{"title":"Rhabdomyolysis Associated Acute Kidney Injury Following a Physical Violence","authors":"Thivaharan Yalini, Kitulwatte Deepthi Gamage","doi":"10.23937/2378-3656/1410367","DOIUrl":"https://doi.org/10.23937/2378-3656/1410367","url":null,"abstract":"Introduction: Physical violence can lead to serious and, rarely, fatal injuries. In addition to head injury, which is the leading cause of death and long-term disability, injuries of the musculoskeletal system and internal organs are important cause of assault-related morbidity. This paper discusses such rare complication of an interpersonal violence rhabdomyolyis associated with Acute Kidney Injury (AKI). Case: A 37-year-old man who claims to be assaulted by a group of people, presented with focal contusions and extensive grazed abrasions over the trunk and limbs. Injuries to brain and other visceral organs were excluded. Serum creatinine and urea were elevated significantly, along with increase in C-reactive protein and liver enzymes. Urinalysis contained red cells and leukocyte esterase, following which rhabdomyolysis was diagnosed. He developed oliguric AKI, and haemodialysis was initiated. He was discharged after eleven days of hospitalization, following improvement in renal functions. Discussion: Rhabdomyolysis is a common cause for oliguric renal failure, and can be traumatic or non-traumatic. Rhabdomyolysis has specific clinical and laboratory parameters, but still requires high level of suspicion, for timely diagnosis. Highly elevated levels creatinine phosphokinase (CPK) is the most specific parameter for the diagnosis of rhabdomyolysis. Myoglobinuria, elevated levels of lactase dehydrogenase and transaminases are also considered valuable markers of rhabdomyolysis. AKI is the commonest systemic complication of rhabdomyolysis and various causative mechanisms have been explained. Conclusion: Rhabdomyolysis requires high index of suspicion when acute kidney injury and altered metabolite levels are suspected in a patient with major or minor muscle injuries, in order to prevent complications or death.","PeriodicalId":10450,"journal":{"name":"Clinical Medical Reviews and Case Reports","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84903790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Laparoscopic Resection of a Gastric Lipoma: A Case Report","authors":"Najih Mohammed, Zentar Aziz","doi":"10.23937/2378-3656/1410368","DOIUrl":"https://doi.org/10.23937/2378-3656/1410368","url":null,"abstract":"","PeriodicalId":10450,"journal":{"name":"Clinical Medical Reviews and Case Reports","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83010428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Severe Malaria with Acute Kidney Injury and Post-Dialysis Hypocalcaemia and Hypertension: A Case Report of a Young Patient Managed in a Resource Limited Setting","authors":"Innocent Wafula","doi":"10.23937/2378-3656/1410366","DOIUrl":"https://doi.org/10.23937/2378-3656/1410366","url":null,"abstract":"Malaria is a leading cause of paediatric morbidity and mortality in Africa. Plasmodium falciparum species is commonly associated with severe complications of malaria including severe anaemia, prostration, altered consciousness, hypoglycaemia, pulmonary oedema, haemoglobinuria, and acute kidney injury (AKI). In patients with these complications, the cornerstone of treatment is prompt administration of antimalarials and the provision of appropriate supportive care. AKI is an established independent predictor for mortality in children with severe malaria. In patients with malaria-associated AKI, cautious fluid administration and renal replacement therapy could be lifesaving. In this case report, a 12-year-old patient was managed for severe malaria complicated by acute kidney injury (AKI) and post-dialysis hypocalcaemia and hypertension. malaria endemic zones. Among the parasites of the genus Plasmodium, (P. falciparum, P. vivax, P. malariae, P. ovale, and P. knowlesi), P. falciparum is the most common species associated with complications such as severe anaemia, prostration, altered consciousness, hypoglycaemia, pulmonary oedema, haemoglobinuria [3], and acute kidney injury [4]. We report a case of an older paediatric patient presenting with severe malaria with acute kidney injury (AKI) and post-dialysis hypocalcemia and hypertension.","PeriodicalId":10450,"journal":{"name":"Clinical Medical Reviews and Case Reports","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84485561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Preventing Progression of Chronic Kidney Disease with Plant-Based Diet","authors":"Panigrahi Gunadhar","doi":"10.23937/2378-3656/1410365","DOIUrl":"https://doi.org/10.23937/2378-3656/1410365","url":null,"abstract":"Chronic kidney