kidney Disease in Children with Idiopathic Nephrotic Syndrome at Dr. Mohammad Hoesin General Hospital Palembang","authors":"Mirza Gifari Maulana, Eka Intan Fitriana, Phey Liana, Hertanti Indah Lestari, Dalilah","doi":"10.37275/oaijmr.v3i1.274","DOIUrl":"https://doi.org/10.37275/oaijmr.v3i1.274","url":null,"abstract":"Nephrotic syndrome (NS) is a kidney disease that is often found in children. NS can cause infectious and non-infectious complications, such as upper respiratory tract infections, urinary tract infections, edema, acute kidney injury (AKI), and hypertension. This study aimed to determine the risk factors of age, gender, nutritional status, hypertension, hematuria, AKI, hyperfiltration, and steroid sensitivity to the progression of chronic kidney disease (CKD) in children with the initial idiopathic NS in the pediatric ward of Dr. Mohammad Hoesin General Hospital Palembang. This study was an analytic observational study with a cross-sectional design. A total of 72 secondary data of research subjects were included in this study. Risk factor analysis was carried out with the help of SPSS version 24 software in univariate, bivariate, and multivariate ways. The most common risk factor for children with the initial idiopathic NS is age ≥10 years, males and females gender obtained the same number, and the nutritional status of obesity, hematuria, AKI, and hyperfiltration have quite low rates. However, hypertension and SRNS have high rates in children with initial idiopathic NS. In conclusion, hypertension and hyperfiltration are risk factors that play a role in initiating the progression of idiopathic NS to CKD in the pediatric ward of Dr. Mohammad Hoesin General Hospital, Palembang.","PeriodicalId":106715,"journal":{"name":"Open Access Indonesian Journal of Medical Reviews","volume":"183 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126782790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characteristics of Laryngomalacia Patients at Department of Otorhinolaryngology-Head and Neck Surgery Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia Period 2021-2022 2021-2022年印度尼西亚巨港市Mohammad Hoesin总医院耳鼻喉科头颈外科喉软化症患者的特征

Open Access Indonesian Journal of Medical Reviews Pub Date : 2022-12-27 DOI: 10.37275/oaijmr.v3i1.273

Fatharani Azka Toer, Puspa Zuleika, Adelien, Lisa Apri Yanti, Fiona Widyasari

{"title":"Characteristics of Laryngomalacia Patients at Department of Otorhinolaryngology-Head and Neck Surgery Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia Period 2021-2022","authors":"Fatharani Azka Toer, Puspa Zuleika, Adelien, Lisa Apri Yanti, Fiona Widyasari","doi":"10.37275/oaijmr.v3i1.273","DOIUrl":"https://doi.org/10.37275/oaijmr.v3i1.273","url":null,"abstract":"Laryngomalacia is a congenital laryngeal disorder that is commonly found as a cause of stridor in infants and children. This disorder causes the collapse of the structures in the larynx resulting in impaired breathing and eating conditions in patients. This study aimed to present the characteristics of laryngomalacia patients at the Department of Otorhinolaryngology-Head and Neck Surgery (ORL-HNS) Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia, period 2021-2022. This was a descriptive observational study that used medical record data as secondary data and primary data in the form of questionnaires in the medical record section and ORL-HNS at Dr. Mohammad Hoesin General Hospital, Palembang, period 2021-2022. Data evaluated included age, gender, clinical symptoms, classification based on Olney distribution, degree of severity, comorbid factors, and therapy. This study showed that most patients were in the age group 3-12 months (52.9%). More were found in males (73.5%). The most common clinical symptoms were eating disorders (51.4%). The most common classification is type 1 (52.9%). Most patients come with a mild degree of severity (61.8%). The most common comorbid factors were neurological diseases (35.1%). The type of medical therapy was given to the majority of patients (94.1%).","PeriodicalId":106715,"journal":{"name":"Open Access Indonesian Journal of Medical Reviews","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128338922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Prostate Cancer and DNA Genes Repair: What Should an Oncologist Know? – A Narrative Review 前列腺癌和DNA基因修复:肿瘤学家应该知道什么?-叙事性回顾

Open Access Indonesian Journal of Medical Reviews Pub Date : 2022-12-08 DOI: 10.37275/oaijmr.v3i1.267

Fernando Santos de Azevedo, Lanúscia Morais de Santana Sá, Uirá Maíra de Resende, Augusto Ribeiro Gabriel, Elisângela de Paula Silveira Lacerda

