中国综合临床最新文献

{"title":"Analysis of neuroendoscopic or microscopic transsphenoidal approach in the treatment of pituitary tumors of different grades and the measures to reduce the common postoperative complications","authors":"W. Dong, Cheng Yue, Yu Zhang, Jianjun Gao, G. Dong, Hua Gao","doi":"10.3760/CMA.J.ISSN.1008-6315.2020.02.016","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6315.2020.02.016","url":null,"abstract":"Objective \u0000To explore the clinical effect of endoscopic assisted or microscopical transsphenoidal surgery in the treatment of different grades of invasive pituitary tumors and the measures to reduce complications. \u0000 \u0000 \u0000Methods \u0000From January 2016 to June 2019, 87 patients with pituitary tumor admitted to the neurosurgery of Tangshan People′s Hospital of Hebei Province were selected as the study objects for retrospective analysis. Among them, 42 patients were included in the endoscopic group and 45 patients were included in the endoscopic group. To compare the related indexes and clinical effects of two different surgical methods, and to analyze the treatment strategies to reduce the common postoperative complications. \u0000 \u0000 \u0000Results \u0000The amount of intraoperative bleeding, the time needed for operation and the hospital stay of patients in endoscopic group were significantly less or shorter than those in microscopical group(intraoperative bleeding volume: (66.19±9.55) ml and (79.78±11.68) ml; operation time: (93.93±9.53) min and (103.33±9.23) min; hospitalization time: (7.71±1.53) d and (10.16±1.33) d). The difference was statistically significant (T values were 5.92, 4.67, 7.94, all P< 0.01). There was no significant difference between the two groups (P= 0.577). There were 2 cases (4.8%) of cerebrospinal fluid leakage in endoscopic group and 12 cases (26.7%) in microscopical group. The difference between the two groups was statistically significant(χ2=5.67, P< 0.05). There were 7 cases (16.7%) of diabetes insipidus in endoscopic group and 22 cases (48.9%) in microscopical group. The difference between the two groups was statistically significant (χ2=5.19, P< 0.05). \u0000 \u0000 \u0000Conclusion \u0000The curative effect of endoscopic transsphenoidal resection of pituitary tumor is similar to that of microscopical resection of pituitary tumor. The patients recover quickly, have fewer complications, and have a short hospital stay. \u0000 \u0000 \u0000Key words: \u0000Neuroendoscopy; Microscope; Pituitary tumor; Complication","PeriodicalId":10365,"journal":{"name":"Clinical Medicine of China","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49316856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research Advances of metronomic Chemotherapy in Non-small Cell Lung Cancer","authors":"Yue Yu","doi":"10.3760/CMA.J.ISSN.1008-6315.2020.02.020","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6315.2020.02.020","url":null,"abstract":"Advanced non-small cell lung cancer is one of the most difficult malignant tumors in the world. At present, chemotherapy is the most common treatment for NSCLC. However, traditional chemotherapy can kill tumor cells as well as normal cells. In order to solve this problem, metronomic chemotherapy came into being. It can inhibit tumor angiogenesis and tumor growth through a continuous high-frequency, low-dose administration. Metronomic chemotherapy can effectively control the disease progression of advanced NSCLC patients, delay their life span and improve their quality of life. Therefore, metronomic chemotherapy has become an effective treatment for advanced non-small cell lung cancer. \u0000 \u0000 \u0000Key words: \u0000Lung cancer; Metronomic Chemotherapy; Tumor","PeriodicalId":10365,"journal":{"name":"Clinical Medicine of China","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45844113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of serum monokine induced by IFN-γ and interleukin9 to HBV pre-C/BCP mutation and their influences on the response to interferon therapy in patients with HBeAg-positive chronic hepatitis B","authors":"Li Yang, Xiaoqing Hu","doi":"10.3760/CMA.J.ISSN.1008-6315.2020.02.015","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6315.2020.02.015","url":null,"abstract":"Objective \u0000To study the correlation of serum monokine induced by IFN-γ(Mig)and interleukin9(IL-9) levels to HBV pre-C/BCP mutation and their influences on the response to interferon therapy in patients with HBeAg-positive chronic hepatitis B(CHB). \u0000 \u0000 \u0000Methods \u0000A total of 110 cases of HBeAg-positive CHB patients in the People′s Hospital of Jianyang City were retrospectively analyzed from February 2015 to February 2018, and all received pegylated-IFN-αtherapy.Before treatment, the gene fragment of HBV pre-C/BCP region was amplified and the patients were divided into two groups: wild type group (61 cases) and mutant group (49 cases). The difference of serum MIG, IL-9 and antiviral treatment effect between the two groups were compared. \u0000 \u0000 \u0000Results \u0000The serum IL-9 of mutant group before treatment ((10.8±1.9) ng/L)was significantly higher than that of wild group((8.3±1.7) ng/L) (P 1 lg 10 in mutation group before treatment was significantly higher than HBsAg decrease≤1 lg 10 ((129.2±37.9) ng/L vs.