Contemporary Oncology最新文献_第4页

Partial mandibulectomy without bony reconstruction in patients with oropharyngeal or mouth cancer 口咽癌或口腔癌患者的部分下颌骨切除术无骨重建

Contemporary Oncology Pub Date : 2019-09-04 DOI: 10.5114/wo.2019.87575

T. Schrom, F. Bast, S. Knipping

{"title":"Partial mandibulectomy without bony reconstruction in patients with oropharyngeal or mouth cancer","authors":"T. Schrom, F. Bast, S. Knipping","doi":"10.5114/wo.2019.87575","DOIUrl":"https://doi.org/10.5114/wo.2019.87575","url":null,"abstract":"Aim of the study Resection of tumours of the oral cavity has significant consequences relating to function and aesthetic properties. Advancements in surgical techniques and microvascular surgery have enabled reconstructive outcomes to reach those of pre-surgery levels with good functional and aesthetic results. However, reconstructive options are not without complications. Material and methods We report the outcome of 23 patients with large tumours of the oral cavity or floor of the mouth, who underwent resection of the tumour and parts of the mandible without bony reconstruction. The patient population consisted of 19 oropharyngeal carcinomas and four floor of the mouth cancers, all of which had stage cT4 (six female and 17 male patients), and with an average patient age of 59.8 years. The pre- and postoperative ability to open the mouth, level of pain while masticating, mastication function pre and post-surgery, and the aesthetic outcome post-surgery were measured. Results The results obtained were deemed pleasantly acceptable by the patients, from aesthetic, functional, and analgesic points of view. Discussion A thorough preoperative work up is required and discussion with a multidisciplinary team is a necessity. This treatment option is more acceptable to the patient than would be expected and provides a satisfactory functional and aesthetic outcome. Therefore, we believe that partial mandibulectomy without bony reconstruction is an acceptable management option for a carefully selected group of patients who may not be suitable for the extensive surgery involved with bony reconstruction.","PeriodicalId":10652,"journal":{"name":"Contemporary Oncology","volume":"35 1","pages":"146 - 150"},"PeriodicalIF":0.0,"publicationDate":"2019-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74631974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Applying nasal airflow – inducing maneuvers with patients with hyposmia after total laryngectomy 应用鼻腔气流诱导手法治疗全喉切除术后低通气患者

Contemporary Oncology Pub Date : 2019-07-16 DOI: 10.5114/wo.2019.86688

Agnieszka Hamerlińska

引用次数: 3

Predictors of stress in close relatives supporting patients with leukaemia 支持白血病患者的近亲的压力预测因素

Contemporary Oncology Pub Date : 2019-06-13 DOI: 10.5114/wo.2019.85883

Anna Kaczmarska-Tabor, H. Wrona-Polańska

引用次数: 0

Detection of somatic mutations in ctDNA derived from adenocarcinoma patients – EGFR tyrosine kinase inhibitor monitoring preliminary study 腺癌患者ctDNA体细胞突变的检测——EGFR酪氨酸激酶抑制剂监测的初步研究

Contemporary Oncology Pub Date : 2019-06-13 DOI: 10.5114/wo.2019.85879

M. Lewandowska, E. Nalejska, Łukasz Żołna, Aleksandra Chrząstek, B. Żurawski, M. Wiśniewska, Manuela Las-Jankowska, K. Roszkowski, J. Kowalewski

{"title":"Detection of somatic mutations in ctDNA derived from adenocarcinoma patients – EGFR tyrosine kinase inhibitor monitoring preliminary study","authors":"M. Lewandowska, E. Nalejska, Łukasz Żołna, Aleksandra Chrząstek, B. Żurawski, M. Wiśniewska, Manuela Las-Jankowska, K. Roszkowski, J. Kowalewski","doi":"10.5114/wo.2019.85879","DOIUrl":"https://doi.org/10.5114/wo.2019.85879","url":null,"abstract":"Aim of the study The main purpose of this study was to assess detection of mutations in the epidermal growth factor receptor (EGFR) gene in circulating tumor DNA (ctDNA) as a tool for EGFR tyrosine kinase inhibitor (TKI) monitoring therapy. Material and methods The study was conducted using 20 samples from 7 adenocarcinoma patients treated with TKIs. Blood samples for ctDNA analysis were collected in 2015–2016. ctDNA was isolated using the QIAamp Circulating Nucleic Acid Kit (Qiagen) and analyzed using the ctEGFR Mutation Detection Kit (EntroGen). Results The most common exon 19 deletion and p.Leu858Arg mutation in exon 21 of the EGFR gene were detected. We observed a correlation between stabilization of patient condition and the lack of p.Thr790Met mutation detection in ctEGFR during TKI treatment (2 out of 7 patients). We also observed a correlation between progression of the disease and p.Thr790Met mutation detection in ctEGFR (3 out of 7 cases). We did not detect ctDNA p.Thr790Metp in two patients in whom progression occurred shortly thereafter. Last but not least, we noticed that good organization during plasma collection and transportation (average time of 6 minutes and 30 seconds) allows to use K2EDTA tubes. Conclusions When tissue is limited or insufficient, analysis of the ctEGFR mutational status can be considered as an alternative tool for qualifying patients with non-small cell lung cancer (NSCLC) for TKI therapy, also as a potential monitoring tool. The plasma p.Thr790Met-negative result needs to be verified for the presence of p.Thr790Met-positive tumor tissue.","PeriodicalId":10652,"journal":{"name":"Contemporary Oncology","volume":"2016 1","pages":"87 - 91"},"PeriodicalIF":0.0,"publicationDate":"2019-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86643296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

