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Bronchoscopy in the COVID-19 Era COVID-19时代的支气管镜检查
Clinical Pulmonary Medicine Pub Date : 2020-11-01 DOI: 10.1097/CPM.0000000000000380
Jennifer T W Krall, Muhammad Ali, M. Maslonka, A. Pickens, C. Bellinger
{"title":"Bronchoscopy in the COVID-19 Era","authors":"Jennifer T W Krall, Muhammad Ali, M. Maslonka, A. Pickens, C. Bellinger","doi":"10.1097/CPM.0000000000000380","DOIUrl":"https://doi.org/10.1097/CPM.0000000000000380","url":null,"abstract":"Bronchoscopy is an aerosol-generating procedure with important diagnostic and therapeutic indications. However, in the era of the coronavirus disease 2019 (COVID-19) pandemic, airway procedures can put health care providers at an increased risk of exposure and transmission of COVID-19. We have reviewed and summarized guidelines from various societies of respiratory medicine to stratify the indications for bronchoscopy and optimize preprocedural, procedural, and postprocedural preparation. Appropriate measures can help decrease exposure to health care workers when performing this aerosol-generating procedure.","PeriodicalId":10393,"journal":{"name":"Clinical Pulmonary Medicine","volume":"27 1","pages":"198 - 202"},"PeriodicalIF":0.0,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47600401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
“Popcorn” Cavitary Pneumonia: A Case Report “爆米花”空洞性肺炎1例报告
Clinical Pulmonary Medicine Pub Date : 2020-09-01 DOI: 10.1097/CPM.0000000000000372
N. Bethuel, L. Edmonds
{"title":"“Popcorn” Cavitary Pneumonia: A Case Report","authors":"N. Bethuel, L. Edmonds","doi":"10.1097/CPM.0000000000000372","DOIUrl":"https://doi.org/10.1097/CPM.0000000000000372","url":null,"abstract":"Upper lobe cavitation carries a broad differential. No review, to our knowledge, includes foreign body in the differential diagnosis. Similarly, reviews of foreign body aspiration do not report lung cavitation. Herein, we report a case of an alert 58-year-old man who presented with sepsis secondary to presumed right upper lobe pneumonia. Computed tomography of the chest was significant for multiple loculated cavitary lesions. Subsequent bronchoscopy revealed a single kernel of popcorn impacted in the bronchus. Our case report highlights the importance of recognizing atypical presentations of foreign body aspiration.","PeriodicalId":10393,"journal":{"name":"Clinical Pulmonary Medicine","volume":"27 1","pages":"139 - 140"},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41355578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How Does the Efficacy and Safety of Triple Inhaled Therapy at 2 Glucocorticoid Doses Compare With 2 Dual Therapies in Moderate-to-Very-Severe COPD? 两种糖皮质激素剂量的三联吸入治疗与两种双重治疗在中重度至极重度COPD中的疗效和安全性比较?
Clinical Pulmonary Medicine Pub Date : 2020-09-01 DOI: 10.1097/CPM.0000000000000379
K. Crane, D. Zappetti
{"title":"How Does the Efficacy and Safety of Triple Inhaled Therapy at 2 Glucocorticoid Doses Compare With 2 Dual Therapies in Moderate-to-Very-Severe COPD?","authors":"K. Crane, D. Zappetti","doi":"10.1097/CPM.0000000000000379","DOIUrl":"https://doi.org/10.1097/CPM.0000000000000379","url":null,"abstract":"","PeriodicalId":10393,"journal":{"name":"Clinical Pulmonary Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43878241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical and Radiologic Improvement Following Tocilizumab Administration in Patients With SARS-CoV-2 托奇利珠单抗治疗严重急性呼吸系统综合征冠状病毒2型患者后的临床和放射学改善
Clinical Pulmonary Medicine Pub Date : 2020-09-01 DOI: 10.1097/CPM.0000000000000375
F. Barkas, Angelos Liontos, E. Svarna, A. Tsili, M. Christaki, I. Rapti, M. Argyropoulou, H. Milionis
{"title":"Clinical and Radiologic Improvement Following Tocilizumab Administration in Patients With SARS-CoV-2","authors":"F. Barkas, Angelos Liontos, E. Svarna, A. Tsili, M. Christaki, I. Rapti, M. Argyropoulou, H. Milionis","doi":"10.1097/CPM.0000000000000375","DOIUrl":"https://doi.org/10.1097/CPM.0000000000000375","url":null,"abstract":"Cytokine release syndrome and acute respiratory distress syndrome are the major complications of coronavirus disease 2019 (COVID-19) and tocilizumab has shown efficacy in this setting We report on 2 severely ill patients with COVID-19 treated with tocilizumab within 7 to 10 days of onset of symptoms Tocilizumab markedly improved their clinical condition and was associated with regression of abnormalities on chest computed tomography within 1 week of tocilizumab administration © 2020 Wolters Kluwer Health, Inc All rights reserved","PeriodicalId":10393,"journal":{"name":"Clinical Pulmonary Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47817163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dexamethasone in Acute Respiratory Distress Syndrome 地塞米松治疗急性呼吸窘迫综合征
