Clinical and Translational Allergy最新文献

{"title":"Socioeconomic status has direct impact on asthma control: Turkish adult asthma registry","authors":"Bahar Arslan,&nbsp;Murat Türk,&nbsp;Serhat Hayme,&nbsp;Ömür Aydin,&nbsp;Derya Gokmen,&nbsp;Gozde Koycu Buhari,&nbsp;Zeynep Celebi Sozener,&nbsp;Bilun Gemicioglu,&nbsp;Ismet Bulut,&nbsp;Sengul Beyaz,&nbsp;Cihan Orcen,&nbsp;Secil Kepil Ozdemir,&nbsp;Metin Keren,&nbsp;Ebru Damadoglu,&nbsp;Tugce Yakut,&nbsp;Ayse Fusun Kalpaklioglu,&nbsp;Ayse Baccioglu,&nbsp;Sumeyra Alan Yalim,&nbsp;Insu Yilmaz,&nbsp;Ilkay Koca Kalkan,&nbsp;Elif Yelda Ozgun Niksarlioglu,&nbsp;Ali Fuat Kalyoncu,&nbsp;Gul Karakaya,&nbsp;Muge Erbay,&nbsp;Sibel Nayci,&nbsp;Fatma Merve Tepetam,&nbsp;Asli Akkor Gelincik,&nbsp;Hulya Dirol,&nbsp;Ozlem Goksel,&nbsp;Selen Karaoglanoglu,&nbsp;Ferda Oner Erkekol,&nbsp;Sacide Rana Isik,&nbsp;Fusun Yildiz,&nbsp;Yasemin Yavuz,&nbsp;Dilek Karadogan,&nbsp;Nurgul Bozkurt,&nbsp;Ummuhan Seker,&nbsp;Ipek Kivilcim Oguzulgen,&nbsp;Ilknur Basyigit,&nbsp;Serap Argun Baris,&nbsp;Elif Yilmazel Ucar,&nbsp;Tuba Erdogan,&nbsp;Mehmet Polatli,&nbsp;Dane Ediger,&nbsp;Fatma Esra Gunaydin,&nbsp;Leyla Pur,&nbsp;Zeynep Yegin Katran,&nbsp;Yonca Sekibag,&nbsp;Enes Furkan Aykac,&nbsp;Dilsad Mungan,&nbsp;Ozcan Gul,&nbsp;Ali Cengiz,&nbsp;Bulent Akkurt,&nbsp;Seyma Ozden,&nbsp;Semra Demir,&nbsp;Derya Unal,&nbsp;Ayse Feyza Aslan,&nbsp;Ali Can,&nbsp;Reyhan Gumusburun,&nbsp;Gulhan Bogatekin,&nbsp;Hatice Serpil Akten,&nbsp;Sinem Inan,&nbsp;Munevver Erdinc,&nbsp;Aliye Candan Ogus,&nbsp;Murat Kavas,&nbsp;Demet Polat Yulug,&nbsp;Mehmet Erdem Cakmak,&nbsp;Saltuk Bugra Kaya,&nbsp;Gulistan Alpagat,&nbsp;Eylem Sercan Ozgur,&nbsp;Oguz Uzun,&nbsp;Sule Tas Gulen,&nbsp;Gulseren Pekbak,&nbsp;Deniz Kizilirmak,&nbsp;Yavuz Havlucu,&nbsp;Halil Donmez,&nbsp;Gulden Pacaci Cetin,&nbsp;Sadan Soyyigit,&nbsp;Bilge Yilmaz Kara,&nbsp;Gulden Pasaoglu Karakis,&nbsp;Adile Berna Dursun,&nbsp;Resat Kendirlinan,&nbsp;Ayse Bilge Ozturk,&nbsp;Can Sevinc,&nbsp;Gokcen Omeroglu Simsek,&nbsp;Oznur Abadoglu,&nbsp;Pamir Cerci,&nbsp;Taskin Yucel,&nbsp;Irfan Yorulmaz,&nbsp;Zahide Ciler Tezcaner,&nbsp;Emel Cadalli Tatar,&nbsp;Ahmet Emre Suslu,&nbsp;Serdar Ozer,&nbsp;Engin Dursun,&nbsp;Arzu Yorgancioglu,&nbsp;Gulfem Elif Celik,&nbsp;Mehmet Atilla Uysal","doi":"10.1002/clt2.70018","DOIUrl":"10.1002/clt2.70018","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Asthma is one of the most common causes of chronic respiratory disease, and countries with low socioeconomic status have both a high prevalence of asthma and asthma-related death.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>In this study, we aimed to determine socioeconomic levels of asthmatic patients according to a national database and investigate the effects of social markers on disease control in our region.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This is an analysis of data from 2053 adult asthma patients from a multicentre chart study in Turkey. Socioeconomic status (SES) data were collected from questionnaires and this form was sent to the patients via e-mail. Parameters related to social status and poor disease control were analyzed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Illiteracy (OR:2.687 [95% CI: 1.235–5.848]; <i>p</i> = 0.013) and lower household income (OR:1,76 [95% CI: 1.002–3.09]; <i>p</i> = 0.049) were found as independent risk factors for hospitalization in the multivariate logistic regression analysis. Therewithal, being aged between 40 and 60 (OR: 1.435 [95% CI: 1.074–1.917]; <i>p</i> = 0.015), illiteracy (OR: 2.188 [95% CI: 1.262–3.795]; <i>p</i> = 0.005) and being employed (OR: 1.466 [95% CI: 1.085–1.847]; <i>p</i> = 0.011) were considered as independent risk factors for systemic corticosteroid use at least 3 days within last 1 year.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>As a result of our national database, education level, household income and working status briefly socioeconomic status have impacts on asthma control. Identification of social markers in asthma and better recognition of risk factors based on the population gives us clues to provide better asthma control in the future.