disease (CKD) is associated with high incidence of morbidity, mortality, and is a costly burden to the healthcare system [1,2]. CKD is now the 8th leading cause of death in the United States and affects 14% of its people [3]. As CKD progresses, cardiovascular mortality rises, eventually becoming the most common cause of death among end-stage renal disease (ESRD) patients [4,5]. There is a growing interest in the dietary treatment of CKD, and a Plant-Based low-protein vegetarian diet has shown to be safe and effective in both treating and in slowing the progression of CKD [6]. These were treated with a stent to RCA and another stent to LAD with excellent angiographic results, with resolution of symptoms. At that time, her medications included Cozaar 50 mg po daily, Lopressor 50 mg po twice daily, Hydrochlorothiazide 25 mg po daily, Nitro-patch 2% topically daily, Zocor 40 mg po daily, Fenofibrate 134 mg po daily, Aspirin 81 mg po daily, Plavix 75 mg po daily, Neurontin 100 mg po daily. On 3/13/2014, after discharge from hospital, she was seen in our Cardiovascular Wellness Clinic for continued care. She weighed 207 pounds (BMI 30.55 kg/m2), blood pressure was 140/80 mm of Hg, and heart rate was 64 beats per minute. The lipid profile revealed a total cholesterol of 254 mg/dl, triglyceride 123 mg/dl, HDL cholesterol 51 mg/dl, and LDL cholesterol were 179 mg/dl. Evaluation of renal function revealed blood urea nitrogen of 31 mg/dl and creatinine was 1.4 mg/dl, and eGFR of 44 ml/min/1.73 m2 of body surface area.","PeriodicalId":10450,"journal":{"name":"Clinical Medical Reviews and Case Reports","volume":"84 6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87917024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Complete Perioral Reconstruction for High Power Electrical Burn","authors":"Abiel Kwok, Colin Hong","doi":"10.23937/2378-3656/1410364","DOIUrl":"https://doi.org/10.23937/2378-3656/1410364","url":null,"abstract":"","PeriodicalId":10450,"journal":{"name":"Clinical Medical Reviews and Case Reports","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91554333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Taher Mohamed Kadry, Habsah Mohamed, Bjerre Lise, M. Franco, M. Donald, Krewski Daniel
{"title":"Systemic Quinolones and Risk of Acute Liver Failure II: Systematic Review of Clinical Trials","authors":"Taher Mohamed Kadry, Habsah Mohamed, Bjerre Lise, M. Franco, M. Donald, Krewski Daniel","doi":"10.23937/2378-3656/1410361","DOIUrl":"https://doi.org/10.23937/2378-3656/1410361","url":null,"abstract":"Background: Quinolones are a class with four generations of synthetic antibiotics characterized by a unique mechanism of action, broad spectrum, potent pharmacologic properties and reasonable safety profile. Their global and growing popularity has been accompanied by an increase in the emergence of antimicrobial resistance and occurrence of unexpected adverse reactions. Nevertheless, physicians continue to prescribe these drugs on an increasing scale, irrespective of the availability of other treatment alternatives. Objective: To systematically review all clinical trials where a quinolone antibiotic was tested or used as a comparator to other drugs or drug combinations, for evidence on quinolones’ association with ALF risk. Methods: We examined 4 major bibliographic databases, 8 clinical trial registries, and major grey literature sources including international conference proceedings, drug review networks and databases of pharmaceutical companies for ongoing or unpublished studies. We also examined the bibliographies of publications selected for inclusion in our review for other relevant studies. PROSPERO registration number: CRD42020148742. Results: We identified 1,264 original clinical trials conducted between 1974 and 2020, in many countries around the world, enlisting men and women from almost all ethnicities, backgrounds, age groups and with different comorbidity burdens. One trial reported a single ALF case with gemifloxacin and the other reported another case with moxifloxacin. Conclusion: There is inadequate evidence from clinical trials to implicate quinolone antibiotics as a cause of acute liver failure.","PeriodicalId":10450,"journal":{"name":"Clinical Medical Reviews and Case Reports","volume":"78 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77190701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Kallmann Syndrome with Brain Changes and Unilateral Renal Agenesis: A Rare Case Report","authors":"M. Shirin, S. Al-Azad, S. Akter, Hasina Firdaus","doi":"10.33425/2768-6647.1006","DOIUrl":"https://doi.org/10.33425/2768-6647.1006","url":null,"abstract":"Kallmann syndrome (KS) is a rare inherited disorder. It is characterized by hypogonadotropic hypogonadism in association with