Clinical Otolaryngology最新文献

{"title":"Compliance and Effectiveness of the Scottish Referral Guidelines for Suspected Head and Neck Cancer: A Comparative Audit of 7088 Referrals","authors":"Oliver G. Denton,&nbsp;Ryan Morrison,&nbsp;Baryab Zahra,&nbsp;Ivy Drake,&nbsp;Jenny Montgomery","doi":"10.1111/coa.70122","DOIUrl":"10.1111/coa.70122","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>In Scotland, patients with suspected head and neck cancer are referred based on the Scottish Referral Guidelines for Suspected Cancer (SRGSC). These were most recently updated in 2014 and 2019. A study using 2015–2016 data reported a compliance rate with the 2014 guidance of 55.1% and an all-cancer detection rate of 11.6% (8.6% primary head and neck cancer). This audit assessed referral compliance with the 2019 SRGSC and investigated what effect this update had on rates of head and neck cancer detection.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>All ‘urgent suspicion of cancer’ referrals to the ENT department in the National Health Service Greater Glasgow and Clyde (NHS GGC) for 2021–2022 were audited and compared to corresponding data from 2015 to 2016.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The number of referrals increased by 110% between 2015–2016 and 2021–2022. SRGSC compliance in referral letters was 72.5%, but only 48.9% when those patients were assessed in the ENT clinic. The all-cancer detection rate was 8.6% (6.2% primary head and neck cancer). The most common reasons for referral were neck lump (28%), persistent hoarseness (15%), and persistent throat pain (11%). The most common primary head and neck cancer sites were oropharynx (18%), larynx (17%), and thyroid (11%). There were significant differences between the 2015–2016 and 2021–2022 cohorts in age at referral, sex, and risk factors.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Compared to corresponding data from 2015 to 2016, there is increased workload in ‘urgent suspicion of cancer’ clinic for fewer cancer diagnoses. When compliant, the SRGSHNC criteria are a valuable predictive tool for cancer diagnosis.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10431,"journal":{"name":"Clinical Otolaryngology","volume":"51 5","pages":"694-699"},"PeriodicalIF":1.9,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147986917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Airway Intervention in Paediatric Angioedema: A National Analysis of Clinical Predictors and Outcomes","authors":"Saharsh Talwar,&nbsp;Aryan Mahajan,&nbsp;Gaurav N. Pathak,&nbsp;Babar K. Rao,&nbsp;Rachel Kaye","doi":"10.1111/coa.70127","DOIUrl":"10.1111/coa.70127","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To characterize paediatric hospitalizations for angioedema and identify the prevalence and outcomes of airway interventions using a large national database.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We performed a cross-sectional analysis of the Kids' Inpatient Database (2003–2019), including paediatric patients (0–20 years) hospitalized with angioedema identified by ICD-9/10 codes. Outcomes included hospital length of stay (LOS), total charges, and in-hospital mortality. Multivariable logistic regression evaluated predictors of airway intervention, and comparative analyses assessed outcome differences between patients with and without airway procedures.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among 4238 paediatric angioedema hospitalizations, 174 (4.1%) underwent airway procedures. Compared to non-intervention cases, these patients had significantly longer LOS (median 6 vs. 2 days, <i>p</i> &lt; 0.001), higher charges ($59 571 vs. $7628, <i>p</i> &lt; 0.001), and higher mortality (5.8% vs. 0.15%, <i>p</i> &lt; 0.001). Black (adjusted odds ratio [AOR] 5.23, 95% CI 1.56–19.30) and Hispanic race (AOR 7.83, 95% CI 1.51–44.89) were associated with higher odds of intervention, while hospitalizations in the Northeast (AOR 0.10, 95% CI 0.015–0.55) and South (AOR 0.13, 95% CI 0.03–0.49) had lower odds compared to the Midwest.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Airway interventions in paediatric angioedema are rare but linked to significantly higher morbidity, mortality, and healthcare costs. Geographic and racial disparities highlight the need to explore systemic factors shaping airway management decisions.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10431,"journal":{"name":"Clinical Otolaryngology","volume":"51 5","pages":"729-735"},"PeriodicalIF":1.9,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/coa.70127","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148136839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determinants of Postoperative Outcomes and Cost in Short-Stay Total Thyroidectomy Hospitalisations: A Retrospective Database Study","authors":"Elisa Bass,&nbsp;Justin Hintze,&nbsp;Brent Chang","doi":"10.1111/coa.70123","DOIUrl":"10.1111/coa.70123","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Predictors of complications and length of stay (LOS) in patients requiring brief inpatient stays after total thyroidectomy remain poorly understood. We identify preoperative risk factors for complications, differentiate predictors of overnight versus two-day stays and estimate associated hospital costs.