Contact (Thousand Oaks (Ventura County, Calif.))最新文献_第4页

Mitochondria from the Outside in: The Relationship Between Inter-Organelle Crosstalk and Mitochondrial Internal Organization. 线粒体由外而内：器官间串联与线粒体内部组织之间的关系。

Contact (Thousand Oaks (Ventura County, Calif.)) Pub Date : 2022-01-01 DOI: 10.1177/25152564221133267

Jonathan R Friedman

{"title":"Mitochondria from the Outside in: The Relationship Between Inter-Organelle Crosstalk and Mitochondrial Internal Organization.","authors":"Jonathan R Friedman","doi":"10.1177/25152564221133267","DOIUrl":"10.1177/25152564221133267","url":null,"abstract":"A fundamental role of membrane-bound organelles is the compartmentalization and organization of cellular processes. Mitochondria perform an immense number of metabolic chemical reactions and to efficiently regulate these, the organelle organizes its inner membrane into distinct morphological domains, including its characteristic cristae membranes. In recent years, a structural feature of increasing apparent importance is the inter-connection between the mitochondrial exterior and other organelles at membrane contact sites (MCSs). Mitochondria form MCSs with almost every other organelle in the cell, including the endoplasmic reticulum, lipid droplets, and lysosomes, to coordinate global cellular metabolism with mitochondrial metabolism. However, these MCSs not only facilitate the transport of metabolites between organelles, but also directly impinge on the physical shape and functional organization inside mitochondria. In this review, we highlight recent advances in our understanding of how physical connections between other organelles and mitochondria both directly and indirectly influence the internal architecture of mitochondria.","PeriodicalId":10556,"journal":{"name":"Contact (Thousand Oaks (Ventura County, Calif.))","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a1/5c/10.1177_25152564221133267.PMC9629538.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40453260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nuclear Interactions: A Spotlight on Nuclear Mitochondrial Membrane Contact Sites. 核相互作用:聚焦于核线粒体膜接触位点。

Contact (Thousand Oaks (Ventura County, Calif.)) Pub Date : 2022-01-01 DOI: 10.1177/25152564221096217

Jana Ovciarikova, Shikha Shikha, Lilach Sheiner

{"title":"Nuclear Interactions: A Spotlight on Nuclear Mitochondrial Membrane Contact Sites.","authors":"Jana Ovciarikova, Shikha Shikha, Lilach Sheiner","doi":"10.1177/25152564221096217","DOIUrl":"https://doi.org/10.1177/25152564221096217","url":null,"abstract":"Membrane contact sites (MCS) are critical for cellular functions of eukaryotes, as they enable communication and exchange between organelles. Research over the last decade unravelled the function and composition of MCS between a variety of organelles including mitochondria, ER, plasma membrane, lysosomes, lipid droplets, peroxisome and endosome, to name a few. In fact, MCS are found between any pair of organelles studied to date, with common functions including lipid exchange, calcium signalling and organelle positioning in the cell. Work in the past year has started addressing the composition and function of nuclear-mitochondrial MCS. Tether components mediating these contacts in yeast have been identified via comprehensive phenotypic screens, which also revealed a possible link between this contact and phosphatidylcholine metabolism. In human cells, and in the protozoan parasites causing malaria, proximity between these organelles is proposed to promote cell survival via a mitochondrial retrograde response. These pioneering studies should inspire the field to explore what cellular processes depend on the exchange between the nucleus and the mitochondrion, given that they play such central roles in cell biology.","PeriodicalId":10556,"journal":{"name":"Contact (Thousand Oaks (Ventura County, Calif.))","volume":"5 ","pages":"25152564221096217"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9623421/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9701611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Remodelling of Nucleus-Vacuole Junctions During Metabolic and Proteostatic Stress. 代谢和蛋白静态应激过程中的核-囊连接重塑

Contact (Thousand Oaks (Ventura County, Calif.)) Pub Date : 2021-05-27 eCollection Date: 2021-01-01 DOI: 10.1177/25152564211016608

Verena Kohler, Sabrina Büttner

{"title":"Remodelling of Nucleus-Vacuole Junctions During Metabolic and Proteostatic Stress.","authors":"Verena Kohler, Sabrina Büttner","doi":"10.1177/25152564211016608","DOIUrl":"10.1177/25152564211016608","url":null,"abstract":"Cellular adaptation to stress and metabolic cues requires a coordinated response of different intracellular compartments, separated by semipermeable membranes. One way to facilitate interorganellar communication is via membrane contact sites, physical bridges between opposing organellar membranes formed by an array of tethering machineries. These contact sites are highly dynamic and establish an interconnected organellar network able to quickly respond to external and internal stress by changing size, abundance and molecular architecture. Here, we discuss recent work on nucleus-vacuole junctions, connecting yeast vacuoles with the nucleus. Appearing as small, single foci in mitotic cells, these contacts expand into one enlarged patch upon nutrient exhaustion and entry into quiescence or can be shaped into multiple large foci essential to sustain viability upon proteostatic stress at the nuclear envelope. We highlight the remarkable plasticity and rapid remodelling of these contact sites upon metabolic or proteostatic stress and their emerging importance for cellular fitness.","PeriodicalId":10556,"journal":{"name":"Contact (Thousand Oaks (Ventura County, Calif.))","volume":" ","pages":"25152564211016608"},"PeriodicalIF":0.0,"publicationDate":"2021-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7610967/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39091629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

