Sina A. Beer, Andrew Hall, Rachel Phillip, Sarah R. Brown, Paula Proszek, Michael Hubank, Amy Holroyd, Elsa Ferris, Ruth M. De Tute, Sadie Roberts, Laura Clayton, Kristian Bowles, Mamta Garg, Anand Lokare, Christina Messiou, Richard S. Houlston, Graham Jackson, Gordon Cook, Roger G. Owen, Mark T. Drayson, Martin F. Kaiser
{"title":"OA-62 Re-Defining Ultra-High-Risk Myeloma by Combining Genomic and Transcriptional Risk Assessment: An Exploratory Study of the UKMRA OPTIMUM/MUKnine Trial","authors":"Sina A. Beer, Andrew Hall, Rachel Phillip, Sarah R. Brown, Paula Proszek, Michael Hubank, Amy Holroyd, Elsa Ferris, Ruth M. De Tute, Sadie Roberts, Laura Clayton, Kristian Bowles, Mamta Garg, Anand Lokare, Christina Messiou, Richard S. Houlston, Graham Jackson, Gordon Cook, Roger G. Owen, Mark T. Drayson, Martin F. Kaiser","doi":"10.1016/S2152-2650(26)03363-X","DOIUrl":"10.1016/S2152-2650(26)03363-X","url":null,"abstract":"","PeriodicalId":10348,"journal":{"name":"Clinical Lymphoma, Myeloma & Leukemia","volume":"26 ","pages":"Pages S40-S41"},"PeriodicalIF":4.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149011154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Charalampos Filippatos, Maria Gavriatopoulou, Alexandros Briasoulis, Ioannis Ntanasis-Stathopoulos, Evangelos Terpos, Despina Fotiou
{"title":"Real-World Experience With Mogamulizumab for Mycosis Fungoides and Sézary Syndrome.","authors":"Charalampos Filippatos, Maria Gavriatopoulou, Alexandros Briasoulis, Ioannis Ntanasis-Stathopoulos, Evangelos Terpos, Despina Fotiou","doi":"10.1016/j.clml.2026.08.018","DOIUrl":"https://doi.org/10.1016/j.clml.2026.08.018","url":null,"abstract":"<p><strong>Background: </strong>Mogamulizumab is an established treatment option for relapsed/refractory mycosis fungoides (MF) and Sézary syndrome (SS); however, large-scale real-world outcome data remain limited.</p><p><strong>Materials and methods: </strong>We conducted a retrospective cohort study on patients with MF or SS who received treatment with mogamulizumab using TriNetX.</p><p><strong>Results: </strong>A total of 394 patients were included (182 [46.2%] MF, 212 [53.8%] SS). The median follow-up was 31.5 months. The 1- and 3-year OS rates were 85.7% and 73.4%, respectively. Corresponding rates among MF and SS patients were 82.0% versus 88.2% and 69.3% versus 76.7%. In univariable analyses, SS was associated with improved OS (Hazard ratio [HR] 0.75, 95% confidence interval [CI] 0.57-0.98; P = .032), whereas nodal involvement predicted inferior survival (HR 1.36, 95% CI 1.01-1.93; P = .043). Following adjustment, both associations were attenuated to non-significant trends (SS: aHR = 0.70, 95% CI: 0.47-1.03, P = .067; nodal involvement: aHR 1.40, 95% CI 0.95-2.06; P = .089). Overall, 154 patients (39.1%) required subsequent systemic therapy, with the 1- and 3-year cumulative incidence being 31.1% (95% CI: 25.7%-35.7%) and 41.0% (95% CI: 35.1%-46.9%), respectively. Elevated LDH independently predicted shorter TTNT (acsHR 1.62, 95% CI 1.29-2.03; P < .001). The 12-month incidences of infection, sepsis, hospitalization, and emergency department visits were 39.8%, 13.5%, 34.3%, and 20.6%, respectively, with similar incidences between MF and SS.</p><p><strong>Conclusions: </strong>In this large real-world cohort, mogamulizumab was associated with durable survival, prolonged treatment-free intervals, and the outcomes observed were consistent with the pattern seen in the MAVORIC trial.</p>","PeriodicalId":10348,"journal":{"name":"Clinical Lymphoma, Myeloma & Leukemia","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149036796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Katie L. Horton, Nehir Banaz, Stephen Walker, Sai Duraisingham, Mamta Garg
