SOHO State of the Art Updates and Next Questions | Challenging Scenarios in the Management of Myeloproliferative Neoplasms.

IF 2.7 4区 医学 Q2 HEMATOLOGY
Joseph Cannova, Shiv Shah, Anand A Patel
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引用次数: 0

Abstract

Philadelphia-chromosome negative (Ph-neg) myeloproliferative neoplasms (MPNs) carry a variable rate of progression to the fibrotic stage of disease and/or the accelerated/blast-phase (AP/BP) of disease. Many of the challenging management scenarios that arise in the treatment of MPNs occur in those with higher-risk myelofibrosis (MF) or MPN-AP/BP. In this review we will focus upon 3 challenging clinical scenarios pertinent to the management of high-risk MPNs. We discuss how to incorporate molecular data into decision making around allogeneic hematopoietic stem cell transplantation in MF, strategies to address splenomegaly in patients with MF with inadequate response to an initial JAK inhibitor, and what sort of treatment approaches can be employed in the management of MPN-AP/BP.

SOHO最新进展和下一个问题:骨髓增生性肿瘤治疗中的挑战。
费城染色体阴性(Ph-neg)骨髓增生性肿瘤(mpn)在疾病的纤维化期和/或疾病的加速/爆发期(AP/BP)的进展速度不同。在mpn治疗中出现的许多具有挑战性的管理方案发生在高风险骨髓纤维化(MF)或MPN-AP/BP患者中。在这篇综述中,我们将重点讨论与高危mpn管理相关的3种具有挑战性的临床情况。我们讨论了如何将分子数据纳入MF患者同种异体造血干细胞移植的决策,解决对初始JAK抑制剂反应不足的MF患者脾肿大的策略,以及可以采用何种治疗方法来管理MPN-AP/BP。
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来源期刊
CiteScore
2.70
自引率
3.70%
发文量
1606
审稿时长
26 days
期刊介绍: Clinical Lymphoma, Myeloma & Leukemia is a peer-reviewed monthly journal that publishes original articles describing various aspects of clinical and translational research of lymphoma, myeloma and leukemia. Clinical Lymphoma, Myeloma & Leukemia is devoted to articles on detection, diagnosis, prevention, and treatment of lymphoma, myeloma, leukemia and related disorders including macroglobulinemia, amyloidosis, and plasma-cell dyscrasias. The main emphasis is on recent scientific developments in all areas related to lymphoma, myeloma and leukemia. Specific areas of interest include clinical research and mechanistic approaches; drug sensitivity and resistance; gene and antisense therapy; pathology, markers, and prognostic indicators; chemoprevention strategies; multimodality therapy; and integration of various approaches.
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