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10334,"journal":{"name":"Clinical and Translational Allergy","volume":"15 1","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11761715/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143045699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aerobiology matters: Why people in the community access pollen information and how they use it","authors":"Danielle E. Medek,&nbsp;Constance H. Katelaris,&nbsp;Andelija Milic,&nbsp;Paul J. Beggs,&nbsp;Edwin R. Lampugnani,&nbsp;Don Vicendese,&nbsp;Bircan Erbas,&nbsp;Janet M. Davies","doi":"10.1002/clt2.70031","DOIUrl":"10.1002/clt2.70031","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Globally, many pollen monitoring networks provide the community with daily pollen information, but there are limited data on health consumer uses and benefits. This research investigated why individuals in the community access pollen information, how they use it, and the perceived benefits.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In- and post-pollen season surveys (2017–2018 and 2018–2019) enquired about symptoms, diagnoses, symptom management, access, benefits and usefulness of pollen information provided by the AusPollen Partnership. Open text responses were examined by thematic analysis. Theme frequency and quantitative data were compared across pollen seasons, within and after the season, and between respondents with and without access to AusPollen information.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Surveys were completed 4044 times by 3604 individuals who predominantly self-reported severe and frequent allergic rhinitis symptoms. Local AusPollen information was accessible to 84.6% of participants, and was reportedly used for preparation and planning (34.6%), guiding activities (32.9%), and medication decisions (28.2%). When asked how pollen information helped, similar themes were evident; but 16.1% also mentioned safety for themselves and others. However, secondary analysis of survey responses indicated that self-reported medication use did not differ between those with or without access to pollen information or between time points surveyed. Suggestions for improvement included extended duration (16.4%), wider geographic range (13.5%), and information on other taxa (17.2%).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>There was a perceived need for localised, detailed and timely pollen information by people with pollen allergy. Whilst responses suggested this helped inform behaviours linked to allergen avoidance, further education strategies on allergic rhinitis control are needed to support patients who self-manage their condition.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10334,"journal":{"name":"Clinical and Translational Allergy","volume":"15 1","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11761002/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143037494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Allergen sensitization patterns: Allergic rhinitis with multimorbidity versus alone—A real-world study","authors":"Ya-Ting Li,&nbsp;Qi-Qing Ye,&nbsp;Ya-Xin Lu,&nbsp;Ke-Xin Yang,&nbsp;Ping-Ping Zhang,&nbsp;Chang Chen,&nbsp;Min Zhou,&nbsp;Pei-Ying Feng,&nbsp;Zhuang-Gui Chen","doi":"10.1002/clt2.70030","DOIUrl":"10.1002/clt2.70030","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Allergic rhinitis (AR) multimorbidity may need to be considered a specific disease because of distinct clinical and immunological differences from AR alone. Allergic multimorbidity often involves polysensitization, where allergen-specific immunoglobulin E (IgE) plays a significant role.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This study aims to explore differences in allergen IgE sensitization patterns between AR alone and AR multimorbidity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A real-world case-control study was conducted with patients diagnosed with AR. Multivariate logistic regression analyzed the associations between AR multimorbidity and allergen sensitivity, allergen-specific IgE levels, and the count of positive allergens.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A cohort of 2275 patients with AR was included, of which 1100 (48.4%) presented with AR alone, while 1175 (51.6%) exhibited AR multimorbidity. Patients with AR multimorbidity had a more diverse allergen profile than those with AR alone. An increased number of positive ingested allergens had a higher odds ratio (OR) for AR multimorbidity compared with inhaled allergens (1.46 vs. 1.96) across all phenotypes. Sensitization to allergens and their allergen-specific IgE levels, including dust mites, cat dander, and milk (<i>p</i> &lt; 0.05), were associated with AR multimorbidity. In children, cat and dog dander were significant allergens associated with AR multimorbidity (<i>p</i> &lt; 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Allergen sensitization patterns in AR multimorbidity differ from those in AR alone. Polysensitization, particularly to ingested allergens, increases the risk of allergic multimorbidity. The risk of allergic multimorbidity also increases with specific allergen positivity and higher allergen-specific IgE levels.