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The National Inpatient Sample for 2016–2021 was used to analyse adult patients undergoing total thyroidectomy with LOS = 1 or 2 days. Multivariate regressions identified predictors of complications and LOS. Costs were transformed logarithmically.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of 26 560 patients, 70% had an overnight stay. Two-day stays were associated with higher complication rates, comorbidity index, neck dissection and increased cost. Hispanic and Asian or Pacific Islander race, comorbidity and surgery in a rural hospital increased the risk of any thyroidectomy-specific complication. Two-day stays had a 29% higher cost than overnight stays.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Preoperative characteristics can help predict complications and LOS following total thyroidectomy. Risk stratification supports cost-effective, patient-centred care planning.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10431,"journal":{"name":"Clinical Otolaryngology","volume":"51 5","pages":"700-707"},"PeriodicalIF":1.9,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148013809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of Probiotic Administration on Tracheoesophageal Voice Prosthesis's Function and Microbial Colonisation: A Pilot Study","authors":"Silvia Mercadante,&nbsp;Gennaro Russo,&nbsp;Massimo Gagliardi,&nbsp;Pasquale Capasso,&nbsp;Lorenzo Bertolino,&nbsp;Iolanda Cafarella,&nbsp;Giulia De Marchi,&nbsp;Carlo Leone,&nbsp;Giuseppe Tortoriello,&nbsp;Emanuele Durante-Mangoni,&nbsp;Rosa Zampino","doi":"10.1111/coa.70133","DOIUrl":"10.1111/coa.70133","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Intro</h3>\u0000 \u0000 <p>Tracheoesophageal voice prosthesis (VP) is an effective method for restoring fluent speech after total laryngectomy, but its microbial colonisation can impair device performance. Aims of this study are to characterise VP microbiological colonisation in laryngectomised patients and assess whether regular probiotic supplementation, plus VP management, could reduce VP contamination, improving function and durability.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A total of 34 patients were enrolled; 15 received standard VP hygiene and management with nystatin four times/day for 5 days before and 5 days after each VP replacement (Group 1) and 19 received the same protocol as Group 1, plus a probiotic supplement (VSL#3, Actial Farmaceutica SRL, Rome, Italy) for 10 days each month throughout the observation period (Group 2). All removed VPs were cultured. Patients underwent a brief questionnaire regarding the VP functionality.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Each patient of both groups had a single VP substitution. The most frequently isolated were <i>Pseudomonas aeruginosa</i>, <i>Staphylococcus aureus</i> and <i>Candida</i> species. When comparing VP microbial cultures at baseline and follow-up, no significant differences were observed in Group 1, while in Group 2, a significant reduction in the detection of multiple microbial species at follow-up was detected. Specifically, a significant decrease was observed in the prevalence of <i>S. aureus</i> methicillin-sensitive (<i>p</i> = 0.05), miscellaneous Gram-negative bacteria (<i>p</i> = 0.04) and <i>Candida albicans</i> (<i>p</i> = 0.02). Survey results showed a significant overall improvement in VP functionality in Group 2 versus Group 1 (<i>p</i> = 0.008).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Microbiological findings and patient opinions suggest a positive impact of probiotics on reducing bacterial contamination and improving VP functionality.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10431,"journal":{"name":"Clinical Otolaryngology","volume":"51 5","pages":"761-769"},"PeriodicalIF":1.9,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148239127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum Cotinine Is Associated With Tympanometric Abnormalities Suggestive of Middle-Ear Pressure Dysregulation in US Adults","authors":"Nilipaer Alimu,&nbsp;Tong Wu,&nbsp;Ayiheng Qukuerhan,&nbsp;Jiankang Liu","doi":"10.1111/coa.70129","DOIUrl":"10.1111/coa.70129","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To examine the association between serum cotinine and tympanometric abnormalities in US adults.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Design</h3>\u0000 \u0000 <p>Cross-sectional study.