(91.5±25.7) ng/L)(P<0.05). The serum IL-9 in the mutant group were(8.8±1.9) ng/L and (8.9±1.6) ng/L at 12 and 24 weeks after treatment respectively, which were significantly lower than that before treatment (all P<0.05). \u0000 \u0000 \u0000Conclusion \u0000The high expression of IL-9 in serum of CHB and HBeAg positive patients before treatment is closely related to the variation of HBV pre-C/BCP region, and the expression of IL-9 is not related to the antiviral effect of interferon.The high expression of MIG in patients before treatment may be more beneficial to the antiviral effect of interferon in patients with HBV pre-C/BCP region variation. \u0000 \u0000 \u0000Key words: \u0000Chronic hepatitis B; Hepatitis B virus pre-C/BCP mutation; Pegylated-IFN-α; Interleukin 9; Monokine induced by IFN-γ","PeriodicalId":10365,"journal":{"name":"Clinical Medicine of China","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42403743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in the treament of talus fracture and its complications","authors":"L. Ding, Shufeng Han, Erlong Jia, Jintao Chen, Chang Liu","doi":"10.3760/CMA.J.ISSN.1008-6315.2020.02.021","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6315.2020.02.021","url":null,"abstract":"Talus fracture is a relatively rare injury. The indication of surgical treatment of talus fracture is the obvious displacement of talus neck or talus body fracture, the purpose of which is to achieve anatomical reduction of the fracture site. The anatomical structure of talus is special, most of its surface is covered by the articular surface, so the injury often involves the articular surface, so the treatment is difficult and the incidence of complications after fracture operation is high, which is prone to ischemic necrosis and traumatic arthritis. Based on the anatomical structure of talus, we reviewed the latest treatment methods of talus fracture and its complications, the advantages and disadvantages of different treatment methods and the existing problems. \u0000 \u0000 \u0000Key words: \u0000Fracture; Talus; Ischemic necrosis; Treament","PeriodicalId":10365,"journal":{"name":"Clinical Medicine of China","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47918898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical observation and study of hormone replacement therapy on postoperative cervical squamous cell carcinoma","authors":"Chengwei He, Tianqi Guo, P. Lei","doi":"10.3760/CMA.J.ISSN.1008-6315.2020.02.004","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6315.2020.02.004","url":null,"abstract":"Objective \u0000To observe the clinical effect of hormone replacement therapy(HRT) on patients with cervical squamous cell carcinoma after operation and its effect on sex hormone, blood fat, bone content and tumor markers, and to evaluate the clinical significance of HRT therapy. \u0000 \u0000 \u0000Methods \u0000From January 2016 to January 2019, a total of 100 patients with cervical squamous cell carcinoma admitted to Zhuhai Maternal and Child Health Hospital were analyzed retrospectively.After surgical treatment, 50 patients were willing to receive hormone replacement therapy as the experimental group and 50 patients received routine treatment as the control group, Kupperma score was used to evaluate the severity of perimenopausal symptoms, and the serum levels of sex hormones, blood fat, bone content and tumor markers in the two groups before and after treatment were detected and the occurrence of adverse reactions were evaluated. \u0000 \u0000 \u0000Results \u0000Before treatment, there was no significant difference in kupperma score, estradiol, follicle-stimulating hormone, luteinizing hormone level, lipid level, bone content and tumor marker level between the two groups(all P>0.05). After HRT treatment, kupperma score in the experimental group was significantly lower than that before treatment((11.47±5.12) vs.(20.46±7.52), t=7.262). In the detection of sex hormones, the levels of estradiol in the experimental group was significantly increased((39.26±7.43) ng/L vs.