Clinical and Experimental Otorhinolaryngology最新文献

{"title":"The Efficacy of Dupilumab as an Adjuvant Treatment After Endoscopic Sinus Surgery for Chronic Rhinosinusitis With Nasal Polyps: A Retrospective Cohort Analysis.","authors":"Chin-Nung Liu, Te-Huei Yeh, Chih-Feng Lin, Yi-Tsen Lin","doi":"10.21053/ceo.2024.00310","DOIUrl":"10.21053/ceo.2024.00310","url":null,"abstract":"<p><strong>Objectives: </strong>Chronic rhinosinusitis with nasal polyps (CRSwNP) demonstrates a high recurrence rate following endoscopic sinus surgery (ESS). The role of adjunctive biologic therapy remains incompletely understood. This study aims to assess the efficacy of dupilumab when used in conjunction with ESS for patients with CRSwNP.</p><p><strong>Methods: </strong>We conducted a retrospective cohort study of type 2 CRSwNP patients who underwent ESS. The study compared patients receiving postoperative dupilumab with those receiving standard care. Changes in the Lund-Kennedy endoscopic score (LKES) and nasal polyp score (NPS) were recorded, and linear mixed models (LMMs) were employed for the primary outcome analysis.</p><p><strong>Results: </strong>The study enrolled 49 CRSwNP patients, with 22 patients in the dupilumab group. Postoperative LKES and NPS decreased in both groups. LMM analysis revealed a significant improvement in LKES (B=-0.61; 95% CI, -0.90 to -0.31; P<0.001) and a more pronounced improvement in NPS (B=-0.14; 95% CI, -0.25 to -0.02; P=0.025) in the dupilumab group compared to controls from preoperative to postoperative measurements.</p><p><strong>Conclusion: </strong>Compared to ESS alone, the adjunctive use of dupilumab in the postoperative period was associated with greater reductions in both NPS and endoscopic scores.</p>","PeriodicalId":10318,"journal":{"name":"Clinical and Experimental Otorhinolaryngology","volume":" ","pages":"271-279"},"PeriodicalIF":3.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12400147/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Balloon Eustachian Tuboplasty in Chronic Suppurative Otitis Media and Dilatory Eustachian Tube Dysfunction: A Randomized Controlled Trial.","authors":"Hye Ah Joo, Sung-Min Park, Yehree Kim, Dong Kyu Lee, Yun Ji Lee, Yeonjoo Choi, Woo Seok Kang, Joong Ho Ahn, Jong Woo Chung, Won-Ho Chung, Ja-Won Koo, Hong Ju Park","doi":"10.21053/ceo.2024.00281","DOIUrl":"10.21053/ceo.2024.00281","url":null,"abstract":"<p><strong>Objectives: </strong>Balloon eustachian tuboplasty (BET) is an emerging treatment for dilatory eustachian tube (ET) dysfunction, yet its efficacy in patients with chronic suppurative otitis media (COM) combined with ET dysfunction remains unclear. This trial aimed to evaluate the efficacy and safety of BET versus medical management (MM) alone in adult patients with COM and chronic dilatory ET dysfunction, as defined by a failed Valsalva maneuver.</p><p><strong>Methods: </strong>This prospective, multicenter, randomized controlled trial enrolled 116 participants (121 ears) between January 2021 and June 2023. Participants were randomly assigned (1:1) to receive either BET combined with MM or MM alone (fluticasone furoate nasal steroid spray). The primary short-term outcome was the normalization of the Valsalva maneuver at 8 weeks, while secondary outcomes included improvements in Eustachian Tube Dysfunction Questionnaire-7 (ETDQ-7) scores and reductions in the air-bone gap (ABG) measured at 8 weeks. Adverse events were monitored in both groups throughout the follow-up period.</p><p><strong>Results: </strong>Of the 116 participants (121 ears), 60 participants (62 ears) received BET and 56 participants (59 ears) received MM alone. There were no significant differences in demographics, baseline characteristics, ETDQ-7 scores, bone conduction thresholds, or ABG between the groups. In the BET group, 46.8% of ears (29/62) achieved a successful Valsalva maneuver compared with 15.3% of ears (9/59) in the MM-only group (P<0.001). The BET group exhibited greater subjective symptom improvement, with an average ETDQ-7 score reduction of -6.2±9.4 compared to -2.6±8.6 in the MM-only group (P=0.028). Additionally, the ABG decreased more significantly in the BET group (-5.8±11.4 dB HL) than in the MM-only group (-1.2±10.5 dB HL) (P=0.023). No serious procedure- or device-related adverse events were observed during the 8-week follow-up.</p><p><strong>Conclusion: </strong>This trial demonstrates that BET combined with MM is superior to MM alone in treating dilatory ET dysfunction in patients with COM, while also maintaining a favorable safety profile.</p>","PeriodicalId":10318,"journal":{"name":"Clinical and Experimental Otorhinolaryngology","volume":" ","pages":"234-241"},"PeriodicalIF":3.