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Setting</h3>\u0000 \u0000 <p>National Health and Nutrition Examination Survey.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Participants</h3>\u0000 \u0000 <p>Adults aged 20 years or older with available data on serum cotinine and tympanometry.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Main Outcome Measures</h3>\u0000 \u0000 <p>The primary outcome was defined as a Type B or Type C tympanogram in either ear. Sensitivity analyses were performed for outcomes defined as a Type C tympanogram in either ear and a Type B tympanogram in either ear.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 13 169 adults were included. In the fully adjusted model, higher serum cotinine was associated with higher odds of the primary tympanometric abnormality outcome. For each log₂ increase in serum cotinine, the odds ratio (OR) was 1.024 (95% confidence interval [CI], 1.011–1.037; <i>p</i> &lt; 0.001). Compared with the lowest quartile, the highest quartile had an OR of 1.295 (95% CI, 1.060–1.582; <i>p</i> = 0.011), with a significant trend across quartiles (<i>p</i> for trend = 0.009). In sensitivity analyses, the association was more evident for Type C tympanometric patterns (OR 1.570, 95% CI 1.259–1.957 for the highest vs. lowest quartile) than for Type B patterns, for which no significant association was observed (OR 0.652, 95% CI 0.406–1.048; <i>p</i> = 0.077).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Higher serum cotinine levels were associated with higher odds of tympanometric abnormalities in US adults. The association was more apparent for Type C than for Type B tympanometric patterns, suggesting that tobacco exposure may be more closely related to negative middle-ear pressure abnormalities than to nonspecific abnormal tympanograms.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10431,"journal":{"name":"Clinical Otolaryngology","volume":"51 5","pages":"736-743"},"PeriodicalIF":1.9,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148162080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality of Life Outcomes in Salvage Laryngectomy Reconstruction","authors":"Zainab Balogun,&nbsp;Joseph Mocharnuk,&nbsp;Fendi Obuekwe,&nbsp;Nia Buckner,&nbsp;Sophia Dang,&nbsp;Marci L. Nilsen,&nbsp;Jonas Johnson,&nbsp;Shaum Sridharan,&nbsp;Mark Kubik","doi":"10.1111/coa.70117","DOIUrl":"10.1111/coa.70117","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To evaluate functional oral intake and patient-reported dysphagia, neck disability, and symptom-specific health-related quality of life (HRQOL) amongst patients who underwent pectoralis major myocutaneous flap (PMMF) versus microvascular free flap reconstruction after salvage laryngectomy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Design</h3>\u0000 \u0000 <p>Retrospective analysis of prospectively collected data.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Setting</h3>\u0000 \u0000 <p>Multidisciplinary head and neck cancer (HNC) Survivorship clinic.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Participants</h3>\u0000 \u0000 <p>Patients with at least 6 months of postoperative follow-up from salvage total laryngectomy/total laryngectomy with partial pharyngectomy and subsequent PMMF or free flap reconstruction were included. Patients who underwent total laryngo-pharyngectomy, with recurrence, with metastatic disease, and/or with missing data were excluded.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Main Outcome Measures</h3>\u0000 \u0000 <p>Functional Oral Intake Scale (FOIS) and validated patient-reported outcome measures, including Eating Assessment Tool-10 (EAT-10), Neck Disability Index (NDI), and measures of pain-, swallowing-, and shoulder-specific University of Washington Quality of Life (UW-QOL) subscale scores.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Twenty-four patients underwent PMMF, and 30 patients underwent microvascular free flaps. Mean EAT-10, NDI, and pain-, swallowing-, and shoulder-specific UW-QOL subscale scores were not significantly different between these two groups. Mean FOIS was slightly higher in patients reconstructed with PMMF (5.67 ± 1.52 vs. 4.57 ± 2.12), <i>p</i> = 0.047, but the clinical relevance of this finding is unclear.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Patient-reported outcomes pertaining to dysphagia, neck disability, and pain-, swallowing- and shoulder-specific HRQOL did not vary significantly between patients reconstructed with PMMF versus microvascular free flap. Future studies with larger cohorts are required to further establish differences in functional outcomes between reconstructive approaches following salvage laryngectomy.