Contemporary Oncology最新文献_第5页

The potential influence of breast cancer estrogen receptors’ distribution on active DNA demethylation 乳腺癌雌激素受体分布对活性DNA去甲基化的潜在影响

Contemporary Oncology Pub Date : 2019-05-27 DOI: 10.5114/wo.2019.85200

K. Linowiecka, Olga Urbanowska-Domańska, Jolanta Guz, M. Foksinski

引用次数: 2

Comparison of the hypothetical 57Co brachytherapy source with the 192Ir source 假设的57Co近距离治疗源与192Ir源的比较

Contemporary Oncology Pub Date : 2016-09-05 DOI: 10.5114/wo.2016.61854

M. Toossi, M. Ghorbani, A. Rostami, M. Khosroabadi, S. Khademi, C. Knaup

{"title":"Comparison of the hypothetical 57Co brachytherapy source with the 192Ir source","authors":"M. Toossi, M. Ghorbani, A. Rostami, M. Khosroabadi, S. Khademi, C. Knaup","doi":"10.5114/wo.2016.61854","DOIUrl":"https://doi.org/10.5114/wo.2016.61854","url":null,"abstract":"Aim of the study The 57Co radioisotope has recently been proposed as a hypothetical brachytherapy source due to its high specific activity, appropriate half-life (272 days) and medium energy photons (114.17 keV on average). In this study, Task Group No. 43 dosimetric parameters were calculated and reported for a hypothetical 57Co source. Material and methods A hypothetical 57Co source was simulated in MCNPX, consisting of an active cylinder with 3.5 mm length and 0.6 mm radius encapsulated in a stainless steel capsule. Three photon energies were utilized (136 keV [10.68%], 122 keV [85.60%], 14 keV [9.16%]) for the 57Co source. Air kerma strength, dose rate constant, radial dose function, anisotropy function, and isodose curves for the source were calculated and compared to the corresponding data for a 192Ir source. Results The results are presented as tables and figures. Air kerma strength per 1 mCi activity for the 57Co source was 0.46 cGyh–1 cm 2 mCi–1. The dose rate constant for the 57Co source was determined to be 1.215 cGyh–1U–1. The radial dose function for the 57Co source has an increasing trend due to multiple scattering of low energy photons. The anisotropy function for the 57Co source at various distances from the source is more isotropic than the 192Ir source. Conclusions The 57Co source has advantages over 192Ir due to its lower energy photons, longer half-life, higher dose rate constant and more isotropic anisotropic function. However, the 192Ir source has a higher initial air kerma strength and more uniform radial dose function. These properties make 57Co a suitable source for use in brachytherapy applications.","PeriodicalId":10652,"journal":{"name":"Contemporary Oncology","volume":"38 1","pages":"327 - 334"},"PeriodicalIF":0.0,"publicationDate":"2016-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87391032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Evaluation of a newly discovered breast cancer susceptibility locus at 6q25.1 in Iranian Azari-Turkish women 伊朗阿扎里-土耳其女性新发现的乳腺癌易感位点6q25.1的评估

