发布求助
文献互助 智能选刊 最新文献

Open Access Indonesian Journal of Medical Reviews最新文献

筛选
英文 中文
Review of Genetic Variants of Butyrylcholinesterase and Their Potential Impact on Human Health 丁基胆碱酯酶基因变异及其对人体健康的潜在影响
Open Access Indonesian Journal of Medical Reviews Pub Date : 2021-08-13 DOI: 10.37275/oaijmr.v1i6.575
Bharmatisna Anggaharsya Nugraha
{"title":"Review of Genetic Variants of Butyrylcholinesterase and Their Potential Impact on Human Health","authors":"Bharmatisna Anggaharsya Nugraha","doi":"10.37275/oaijmr.v1i6.575","DOIUrl":"https://doi.org/10.37275/oaijmr.v1i6.575","url":null,"abstract":"Butyrylcholinesterase (BChE) is an enzyme found in plasma and many other parts of the body. It is enzyme that hydrolyses drugs containing ester bonds such as drugs acting at the neuromuscular junction (succinylcholine) and local anaesthetics (procaine). Examination of the gene for mutations or polymorphisms causing the observed biochemical phenotypes has isolated those responsible for all the most widely known variants. The molecular bases of several genetic variants of BChE have been reported, such as the Atypical variant, fluoride-resistant variant, silent variant, K variant, J variant and C5 variant. In general, BChE polymorphisms have been shown to produce enzymes with varying levels of catalytic activity. Genetic variants of human butyrylcholinesterase were one of the first examples in the new field of pharmacogenetics when it was recognized that abnormal response to the succinylcholine was due to a mutated enzyme with low binding affinity. Beside that, variant of BChE has potential impact for Alzheimer disease patology.","PeriodicalId":106715,"journal":{"name":"Open Access Indonesian Journal of Medical Reviews","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130804671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ethics in Gene Editing 基因编辑中的伦理
Open Access Indonesian Journal of Medical Reviews Pub Date : 2021-08-13 DOI: 10.37275/oaijmr.v1i6.576
I. M. Diana
{"title":"Ethics in Gene Editing","authors":"I. M. Diana","doi":"10.37275/oaijmr.v1i6.576","DOIUrl":"https://doi.org/10.37275/oaijmr.v1i6.576","url":null,"abstract":"For thousands of years, humans have felt the need to understand the world around them—and ultimately manipulate it to best serve their needs. There are always ethical questions to address, especially when the manipulation involves the human genome. There is currently an urgent need to actively pursue those conversations as com- mercial gene sequencing and editing technologies have become more accessible and affordable. Gene Editing has enormous potential both as a research tool and a therapeutic intervention. While other types of gene editing are relatively uncontroversial, gene editing has been strongly resisted.","PeriodicalId":106715,"journal":{"name":"Open Access Indonesian Journal of Medical Reviews","volume":"56 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117127512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信