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10431,"journal":{"name":"Clinical Otolaryngology","volume":"51 5","pages":"687-693"},"PeriodicalIF":1.9,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147940160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammatory Myofibroblastic Tumour of Head and Neck: A Systematic Review Plus Meta-Analysis","authors":"Alireza Sharifi,&nbsp;Mohaddeseh Zojaji,&nbsp;Narges Badragheh,&nbsp;Mehran Jamali,&nbsp;Sahar Ghaedsharaf,&nbsp;Maryam Yaghoubi Hamgini,&nbsp;Mohammad E. Ghaffari,&nbsp;Samad Samadizadeh,&nbsp;Hassan H. Ramadan,&nbsp;Meghan T. Turner","doi":"10.1111/coa.70120","DOIUrl":"10.1111/coa.70120","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>This systematic review with meta-analysis is aimed to examine clinical presentations, pathologic and imaging findings, treatment approaches, and prognosis of inflammatory myofibroblastic tumour.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>PubMed, Medline, Scopus, Cochrane Central Register of Control Trials, Web of Science, Google Scholar, and Embase were systematically searched up to February 2026. The search strategy was structured by a combination of relevant keywords and medical subheadings. This review adhered to Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines and Population, Intervention, Comparison, and Outcome (PICO) statement.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 22 studies, including 337 patients, met the inclusion criteria. Most of the tumours originated from the sinonasal space (40.1%, proportion = 163), and the maxilla bone and hypopharynx had the least frequency (0.3%, proportion = 1). The most prevalent manifestations were proptosis and facial pain/swelling. Regarding immunohistochemical findings, tumours were mostly positive for vimentin and SMA, while they were commonly negative for desmin, S-100, anaplastic lymphoma kinase, and CD34. Many patients were treated with surgical resection alone without any recurrence occurring. Recurrence occurred in 21.6% (proportion = 67). Metastases occurred in 8.8% (proportion = 8).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The diagnosis of head and neck inflammatory myofibroblastic tumour appears related to the presence of vimentin, SMA, desmin, anaplastic lymphoma kinase, CD34, and S-100 on immunohistochemistry. The enhancement pattern on computed tomography cannot help diagnosis, but absence of calcification may distinguish tumour from other differential diagnoses. Surgical resection with a free margin is the most common treatment approach. Metastasis and malignant transformation rarely occur in this tumour of the head and neck region.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10431,"journal":{"name":"Clinical Otolaryngology","volume":"51 5","pages":"620-634"},"PeriodicalIF":1.9,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147986902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the NHS R67 Monogenic Hearing Loss Panel in a Single UK Centre","authors":"Irmak Sakin,&nbsp;Chloe Swords,&nbsp;Jessica Ball,&nbsp;Elizabeth Oakley-Hannibal,&nbsp;Harriet Cunniffe,&nbsp;Simon Holden,&nbsp;Manohar Bance,&nbsp;Jessica Bewick","doi":"10.1111/coa.70125","DOIUrl":"10.1111/coa.70125","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>The NHS R67 genetic hearing loss panel was introduced in England in 2021 and has expanded the diagnostic approach to hearing loss. This study aimed to evaluate the diagnostic yield and clinical utility of the panel in paediatric and adult patients assessed through a tertiary multidisciplinary genetic hearing loss clinic.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A retrospective case review was conducted of patients referred to a tertiary genetic hearing loss multidisciplinary clinic who underwent R67 monogenic hearing loss analysis. Demographic data, referral patterns, family history, hearing loss severity, age at diagnosis, congenital cytomegalovirus testing, radiological findings, genetic results and hearing habilitation or rehabilitation strategies were analysed descriptively. Diagnostic yield was compared across hearing loss severity categories.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Eighty-four patients were included, comprising 46 children and 38 adults. A monogenic diagnosis was identified in 48.8% of patients overall, with a higher yield in children than adults: 63.0% versus 31.6%, respectively. Variants of uncertain significance were identified in 7.1% of patients. Hearing loss severity was significantly associated with identification of a genetic cause, although 35% of patients with an identified genetic cause had mild or moderate hearing loss.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The R67 monogenic hearing loss panel is a valuable diagnostic tool for investigating sensorineural hearing loss in children and adults, particularly when delivered through multidisciplinary clinics that support counselling and clinical decision-making. Further reporting is needed to refine referral criteria and support patient selection for targeted therapies.