Open Access Indonesian Journal of Medical Reviews最新文献

{"title":"Long-Term Comparative Effectiveness of Transcatheter Aortic Valve Replacement (TAVR) Versus Surgical Aortic Valve Replacement (SAVR) in High-Risk Aortic Stenosis Patients: A Meta-Analysis","authors":"I. Gede, Andrika Indrayoga Senthanu, Dewa Ayu, Agung Maya, Gayatri, Gede Andrika, Indrayoga Senthanu","doi":"10.37275/oaijmr.v4i3.600","DOIUrl":"https://doi.org/10.37275/oaijmr.v4i3.600","url":null,"abstract":"Transcatheter aortic valve replacement (TAVR) has become an alternative to surgical aortic valve replacement (SAVR) for high-risk patients with severe aortic stenosis (AS). This meta-analysis aims to compare the long-term outcomes of TAVR and SAVR in this population. A systematic search of PubMed, Embase, and the Cochrane Library was conducted up to December 2023. Randomized controlled trials (RCTs) and observational studies comparing TAVR and SAVR with a minimum follow-up of one year were included. The primary outcome was all-cause mortality. Secondary outcomes included cardiovascular mortality, stroke, myocardial infarction (MI), and rehospitalization. Twenty-three studies involving 15,482 patients (TAVR=7,785, SAVR=7,697) were included. The mean follow-up period was 3.2 years (range 1-5 years). There was no significant difference in all-cause mortality between TAVR and SAVR (Hazard Ratio [HR] 1.02, 95% CI 0.95-1.09, p=0.63). Similarly, there were no differences in cardiovascular mortality (HR 1.05, 95% CI 0.96-1.15, p=0.28), stroke (HR 0.98, 95% CI 0.87-1.10, p=0.75), or MI (HR 0.94, 95% CI 0.82-1.08, p=0.39). However, TAVR was associated with a lower rate of rehospitalization (HR 0.85, 95% CI 0.78-0.93, p=0.001). TAVR is a viable alternative to SAVR in high-risk patients with AS, demonstrating comparable long-term survival and safety outcomes. The reduced rehospitalization rate associated with TAVR may be an important consideration for these patients.","PeriodicalId":106715,"journal":{"name":"Open Access Indonesian Journal of Medical Reviews","volume":"26 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141660668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the Quality of Pharmaceutical Services at Outpatient Health Centers, East Sumba Regency, Indonesia","authors":"Silvia Claudia Talalab, Jason M. Peranginnangin, Tri Wijayanti","doi":"10.37275/oaijmr.v4i2.550","DOIUrl":"https://doi.org/10.37275/oaijmr.v4i2.550","url":null,"abstract":"Public administration services are one way to demonstrate maximum government performance in providing welfare and meeting community needs. One important sector in public services is pharmaceutical services at Health Centers. This research uses a descriptive method with a cross-sectional design. Primary data was obtained through observation, interviews and documentation. Secondary data was obtained from the 2022 Health Centers Medicine Usage Report and Request Sheet (LPLPO) and the 2021 Health Centers Drug Requirements Plan (RKO). Of the 28 indicators of the quality of pharmaceutical services, 15 of the third indicators of the Health Centers meet the standards, 10 of the third indicators of the Health Centers do not meet the standards, 1 indicators only one Health Center meets and 2 indicators only two Health Centers fulfill. Factors that influence the quality of management of pharmaceutical preparations at the East Sumba Regency outpatient Health Centers are human resources that do not come from pharmacy. The quality of pharmaceutical services at the East Sumba Regency outpatient Health Centers still needs to be improved. Pharmacists are needed as pharmaceutical personnel to maximize pharmaceutical services to the community.","PeriodicalId":106715,"journal":{"name":"Open Access Indonesian Journal of Medical Reviews","volume":"134 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140750640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formulation and Characterization of Mefenamic Acid Self Nanoemulsifying Drug Delivery System (SNEDDS) Preparations","authors":"Farrah Bintang Sabiti, Sukarno","doi":"10.37275/oaijmr.v4i1.461","DOIUrl":"https://doi.org/10.37275/oaijmr.v4i1.461","url":null,"abstract":"Mefenamic acid is included in BCS (biopharmaceutical classification system) class II, namely high permeability and low solubility. This research aims to obtain a good formula for oleic acid oil, tween 80, and PEG 400 according to the characterization test of emulsification time, % transmittance, drug loading, globule size, and zeta potential. This research was an