Contemporary Oncology Pub Date : 2016-09-05 DOI: 10.5114/wo.2016.61851

Ziba Garehdaghchi, S. Derakhshan, M. Khaniani

{"title":"Evaluation of a newly discovered breast cancer susceptibility locus at 6q25.1 in Iranian Azari-Turkish women","authors":"Ziba Garehdaghchi, S. Derakhshan, M. Khaniani","doi":"10.5114/wo.2016.61851","DOIUrl":"https://doi.org/10.5114/wo.2016.61851","url":null,"abstract":"Aim of the study A recent breast cancer genome-wide association study (GWAS) identified single-nucleotide polymorphism (SNP) rs2046210 on 6q25.1 showing a strong association with breast cancer risk. Numerous association studies have been conducted to investigate the relationship between this polymorphism and breast cancer risk in various populations. There have been conflicting reports about the association of this locus with breast cancer risk in different ethnic groups. For the first time, this study has investigated the association of rs2046210 SNP with breast cancer risk in Iranian Azari-Turkish women in North West Iran. Material and methods In this study 192 breast cancer subjects and 186 healthy controls were genotyped using Taqman SNP genotyping assays for different SNP rs2046210 alleles. Results No significant association between rs2046210 SNP alleles and the risk of breast cancer was detected in Iranian Azari-Turkish women. Conclusions The data suggests that rs2046210SNP does not play a role in the aetiology of breast cancer in the Iranian Azari-Turkish population, and it indicates possible genetic differences for breast cancer between different population ancestries. Our result is an important contribution to the literature about genetic susceptibility for breast cancer in Asian populations. Additional studies are required to confirm our findings.","PeriodicalId":10652,"journal":{"name":"Contemporary Oncology","volume":"6 1","pages":"308 - 310"},"PeriodicalIF":0.0,"publicationDate":"2016-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85370977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Notch signalling pathway as an oncogenic factor involved in cancer development Notch信号通路作为致癌因子参与癌症发展

Contemporary Oncology Pub Date : 2016-09-05 DOI: 10.5114/wo.2016.61845

M. Brzozowa-Zasada, A. Piecuch, Anna Dittfeld, Ł. Mielańczyk, M. Michalski, G. Wyrobiec, M. Harabin-Słowińska, J. Kurek, R. Wojnicz

{"title":"Notch signalling pathway as an oncogenic factor involved in cancer development","authors":"M. Brzozowa-Zasada, A. Piecuch, Anna Dittfeld, Ł. Mielańczyk, M. Michalski, G. Wyrobiec, M. Harabin-Słowińska, J. Kurek, R. Wojnicz","doi":"10.5114/wo.2016.61845","DOIUrl":"https://doi.org/10.5114/wo.2016.61845","url":null,"abstract":"Notch signalling is an evolutionarily conserved signalling pathway, which plays a significant role in a wide array of cellular processes including proliferation, differentiation, and apoptosis. Nevertheless, it must be noted that Notch is a binary cell fate determinant, and its overexpression has been described as oncogenic in a broad range of human malignancies. This finding led to interest in therapeutically targeting this pathway especially by the use of GSIs, which block the cleavage of Notch at the cell membrane and inhibit release of the transcriptionally active NotchIC subunit. Preclinical cancer models have clearly demonstrated that GSIs suppress the growth of such malignancies as pancreatic, breast, and lung cancer; however, GSI treatment in vivo is associated with side effects, especially those within the gastrointestinal tract. Although intensive studies are associated with the role of γ-secretase in pathological states, it should be pointed out that this complex impacts on proteolytic cleavages of around 55 membrane proteins. Therefore, it is clear that GSIs are highly non-specific and additional drugs must be designed, which will more specifically target components of the Notch signalling.","PeriodicalId":10652,"journal":{"name":"Contemporary Oncology","volume":"70 1","pages":"267 - 272"},"PeriodicalIF":0.0,"publicationDate":"2016-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88533664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 37

Particular aspects in the cytogenetics and molecular biology of salivary gland tumours – current review of reports 唾液腺肿瘤的细胞遗传学和分子生物学的特殊方面-目前的报告综述

Contemporary Oncology Pub Date : 2016-09-05 DOI: 10.5114/wo.2016.61847

Aleksandra Ochal-Choińska, E. Osuch-Wójcikiewicz

引用次数: 8

Primary mediastinal B-cell lymphoma – metabolic and anatomical features in 18FDG-PET/CT and response to therapy 原发性纵隔b细胞淋巴瘤:18FDG-PET/CT的代谢和解剖特征及对治疗的反应

