Clinical Medicine Insights. Cardiology最新文献

{"title":"The Risk of Left Atrial Appendage Thrombus in Patients With Atrial Flutter Versus Atrial Fibrillation","authors":"G. Moady, Gal Rubinstein, Loai Mobarki, A. Shturman, Tsafrir Or, S. Atar","doi":"10.1177/11795468231221404","DOIUrl":"https://doi.org/10.1177/11795468231221404","url":null,"abstract":"Objective: Patients with atrial fibrillation (AF) are at increased risk of thromboembolic events originating mainly from left atrial appendage thrombus (LAAT). Patients with atrial flutter (AFL) are treated with anticoagulation based on the same criteria as patients with AF. However, whether patients with AFL have similar thromboembolic risk as AF is unclear. In the current study we aimed to estimate the prevalence of LAAT in patients with AFL undergoing trans-esophageal echocardiography (TEE). Methods/results: We included 438 patients (404 with AF and 34 with AFL) scheduled for TEE to rule out LAAT before cardioversion (patients who reported no or inadequate anticoagulation before cardioversion). Demographic and echocardiographic data were compared between patients with and without LAAT. Despite a similar CHA2DS2-VASC score (3.8 ± 1.3 vs 3.4 ± 1.5 in the AF and AFL groups, respectively, P = .09), LAAT was documented in 12 (2.8%) in the AF group and in no patient in the AFL group (P < .0001). Conclusion: Based on our results and previous studies, it seems reasonable to re-evaluate the need for oral anticoagulation in specific populations with AFL such as those with solitary AFL (without a history of AF episodes) undergoing successful ablation and in those with low CHA2DS2-VASC score.","PeriodicalId":10419,"journal":{"name":"Clinical Medicine Insights. Cardiology","volume":"46 2","pages":""},"PeriodicalIF":3.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139395745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Inotropes for Use With the Impella Device in Cardiogenic Shock.","authors":"Essilvo Sulejmani, Nathaniel Wayne, Laura Provost, Aaron Chase, Andrea Sikora","doi":"10.1177/11795468231221416","DOIUrl":"10.1177/11795468231221416","url":null,"abstract":"","PeriodicalId":10419,"journal":{"name":"Clinical Medicine Insights. Cardiology","volume":"17 ","pages":"11795468231221416"},"PeriodicalIF":3.0,"publicationDate":"2023-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10748890/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139033157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Salt-Sensitive Hypertension: Mediation by Salt-Induced Hypervolemia and Phosphate-Induced Vascular Calcification.","authors":"Ronald B Brown","doi":"10.1177/11795468231158206","DOIUrl":"10.1177/11795468231158206","url":null,"abstract":"<p><p>Preventing hypertension by restricting dietary salt intake, sodium chloride, is well established in public health policy, but a pathophysiological mechanism has yet to explain the controversial clinical finding that some individuals have a greater risk of hypertension from exposure to salt intake, termed salt-sensitive hypertension. The present perspective paper synthesizes interdisciplinary findings from the research literature and offers novel insights proposing that the pathogenesis of salt-sensitive hypertension is mediated by interaction of salt-induced hypervolemia and phosphate-induced vascular calcification. Arterial stiffness and blood pressure increase as calcification in the vascular media layer reduces arterial elasticity, preventing arteries from expanding to accommodate extracellular fluid overload in hypervolemia related to salt intake. Furthermore, phosphate has been found to be a direct inducer of vascular calcification. Reduction of dietary phosphate may help reduce salt-sensitive hypertension by lowering the prevalence and progression of vascular calcification. Further research should investigate the correlation of vascular calcification with salt-sensitive hypertension, and public health recommendations to prevent hypertension should encourage reductions of both sodium-induced hypervolemia and phosphate-induced vascular calcification.</p>","PeriodicalId":10419,"journal":{"name":"Clinical Medicine Insights. Cardiology","volume":"17 ","pages":"11795468231158206"},"PeriodicalIF":2.3,"publicationDate":"2023-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10331233/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10191205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of the COVID-19 pandemic on the incidence of non-suicidal self-injury; a comparison between Iran and Belgium","authors":"Shokoufeh Vatandoost, Imke Baetens, Joyce Van Den Meersschaut, Martijn Van Heel, Lisa Van Hove","doi":"10.1177/11795573231206378","DOIUrl":"https://doi.org/10.1177/11795573231206378","url":null,"abstract":"Introduction The outbreak of COVID-19 has heightened mental health challenges among adolescents worldwide, while also hindering the development of effective emotion regulation strategies. Nevertheless, there exists a pertinent requirement to further investigate the psychological ramifications of COVID-19 on adolescents, as well as to discern disparities in these impacts across various nations. In order to address this gap in research, this study compares the prevalence of NSSI (characterized by purposefully injuring one's own body tissues without suicidal intention or engaging in behaviors that are not socially approved or sanctioned.), emotion regulation strategies, and psychopathology (internalization and externalization) among Belgian and Iranian adolescents pre- and during the COVID-19 pandemic. Method Adolescents between the ages of 13-21 from Iran and Belgium participated in a two-wave