What the VAP: The Expanded VAP Family of Proteins Interacting With FFAT and FFAT-Related Motifs for Interorganellar Contact. VAP是什么:扩展的VAP蛋白家族与FFAT和FFAT相关基序相互作用的细胞器间接触。

Contact (Thousand Oaks (Ventura County, Calif.)) Pub Date : 2021-05-09 eCollection Date: 2021-01-01 DOI: 10.1177/25152564211012246

Jacques Neefjes, Birol Cabukusta

{"title":"What the VAP: The Expanded VAP Family of Proteins Interacting With FFAT and FFAT-Related Motifs for Interorganellar Contact.","authors":"Jacques Neefjes, Birol Cabukusta","doi":"10.1177/25152564211012246","DOIUrl":"https://doi.org/10.1177/25152564211012246","url":null,"abstract":"Membrane contact sites are formed by tether proteins that have the ability to bring two organellar membranes together. VAP proteins are a family of endoplasmic reticulum (ER)-resident tether proteins specialized in interacting with FFAT (two phenylalanines in an acidic tract) peptide motifs in other proteins. If the FFAT-motif-containing proteins reside on other organelles, VAP proteins form contact sites between these organelles and the ER. The role of VAPA and VAPB, the two founding members of the VAP family in recruiting proteins to the ER and forming membrane contact sites is well appreciated as numerous interaction partners of VAPA and VAPB at different intracellular contact sites have been characterized. Recently, three new proteins -MOSPD1, MOSPD2 and MOSPD3-have been added to the VAP family. While MOSPD2 has a motif preference similar to VAPA and VAPB, MOSPD1 and MOSPD3 prefer to interact with proteins containing FFNT (two phenylalanines in a neutral tract) motifs. In this review, we discuss the recent advances in motif binding by VAP proteins along with the other biological processes VAP proteins are involved in.","PeriodicalId":10556,"journal":{"name":"Contact (Thousand Oaks (Ventura County, Calif.))","volume":" ","pages":"25152564211012246"},"PeriodicalIF":0.0,"publicationDate":"2021-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/25152564211012246","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39032659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Regulation of Plasma Membrane Sterol Homeostasis by Nonvesicular Lipid Transport. 非囊性脂质转运对质膜固醇稳态的调节。

Contact (Thousand Oaks (Ventura County, Calif.)) Pub Date : 2021-01-01 DOI: 10.1177/25152564211042451

Dylan Hong Zheng Koh, Yasunori Saheki

{"title":"Regulation of Plasma Membrane Sterol Homeostasis by Nonvesicular Lipid Transport.","authors":"Dylan Hong Zheng Koh, Yasunori Saheki","doi":"10.1177/25152564211042451","DOIUrl":"https://doi.org/10.1177/25152564211042451","url":null,"abstract":"Sterol contributes to the structural integrity of cellular membranes and plays an important role in the regulation of cell signaling in eukaryotes. It is either produced in the endoplasmic reticulum or taken up from the extracellular environment. In most eukaryotic cells, however, the majority of sterol is enriched in the plasma membrane. Thus, the transport of sterol between the plasma membrane and other organelles, including the endoplasmic reticulum, is crucial for maintaining sterol homeostasis. While vesicular transport that relies on membrane budding and fusion reactions plays an important role in bulk sterol transport, this mode of transport is slow and non-selective. Growing evidence suggests a critical role of nonvesicular transport mediated by evolutionarily conserved families of lipid transfer proteins in more rapid and selective delivery of sterol. Some lipid transfer proteins act primarily at the sites of contacts formed between the endoplasmic reticulum and other organelles or the plasma membrane without membrane fusion. In this review, we describe the similarities and differences of sterol biosynthesis and uptake in mammals and yeast and discuss the role of their lipid transfer proteins in maintaining plasma membrane sterol homeostasis.","PeriodicalId":10556,"journal":{"name":"Contact (Thousand Oaks (Ventura County, Calif.))","volume":"4 ","pages":"25152564211042451"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/97/6c/10.1177_25152564211042451.PMC10259818.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10301670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Interactome Analysis of the ER Stress Sensor Perk Uncovers Key Components of ER-Mitochondria Contact Sites and Ca²⁺ Signalling. 内质网应激传感器Perk的相互作用组分析揭示了内质网线粒体接触位点和Ca2+信号传导的关键成分。

Contact (Thousand Oaks (Ventura County, Calif.)) Pub Date : 2021-01-01 DOI: 10.1177/25152564211052392