Contemporary Oncology Pub Date : 2016-09-05 DOI: 10.5114/wo.2016.61849

A. Kocurek, B. Małkowski, A. Giza, W. Jurczak

{"title":"Primary mediastinal B-cell lymphoma – metabolic and anatomical features in 18FDG-PET/CT and response to therapy","authors":"A. Kocurek, B. Małkowski, A. Giza, W. Jurczak","doi":"10.5114/wo.2016.61849","DOIUrl":"https://doi.org/10.5114/wo.2016.61849","url":null,"abstract":"Aim of the study Determining the role of PET/CT imaging in the evaluation of treatment efficacy in primary mediastinal B-cell lymphoma (PMBCL). Material and methods Retrospective analysis of seven PMBCL patients, treated at the University Hospital in Krakow, with interim PET/CT after the third course of chemo-immunotherapy.The analysis was based on the calculation of exact tumour volume and metabolic activity, compared with initial values (directly after diagnosis). Results Patients (five females, two males, average age 26.2 years, range 18–40 years), in clinical stage IIBX at diagnosis, were treated with eight cycles of R-CHOP-14 regimen, with radiotherapy consolidation (7/7) and central nervous system prophylaxis (6/7). The observed decrease in tumour volume between the initial staging and the interim PET ranged 72–89%. The mean ΔSUVmax reduction between initial (when available) and interim PET was 87% (range 84–89%). In 3/7 cases in the interim PET/CT, the uptake of the tumour was higher than the liver (Deauville Criteria score 4–5), and in 4/7 it was lower than the liver but higher than mediastinal blood pool structures (score 3 according to Deauville Criteria). After a median follow-up of 58 months – OS and EFS is 100%. Conclusions The excellent clinical outcome in the study group corresponds with very good metabolic and volumetric response in the interim PET. The ΔSUVmax seems to be easier in implementation and has a more significant impact than other measurements.","PeriodicalId":10652,"journal":{"name":"Contemporary Oncology","volume":"29 1","pages":"297 - 301"},"PeriodicalIF":0.0,"publicationDate":"2016-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78232116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Male breast cancer: a clinicopathological study of an Egyptian population (Alexandria experience) 男性乳腺癌:埃及人群的临床病理研究(亚历山大经验)

Contemporary Oncology Pub Date : 2016-09-05 DOI: 10.5114/wo.2016.61855

M. Soliman, M. Hetnał

{"title":"Male breast cancer: a clinicopathological study of an Egyptian population (Alexandria experience)","authors":"M. Soliman, M. Hetnał","doi":"10.5114/wo.2016.61855","DOIUrl":"https://doi.org/10.5114/wo.2016.61855","url":null,"abstract":"Aim of the study The purpose of this retrospective study is to evaluate the clinicopathological features and treatment results of male breast cancer presented to our tertiary referral center. Material and methods Between January 1998 and December 2005, a total of 39 men with breast cancer treated at Alexandria Main University Hospital and their medical records were reviewed. Results The median age of patients was 59 years. Only 3 (7.7%) patients had positive family history. All patients presented by breast swellings that were associated with axillary mass in about one third of them. Around 80% had hormone receptor positive (estrogen and/or progesterone receptors). Two third of patients had advanced T-stage (T3 and T4). Left sided breast cancer occurred in 51.3%. Infiltrating ductal carcinoma was the most common type of histology encountered and grade 2 was the predominant grade of tumor. Modified radical mastectomy was the most common (87.2%) type of surgery done followed by chemotherapy for 32 patients and loco-regional radiotherapy for 20 patients. Tamoxifen was administered in 31 patients. Distant relapse occurred in 7 patients (17.9%) and local recurrence occurred in 2 patients (5.1%). The 5-year disease-free survival (DFS) was 82% and the 5-year overall survival (OS) rate was 84%. Only negative axillary lymph node and positive hormone receptor status were significantly associated with favorable DFS and OS. T-stage, grade of tumor and type of chemotherapy given had no statistically significant impact on either DFS or OS. Conclusions Male breast cancer is still under-investigated and further researches are warranted.","PeriodicalId":10652,"journal":{"name":"Contemporary Oncology","volume":"14 1","pages":"335 - 340"},"PeriodicalIF":0.0,"publicationDate":"2016-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75498066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Interferon-α reduces the gefitinib sensitivity of human non-small cell lung cancer 干扰素α降低人非小细胞肺癌对吉非替尼的敏感性