experimental study by formulating mefenamic acid in the form of SNEDDS which was made 1 formula was made in the form of SNEDDS with the composition of oleic acid, tween 80, and PEG 400 and characterization tests were carried out for emulsification time, % transmittance, drug loading, globule size, zeta potential. The yield of the oleic acid formula is 1%, tween 80 is 8%, and PEG 400 is 1%. The emulsification time characterization test resulted in 17 seconds, % transmittance of 97%, drug loading of 179.81 mg, globular size of 85.8 nm and zeta potential of -1.6 mV.","PeriodicalId":106715,"journal":{"name":"Open Access Indonesian Journal of Medical Reviews","volume":"51 19","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139447125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimization and Characterization of Fenofibrate Self-Nanoemulsifying Drug Delivery System (SNEDDS) Preparations","authors":"Sukarno, Ilham Kuncahyo, Endang Dyah Ikasari","doi":"10.37275/oaijmr.v4i1.451","DOIUrl":"https://doi.org/10.37275/oaijmr.v4i1.451","url":null,"abstract":"Fenofibrate is a third-generation fibric acid derivative included in BCS (biopharmaceutical classification system) class II, namely high permeability, low solubility. This research aims to obtain the optimum formula for miglyol oil, cremophor RH 40 and PEG 400 according to characterization tests of emulsification time, % transmittance, drug loading, globule size, and zeta potential. This research is an experimental study by formulating fenofibrate in the form of SNEDDS, which was made in 16 formulas using the D-optimal method, which was formulated in the form of SNEDDS with the composition miglyol, cremophor RH 40 and PEG 400 and characterization tests were carried out for emulsification time, % transmittance, drug loading, size. globules, zeta potential to obtain the optimum formula, and then analyzed using the one sample T-Test. The optimization results obtained the optimum formula, namely miglyol at 4%; cremophor RH 40 is 5%, and PEG 400 at 1%. Characterization test: emulsification time was 24 seconds, Transmittance % was 98.7%, Drug loading was 181 mg, globule size was 126 nm, and zeta potential of 12.26 mV. The dissolution test of the fenofibrate capsule dissolved 57.05%, while the fenofibrate SNEDDS capsule was 64.86%. This means that the dissolution of the optimum formula for SNEDDS fenofibrate is better than pure fenofibrate.","PeriodicalId":106715,"journal":{"name":"Open Access Indonesian Journal of Medical Reviews","volume":"21 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139172962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Drug Management and Improvement Strategies Using the Hanlon Method in the Pharmacy Installation of Dr. Moewardi General Hospital, Surakarta, Indonesia","authors":"Lanny Imelia, RA.Oetari, Samuel Budi Harsono","doi":"10.37275/oaijmr.v3i6.446","DOIUrl":"https://doi.org/10.37275/oaijmr.v3i6.446","url":null,"abstract":"A hospital pharmacy (FRS) is a unit in a hospital that carries out health efforts by providing quality health services. Medication management in FRS is an important management aspect in achieving service quality. Therefore, IFRS must be managed effectively and efficiently. Inefficiency in use can have a negative impact on hospitals both medically and economically. The aim of this study was to evaluate drug management, including selection, procurement, distribution, and use, based on the 2020 National Formulary standards and improvement strategies using the Hanlon method at the pharmacy installation of Dr. Moewardi General Hospital in 2020. This research is a type of descriptive research with retrospective and concurrent data collection. Data was taken from retrospective data in 2020 and data at the time the research was conducted. Research materials include primary data obtained from observation of research data in the form of document selection, procurement, distribution, and use of medicine in the IFRS Dr. Moewardi General Hospital. Secondary data was obtained from interviews with the head of the pharmacy installation at Dr. Moewardi General Hospital Surakarta, the head of planning, and the head of ULP (procurement services unit). The results of the research show that 1) Medication management in the pharmacy installation at Dr. Moewardi General Hospital Surakarta is not yet efficient at this stage of selection. It is known that the availability of existing medicines does not comply with FORNAS standards in 2020. then, in stage procurement, there is 1 out of 5 indicators that meet the standard; in stage distribution, 5 indicators were obtained, or all of them were not standard, and in staged use, it was found that 1 of the 5 indicators met the standard. 