Maria Livia Sassano, Rita Derua, Etienne Waelkens, Patrizia Agostinis, Alexander R van Vliet

{"title":"Interactome Analysis of the ER Stress Sensor Perk Uncovers Key Components of ER-Mitochondria Contact Sites and Ca2+ Signalling.","authors":"Maria Livia Sassano, Rita Derua, Etienne Waelkens, Patrizia Agostinis, Alexander R van Vliet","doi":"10.1177/25152564211052392","DOIUrl":"https://doi.org/10.1177/25152564211052392","url":null,"abstract":"We recently reported that the ER stress kinase PERK regulates ER-mitochondria appositions and ER- plasma membrane (ER-PM) contact sites, independent of its canonical role in the unfolded protein response. PERK regulation of ER-PM contacts was revealed by a proximity biotinylation (BioID) approach and involved a dynamic PERK-Filamin A interaction supporting the formation of ER-PM contacts by actin-cytoskeleton remodeling in response to depletion of ER-Ca2+ stores. In this report, we further interrogated the PERK BioID interactome by validating through co-IP experiments the interaction between PERK and two proteins involved in Ca2+ handling and ER-mitochondria contact sites. These included the vesicle associated membrane (VAMP)-associated proteins (VAPA/B) and the main ER Ca2+ pump sarcoplasmic/endoplasmic reticulum Ca ATPase 2 (SERCA2). These data identify new putative PERK interacting proteins with a crucial role in membrane contact sites and Ca2+ signaling further supporting the uncanonical role of PERK in Ca2+ signaling through membrane contact sites (MCSs).","PeriodicalId":10556,"journal":{"name":"Contact (Thousand Oaks (Ventura County, Calif.))","volume":"4 ","pages":"25152564211052392"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/06/cf/10.1177_25152564211052392.PMC10243573.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10301671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

A Glimpse of the Structural Biology of the Metabolism of Sphingosine-1-Phosphate. 鞘氨醇-1-磷酸代谢的结构生物学初探。

Contact (Thousand Oaks (Ventura County, Calif.)) Pub Date : 2021-01-01 DOI: 10.1177/2515256421995601

Ruobing Ren, Bin Pang, Yufei Han, Yihao Li

{"title":"A Glimpse of the Structural Biology of the Metabolism of Sphingosine-1-Phosphate.","authors":"Ruobing Ren, Bin Pang, Yufei Han, Yihao Li","doi":"10.1177/2515256421995601","DOIUrl":"https://doi.org/10.1177/2515256421995601","url":null,"abstract":"As a key sphingolipid metabolite, sphingosine-1-phosphate (S1P) plays crucial roles in vascular and immune systems. It regulates angiogenesis, vascular integrity and homeostasis, allergic responses, and lymphocyte trafficking. S1P is interconverted with sphingosine, which is also derived from the deacylation of ceramide. S1P levels and the ratio to ceramide in cells are tightly regulated by its metabolic pathways. Abnormal S1P production causes the occurrence and progression of numerous severe diseases, such as metabolic syndrome, cancers, autoimmune disorders such as multiple sclerosis, and kidney and cardiovascular diseases. In recent years, huge advances on the structure of S1P metabolic pathways have been accomplished. In this review, we have got a glimpse of S1P metabolism through structural and biochemical studies of: sphingosine kinases, S1P transporters and S1P receptors, and the development of therapeutics targeting S1P signaling. The progress we summarize here could provide fresh perspectives to further the exploration of S1P functions and facilitate the development of therapeutic molecules targeting S1P signaling with improved specificity and therapeutic effects.","PeriodicalId":10556,"journal":{"name":"Contact (Thousand Oaks (Ventura County, Calif.))","volume":"4 ","pages":"2515256421995601"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/2515256421995601","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10302700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

A Tetrameric Assembly of Saposin A: Increasing Structural Diversity in Lipid Transfer Proteins. 皂苷A的四聚体组装:增加脂质转移蛋白的结构多样性。

Contact (Thousand Oaks (Ventura County, Calif.)) Pub Date : 2021-01-01 DOI: 10.1177/25152564211052382

Maria Shamin, Samantha J Spratley, Stephen C Graham, Janet E Deane

引用次数: 1

Corrigendum to "Getting in Touch is an Important Step: Control of Metabolism at Organelle Contact Sites". “接触是重要的一步:控制细胞器接触部位的代谢”的勘误表。

Contact (Thousand Oaks (Ventura County, Calif.)) Pub Date : 2021-01-01 DOI: 10.1177/25152564211031738

引用次数: 0

Sigma 1 Receptor, Cholesterol and Endoplasmic Reticulum Contact Sites. Sigma 1受体、胆固醇和内质网接触部位。

Contact (Thousand Oaks (Ventura County, Calif.)) Pub Date : 2021-01-01 DOI: 10.1177/25152564211026505

Vladimir Zhemkov, Jen Liou, Ilya Bezprozvanny

引用次数: 3