Contemporary Oncology Pub Date : 2016-09-05 DOI: 10.5114/wo.2016.61853

Chi Pan, Shanshan Weng, Yin Duan, L. Ding, Su-zhan Zhang, Jian-jin Huang

{"title":"Interferon-α reduces the gefitinib sensitivity of human non-small cell lung cancer","authors":"Chi Pan, Shanshan Weng, Yin Duan, L. Ding, Su-zhan Zhang, Jian-jin Huang","doi":"10.5114/wo.2016.61853","DOIUrl":"https://doi.org/10.5114/wo.2016.61853","url":null,"abstract":"Aim of the study Many studies have shown that interferon-α (IFN-α) enhances the antiproliferative effect of gefitinib in some solid tumours. We aimed to determine the effect of combining IFN-α with gefitinib in human non-small cell lung cancer (NSCLC) cell lines (A549, H1299, HCC827) with different EGFR and K-Ras gene statuses. Material and methods An MTT assay was used to assess cell proliferation. Apoptosis was detected by an Annexin V/propidium iodide assay using flow cytometry, and western blotting was used to determine the expression of epidermal growth factor receptor/phosphorylated epidermal growth factor receptor (EGFR/p-EGFR) and signal transducers and activators of transcription 3/phosphorylated signal transducers and activators of transcription 3 (STAT3/p-STAT3). Results There was an additive interaction when gefitinib was combined with IFN-α in all cell lines; however, there was antagonism when gefitinib followed IFN-α pretreatment in three cell lines. Notably, IFN-α pretreatment significantly reduced the gefitinib sensitivity of HCC827 cells. Surprisingly, while IFN-α inhibited STAT3 phosphorylation in cell lines, gefitinib could do so. Conclusions The results might confirm the hypothesis that IFN-α induces gefitinib sensitivity of NSCLC, and IFN-α inhibits phosphorylation of STAT3, which may be dependent on EGFR signal activation playing a role in the reduction of gefitinib sensitivity after IFN-α treatment in NSCLC cell lines.","PeriodicalId":10652,"journal":{"name":"Contemporary Oncology","volume":"71 1","pages":"320 - 326"},"PeriodicalIF":0.0,"publicationDate":"2016-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77113901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of mTOR expression on clinical outcome in paediatric patients with B-cell acute lymphoblastic leukaemia – preliminary report mTOR表达对儿童b细胞急性淋巴细胞白血病患者临床预后的影响——初步报告

Contemporary Oncology Pub Date : 2016-09-05 DOI: 10.5114/wo.2016.61848

Edyta Ulińska, Katarzyna Mycko, Elżbieta Sałacińska-Łoś, A. Pastorczak, A. Siwicka, W. Młynarski, M. Matysiak