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12400141/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143122474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosis of Anosmia in Middle Age, But Not in Older Adulthood, Increases Alzheimer Dementia Risk.","authors":"Jin Kook Kim, Jae Hoon Cho","doi":"10.21053/ceo.2024.00345","DOIUrl":"10.21053/ceo.2024.00345","url":null,"abstract":"<p><strong>Objectives: </strong>Many studies have reported that patients with anosmia exhibit an increased incidence of dementia later in life. However, most of these studies have focused exclusively on individuals aged 65 or older, leaving a gap in research on middle-aged subjects (40-65 years).</p><p><strong>Methods: </strong>We conducted a retrospective cohort study using Korea's National Health Insurance claims data. The study targeted participants aged 40 years and above by randomly selecting 40% of individuals who underwent the 2009 national health check-up. The cohort was divided into two groups: the anosmia group (n=8,023), comprising individuals diagnosed with anosmia between 2006 and 2008, and the control group (n=2,680,534), consisting of the remaining participants. Subsequently, we followed the participants to monitor the occurrence of Alzheimer and vascular dementia from 2011 to 2020.</p><p><strong>Results: </strong>After adjusting for various factors, the incidence of Alzheimer dementia was significantly higher in the anosmia group compared to the control group (hazard ratio [HR], 1.15; 95% CI, 1.04-1.28). Stratification by age revealed that the risk of developing dementia was significantly elevated in anosmia patients under 65 years (HR, 1.28; 95% CI, 1.07-1.54), whereas no significant increase was observed in those over 65 years (HR, 1.10; 95% CI, 0.97-1.24). Vascular dementia was not statistically associated with anosmia.</p><p><strong>Conclusion: </strong>A diagnosis of anosmia in middle age increases the risk of developing Alzheimer dementia, while no such increase is observed in older individuals.</p>","PeriodicalId":10318,"journal":{"name":"Clinical and Experimental Otorhinolaryngology","volume":" ","pages":"264-270"},"PeriodicalIF":3.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12400145/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strategies to Develop Regenerative Medicine Approaches for Olfactory Disorders.","authors":"Do Hyun Kim, Michael Wang, Sarah Kim, David W Jang, Tiffany Ko, Bradley J Goldstein","doi":"10.21053/ceo.2025-00065","DOIUrl":"10.21053/ceo.2025-00065","url":null,"abstract":"<p><p>Olfactory loss affects more than 12% of the population, with prevalence increasing in aging individuals. Multiple conditions can lead to a loss of smell (hyposmia or anosmia), including post-viral damage from coronavirus disease 2019 (COVID-19) or influenza, head injuries, sinusitis, or neurodegenerative conditions such as Alzheimer or Parkinson disease. Although treatments like surgery, anti-inflammatory medications, or olfactory training can be beneficial in certain cases, there remains an unmet need for effective therapies addressing many common causes of olfactory dysfunction. This is particularly true for cases attributed to damage of olfactory neurons that fail to spontaneously recover. Regenerative medicine approaches, aimed at either stimulating the regrowth of sensory neural structures or replacing them through cell-based therapies, have attracted considerable interest for treating various neurological disorders, including olfactory loss. Here, we summarize the intrinsic regenerative capabilities of the peripheral olfactory system, focusing on current research strategies and the existing barriers that must be overcome for successful translational applications. A major unmet need in this field involves the establishment of reliable and widely accepted culture models for expanding and differentiating olfactory stem or progenitor cells from rodents and humans, both for use in vitro assays and as potential material for cell-based therapies.</p>","PeriodicalId":10318,"journal":{"name":"Clinical and Experimental Otorhinolaryngology","volume":" ","pages":"204-209"},"PeriodicalIF":3.4,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12404284/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143980780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cost-Effectiveness of Hearing Aids in South Korea: A Multistate Markov Model Analysis.","authors":"Heonjeong Oh, Chul Young Yoon, Junhun Lee, Young Joon Seo, Wankyo Chung, Moo Kyun Park","doi":"10.21053/ceo.2024.00255","DOIUrl":"10.21053/ceo.2024.00255","url":null,"abstract":"<p><strong>Objectives: </strong>This study evaluated the cost-effectiveness of using hearing aids among individuals aged 50 and older with varying levels of hearing loss in South Korea.