胃食管反流对慢性鼻炎的因果效应:双向双样本孟德尔随机研究

IF 1.7 4区 医学 Q2 OTORHINOLARYNGOLOGY
Xiang Xin, Yang Yang, Li Xuelei, Yao Hongbing, Tang Xinye, Liang Jia
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引用次数: 0

摘要

导言:观察性研究表明,胃食管反流(GER)与慢性鼻炎(CRS)或慢性鼻炎(CR)之间存在双向关联,但这种关联是否因果关系尚不清楚:本研究采用双向双样本孟德尔随机分析法(MR)研究胃食管反流与慢性鼻炎或慢性鼻窦炎之间的因果关系:方法:利用大型全基因组关联研究(GWAS)的汇总数据,选择欧美血统人群中与 GER、CRS 和 CR 独立相关的遗传位点作为工具变量(IV)。采用反方差加权(IVW)法分析MR的随机效应模型,并以几率比(OR)作为评价指标,探讨GER与CRS或CR之间的双向因果关系。使用MR-pleiotropy Residual Sum and Outliers(MR-PRESSO)检测单核苷酸多态性(SNP)异常值。MR-Egger截距检验检测了SNP的水平褶积性。剔除 "敏感性分析检验了 MR 结果是否受到单个 SNP 的影响:IVW的主要结果显示,GER增加了CRS的风险(OR = 1.3795,95% CI = 1.188-1.603,p 结论:GER增加了CRS的风险:这项磁共振分析显示,基因预测的 GER 对 CRS 或 CR 风险的增加有因果关系,但反之亦然。这些结果对临床实践中 CRS(尤其是难治性 CRS)或 CR 的管理具有重要意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Causal Effects of Gastroesophageal Reflux on Chronic Rhinosinusitis: A Bidirectional Two-Sample Mendelian Randomization Study.

Introduction: Observational studies have shown a bidirectional association between gastroesophageal reflux (GER) and chronic rhinosinusitis (CRS) or chronic rhinitis (CR), but it is not clear whether this association is causal.

Objectives: This study was to investigate the causality between GER and CRS or CR using bidirectional two-sample Mendelian randomization (MR) analysis.

Methods: Using pooled data from large genome-wide association studies (GWAS), genetic loci independently associated with GER, CRS and CR in populations of European and American ancestry were selected as instrumental variables (IVs). The inverse variance weighted (IVW) method was used to analyse the random effects model of MR, and the odds ratio (OR) was used as the evaluation index to explore the bidirectional causality between GER and CRS or CR. Single nucleotide polymorphism (SNP) outliers were detected using MR-pleiotropy Residual Sum and Outliers (MR-PRESSO). The MR-Egger intercept test examined the horizontal pleiotropy of SNPs. The "leave-one-out" sensitivity analysis examined whether MR results were affected by a single SNP.

Results: The main results of IVW showed that GER increased the risk of CRS (OR = 1.3795, 95% CI = 1.188-1.603, p < 0.0500) and CR (OR = 1.3941, 95% CI = 1.1671-1.6652, p < 0.0500). The obtained SNPs as IVs for GER, CRS and CR had no significant horizontal pleiotropy, heterogeneity or bias. Regarding the reverse directions, no notable associations could be found.

Conclusion: This MR analysis revealed that genetically predicted GER had a causal effect on an increased risk of CRS or CR, but not vice versa. These results have great implications for the management of CRS (especially for refractory CRS) or CR in clinical practice.

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来源期刊
Clinical Otolaryngology
Clinical Otolaryngology 医学-耳鼻喉科学
CiteScore
4.00
自引率
4.80%
发文量
106
审稿时长
>12 weeks
期刊介绍: Clinical Otolaryngology is a bimonthly journal devoted to clinically-oriented research papers of the highest scientific standards dealing with: current otorhinolaryngological practice audiology, otology, balance, rhinology, larynx, voice and paediatric ORL head and neck oncology head and neck plastic and reconstructive surgery continuing medical education and ORL training The emphasis is on high quality new work in the clinical field and on fresh, original research. Each issue begins with an editorial expressing the personal opinions of an individual with a particular knowledge of a chosen subject. The main body of each issue is then devoted to original papers carrying important results for those working in the field. In addition, topical review articles are published discussing a particular subject in depth, including not only the opinions of the author but also any controversies surrounding the subject. • Negative/null results In order for research to advance, negative results, which often make a valuable contribution to the field, should be published. However, articles containing negative or null results are frequently not considered for publication or rejected by journals. We welcome papers of this kind, where appropriate and valid power calculations are included that give confidence that a negative result can be relied upon.
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