Clinical Pulmonary Medicine Pub Date : 2020-09-01 DOI: 10.1097/cpm.0000000000000378
W. Whalen, D. Zappetti
{"title":"Dexamethasone in Acute Respiratory Distress Syndrome","authors":"W. Whalen, D. Zappetti","doi":"10.1097/cpm.0000000000000378","DOIUrl":"https://doi.org/10.1097/cpm.0000000000000378","url":null,"abstract":"Synopsis: In patients with moderate-to-severe acute respiratory distress syndrome (ARDS), defined as an arterial oxygen partial pressure/ fractional inspired oxygen (PaO2/FiO2) of 200 mmHg or less with a positive end-expiratory pressure (PEEP) of 10 cm H2O or greater and FiO2 > 0.5, administration of dexamethasone within 24 hours of ARDS onset led to more ventilator-free days, and a reduction of all-cause mortality with no difference in adverse events. Source: Villar, J, Ferrando, C, Martínez, D, et al. Dexamethasone treatment for the acute respiratory distress syndrome: a multicenter, randomised controlled trial. Lancet Respir Med. 2020;8:267–276.","PeriodicalId":10393,"journal":{"name":"Clinical Pulmonary Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45106151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antibiotic Use and Stewardship in Cystic Fibrosis: A Review for Noncystic Fibrosis Providers 囊性纤维化的抗生素使用和管理：非囊性纤维化提供者综述
Clinical Pulmonary Medicine Pub Date : 2020-09-01 DOI: 10.1097/CPM.0000000000000370
E. Orsini, Cyndee C. Miranda, E. Dasenbrook
{"title":"Antibiotic Use and Stewardship in Cystic Fibrosis: A Review for Noncystic Fibrosis Providers","authors":"E. Orsini, Cyndee C. Miranda, E. Dasenbrook","doi":"10.1097/CPM.0000000000000370","DOIUrl":"https://doi.org/10.1097/CPM.0000000000000370","url":null,"abstract":"Antibiotics form the foundation of comprehensive cystic fibrosis (CF) therapy and are responsible for invaluable gains in life expectancy and quality of life. Although antibiotic stewardship may be perceived to be in conflict with appropriate CF care, there are many potential benefits to antibiotic stewardship in CF. Antimicrobial stewardship teams can provide a collaborative approach to CF care and provide assistance with antibiotic selection, therapeutic drug monitoring, and recommendation of best practices supported by evidenced-based guidelines. The aim of this review is to introduce the rationale for the use of antibiotics in CF care, examine the evidence behind current antibiotic practices, and discuss the potential role of antibiotic stewardship in CF care.","PeriodicalId":10393,"journal":{"name":"Clinical Pulmonary Medicine","volume":"27 1","pages":"131 - 138"},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43330495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immunotherapy-induced Pneumonitis: A Review of Diagnostic Workup and Treatment Guidelines 免疫疗法诱导的肺炎：诊断方法和治疗指南综述
Clinical Pulmonary Medicine Pub Date : 2020-09-01 DOI: 10.1097/CPM.0000000000000373
K. Gershner
{"title":"Immunotherapy-induced Pneumonitis: A Review of Diagnostic Workup and Treatment Guidelines","authors":"K. Gershner","doi":"10.1097/CPM.0000000000000373","DOIUrl":"https://doi.org/10.1097/CPM.0000000000000373","url":null,"abstract":"Lung cancer remains the leading cause of cancer-related deaths worldwide; however, new developments in treatment, specifically immune checkpoint inhibitors, have demonstrated improved progression-free survival. Unfortunately, these medications are not without side effects, including the potentially life-threatening side effect of immune-related pneumonitis. There are a paucity of data with regard to risk factors and diagnostic criteria, leading to a complicated diagnostic dilemma for providers. In addition, guidelines as regards treatment and reinitiation of therapy are sparse at best. Both these factors lead to significant uncertainty in regard to this disease entity. As use of immune checkpoint inhibitors increases, more and more clinicians will be faced with this diagnostic and treatment quandary. Here, we review the current diagnostic and treatment guidelines for immune-related pneumonitis and shed light on future research directions.","PeriodicalId":10393,"journal":{"name":"Clinical Pulmonary Medicine","volume":"27 1","pages":"141 - 147"},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48398095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Laboratory Diagnosis of COVID-19 新冠肺炎的实验室诊断