(13.78±7.52) ng/L, t=12.345), and the levels of follicle stimulating hormone((34.25±7.61) U/L vs.(62.18±19.12) U/L, t=8.245)and luteinizing hormone((20.31±6.25) U/L vs.(35.08±6.27) U/L, t=5.452, P=0.004) in the experimental group were significantly decreased.In the detection of blood lipid level, bone content and tumor markers, high-density lipoprotein((1.62±0.33) mmol/L vs(1.34±0.26) mmol/L, t=4.592, P=0.008) and alkaline phosphatase levels((66.21±25.75) U/L vs.(46.88±9.06) U/L, t=5.912, P=0.001)was significantly increased, the low density lipoprotein((2.78±0.43) mmol/L vs.(2.87±0.78) mmol/L, t=4.265, P=0.012)and total cholestenone((4.02±0.45) mmol/L vs.(4.23±0.91) mmol/L, t=5.761, P=0.002) levels were significantly decreased in the experimental group, with statistically significant differences(all P 0.05); there was no significant difference in the above indicators between the experimental group and the control group before and after treatment (P> 0.05); there was no significant increase in adverse reactions such as breast swelling and pain (3 cases), body mass increase (2 cases), bleeding (1 case), body pain (4 cases), vomiting (4 cases), etc. between the experimental group and the control group (2, 1, 2, 3, 1 case) There was no statistical significance (P> 0.05). \u0000 \u0000 \u0000Conclusion \u0000HRT treatment of cervical squamous cell carcinoma patients after surgery can significantly improve the peri menstrual syndrome caused by low estrogen level, and did not significantly increase the risk of recurrence of cervical cancer patients an","PeriodicalId":10365,"journal":{"name":"Clinical Medicine of China","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48281488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the efficacy of midcaudal combined approach and cephalic middle approach in laparoscopic complete mesocolic excision for right hemicolon cancer with incomplete ileus","authors":"Hongsheng Zhao, Jiyong Pan, Ruifeng Yan, Zijun Guo, Long Yan","doi":"10.3760/CMA.J.ISSN.1008-6315.2020.02.006","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6315.2020.02.006","url":null,"abstract":"Objective \u0000To compare the effect of midcaudal combined approach and the cephalic middle approach in laparoscopic complete mesocolic excision (CME) in the treatment of right colon cancer complicated with incomplete intestinal obstruction. \u0000 \u0000 \u0000Methods \u0000From January 2014 to January 2019, 90 patients with right colon cancer complicated with incomplete intestinal obstruction admitted to the Third People′s Hospital of Dalian were retrospectively analyzed.All patients underwent laparoscopic right hemicolectomy, CME plus D3 lymph node dissection.According to the choice of different surgical approaches, 44 patients were treated with the midcaudal combined approach (observation group) and the other 46 patients were treated with cephalic middle approach (control group). The intraoperative, postoperative and complications of the two groups were compared statistically. \u0000 \u0000 \u0000Results \u0000Compared with the control group, the bleeding volume in the observation group was significantly reduced ((105.3±22.6) ml vs.(309.6±28.0) ml, t=13.698), the operation time was significantly shortened ((165.2±17.9) min vs.(219.5±21.5) min, t=8.327), and the differences were statistically significant (all P 0.05). \u0000 \u0000 \u0000Conclusion \u0000It is safe and feasible to use the middle caudal approach in laparoscopic CME for right colon cancer complicated with incomplete ileus. Compared with the cephalic middle approach, it can reduce thebleeding volume and shorten the operation time. \u0000 \u0000 \u0000Key words: \u0000Right colon cancer; Incomplete intestinal obstruction; Complete mesocolon resection; Midcaudal combined approach","PeriodicalId":10365,"journal":{"name":"Clinical Medicine of China","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41458618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on the treatment course of Bifidobacterium combined with quadruple therapy including furazolidone and tetracycline for rescue eradication of Helicobacter pylori","authors":"Haitao Wang, Jie Zhang, Xiaozhong Jiang","doi":"10.3760/CMA.J.ISSN.1008-6315.2020.02.007","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6315.2020.02.007","url":null,"abstract":"Objective \u0000To explore the effect of the eradication rate and adverse reactions of different courses of Bifidobacterium combined with quadruple therapy containing furazolidone and tetracycline for rescue eradication of Helicobacter pylori. \u0000 \u0000 \u0000Methods \u0000From December 2016 to May 2019, 348 patients with chronic gastritis who failed to eradicate Hp for the first time