{"title":"Prostate Cancer and DNA Genes Repair: What Should an Oncologist Know? – A Narrative Review","authors":"Fernando Santos de Azevedo, Lanúscia Morais de Santana Sá, Uirá Maíra de Resende, Augusto Ribeiro Gabriel, Elisângela de Paula Silveira Lacerda","doi":"10.37275/oaijmr.v3i1.267","DOIUrl":"https://doi.org/10.37275/oaijmr.v3i1.267","url":null,"abstract":"Prostate cancer is a very prevalent disease in men, especially in Western countries. The treatment of this neoplasm, both localized and locally advanced, is based on the clinical risk analysis (Gleason, tumor size, PSA, and other factors) and is founded on surgery and/or radiotherapy with or without androgen blockade with a GnRH analog (hormone gonadotropin releaser). However, in patients who invariably progress to a metastatic disease scenario, the tumors may present a heterogeneous behavior, depending on whether or not they are sensitive to androgen blockade therapy. Due to the poor prognosis of the metastatic castration-resistant scenario, current research carried out in the molecular biology and genetics field has identified several gene alterations associated with the development of prostate cancer, which correlate with clinical risk, therapeutic predictive responses, and prognosis. Among the associated gene alterations, the genes of the DNA repair pathway are correlated with diseases that present: a higher risk of recurrence; early metastasis; worse cancer-specific survival; familial risk, and predictive responses to new targeted therapies. Therefore, the breast cancer susceptibility genes, BRCA1 and BRCA2 (and other variants), present in the DNA repair machinery are being investigated to provide more (and better) therapeutic options for the treatment of the disease in the advanced scenario. This review was aimed to describe the malignant prostate disease, especially with regard to DNA repair mechanisms, genomic analysis of prostate cancer, predictive and prognostic implications, as well as on the development of poly-(ADP-ribose) polymerase (PARP) inhibitors, synthetic lethality mechanisms, and BRCAness phenomenon.","PeriodicalId":106715,"journal":{"name":"Open Access Indonesian Journal of Medical Reviews","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130474064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of Molecular Docking Chemical Content of Lime (Citrus aurantiifolia (Christm.) Swingle) Against Diabetes Mellitus Therapy Targets and Prediction of Pharmacokinetic Profiles and Toxicity 酸橙(Citrus aurantiifolia, Christm.)分子对接化学成分分析抗糖尿病治疗靶点及药代动力学特征和毒性预测

Open Access Indonesian Journal of Medical Reviews Pub Date : 2022-11-10 DOI: 10.37275/oaijmr.v2i6.259

Kadar Ismah, Supriyadi

{"title":"Analysis of Molecular Docking Chemical Content of Lime (Citrus aurantiifolia (Christm.) Swingle) Against Diabetes Mellitus Therapy Targets and Prediction of Pharmacokinetic Profiles and Toxicity","authors":"Kadar Ismah, Supriyadi","doi":"10.37275/oaijmr.v2i6.259","DOIUrl":"https://doi.org/10.37275/oaijmr.v2i6.259","url":null,"abstract":"Diabetes mellitus drugs currently available are sulfonylureas, biguanides, thiazolidines, and alpha glucoside inhibitors which are widely used to control hyperglycemia. These drugs cannot prevent complications of diabetes, and these drugs should not be used continuously because it causes undesirable pathological conditions. The essential oil in lime peel is rich in phenolics, especially flavonoids, which can prevent oxidative stress. This research was carried out computationally to determine the affinity of the compound mechanism in lime, pharmacokinetic profile, and toxicity of the chemical content of lime which is thought to have antihyperglycemic activity using chemoinformatics studies. The hardware used is an Asus laptop X441UB-GA502T Intel Core I5 – 8250 DDR 4 4GB HD 1TB VGA mix 110 2GB screen 14 \"DVD-RW WIN 10 ORI. The software used is PLANTS (PROTEIN-LIGAND ANT SYSTEM), YASARA, Marvin sketch, Swisstargetprediction, SwissADME, and Toxtree. All compounds in lime were most active against the target protein PPARγ with an average value of -78.0092, while the positive control value of thiazolidinediones was -90.3393. The highest inhibitory affinity of the compound contained in lime was hesperidin with the target protein DPP-4 of -113.614, higher than the positive control sitagliptin with an inhibitory affinity value of -107.591. Hesperidin absorption in the digestive tract is low, the topology polar surface area (TPSA) value is 234.29Å2, and low polarity and high lipophilicity. There are unexpected heterocyclic compounds, so it becomes a warning against the potential for genotoxic carcinogenicity, namely oxygen element \"o\".","PeriodicalId":106715,"journal":{"name":"Open Access Indonesian Journal of Medical Reviews","volume":"50 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114423341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0