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10431,"journal":{"name":"Clinical Otolaryngology","volume":"51 5","pages":"708-713"},"PeriodicalIF":1.9,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148027671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing Quality of Life in Smell and Taste Disorders With Other Chronic Conditions—A Narrative Review","authors":"Natalia Glibbery,&nbsp;David Turner,&nbsp;Duncan Boak,&nbsp;Carl Philpott","doi":"10.1111/coa.70119","DOIUrl":"10.1111/coa.70119","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Smell and taste disorders (SATDs) are increasingly prevalent but remain underrecognised, significantly affecting patients' physical, social and psychological well-being. We recently published a large cohort study reporting Olfactory Disorder Questionnaire (ODQ), EQ-5D-5L (EuroQol Five-Dimension Five-Level) and EQ-5D-5L Visual Analogue Scale (VAS) scores for patients with SATDs. These results highlight the considerable impact of SATDs on quality of life and mental health. This review seeks to evaluate the disease burden of SATDs by comparing their impact on quality of life and mental health with other chronic conditions, using established metrics such as EQ-5D-5L and BDI from the existing literature.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A literature review was conducted from 1 January 2010 to 10 August 2024, to identify systematic reviews reporting EQ-5D-5L or BDI values in chronic conditions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Our findings show that EQ-5D-5L and BDI scores for patients with SATDs are comparable to those reported for other chronic conditions, including diabetes, stroke, cardiovascular, respiratory and ENT disorders.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>These results highlight the significant burden olfactory dysfunction imposes on individuals. However, unlike other chronic conditions with established treatment protocols, effective therapies for SATDs remain limited, emphasising a critical gap in both research and care. Increased awareness and further research are essential to develop effective treatments and improve outcomes for this often-overlooked population.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10431,"journal":{"name":"Clinical Otolaryngology","volume":"51 5","pages":"613-619"},"PeriodicalIF":1.9,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148263521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short-Term Complications Are Rare After Cholesteatoma Surgery","authors":"Agnes Modée Borgström,&nbsp;Cecilia Engmér Berglin,&nbsp;Johan Knutsson,&nbsp;Åsa Bonnard","doi":"10.1111/coa.70111","DOIUrl":"10.1111/coa.70111","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To evaluate the incidence and nature of short-term complications following cholesteatoma surgery in a heterogeneous cohort.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Design</h3>\u0000 \u0000 <p>A retrospective cohort study including complete coverage of cholesteatoma surgery in a Swedish region between 1 January 2005 and 31 December 2015. A total of 966 patients were followed for 6 weeks postoperatively. Severe complications were defined as facial palsy, thromboembolic events, cerebrospinal fluid (CSF) leakage, serious postoperative infection, or death within 6 weeks of surgery.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Severe complications were uncommon, occurring in 14 patients (1.4%). Thromboembolic events were observed in five patients (0.5%), two of which (0.2%) resulted in postoperative mortality—one following cardiac arrest in the postoperative care unit and one due to a thromboembolic event approximately 3 weeks after surgery. Serious infections occurred in five patients (0.5%): three retroauricular abscesses, one case of meningitis, and one infected preauricular fistula with abscess formation. Additional severe complications included three cases of facial palsy and one case of CSF leakage.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Cholesteatoma surgery demonstrates a low rate of severe short-term complications, underscoring its overall safety with risks mainly attributable to general surgical or medical causes rather than cholesteatoma-specific factors. The present cholesteatoma-specific data constitute a solid basis for preoperative counselling and benchmarking within otology.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10431,"journal":{"name":"Clinical Otolaryngology","volume":"51 5","pages":"660-665"},"PeriodicalIF":1.9,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/coa.70111","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147728821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}