{"title":"Impact of mTOR expression on clinical outcome in paediatric patients with B-cell acute lymphoblastic leukaemia – preliminary report","authors":"Edyta Ulińska, Katarzyna Mycko, Elżbieta Sałacińska-Łoś, A. Pastorczak, A. Siwicka, W. Młynarski, M. Matysiak","doi":"10.5114/wo.2016.61848","DOIUrl":"https://doi.org/10.5114/wo.2016.61848","url":null,"abstract":"Aim of the study To characterise expression of mTOR (mammalian target of rapamycin) in childhood B-cell acute lymphoblastic leukaemia (ALL), and to evaluate a possible link between mTOR and clinical characteristics. Material and methods The examined group consisted of 21 consecutive patients, aged 1–18 years, diagnosed with B-cell ALL in 2010, and 10 relapsed B-cell ALL patients diagnosed for the first time between 2009 and 2011, who developed relapse before 2014. All subjects were treated in the Department of Paediatric Haematology and Oncology of the Medical University of Warsaw according to the ALL-IC BFM 2002 Protocol. We evaluated mTOR and phospho-mTOR expression by immunohistochemistry using rabbit monoclonal antibodies. Results mTOR expression was found to be significantly associated with the risk of relapse and was more frequent in ALL recurrence. No significant relationship was detected between mTOR expression and other features of high-risk disease in paediatric ALL. Conclusions mTOR activity could be considered a high-risk feature in paediatric B-cell ALL. Expression of mTOR kinase is observed remarkably more frequently in disease recurrence than at first diagnosis, indicating higher proliferative and survival potential of leukaemic cells in relapse. Routine analysis of mTOR activity could be performed to select patients that may potentially benefit from mTOR inhibitors (MTI) treatment.","PeriodicalId":10652,"journal":{"name":"Contemporary Oncology","volume":"20 1","pages":"291 - 296"},"PeriodicalIF":0.0,"publicationDate":"2016-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81538111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Patterns of care in patients with muscle-invasive bladder cancer – a retrospective cohort study 肌肉浸润性膀胱癌患者的护理模式——一项回顾性队列研究

Contemporary Oncology Pub Date : 2016-09-05 DOI: 10.5114/wo.2016.61857

S. Poletajew, R. Biernacki, P. Buraczyński, J. Chojnacki, S. Czarniecki, D. Gajewska, T. Pohaba, J. Sondka, M. Skrzypczyk, T. Suchojad, D. Wojtkowiak, B. Zaforemski, Ł. Zapała, A. Zemła, P. Radziszewski

{"title":"Patterns of care in patients with muscle-invasive bladder cancer – a retrospective cohort study","authors":"S. Poletajew, R. Biernacki, P. Buraczyński, J. Chojnacki, S. Czarniecki, D. Gajewska, T. Pohaba, J. Sondka, M. Skrzypczyk, T. Suchojad, D. Wojtkowiak, B. Zaforemski, Ł. Zapała, A. Zemła, P. Radziszewski","doi":"10.5114/wo.2016.61857","DOIUrl":"https://doi.org/10.5114/wo.2016.61857","url":null,"abstract":"A potential reason for poor survival among patients with muscle-invasive bladder cancer (MIBC) in Poland is initial disqualification from curative treatment due to advanced stage of the disease or low performance status. The aim of this study was to describe patterns of care in patients with newly diagnosed MIBC. This is a multicentre retrospective cohort study involving 296 consecutive patients with primary histologically diagnosed MIBC. Therapeutic decisions and potentially underlying clinical factors were analysed. Full clinical data was available for 285 patients. One hundred and sixty-four (57.5%) patients were qualified for radical cystectomy (RC), 32 (11.2%) patients for a second step of transurethral resection of the bladder tumour (TURBT) intentionally followed by systemic chemotherapy, four (1.4%) patients after complete TURBT were qualified for adjuvant intravesical chemotherapy only, while the remaining 85 (29.8%) patients were qualified for palliative treatment in the form of chemotherapy and/or radiotherapy and/or best supportive care. Patients disqualified from curative treatment were older (78 vs. 69 years, p < 0.02), had lower BMI values (24.5 vs. 25.7 kg/m2, p < 0.02), lower haemoglobin concentration (11.6 vs. 12.9 mg/l, p < 0.02), declared lower rate of nicotine abuse (50.5% vs. 72.1%, p < 0.02), and had a shorter time interval between first symptom and diagnosis (30 vs. 60 days, p = 0.02). As the majority of Polish patients with primary MIBC receive curative treatment, the stage of the disease alone seems not to be the leading cause of poor survival. However, appropriateness of qualification for RC and treatment quality needs to be assessed for final conclusion on the factors influencing outcomes of treatment in Poland.","PeriodicalId":10652,"journal":{"name":"Contemporary Oncology","volume":"1 1","pages":"341 - 343"},"PeriodicalIF":0.0,"publicationDate":"2016-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89274851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4