{"title":"Idiotypes, T-cell receptors, and T-B cooperation.","authors":"C A Janeway","doi":"10.1007/978-1-4615-9131-3_7","DOIUrl":"https://doi.org/10.1007/978-1-4615-9131-3_7","url":null,"abstract":"<p><p>T cells are responsible for virtually all the characteristics of the mammalian immune system except the production of serum antibody, in which they play a vital regulatory role. As such, they are central to our understanding of the immune system. T cells recognize cell-bound antigens with great precision, in association with self MHC antigens. They do this by means of antigen-specific receptors, whose antigen-combining sites are encoded in conventional VH genes. There is evidence that T cells carry at least two kinds of specific receptors, one for MHC antigens and one for non-MHC antigens. Both of these would bear VH-encoded and distinct idiotypic determinants. The process by which antigens associate with MHC-gene products on cell surfaces is poorly understood at present, and so is the process by which the two types of receptors communicate with each other. T cells are divisible into a number of subpopulations playing unique functional roles in the regulation of antibody responses. If one examines them further for other functions, even greater complexity emerges. Thus, all T cells may not have the same kind of receptor, which would not be surprising given the wide variety of functions they perform. Future work will undoubtedly focus on these important questions.</p>","PeriodicalId":10609,"journal":{"name":"Contemporary topics in immunobiology","volume":"9 ","pages":"171-203"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17219215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"An immunologic network.","authors":"D A Rowley, H Köhler, J D Cowan","doi":"10.1007/978-1-4615-9131-3_8","DOIUrl":"https://doi.org/10.1007/978-1-4615-9131-3_8","url":null,"abstract":"<p><p>The immune system is a complex network of molecules and cells specifically connected by the complementarity of receptors for antigen and receptors for receptors. The network includes multiple positive- and negative-feedback loops, which modulate the type, magnitude, and duration of responses. The great challenge is to devise ways to manipulate the system specifically to induce effective autoimmunity to cancer, to prevent allograft rejection, and to turn off undesirable responses in allergies and autoimmune diseases. Recognition of the immune system as a network helps to explain why these objectives are so difficult and why manipulation of multiple components to achieve desired regulation may be required. But presumably manipulation must be focused on connectivity between receptor for epitope and receptor for receptor to achieve a high degree of specific regulation.</p>","PeriodicalId":10609,"journal":{"name":"Contemporary topics in immunobiology","volume":"9 ","pages":"205-30"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17503338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Evidence for membrane-bound antibodies directed against antigens expressed on tumors.","authors":"S von Kleist, M King, C Huet","doi":"10.1007/978-1-4684-3677-8_8","DOIUrl":"https://doi.org/10.1007/978-1-4684-3677-8_8","url":null,"abstract":"","PeriodicalId":10609,"journal":{"name":"Contemporary topics in immunobiology","volume":"10 ","pages":"177-89"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18419335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A review of data, problems, and open questions pertaining to in situ tumor immunity.","authors":"S W Russell, I P Witz, R B Herberman","doi":"10.1007/978-1-4684-3677-8_1","DOIUrl":"https://doi.org/10.1007/978-1-4684-3677-8_1","url":null,"abstract":"","PeriodicalId":10609,"journal":{"name":"Contemporary topics in immunobiology","volume":"10 ","pages":"1-20"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18045833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cancer: a problem in somatic cell evolution.","authors":"J L Collins, P Q Patek, M Cohn","doi":"10.1007/978-1-4684-3701-0_1","DOIUrl":"https://doi.org/10.1007/978-1-4684-3701-0_1","url":null,"abstract":"","PeriodicalId":10609,"journal":{"name":"Contemporary topics in immunobiology","volume":"11 ","pages":"1-79"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17227060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Mononuclear cells and IgG associated with human malignant tissue.","authors":"O Tønder, R Matre, F Wesenberg","doi":"10.1007/978-1-4684-3677-8_7","DOIUrl":"https://doi.org/10.1007/978-1-4684-3677-8_7","url":null,"abstract":"","PeriodicalId":10609,"journal":{"name":"Contemporary topics in immunobiology","volume":"10 ","pages":"167-76"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/978-1-4684-3677-8_7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18419334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Discrimination of self and non-self in plants.","authors":"R B Knox, A E Clarke","doi":"10.1007/978-1-4615-9131-3_1","DOIUrl":"10.1007/978-1-4615-9131-3_1","url":null,"abstract":"","PeriodicalId":10609,"journal":{"name":"Contemporary topics in immunobiology","volume":"9 ","pages":"1-36"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17219214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Tumor immunity in the peritoneal cavity.","authors":"G Berke, B Schick","doi":"10.1007/978-1-4684-3677-8_14","DOIUrl":"https://doi.org/10.1007/978-1-4684-3677-8_14","url":null,"abstract":"","PeriodicalId":10609,"journal":{"name":"Contemporary topics in immunobiology","volume":"10 ","pages":"297-315"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18016981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cellular basis for regulation of tumor growth.","authors":"R Evans","doi":"10.1007/978-1-4684-3677-8_12","DOIUrl":"https://doi.org/10.1007/978-1-4684-3677-8_12","url":null,"abstract":"","PeriodicalId":10609,"journal":{"name":"Contemporary topics in immunobiology","volume":"10 ","pages":"255-66"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18419336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Evidence for mononuclear phagocytes in solid neoplasms and appraisal of their nonspecific cytotoxic capabilities.","authors":"S W Russell, G Y Gillespie, J L Pace","doi":"10.1007/978-1-4684-3677-8_6","DOIUrl":"https://doi.org/10.1007/978-1-4684-3677-8_6","url":null,"abstract":"","PeriodicalId":10609,"journal":{"name":"Contemporary topics in immunobiology","volume":"10 ","pages":"143-66"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18419333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}