The influence of leptin on the process of carcinogenesis 瘦素对癌变过程的影响

Contemporary Oncology Pub Date : 2019-06-13 DOI: 10.5114/wo.2019.85877

Patrycja Modzelewska, Sylwia Chludzińska, J. Lewko, J. Reszeć

引用次数: 34

Cobas 4800 HPV detection in cervical samples of Polish women 波兰妇女宫颈样本Cobas 4800 HPV检测

Contemporary Oncology Pub Date : 2019-06-13 DOI: 10.5114/wo.2019.85880

B. Smolarz, D. Samulak, K. Szyłło, Marianna Makowska, H. Romanowicz, Z. Kojs, M. Michalska

引用次数: 5

Body mass index and nipple preservation are major contributors to satisfaction and aesthetic outcome rates after implant-based immediate breast reconstruction 身体质量指数和乳头保留是满意度和美学结果的主要贡献者植入式乳房重建后立即

Contemporary Oncology Pub Date : 2019-06-13 DOI: 10.5114/wo.2019.85881

S. Ukleikins, A. Irmejs, A. Gilis, E. Tauvena, J. Maksimenko, G. Trofimovičs, J. Gardovskis

{"title":"Body mass index and nipple preservation are major contributors to satisfaction and aesthetic outcome rates after implant-based immediate breast reconstruction","authors":"S. Ukleikins, A. Irmejs, A. Gilis, E. Tauvena, J. Maksimenko, G. Trofimovičs, J. Gardovskis","doi":"10.5114/wo.2019.85881","DOIUrl":"https://doi.org/10.5114/wo.2019.85881","url":null,"abstract":"Introduction Immediate breast reconstructions (IBR) have become an integral part of modern breast cancer management. However, in a small breast unit the spectrum of methods used for IBR could be limited, which could result in poorer results in some cases. The aim of the study is to evaluate the patient satisfaction and aesthetic outcome results in a breast unit where only implant-based IBR were performed. Material and methods During 2009–2016, 64 cases of implant-based IBR were performed in the university hospital. 55 patients completed the questionnaire and 38 underwent evaluation by a plastic surgeon. 33 skin-sparing and 22 nipple-sparing mastectomies were included. The study included 30 two-stage expander/implant and 25 direct-toimplant IBR cases. Results Overall satisfaction was reported by 89% of respondents. 93% were satisfied with appearance in clothes and 82% with appearance in a bra. There was a significant difference with satisfaction in nude appearance between groups with a removed (3%) and a spared nipple (46%). The plastic surgeon evaluated overall outcome as satisfactory in 61% and poor in 39%. Spearman coefficient showed a moderate negative correlation between body mass index (BMI) and aesthetic outcome (p = 0.02), as well as BMI and volume differences between breasts (p = 0.03). Patients evaluated their breast symmetry as satisfactory in 55%, and the plastic surgeon concluded the same in 55% of 38 cases. Conclusions Most of the patients were satisfied with the aesthetic outcome of IBR. Nipple preservation considerably improved satisfaction rates. However, implant-based IBR revealed suboptimal cosmetic results in the subset of cases with increased BMI and other IBR methods should be considered in those cases.","PeriodicalId":10652,"journal":{"name":"Contemporary Oncology","volume":"64 1","pages":"96 - 99"},"PeriodicalIF":0.0,"publicationDate":"2019-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77187511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Ossifying fasciitis at an extraordinary site – a case report and analysis of diagnostic pitfalls 骨化性筋膜炎在一个特殊的地方-一个病例报告和分析诊断陷阱