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10334,"journal":{"name":"Clinical and Translational Allergy","volume":"15 1","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11753898/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143021648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut microbial alteration in chronic spontaneous urticaria unresponsive to second generation antihistamines and its correlation with disease characteristics- a cross-sectional case-control study","authors":"Indrashis Podder,&nbsp;David Pesqué,&nbsp;Nerea Carrón,&nbsp;Pedro Iñaki González Torres,&nbsp;Ramon M. Pujol,&nbsp;Ana M. Giménez-Arnau","doi":"10.1002/clt2.70027","DOIUrl":"10.1002/clt2.70027","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Gut microbial involvement has been speculated in chronic spontaneous urticaria (CSU). The aim of the study was to compare the gut microbiome composition and diversity in CSU patients uncontrolled with second-generation antihistamines (sgAHs) and healthy individuals, as well as to explore any association between gut microbiome and disease characteristics.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A cross-sectional case-control study including 20 CSU patients unresponsive to standard doses of sgAHs, and 15 age-and-sex matched healthy controls was conducted. Clinico-demographic profile, laboratory investigations and stool analysis were conducted in all study participants. 16S RNA gene sequencing and DNA isolation was performed for all stool samples, followed by bioinformatic analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The CSU patients (mean age 39.5 ± 9.3, M:F 1:4) and healthy controls (mean age 35 ± 13, M:F 1:2) were statistically comparable. The median (IQR) duration of CSU was 42 months (7–81). Concomitant angioedema and concomitant symptomatic dermographism were present in 30% and 20% CSU patients, respectively. At inclusion, 60% patients were receiving add-on omalizumab, while the remaining 40% were on up-dosed sgAHs. Stool microbial analysis revealed increased diversity and higher microbial richness in CSU patients compared with healthy individuals. CSU patients showed reduced load of short-chain fatty acid (SCFA) producing microbiota and increased load of opportunistic pathogens. The Firmicutes/Bacteroides (F/B) ratio was higher in CSU patients. Among CSU patients, higher Bacteroides and reduced Firmicutes count were associated with higher disease activity and poor control; however, there was no link with the type of therapy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Gut microbial dysbiosis is seen in CSU and is linked with disease control.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10334,"journal":{"name":"Clinical and Translational Allergy","volume":"15 1","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11732700/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142982930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advances in research on common targets of neurological and sex hormonal influences on asthma","authors":"Wenting Zhou,&nbsp;Huan Chen,&nbsp;Xinyu Chen,&nbsp;Jing Gao,&nbsp;Wenting Ji","doi":"10.1002/clt2.70022","DOIUrl":"10.1002/clt2.70022","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Asthma is currently one of the most common of respiratory diseases, severely affecting the lives of patients. With the in-depth study of the role of the nervous system and sex hormones on the development of asthma, it has been found that the nervous system and sex hormones are related to each other in the pathway of asthma.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To investigate the effects of sex hormones and the nervous system on the development of asthma.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In this review, we searched for a large number of relevant literature to elucidate the unique mechanisms of sex hormones and the nervous system on asthma development, and summarized several common targets in the pathways of sex hormones and the nervous system on asthma.