longitudinal design. In Iran, the sample consisted of 117 adolescents in wave 1 (April 2019) and 142 adolescents in wave 2 (Nov 2020). The Belgian sample consisted of 376 participants in wave 1 and 356 adolescents in wave 2. NSSI was assessed using the Self-Harm Inventory (SHI). Emotion Regulation was examined via the Emotion Regulation Inventory (ERI). The S trengths and Difficulties Questionnaire for Youth (SDQ) was used to assess psychological symptoms. Result Across the whole sample, lifetime NSSI prevalence was 35% in the first wave and 43.8% in the second wave. Longitudinal analysis across waves and counties did not show an increase in the prevalence of NSSI but did find that emotion dysregulation and internalizing symptoms are important risk factors for NSSI across countries. Emotional suppression and emotional dysregulation were the most prevalent emotion regulation strategies in Iran, whereas emotional integration was most prevalent in the Belgian sample. Conclusion Our study highlights cultural differences on the impact of COVID-19 on adolescent mental health. But it also indicates the importance of certain universal risk factors, for example, emotional dysregulation. These findings can inform developers to tailor programs for (early) intervention culturally.","PeriodicalId":10419,"journal":{"name":"Clinical Medicine Insights. Cardiology","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135773248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality of life, depressive symptoms, suicidal behavior and social support among pregnant adolescents in Mexico","authors":"Enrique Soto-Chavarría, Carlos Hidalgo-Rasmussen, Lourdes Nieto","doi":"10.1177/11795573231204015","DOIUrl":"https://doi.org/10.1177/11795573231204015","url":null,"abstract":"Background Suicidal behavior in adolescents is a public health problem. Although it has been reported that there is a link between suicidal behavior and Quality of life (QoL), this relationship has not been explored in pregnant adolescents, nor have depressive symptoms been examined as mediators and social support as a moderator in a moderated mediation model. Methods In 2021, 143 pregnant adolescents between 13 and 19 years old from different states in Mexico were evaluated. The KIDSCREEN-52 instrument was applied to evaluate the Health-Related Quality of Life, the scale of expectation of living and dying of Okasha, the Edinburgh Postpartum Depression Scale, the family and partner support scale (AFA-R) and sociodemographic information. Moderated mediation analyses were completed. Results A relationship between QoL and suicidal behavior was found, and that relationship was mediated by depressive symptoms on all eighteen models. In addition, social support from the family moderated the mediation of depressive symptoms in 4 of 9 QoL dimensions, and social support from the partner moderated the mediating effect of depressive symptoms in 8 of 9 QoL dimensions. Conclusion The relationship between QoL and suicidal behavior was consistent with previous studies. The moderating role of social support and the mediation of depressive symptoms on the relationship between QoL and suicidal behavior were also consistent with the literature. Professionals who work with pregnant adolescents should consider both depressive symptoms and social support as important factors that influence QoL and suicidal behaviors.","PeriodicalId":10419,"journal":{"name":"Clinical Medicine Insights. Cardiology","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135771723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors affecting the association between maternal adverse childhood experiences and preschool children’s behavioural problems: a systematic review of mediators and moderators","authors":"Stefan Kurbatfinski, Nicole Letourneau, Deborah Dewey, Andrew F. Hayes, K. Alix Hayden, Lubna Anis, Aliyah Dosani","doi":"10.1177/11795573231212175","DOIUrl":"https://doi.org/10.1177/11795573231212175","url":null,"abstract":"Background Adverse childhood experiences (ACEs) are pernicious events (e.g., physical abuse) that occur before 18 years of age within the household. Mothers’ ACEs are associated intergenerationally with their preschool children’s (two-to-five-year-old) behavioural problems, impacting lifelong mental health trajectories. Mediators (e.g., mental health) may explain how mothers’ ACEs exert their influence on children's behavioural development whereas moderators (e.g., child sex) may affect the strength and direction of the association, revealing potential points of intervention. Therefore, this study aimed to: (1) identify mediators and moderators of this association; and (2) describe and compare moderation and mediation outcomes. Methods This review (#CRD42022307214) extracted data from peer-reviewed literature formally analyzing at least one moderating or mediating variable of the association between maternal ACEs and preschool children’s behavioural problems using MEDLINE, Embase, APA PsycINFO, Cochrane Central Register of Controlled Trials, CINAHL, SCOPUS, and Web of Science databases (n = 7). Validity was assessed using the Joanna Briggs Institute checklists. Results Thirteen full-text studies with moderate-to-high validity were identified. Most studies examined mediating variables, with unanimous support for mediation through maternal depression. The mediating roles of adult attachment styles and anxiety were conflicting. No studies examined environmental factors (e.g., neurotoxins). Conclusions Mothers’ depression is a significant contributor to children’s behavioural problems in the context of ACEs and should be a target of early intervention