Contemporary Oncology Pub Date : 2019-06-13 DOI: 10.5114/wo.2019.85884

Łukasz Kowalczyk, Marcin Braun, B. Tomasik, Dominika Piasecka, Dominika Michno, J. Fijuth, D. Jesionek-Kupnicka, R. Kordek

引用次数: 2

Salivary and serum concentrations of selected pro- and antiinflammatory cytokines in relation to oral lesions among children undergoing maintenance therapy of acute lymphoblastic leukemia 在接受急性淋巴细胞白血病维持治疗的儿童中，唾液和血清中选定的促炎和抗炎细胞因子浓度与口腔病变有关

Contemporary Oncology Pub Date : 2019-06-13 DOI: 10.5114/wo.2019.85878

Przemysław M. Krzaczek, M. Mitura-Lesiuk, Joanna Zawitkowska, Beata Petkowicz, B. Wilczynska, K. Drabko

{"title":"Salivary and serum concentrations of selected pro- and antiinflammatory cytokines in relation to oral lesions among children undergoing maintenance therapy of acute lymphoblastic leukemia","authors":"Przemysław M. Krzaczek, M. Mitura-Lesiuk, Joanna Zawitkowska, Beata Petkowicz, B. Wilczynska, K. Drabko","doi":"10.5114/wo.2019.85878","DOIUrl":"https://doi.org/10.5114/wo.2019.85878","url":null,"abstract":"Acute lymphoblastic leukemia is the most common type of childhood cancer, accounting for about 23% of all cancers diagnosed in this age group. The last stage of radical treatment is remission maintenance, during which hospitalization is not necessary. The lesions occurring in the oral cavity caused by medications and chemotherapy may also be directly related to hematological and systemic disorders. The aim of this study was to examine the levels of selected pro- and anti-inflammatory cytokines in saliva and serum of both patients undergoing remission maintenance and those after the cessation of therapy who reported to the hematology clinic of the Pediatric University Hospital in Lublin. The results were later analyzed in relation to the frequency of oral lesions and subjective intensity of oral complaints. The study revealed significant differences in salivary and serum concentrations of TNF-α and IL-10 between test and control groups. Oral lesions were more frequent in patients receiving therapy compared to the control group. Subjective afflictions described by the Visual Analog Scale (VAS) mean values were highest in the control group.","PeriodicalId":10652,"journal":{"name":"Contemporary Oncology","volume":"54 1","pages":"81 - 86"},"PeriodicalIF":0.0,"publicationDate":"2019-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85803891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Comparison of health locus of control in oncological and non-oncological patients 肿瘤患者与非肿瘤患者健康控制点的比较

Contemporary Oncology Pub Date : 2019-05-31 DOI: 10.5114/wo.2019.85638

Katarzyna Gibek, T. Sacha

{"title":"Comparison of health locus of control in oncological and non-oncological patients","authors":"Katarzyna Gibek, T. Sacha","doi":"10.5114/wo.2019.85638","DOIUrl":"https://doi.org/10.5114/wo.2019.85638","url":null,"abstract":"Aim of the study The aim of the study was to investigate whether there are differences in the various dimensions of the health locus of control between oncological and non-oncological patients and to determine whether there is a relationship between the level of health locus of control and the type, duration of disease and gender. Material and methods The study was conducted at the Department of Hematology and the 1st Department of Cardiology of the University Hospital in Krakow. 204 patients were enrolled. Our own questionnaire developed for this purpose and the Multidimensional Health Locus of Control scale were used. The US normalization group and the Polish standardization groups of the chronically ill patients were used for comparative analysis. Results Analysis showed significant differences between women and men in the Internal control scale (p < 0.02). The respondents from both groups showed lower scores in the Internal locus of control and much higher scores in the dimension Powerful Others. In the group of oncological patients, a negative correlation was found between the Internal scale of health locus of control and the duration of the disease (p = 0.007). There was a significant difference between oncological and non-oncological patients in the Powerful Others scale (p < 0.004). Conclusions The results suggest that oncologically ill patients could be more convinced that others are responsible for their health when compared to non-oncological patients. The longer the disease persists in oncological patients, the weaker is their internal motivation to achieve good treatment results.","PeriodicalId":10652,"journal":{"name":"Contemporary Oncology","volume":"34 1","pages":"115 - 120"},"PeriodicalIF":0.0,"publicationDate":"2019-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74412197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15