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>We summarize several common important targets in the pathways of action of sex hormones and the nervous system in asthma, provide new directions and ideas for asthma treatment, and discuss current therapeutic limitations and future possibilities. Finally, the article predicts future applications of several important targets in asthma therapy.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10334,"journal":{"name":"Clinical and Translational Allergy","volume":"15 1","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11725405/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142969876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic rhinosinusitis with nasal polyps: Key considerations in the multidisciplinary team approach","authors":"Oliver Pfaar,&nbsp;Anju T. Peters,&nbsp;Camille Taillé,&nbsp;Thijs Teeling,&nbsp;Jared Silver,&nbsp;Robert Chan,&nbsp;Peter W. Hellings","doi":"10.1002/clt2.70010","DOIUrl":"10.1002/clt2.70010","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Chronic rhinosinusitis with nasal polyps (CRSwNP) is a recurrent inflammatory disease associated with several comorbidities and a significant disease burden for patients. Treatments include corticosteroids and sinonasal surgery, but these can be associated with the risk of adverse events and nasal polyp recurrence. Biologic treatments such as mepolizumab can be used as an add-on treatment and are effective at reducing surgery and corticosteroid use.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Main text</h3>\u0000 \u0000 <p>Patients with CRSwNP may be seen by a specialist in one of several different areas and often experience delayed diagnosis due to the need to see multiple physicians, as well as misdiagnosis resulting from lack of sufficient expertise within any one speciality. Multidisciplinary team (MDT) approaches have been shown to be effective in optimising the treatment and clinical management of other respiratory diseases, such as aspirin-exacerbated respiratory disease and severe asthma. In CRSwNP, an MDT approach may reduce diagnostic delays, mitigate secondary disease burden, and reduce overprescription of corticosteroids and antibiotics.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This article provides an overview of the patient perspective of MDTs, existing approaches and barriers to adoption, lessons learnt from allied and rare diseases, how to address under-recognised aspects of CRSwNP, and other key considerations for developing an MDT approach.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10334,"journal":{"name":"Clinical and Translational Allergy","volume":"15 1","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11723824/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142963242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prednisolone versus antihistamine for allergic rhinitis: No significant difference found in randomized trial","authors":"Carl Skröder,&nbsp;Laila Hellkvist,&nbsp;Ulla Westin,&nbsp;Pernilla Sahlstrand-Johnsson,&nbsp;Kerstin Hansson,&nbsp;Agneta Karlsson,&nbsp;Åslög Dahl,&nbsp;Leif Bjermer,&nbsp;Lars Olaf Cardell","doi":"10.1002/clt2.70017","DOIUrl":"10.1002/clt2.70017","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Seasonal allergic rhinitis (AR) impacts public health by affecting work productivity and quality of life. The Swedish tree pollen season starts in February with alder and hazel pollination, followed by birch and ends with oak in May. Systemic corticosteroids are often prescribed when topical treatments fail, despite limited evidence supporting their efficacy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To compare the effectiveness of prednisolone tablets versus antihistamine tablets in reducing symptoms and medication usage in patients with moderate to severe tree pollen-induced AR.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This interventional single-center, double-blinded randomized trial included 34 patients. Treatment was initiated, and symptoms were registered during the tree pollen season. The two groups received either prednisolone tablets (20 mg) or ebastine tablets (20 mg) for 7 days. Treatment effects were evaluated by comparing daily symptom scores, use of topical medication, and a combined symptom-medical score between the groups. Quality of life was recorded at the start and after 3 weeks.