</p><p><strong>Methods: </strong>A state-transition Markov model was employed to assess the cost-effectiveness of hearing aid utilization from a societal perspective. We simulated a cohort of patients aged 50, tracking their progression through normal, mild, moderate, and severe stages of hearing loss until death or age 80. The incremental cost-effectiveness ratio (ICER) per quality-adjusted life year gained was determined using both published and calculated data on the costs and effectiveness of hearing aids.</p><p><strong>Results: </strong>The respective ICERs were $8,571 for men and $10,635 for women. These figures are significantly below the willingness-to-pay (WTP) threshold of $31,721, which corresponds to the per capita gross domestic product (GDP) in 2020. The probabilities of cost-effectiveness were 83.6% for men and 73.4% for women at this WTP threshold. The lower ICERs observed in men can likely be attributed to the earlier onset of hearing loss and the rapid progression from normal, mild, moderate, and severe stages of hearing loss to death.</p><p><strong>Conclusion: </strong>Hearing aids represent a highly cost-effective intervention for adults aged 50 and older in Korea, regardless of the degree of hearing loss, even in mild cases. In light of the rapidly aging population, it would be prudent for government policymakers to consider the cost-effectiveness of hearing aids in their decision-making processes.</p>","PeriodicalId":10318,"journal":{"name":"Clinical and Experimental Otorhinolaryngology","volume":" ","pages":"143-151"},"PeriodicalIF":2.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12146607/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EFNA2 Mediates Stiffness-Regulated Hypopharyngeal Cancer Progression.","authors":"Songqun Hu, Yuanru Liu, Min Cheng, Min Xu, Huiting Liu, Ying Shan, Haosheng Ni, Tian Xia, Qicheng Zhang, Zhenxin Zhang, Bo You","doi":"10.21053/ceo.2024.00315","DOIUrl":"10.21053/ceo.2024.00315","url":null,"abstract":"<p><strong>Objectives: </strong>Hypopharyngeal cancer (HPC), originating from the hypopharyngeal mucosa, is associated with a poor prognosis. Extracellular matrix (ECM) stiffness is closely linked to tumor progression and patient outcomes. This study aimed to investigate the effects of matrix stiffness and to identify molecular markers relevant to HPC prognosis, with the goal of improving clinical outcomes.</p><p><strong>Methods: </strong>Immunohistochemical analysis and cervical enhanced computed tomography (CT) data were used to evaluate correlations among CT values, matrix stiffness, and prognosis, and to develop a prognostic model for HPC. Cell culture models with varying matrix stiffness were established using polypropylene hydrogel. Western blotting, colony formation, EDU incorporation, and Transwell assays were employed to assess the effects of matrix stiffness on proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT). High-throughput sequencing identified differentially expressed genes in HPC cells cultured on matrices of differing stiffness. Gene editing, in vivo subcutaneous tumorigenesis studies, and Western blotting were performed to elucidate the molecular mechanisms by which high matrix stiffness influences HPC progression and the role of ephrin A2 (EFNA2) in proliferation, migration, and EMT.</p><p><strong>Results: </strong>Arterial phase CT values were positively correlated with matrix stiffness. Increased matrix stiffness was associated with lymph node metastasis, diminished therapeutic response, and poorer prognosis. Furthermore, metastatic lymph nodes in HPC patients exhibited higher CT values than those in patients with nasopharyngeal carcinoma. A high-stiffness ECM promoted proliferation, migration, and EMT in HPC cells. Mechanistically, a stiff ECM enhanced EFNA2 expression, thereby promoting proliferation, migration, EMT, and tumor growth in vivo.</p><p><strong>Conclusion: </strong>EFNA2 and elevated matrix stiffness jointly contribute to the malignant phenotype in HPC. EFNA2 may represent a potential therapeutic target for managing HPC progression induced by high matrix stiffness.</p>","PeriodicalId":10318,"journal":{"name":"Clinical and Experimental Otorhinolaryngology","volume":" ","pages":"188-199"},"PeriodicalIF":2.