to prevent lifelong challenges. Future research should focus on examining more moderating variables and consider the roles of environmental factors. More research is needed on the moderating and mediating roles of genes.","PeriodicalId":10419,"journal":{"name":"Clinical Medicine Insights. Cardiology","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135776375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FDA approval of Zurzuvae (zuranolone) to combat postpartum depression","authors":"Areeba Fareed, Rayyan Vaid","doi":"10.1177/11795573231208983","DOIUrl":"https://doi.org/10.1177/11795573231208983","url":null,"abstract":"","PeriodicalId":10419,"journal":{"name":"Clinical Medicine Insights. Cardiology","volume":"69 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135772955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Massive Biventricular Thrombi in a Patient with Endometrial Adenocarcinoma Diagnosed on Computed Tomography Angiography.","authors":"Shiva Barforoshi,&nbsp;Justin Sharim,&nbsp;Matthew J Budoff","doi":"10.1177/11795468231182762","DOIUrl":"https://doi.org/10.1177/11795468231182762","url":null,"abstract":"<p><p>Biventricular thrombi are a rare clinical entity and only reported in several case reports. Given ventricular thrombi are high risk for cardioembolic events, accurate detection and therapeutic management has an important influence on clinical outcomes. We present a case of a patient with biventricular thrombi that was initially diagnosed on computed tomography angiography, emphasizing its clinical utility as a rapid, non-invasive imaging modality for early detection.</p>","PeriodicalId":10419,"journal":{"name":"Clinical Medicine Insights. Cardiology","volume":"17 ","pages":"11795468231182762"},"PeriodicalIF":3.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10291531/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9717592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiothyreosis: Epidemiological, clinical and therapeutic approach.","authors":"Elleuch Mouna,&nbsp;Ben Bnina Molka,&nbsp;Ben Teber Sawssan,&nbsp;Ben Salah Dhoha,&nbsp;Boujelbene Khouloud,&nbsp;Charfi Nadia,&nbsp;Mnif Fatma,&nbsp;Mnif Fatma,&nbsp;Mnif Mouna,&nbsp;Rekik Nabila,&nbsp;Hadj Kacem Faten,&nbsp;Abid Mohamed","doi":"10.1177/11795468231152042","DOIUrl":"https://doi.org/10.1177/11795468231152042","url":null,"abstract":"<p><strong>Introduction: </strong>Cardiothyreosis corresponds to the cellular effects of free thyroid hormones on the vascular wall and the myocardium. We aim to describe the clinical, para-clinical and therapeutic aspects of cardiothyreosis and to detail prognostic factors.</p><p><strong>Methods: </strong>We conducted a descriptive retrospective study at the Endocrinology-Diabetology Department of the Hedi Chaker University Hospital in Sfax-Tunisia. We collected medical records of 100 patients with cardiothyreosis between January 1999 and December 2019. We included patients with cardiothyreosis who underwent adequate cardiac evaluation. We excluded patients with cardiac abnormalities related to conditions other than hyperthyroidism, patients who died and patients without cardiothyreosis.</p><p><strong>Results: </strong>We included 100 adult patients (43 men and 57 women). The mean age was 49.3 ±12.9 years (20-79 years). The diagnosis of cardiothyreosis was concomitant with that of hyperthyroidism in 72% of cases. Weight loss and palpitations were the two most frequently reported signs in 91% of cases each. Hypertension was systolic in 15 patients. The average heart rate was 103.1 beats/min (52-182 bpm). The mean TSH and FT4 levels were 0.042 μIU/ml and 59.6 pmol/l, respectively. Rhythm disorders and heart failure were the most common cardiac complications with 81 and 56 cases, respectively. Cardiac ultrasound showed dilatation of the left atrium in 28.3% of patients. Pulmonary arterial hypertension was present in 43% of cases. 57 patients had been treated with benzylthiouracil at a mean dose of 157.45 mg/day. Radical treatment with radioactive iodine was indicated in 81 patients. The evolution of cardiothyreosis was favourable in 58 patients.</p><p><strong>Conclusion: </strong>Cardiothyreosis is a serious complication of hyperthyroidism. Future prospective studies will be of great help to better characterise and manage cardiothyreosis.</p>","PeriodicalId":10419,"journal":{"name":"Clinical Medicine Insights. Cardiology","volume":"17 ","pages":"11795468231152042"},"PeriodicalIF":3.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ee/50/10.1177_11795468231152042.PMC9885034.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10642164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reverse McConnell's: A Sign of Acute Pulmonary Embolism.","authors":"Andrew Sagalov,&nbsp;Mukul Bhattarai,&nbsp;Ashley Eggert,&nbsp;Shruti Hegde","doi":"10.1177/11795468231178665","DOIUrl":"https://doi.org/10.1177/11795468231178665","url":null,"abstract":"<p><p>Regional right ventricular dysfunction with akinesia of the mid-free wall with normal apical motion known as McConnell's sign is an under-reported echocardiographic finding in the setting of pulmonary embolism. We conducted a literature review and systematic analysis, while describing 2 cases of pulmonary embolism with findings of reverse McConnell's sign.</p>","PeriodicalId":10419,"journal":{"name":"Clinical Medicine Insights. Cardiology","volume":"17 ","pages":"11795468231178665"},"PeriodicalIF":3.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/7b/9e/10.1177_11795468231178665.PMC10259134.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9635629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}