anosmia or hyposmia, results from defective migration of gonadotropin-releasing hormone producing neurons and olfactory axons. Because KS is a disease due to mutation of genes, patients with KS often display midline head and brain abnormalities such as cleft lip and/or palate and corpus callosum dysgenesis, septo-optic dysplasia, renal agenesis and other phenotypic abnormalities. Here we report a case of 19 years old boy presented with non-development of secondary sex characters, small penis, anosmia and clubfoot. Karyotype was 46XY and hormonal measurement revealed hypogonadotropic hypogonadism. MRI of the brain revealed bilateral agenesis of the olfactory bulb and sulcus, corpus callosal dysgenesis, septo-optic dysplasia and smaller pituitary gland. USG of abdomen revealed right renal agenesis.","PeriodicalId":10450,"journal":{"name":"Clinical Medical Reviews and Case Reports","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80424155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Bedside Techniques: Horseshoe Cartilage Ring-Preserving Tracheostomy for Preventing Stomal Site Stenosis","authors":"K. Nakamoto, T. Fujii, Mika Kajiyama, Y. Kawamura","doi":"10.33425/2768-6647.1007","DOIUrl":"https://doi.org/10.33425/2768-6647.1007","url":null,"abstract":"Introduction Post-tracheostomy cuff site stenosis (CSS) can be resolved using a soft cuff cannula [1], but there is no established treatment for stomal site stenosis (SSS), including subglottic stenosis (SGS), which can arise as a complication of tracheostomy [2,3]. To prevent SSS, we commonly use a tracheostomy procedure in which the framework of the horseshoe cartilage rings is preserved, as the trachea is opened transversely at the inter-cartilage ligament. This procedure is quite simple and involves a cannula being smoothly inserted using a percutaneous tracheostomy kit (PCT kit). As the number of tracheostomy procedures required has increased due to COVID19-related pneumonia, a standard tracheostomy procedure should be re-established.","PeriodicalId":10450,"journal":{"name":"Clinical Medical Reviews and Case Reports","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89024723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Premature Pubarche Secondary to Herbal Oil Exposure","authors":"K. Jeyamurugan, Haiyan Lu","doi":"10.33425/2768-6647.1008","DOIUrl":"https://doi.org/10.33425/2768-6647.1008","url":null,"abstract":"Premature pubarche (PP) is characterized by the growth of pubic hair before the age of 8 years in girls and 9 years in boys. In 80 to 95% of cases, PP is related to premature adrenarche (PA) secondary to idiopathic premature secretion of adrenal androgens. Although prepubertal pubarche is considered a variant of normal development, pathological causes should be ruled out, prompting a search for a source of androgen. Although hyperandrogenemia may be endogenous or exogenous in origin, most persons with prepubertal pubarche have normal serum concentrations of sex steroids, and an underlying cause is not identified. In such cases, possible exposure to endocrine disruptors should be considered. We report a case of premature pubarche in a 9-month-old boy who developed isolated pubarche after exposure to an herbal oil containing multiple essential oils including lavender, clary sage, grapefruit and peppermint. Pubarche resolved shortly after the use of herbal oil was discontinued.","PeriodicalId":10450,"journal":{"name":"Clinical Medical Reviews and Case Reports","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90910138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Gilets Jaunes, A Case of Collective Schizophrenia in France","authors":"F. Pirot","doi":"10.33425/2768-6647.1009","DOIUrl":"https://doi.org/10.33425/2768-6647.1009","url":null,"abstract":"This paper presents the application of the recently confirmed principles in which schizophrenia can first be diagnosed by actually looking at the discursive regime and observing contradictions i.e. taking schizophrenia to the word, a permanent process of self-breaking of the brain. The Gilets Jaunes self-destroyed their brains with the diesel fumes of the cars while agitating their demands against the government; this is the core of a movement that started with a mobilization order against high diesel taxes. Not only they campaigned both for lower taxes and for a stronger governmental welfare system, an obvious contradiction (first criteria) but they degenerated their brains progressively (second criteria). It is a dynamic, a process as in the pure etymology of schizophrein.","PeriodicalId":10450,"journal":{"name":"Clinical Medical Reviews and Case Reports","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87171475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}