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12146608/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Septal Swell Body Reduction for Patients With Nasal Airway Obstruction: A Systematic Review and Meta-Analysis.","authors":"Ji-Sun Kim, Gulnaz Stybayeva, Se Hwan Hwang","doi":"10.21053/ceo.2024.00341","DOIUrl":"10.21053/ceo.2024.00341","url":null,"abstract":"<p><strong>Objectives: </strong>The septal swell body, a distinct anatomical structure in the anterior nasal septum, is a significant contributor to nasal obstruction and affects airflow dynamics and nasal resistance. This meta-analysis evaluated the impact of septal swell body volume reduction (SSBVR).</p><p><strong>Methods: </strong>A systematic review was conducted using PubMed, Scopus, Embase, Web of Science, and Cochrane databases through October 2024. Outcomes included changes in nasal obstruction scores, cross-sectional area, and nasal airway resistance before and after SSBVR. Standardized mean differences (SMDs) were calculated, and the effectiveness of SSBVR combined with turbinate surgery was compared to turbinate surgery alone.</p><p><strong>Results: </strong>Seven studies involving 232 patients were analyzed. SSBVR significantly improved cross-sectional area (SMD, -1.05; 95% CI, -1.88 to -0.21) and nasal airway resistance (SMD, -0.67; 95% CI, -0.89 to -0.45). Nasal obstruction scores showed significant improvements up to 12 months (SMD, 2.54; 95% CI, 1.81 to 3.26). When SSBVR was added to turbinate surgery, nasal obstruction scores improved further (SMD, 0.47; 95% CI, 0.24 to 0.70) compared to turbinate surgery alone, though no significant differences were found in cross-sectional area or nasal airway resistance. Subgroup analyses demonstrated time-dependent improvements in nasal obstruction scores and varied effectiveness based on treatment modality.</p><p><strong>Conclusion: </strong>SSBVR significantly improves nasal obstruction and airflow metrics, with additional benefits when combined with turbinate surgery. Further randomized trials are warranted to validate these findings and guide optimal treatment strategies.</p>","PeriodicalId":10318,"journal":{"name":"Clinical and Experimental Otorhinolaryngology","volume":" ","pages":"171-179"},"PeriodicalIF":2.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12146611/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142982909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk Factors Associated With the Occurrence and Recurrence of Benign Paroxysmal Positional Vertigo in Koreans: A Nested Case-Control Study.","authors":"Jae Sang Han, Yun-Hee Lee, Ji Hyung Lim, Dong-Hee Lee, Sang Hyun Kwak, Jae-Hyun Seo","doi":"10.21053/ceo.2024.00207","DOIUrl":"10.21053/ceo.2024.00207","url":null,"abstract":"<p><strong>Objectives: </strong>Benign paroxysmal positional vertigo (BPPV) is the most prevalent cause of vertigo. This study aims to analyze the risk factors associated with the occurrence and recurrence of BPPV.</p><p><strong>Methods: </strong>A database maintained by the Korean National Health Insurance Service was used to analyze 434,552 patients diagnosed with BPPV from 2011 to 2017. The propensity score matching technique was employed to pair each participant with a control patient who did not have BPPV, ensuring equivalence in age, sex, residential status, and socioeconomic status. BPPV recurrence was defined as a new episode occurring more than 90 days after the initial treatment. Logistic regression analysis was conducted to examine the incidence of BPPV, while Cox proportional hazards models were used to investigate the risk factors associated with its recurrence.</p><p><strong>Results: </strong>BPPV was found to be 2.2 times more prevalent in women, particularly peaking between the ages of 50 and 59. The 5-year recurrence rate for BPPV stood at 39.8%, with a significant number of cases reoccurring within the first year. The incidence of BPPV was statistically significantly linked to several underlying medical conditions, including vitamin D deficiency, thyroid hormone abnormalities, head trauma, and inner ear disorders. Notable risk factors for BPPV recurrence included advanced age, female sex, rural residence, low socioeconomic status, and the presence of inner ear diseases.</p><p><strong>Conclusion: </strong>Our study provides significant insights into the risk factors linked to both the occurrence and recurrence of BPPV. Notably, there appears to be a connection with vitamin D levels, thyroid hormones, and estrogen. Additionally, conditions such as inner-ear disorders, head trauma, and otologic surgery were found to be strongly associated with both the initial onset and subsequent recurrence of BPPV.</p>","PeriodicalId":10318,"journal":{"name":"Clinical and Experimental Otorhinolaryngology","volume":" ","pages":"123-133"},"PeriodicalIF":2.