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Both interventions demonstrated efficacy in enhancing quality of life metrics. The area under the curve (AUC) for the combined symptom severity and medication usage score averaged 34.0 (SD = 19.1, 95% CI = 24.5–43.4) in the group treated with prednisolone. This was marginally lower than the control group, with an AUC of 32.6 (SD = 13.2, 95% CI = 25.6–39.7). The difference was not statistically significant (<i>p</i> = 0.80). Both groups exhibited only mild adverse events, which were statistically comparable in frequency and severity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Prednisolone tablets did not show superior efficacy over antihistamine tablets in reducing symptoms or medication usage in tree pollen-induced AR. These results suggest that systemic corticosteroids may not provide additional benefits over antihistamines, and clinicians should prioritize individualized treatment based on patient preferences and tolerability.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10334,"journal":{"name":"Clinical and Translational Allergy","volume":"15 1","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11717555/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142945735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Total immunoglobulin E levels in induced sputum reflect asthma control status","authors":"Wenhui Chen,&nbsp;Xiaofang Liu,&nbsp;Xiujuan Yao,&nbsp;Yanghe Hao,&nbsp;Zhuo Zhou,&nbsp;Chengshuo Wang,&nbsp;Ming Wang,&nbsp;Luo Zhang","doi":"10.1002/clt2.70021","DOIUrl":"10.1002/clt2.70021","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Most patients with severe asthma are sensitized to at least one allergen. Whether local immunoglobulin E (IgE) in induced sputum reflects asthma control status has not been investigated.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Patients with asthma were classified as well controlled, partly controlled, and uncontrolled asthma (UCA) according to Global Initiative for Asthma 2022 guidelines. Lung function and fractional exhaled nitric oxide (FeNO) were evaluated. Induced sputum was collected and total IgE and Phadiatop (IgE to common inhalant allergens) measurements were performed. General clinical characteristics and pulmonary inflammation indicators were analyzed between the three groups of asthmatic patients. Univariate and multifactor ordinal logistic regression were used to model the relationship between pulmonary inflammation indicators and asthma control status. The ability of sputum total IgE in identifying different levels of asthma control was assessed by receiver operating characteristic curve (ROC).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Patients with UCA had worse lung function and airway inflammation as indicated by lower levels of forced expiratory volume in 1s (FEV1)%pred, FEV1/FVC, MEF75%pred, MEF50%pred and MEF25%pred, and higher levels of FeNO and sputum eosinophil% compared with the WCA group. In addition, higher levels of total sputum IgE and Phadiatop were found in patients with UCA than in patients with WCA and PCA. Univariate and multifactor ordinal logistic regression analysis indicated that sputum total IgE was the unique significant risk factor for poor asthma control (adjusted odds ratio = 6.25; 95% CI, 1.07–36.55; <i>p</i> &lt; 0.05) among pulmonary inflammation indicators including different indices of pulmonary function test, sputum IgE and FeNO. Sputum total IgE levels showed a significant correlation with asthma control scores (<i>r</i> = 0.53, <i>p</i> &lt; 0.001). Moreover, ROC analysis showed that the predictive value of sputum total IgE for patients with UCA was 0.82 (95% CI, 0.74–0.9).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Sputum total IgE reflects levels of asthma control, and can be used as an indicator of UCA.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10334,"journal":{"name":"Clinical and Translational Allergy","volume":"15 1","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/clt2.70021","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142930737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The present and future of digital health, digital medicine, and digital therapeutics for allergic diseases","authors":"He Zhang,&nbsp;Yang Cao,&nbsp;Haibo Jiang,&nbsp;Qilin Zhou,&nbsp;Qintai Yang,&nbsp;Lei Cheng","doi":"10.1002/clt2.70020","DOIUrl":"10.1002/clt2.70020","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Digital health, digital medicine, and digital therapeutics integrate advanced computer technologies into healthcare, aiming to improve efficiency and patient outcomes. These technologies offer innovative solutions for the management of allergic diseases, which affect a significant proportion of the global population and are increasing in prevalence.