2) The improvement strategy uses the Hanlon method in drug management, namely prioritizing problem repairs sequentially, starting from the percentage of conformity with the number of drug items available with FORNAS to the number of drug items per prescription sheet.","PeriodicalId":106715,"journal":{"name":"Open Access Indonesian Journal of Medical Reviews","volume":"11 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138597363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of Studies on the Role of Hormones in Micropenis Disorders: A Systematic Literature Review","authors":"Rizki Jaya Amal, Irfansyah, Muhammad Arif Hasan, Aulia Putra Rahman","doi":"10.37275/oaijmr.v3i6.420","DOIUrl":"https://doi.org/10.37275/oaijmr.v3i6.420","url":null,"abstract":"A deep understanding of the role of specific hormones in genital development is key to designing effective therapeutic approaches. Factors such as testosterone deficiency, growth hormone disorders, or other hormonal imbalances can be targets for hormonal interventions that can affect penis size. This study aimed to explore the role of hormonal aspects in micropenis disorders. The literature search process was carried out on various databases (PubMed, Web of Sciences, EMBASE, Cochrane Libraries, and Google Scholar) regarding the role of hormonal aspects in micropenis disorders. This study follows the preferred reporting items for systematic reviews and meta-analysis (PRISMA) recommendations. Aspects of the hormonal role in micropenis include several key elements that influence the development of genital organs in men. Hormones, such as testosterone, growth hormone, estrogen, and dihydrotestosterone (DHT), play an important role in stimulating penis growth and development. Proper hormonal balance is necessary for normal genital development, and disturbances in the production of or response to these hormones may contribute to conditions such as micropenis.","PeriodicalId":106715,"journal":{"name":"Open Access Indonesian Journal of Medical Reviews","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139250857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a Reliable Information System for Medical Device Inventory in Hospitals: A Systematic Literature Review","authors":"Suryati","doi":"10.37275/oaijmr.v3i6.421","DOIUrl":"https://doi.org/10.37275/oaijmr.v3i6.421","url":null,"abstract":"Developing an information system for medical equipment inventory in hospitals not only includes technical aspects but also involves an in-depth understanding of the operational needs of the hospital itself. By utilizing the latest technology, such as the Internet of Things (IoT), and efficient data integration, hospitals can ensure that the information systems developed can adapt to the dynamics of future technological needs and developments. This study aimed to explore the development of a reliable information system for inventory of medical equipment in hospitals. The literature search process was carried out on various databases (PubMed, Web of Sciences, EMBASE, Cochrane Libraries, and Google Scholar) regarding the development of a reliable information system for the inventory of medical devices in hospitals. This study follows the preferred reporting items for systematic reviews and meta-analysis (PRISMA) recommendations. Developing an information system for medical device inventory in hospitals is a crucial step in improving the efficiency, availability, and management of health resources. Developing an information system for medical device inventory in hospitals is not just about recording and monitoring but also providing a holistic solution to improve operational efficiency and patient service.","PeriodicalId":106715,"journal":{"name":"Open Access Indonesian Journal of Medical Reviews","volume":"90 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139250895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Drug Management at the Pharmacy Installation of \"X\" Regency Health Office Indonesian in 2021","authors":"Echa Malinda, Naha Ndjurumbaha, Gunawan Pamudji, Widodo, Ismi Rahmawati","doi":"10.37275/oaijmr.v3i5.357","DOIUrl":"https://doi.org/10.37275/oaijmr.v3i5.357","url":null,"abstract":"Improving public health status can be influenced by the drug management process, one of the components of which is the availability of good drugs. This study