were selected from the outpatient department of digestive medicine of Kailuan General Hospital affiliated to North China University of Technology.Group A, B and C were randomly divided by Excel, Group A(116 patients): 14-day quadruple therapy (Eprazole+ colloidal bismuth pectin+ furazolidone + tetracycline); group B(116 patients): Bifidobacterium was given 14 days on the basis of treatment in group A; group C(116 patients): 7 days Bifidobacterium was given in the second week of treatment in group A 4 weeks after the end of eradication treatment, 14 C urea breath test was reexamined, to compare the eradication rate and the incidence of adverse reactions. \u0000 \u0000 \u0000Results \u0000The eradication rates were 80.2%, 84.5% and 82.3% respectively according to intention treatment.The eradication rates were 88.6%, 90.7% and 89.7%, respectively according to perprotocol.There was no significant difference between the three groups(according to intention to treat analysis: χ2=0.755, P=0.685; according to the perprotocol analysis: χ2=0.271, P=0.873). The incidence of adverse reactions in three groups was 16.4%, 6.3% and 7.3% respectively, the difference was statistically significant(χ2=7.561, P=0.023). Group B was significantly lower than group A(χ2=5.570, P=0.017), the difference was statistically significant, but there was no statistically significant difference between group C and group A(χ2=4.362, P=0.037). \u0000 \u0000 \u0000Conclusion \u0000After 14 days of Bifidobacterium tetrad live tablet assisted with tetrad therapy containing furazolidone and tetracycline, the adverse reactions could be significantly reduced, but Bifidobacterium could not significantly improve the eradication rate. \u0000 \u0000 \u0000Key words: \u0000Helicobacter pylori; Quadruple therapy; Eradication rate; Rescue eradication therapy; Bifidobacterium","PeriodicalId":10365,"journal":{"name":"Clinical Medicine of China","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46729129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of interleukin6 on the malignant progression of ovarian cancer","authors":"Tongshuo Zhang, Ziyue Zhang, Weixin Li, Xiaoqin Guo","doi":"10.3760/CMA.J.ISSN.1008-6315.2020.02.018","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6315.2020.02.018","url":null,"abstract":"Modern oncology believes that tumor-associated inflammation is one of the prominent features of tumor microenvironment.The occurrence and development of ovarian cancer is inseparable from the influence of inflammatory factors in the microenvironment.Interleukin-6 (IL-6) is an important pro-inflammatory factor that regulates tumor cell growth.Current studies found that the expression of IL-6 and IL-6 receptor both increase in patients with ovarian cancer, which are closely related to poor clinical prognosis.The mechanism of effect of IL-6 on the malignant progression of ovarian cancer has been a research hotspots in the field of tumor microenvironment.In combination of the research results of this group in recent years, we mainly review the role of IL-6 in ovarian cancer including proliferation, invasion and metastasis, blood system disorders and drug resistance.Then, we introduce the research frontiers and application prospects of IL-6 targeted therapy for ovary cancer. \u0000 \u0000 \u0000Key words: \u0000Ovarian cancer; Interleukin6; Inflammation; Tumor microenvironment; Malignant progression","PeriodicalId":10365,"journal":{"name":"Clinical Medicine of China","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43826683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on the effect of different frequencysling exercise therapyon stroke patients","authors":"Chaoqin Mao, Lizhi Yang, Zhiwen He, Jie Ma, Lilei Dai, Gang Wang","doi":"10.3760/CMA.J.ISSN.1008-6315.2020.02.012","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6315.2020.02.012","url":null,"abstract":"Objective \u0000To investigate the effects of different frequency sling exercise therapy (SET) on the balance of trunk control and walking ability in stroke patients. \u0000 \u0000 \u0000Methods \u0000A total of 90 patients with stroke who were admitted to the Department of Rehabilitation Medicine, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, from January 2018 to December 2018, received sling exercise therapy on a routine basis and were divided into 1 time/Day low frequency group, 2 time/Day medium frequency group, 3 time/Day high frequency group, 20 min/time, for a total of 3 months.After 1, 2 and 3 months, trunk control test (TCT), Berg balance scale(BBS), functional ambulation classification (FAC) and modified Barthel Index (MBI) were used to evaluate the three groups of patients. \u0000 \u0000 \u0000Results \u0000There were significant differences in TCT, BBS, FAC and MBI between the low, middle and high frequency groups (all P 0.05). There was no significant difference between fAC and MBI in the low, medium and high frequency group, but there was no significant difference between the two groups after training for 2 and 3 months There were significant differences between fAC ((1.84±0.41), (2.39±0.44), (3.29 ± 0.33) and MBI ((27.32 ± 9.33), (34.45 ± 9.21), (44.77 ± 10.27) and (41.33±11.21), (52.73±12.31), (75.94±13.22)). There was significant difference between the high frequency group and the low frequency group (P< 0.05). \u0000 \u0000 \u0000Conclusion \u0000Multiple sling exercise therapy in one day can further improve the balance of trunk control and walking ability of stroke patients, and shorten the course of disease. \u0000 \u0000 \u0000Key words: \u0000Stroke; Sling exercise therapy; Trunk control balance; Walking ability","PeriodicalId":10365,"journal":{"name":"Clinical Medicine of China","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48077824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between the deletion of phosphatase and tensin homolog gene on chromosome 10, syncytin-1 and the damage of maternal endothelium and trophoblast in preeclampsia placenta","authors":"Xiaoshan Fang, Huijin Feng","doi":"10.3760/CMA.J.ISSN.1008-6315.2020.02.017","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-6315.2020.02.017","url":null,"abstract":"Objective \u0000To study the correlation between phosphatase and tensin homolog deleted on chromosome ten(PTEN), Syncytin-1 in preeclamptic placenta and maternal endothelial injury, trophoblast injury. \u0000 \u0000 \u0000Methods \u0000From February 2015 to December 2017, 46 patients diagnosed as preeclampsia and delivered in Xiaolan Hospital Affiliated to Southern Medical University and 80 pregnant women with normal delivery in the same period were selected.Before delivery, maternal peripheral blood was collected and the content of endothelial injury markers was determined; after delivery, the placenta was retained and the expression of PTEN, Syncytin-1, apoptosis gene and the contents of oxidative stress markers were measured. \u0000 \u0000 \u0000Results \u0000The mRNA expression of PTEN in placental tissue of preeclampsia was significantly higher than that of normal placental tissue(t=32.797, P<0.000), and the mRNA expression of Syncytin-1 was significantly lower than that of normal placental tissue(t=28.506, P<0.001); the content of ET-1 and sFlt-1 in the blood circulation of the maternal body of preeclampsia was significantly higher than thsoe of normal pregnant women(t=39.884, 40.243; all P<0.000) and positively correlated with the mRNA expression of PTEN in placenta(correlation coefficient=0.674, 0.596; P=0.004, 0.007), negatively correlated with the mRNA expression of Syncytin-1 in placenta(correlation coefficient=-0.615, -0.637; P<0.009, 0.008); the content of NO, PGI2, VEGF and PLGF were significantly lower than thse of normal pregnant women(t=30.944, 27.404, 32.827, 26.644; all P<0.001) and negatively correlated with the mRNA expression of PTEN in placenta(correlation coefficient=-0.648, -0.592, -0.537, -0.613; P=0.006, 0.009, 0.013, 0.007), positively correlated with the mRNA expression of Syncytin-1 in placenta(correlation coefficient=0.632, 0.572, 0.537, 0.654; P<0.010, 0.013, 0.015, 0.009); The contents of NOX4, MDA, 8-OHdG and the mRNA expression of Fas, FasL, Bax, GRP78, CHOP, Caspase-3 in placental tissue of preeclampsia was significantly higher than that of normal placental tissue(t=27.714, 27.704, 26.786, 27.964, 22.622, 25.496, 25.893, 30.837, 28.975; all P<0.001) and positively correlated with the mRNA expression of PTEN in placenta(correlation coefficient=0.703, 0.651, 0.593, 0.628, 0.449, 0.552, 0.612, 0.569, 0.502; P<0.003, 0.007, 0.004, 0.006, 0.016, 0.010, 0.006, 0.012, 0.018), negatively correlated with the mRNA expression of Syncytin-1 in placenta(correlation coefficient=-0.615, -0.714, -0.577, -0.548, -0.512, -0.585, -0.619, -0.495, -0.662; P<0.009, 0.001, 0.013, 0.015, 0.018, 0.011, 0.009, 0.023, 0.003); The contents of PrxII, PrxIII, SOD and mRNA expression of Bcl-2 in placental tissue of preeclampsia was significantly lower than that of normal placental tissue(t=26.115, 23.502, 17.194; all P<0.000) and negatively correlated with the mRNA expression of PTEN in placenta(correlation coefficient=-0.713, -0.657, -0.591, -0.642; P<0.001, 0.006, 0.009, 0.007), posi","PeriodicalId":10365,"journal":{"name":"Clinical Medicine of China","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43587917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}