Clinical Pulmonary Medicine Pub Date : 2020-09-01 DOI: 10.1097/CPM.0000000000000374
M. Asgharzadeh, M. R. Valiollahzadeh, Behroz Mahdavi Poor, H. Samadi kafil, V. Asgharzadeh, Ali Vegari, M. Pourostadi, Z. Sanaat, J. Rashedi
{"title":"Laboratory Diagnosis of COVID-19","authors":"M. Asgharzadeh, M. R. Valiollahzadeh, Behroz Mahdavi Poor, H. Samadi kafil, V. Asgharzadeh, Ali Vegari, M. Pourostadi, Z. Sanaat, J. Rashedi","doi":"10.1097/CPM.0000000000000374","DOIUrl":"https://doi.org/10.1097/CPM.0000000000000374","url":null,"abstract":"SARS-CoV-2 in bats was transmitted to humans by a peridomestic mammal in China and it was transmitted from humans to humans very quickly through coughing and sneezing and is spread all over the world and created coronavirus disease 2019. The disease causes a variety of symptoms in patients and it has killed a significant number of people around the world, especially people with underlying diseases such as heart disease, diabetes, and high blood pressure. Early diagnosis of patients is very important to prevent the transmission of the disease from humans to humans and the spread of the virus. The virus causes abnormal computed tomography scans, lymphopenia, leukopenia, increased C-reactive protein, lactate dehydrogenase, aspartate aminotransferase, and alanine aminotransferase in a significant number of patients. The standard method for diagnosing SARS-CoV-2 infection is real-time reverse transcriptase polymerase chain reaction with 2 genes RdRp and E being identified together in 1 experiment. Other methods such as cell culture, reverse transcription loop-mediated isothermal amplification, next-generation sequencing, fluorescence in situ hybridization, and antigenic assessment can be used to study and identify the virus. IgG and IgM antibodies against S and N proteins are evaluated to recognize people who have been previously infected with the virus.","PeriodicalId":10393,"journal":{"name":"Clinical Pulmonary Medicine","volume":"27 1","pages":"148 - 153"},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48443937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
The Association Between Pneumonia and Heart failure 肺炎和心力衰竭之间的关系
Clinical Pulmonary Medicine Pub Date : 2020-09-01 DOI: 10.1097/CPM.0000000000000371
L. Ong
{"title":"The Association Between Pneumonia and Heart failure","authors":"L. Ong","doi":"10.1097/CPM.0000000000000371","DOIUrl":"https://doi.org/10.1097/CPM.0000000000000371","url":null,"abstract":"Heart failure (HF) may be associated with pneumonia as HF is one of the most common complications of patients who have a primary diagnosis of pneumonia. Patients who develop HF from pneumonia are associated with higher severity of pneumonia and higher mortality rate. The purpose of this review was to summarize the association between pneumonia and HF with the available literature and discuss the pathophysiology underlying it. Ten studies have been included in this review to support the association between pneumonia and HF. Awareness of this association is essential for clinical management and to improve the outcomes of the patients.","PeriodicalId":10393,"journal":{"name":"Clinical Pulmonary Medicine","volume":"27 1","pages":"125 - 130"},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47864732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Should Every Patient Admitted for a Community-acquired Pneumonia Get Blood Cultures to Detect Bacteremia? 每个社区获得性肺炎患者都应该接受血培养以检测菌血症吗?
Clinical Pulmonary Medicine Pub Date : 2020-07-01 DOI: 10.1097/CPM.0000000000000368
M. H. Pierre-Louis, D. Zapetti
{"title":"Should Every Patient Admitted for a Community-acquired Pneumonia Get Blood Cultures to Detect Bacteremia?","authors":"M. H. Pierre-Louis, D. Zapetti","doi":"10.1097/CPM.0000000000000368","DOIUrl":"https://doi.org/10.1097/CPM.0000000000000368","url":null,"abstract":"","PeriodicalId":10393,"journal":{"name":"Clinical Pulmonary Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/CPM.0000000000000368","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46848829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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