aimed to find out the overall process description of drug management, which includes the planning, procurement, storage, and distribution stages, as well as to know the evaluation of drug management related to compliance with the indicators of the Ministry of Health of the Republic of Indonesia & JICA 2010. This study used a type of research descriptive data collection with retrospective and concurrent. Data analysis was carried out by explaining the drug management process at the \"X\" Regency Health Office, measuring the value of each drug management indicator, and then making a problem-solving based on the Hanlon method. The results of the evaluation of drug management at the Pharmacy Installation of the \"X\" Regency Health Office were the suitability of the available drug items with the Fornas of 54%; percentage of fund allocation procurement drugs by 93%; percentage suitability of drug planning and procurement by 73%; the percentage of drug planning accuracy is 84%; percentage and value of expired drugs by 8% worth Rp. 39,888,756; The accuracy of drug distribution is 94%; drug availability12-18 months of 94%; and the percentage of drug blanks is 2%. Some indicators are not up to standard, so improvements are made using the Hanlon method.","PeriodicalId":106715,"journal":{"name":"Open Access Indonesian Journal of Medical Reviews","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126559560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ashy Dermatosis: A Narrative Literature Review","authors":"Anindya Oktafiani, M. Irawanto","doi":"10.37275/oaijmr.v3i5.356","DOIUrl":"https://doi.org/10.37275/oaijmr.v3i5.356","url":null,"abstract":"Ashy dermatosis (AD) or erythema dyschromicum perstans (EDP) is a type of hyperpigmented macules characterized by asymptomatic, gray macular lesions with a symmetrical distribution. Some of the predisposing factors for ashy dermatosis are intestinal parasitic infections, a bad environment such as consumption of ammonium nitrate, X-ray contrast media and genetic factors such as the HLA-DR4 allele. The clinical manifestations of ashy dermatosis are hyperpigmented or gray macules with slow progression and pigmentation abnormalities in the inner epidermal layer. The differential diagnosis of ashy dermatosis is with lichen planus pigmentosus, idiopathic eruptive macular pigmentation, and Riehl's melanosis. Diagnosis of ashy dermatosis needs to be linked between clinical findings and histopathological examination, other supporting examinations and differentiating it from other differential diagnoses. Management for patients with ashy dermatosis is with topical or systemic agents. For now, a combination of laser and tacrolimus ointment is recommended.","PeriodicalId":106715,"journal":{"name":"Open Access Indonesian Journal of Medical Reviews","volume":"95 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124261327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of Pocketbooks as an Education and Compliance Module for Diabetes Mellitus Patients at the Kaliwungu Health Center, Kudus, Indonesia","authors":"Eka Fitriani, R. Herowati, Lucia Vita, I. Dewi","doi":"10.37275/oaijmr.v3i4.351","DOIUrl":"https://doi.org/10.37275/oaijmr.v3i4.351","url":null,"abstract":"Diabetes mellitus (DM) is a chronic disease that requires long-term treatment. Management of DM patients is one of them by providing education. This study aimed to determine the product trial of developing a pocketbook as an educational module using the assessment parameters of experts and DM patients who meet the eligibility criteria at Kaliwungu Health Center, Kudus. This study used qualitative and quantitative analysis. Qualitative analysis in the form of suggestions and input from experts, and quantitative analysis in the form of assessment scores. The method used in this research is research and development. Product development with Borg and Gall procedures. Product trials of pocket book development as a DM patient education module at Kaliwungu Health Center, Kudus, using expert parameters including media experts at 100%, material expert I with a value of 84%, material expert II with a value of 92.3%, material expert III with a value of 100%, expert practitioners with a value of 100% and DM patients with an average value of 80.5% in the category worth using with revision.","PeriodicalId":106715,"journal":{"name":"Open Access Indonesian Journal of Medical Reviews","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115378199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}