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Body</h3>\u0000 \u0000 <p>This review examines the current progress and future potential of digital health in allergic disease management. It highlights key advancements, including telehealth, mobile health (mHealth), artificial intelligence, clinical decision support systems (CDSS), and digital biomarkers, with a focus on their relevance to allergic disease management. The role of digital tools in improving treatment adherence, enabling remote care, and integrating environmental and patient data into personalized care models is discussed. Challenges such as data privacy, interoperability, and equitable access are addressed, alongside potential strategies to overcome these barriers.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Digital therapy will play an important role in allergic diseases, and the further development of digital therapies will effectively promote the development of clinical research, digital biomarkers, hypoallergenic environments and digital twins. More research is needed to support the progress of digital therapy for allergic diseases.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10334,"journal":{"name":"Clinical and Translational Allergy","volume":"15 1","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/clt2.70020","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142926668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disease control and quality of life in chronic spontaneous urticaria and recurrent angioedema are strongly linked, but not in all patients","authors":"Sophia Neisinger,&nbsp;Pascale Salameh,&nbsp;Annika Gutsche,&nbsp;Felix Aulenbacher,&nbsp;Frank Siebenhaar,&nbsp;Marcus Maurer","doi":"10.1002/clt2.70026","DOIUrl":"10.1002/clt2.70026","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Patient-reported outcome measures (PROMs) help to assess disease control and quality of life (QoL) in chronic spontaneous urticaria (CSU) and recurrent angioedema (RA). This study aimed to assess the correlation between two different concepts: disease control and QoL, using disease-specific PROMs.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We analyzed data from 445 CSU and 330 RA patients who completed both a disease control and QoL PROM as part of the clinical routine. We included the UCT and CU-Q2oL for CSU and AECT and AE-QoL for RA.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In CSU and RA, disease control scores positively correlated with QoL scores (Spearman's rho correlation coefficient (CR) −0.757, −0.735; <i>p</i> &lt; 0.001) with better disease control corresponding to better quality of life. However, 5.9% of CSU patients and 28% of RA patients with complete disease control had impaired QoL. In CSU, QoL was impaired in 69.2% of patients based on the CU-Q2oL and in 62.7% of patients based on a single numeric question from the UCT, with a mismatch in 89/445 patients. In RA, QoL was impaired in 58.5% using the AE-QoL and in 52.7% using a single numeric question from the AECT30mo, with a mismatch in 69/330 patients. Different domains of the QoL PROMs showed different degrees of influence on disease control, with “Itching/Embarrassment” showing the strongest correlation with the UCT (CR −0.804; <i>p</i> &lt; 0.001) and “Functioning” with the AECT3mo (CR −0.824; <i>p</i> &lt; 0.001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Although most patients with controlled disease have better quality of life, unexpectedly, quality of life remains impaired in up to one-fourth of patients with completely controlled CSU and RA. Reasons behind this should be investigated in further studies.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10334,"journal":{"name":"Clinical and Translational Allergy","volume":"15 1","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/clt2.70026","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142926656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}