{"title":"PA-016 Accurate Assessment of Treatment Response in AL Amyloidosis Using Mass Spectrometry","authors":"Katie L. Horton, Nehir Banaz, Stephen Walker, Sai Duraisingham, Mamta Garg","doi":"10.1016/S2152-2650(26)03387-2","DOIUrl":"10.1016/S2152-2650(26)03387-2","url":null,"abstract":"","PeriodicalId":10348,"journal":{"name":"Clinical Lymphoma, Myeloma & Leukemia","volume":"26 ","pages":"Page S55"},"PeriodicalIF":4.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149010609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Martha Paola Anchondo Commesse, Jessica Pamela Salinas Espinosa, Diego Jose Fuentes Cañas, Alejandro López Ochoa, Andrea Victoria Pacheco, Ana Echenique Alcázar, Diego Franco Hernández, Edgar Ricardo Olivas-Domínguez, Magaly Valeria Escobedo Cruz, Karla Mariana Castro Bórquez, Miranda de la Luz Franco, Juan Pablo Capdevila, Jorge Arturo Hurtado Martinez
{"title":"PA-019 AI Doctor-in-the-Loop Abstraction: Enhancing Completeness in Flow Cytometry Data Abstraction for Multiple Myeloma Genomic and Immune Profiling","authors":"Martha Paola Anchondo Commesse, Jessica Pamela Salinas Espinosa, Diego Jose Fuentes Cañas, Alejandro López Ochoa, Andrea Victoria Pacheco, Ana Echenique Alcázar, Diego Franco Hernández, Edgar Ricardo Olivas-Domínguez, Magaly Valeria Escobedo Cruz, Karla Mariana Castro Bórquez, Miranda de la Luz Franco, Juan Pablo Capdevila, Jorge Arturo Hurtado Martinez","doi":"10.1016/S2152-2650(26)03390-2","DOIUrl":"10.1016/S2152-2650(26)03390-2","url":null,"abstract":"","PeriodicalId":10348,"journal":{"name":"Clinical Lymphoma, Myeloma & Leukemia","volume":"26 ","pages":"Page S57"},"PeriodicalIF":4.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149010793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jin Lu, Gang An, Jie Jin, Jianqing Mi, Wenming Chen, Ai-Bin Liang, Jian Li, Juan Du, Cheng-Cheng Fu, Chunrui Li, Xi Zhang, Lily Zhou, Jia Feng, Xiaolei Wei, Ying Lu, Ting Niu, Rong Fu, Wan-Hong Zhao, Heng Mei, Rong Zhan, Zhong-Jun Xia
{"title":"OA-09 BCMA CAR T-Cell Therapy (Equecabtagene Autoleucel, Eque-Cel) for Multiple Myeloma in Chinese Clinical Practice: A Large Real-World Evidence of 281 Patients","authors":"Jin Lu, Gang An, Jie Jin, Jianqing Mi, Wenming Chen, Ai-Bin Liang, Jian Li, Juan Du, Cheng-Cheng Fu, Chunrui Li, Xi Zhang, Lily Zhou, Jia Feng, Xiaolei Wei, Ying Lu, Ting Niu, Rong Fu, Wan-Hong Zhao, Heng Mei, Rong Zhan, Zhong-Jun Xia","doi":"10.1016/S2152-2650(26)03310-0","DOIUrl":"10.1016/S2152-2650(26)03310-0","url":null,"abstract":"","PeriodicalId":10348,"journal":{"name":"Clinical Lymphoma, Myeloma & Leukemia","volume":"26 ","pages":"Pages S5-S6"},"PeriodicalIF":4.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149010890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nour Alassi, Claudio Cerchione, Milena Urbini, Alessandra Merlotti, Alexandra Poos, Sarah Tassinari, Tania Rossi, Sofia Cortesi, Alice Rossi, Gerardo Musuraca, Giovanni Martinelli, Nicola Normanno, Daniel Remondini, Niels Weinhold, Matteo Marchesini
Neha Korde, Carlyn Tan, Maximilian Merz, Sridevi Rajeeve, Malin Hultcrantz, Sham Mailankody, Kylee Maclachlan, Ross Firestone, Urvi A. Shah, Hamza Hashmi, Alexander Lesokhin, Hani Hassoun, Francesco Maura, Gunjan Shah, Eric Jurgens, Michael Scordo, Heather Landau, Julia Caple, Jayme O'Connor, Meredith Hyland, Saad Z. Usmani
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