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12146605/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142834184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vestibular Aqueduct and Temporal Bone Radioanatomy in Patients With and Without Meniere Disease: A Retrospective Cross-Sectional Analysis With Implications for Endolymphatic Sac Surgery.","authors":"Jeanne Bernard, Dario Ebode, Priya Vishnumurthy, Antonino Maniaci, Maria-Pia Tuset, Mario Lentini, Ralph Haddad, Giannicola Iannella, Mary Daval, Justin Michel, Stéphane Gargula","doi":"10.21053/ceo.2024.00334","DOIUrl":"10.21053/ceo.2024.00334","url":null,"abstract":"<p><strong>Objectives: </strong>The vestibular aqueduct (VA) exhibits significant anatomical variability. These variations and their spatial relationships with neighboring structures may pose technical challenges during endolymphatic sac surgery. We aimed to characterize the anatomical features of the VA and its relationship with surrounding structures in patients with severe Meniere disease compared to controls using high-resolution computed tomography (CT).</p><p><strong>Methods: </strong>This retrospective study included 65 patients (126 ears) who underwent temporal bone CT. The Meniere group comprised 26 patients (26 affected ears) meeting the American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS) criteria for intractable disease; the contralateral ear group included 24 ears, and the control group comprised 39 patients (76 ears) with unrelated conditions. Measurements included VA thickness (A), width (B/B´), the distance between the posterior semicircular canal (PSCC) and posterior fossa (C), PSCC depth (D/D´), and operculum depth (E/E´). Correlations were analyzed, and k-means clustering was applied to classify anatomical variations. Reliability was assessed using intra- and inter-observer tests.</p><p><strong>Results: </strong>VA width (B) correlated positively with the PSCC-meningeal distance (C) (r=0.683, P<0.001) and negatively with PSCC depth (D´) (r=-0.290, P<0.01) and operculum depth (E´) (r=-0.520, P<0.001). Patients with a narrower VA exhibited a reduced PSCC-meningeal distance and a deeper operculum position. The Meniere group demonstrated significantly narrower VA and shorter PSCC-dura distances compared to controls (P<0.001). Cluster analysis identified three anatomical patterns, with 61.5% of intractable Meniere ears versus 14.5% of controls and 41.6% of contralateral ears falling into the cluster characterized by smaller VA dimensions, shorter PSCC-dura distances, and deeper operculum positions.</p><p><strong>Conclusion: </strong>A narrow VA correlates with a reduced PSCC-meningeal distance and a deeper operculum position, potentially complicating endolymphatic sac surgery. These anatomical variations are more prevalent in patients with severe Meniere disease, highlighting the need for tailored surgical approaches.</p>","PeriodicalId":10318,"journal":{"name":"Clinical and Experimental Otorhinolaryngology","volume":" ","pages":"162-170"},"PeriodicalIF":2.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12146606/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Systematic Classification of Surgical Approaches for the Sphenoid Sinus: Establishing a Standardized Nomenclature for Endoscopic Sphenoid Sinus Surgery.","authors":"Marn Joon Park, Jakob L Fischer, Vijay R Ramakrishnan, Kevin C Welch, Dong-Young Kim, Tae-Bin Won, Jae Hoon Cho, Sue Jean Mun, Jivianne T Lee, Daniel M Beswick, Marilene B Wang, Jeffrey D Suh","doi":"10.21053/ceo.2025.00069","DOIUrl":"10.21053/ceo.2025.00069","url":null,"abstract":"<p><p>The sphenoid sinus presents significant challenges during endoscopic sinus surgery. It is essential that surgeons employ strategies that effectively address sphenoid pathology while minimizing surgical risks and optimizing outcomes. Although nomenclature for maxillary and frontal sinus surgery is well established, there is currently no standardized nomenclature for sphenoid sinus surgery. We present a comprehensive review of techniques for accessing the sphenoid sinus and propose a common surgical classification system to better define and categorize these approaches. Each technique is classified based on surgical extent, anticipated operation time, complexity, potential complications, and expected wound healing, aligning with established standards in the literature. The proposed sphenoidotomy types are as follows: type I, sphenoid ostial dilation; type IIa, transnasal sphenoidotomy (sphenoidotomy without ethmoidectomy); type IIb, transethmoidal sphenoidotomy (sphenoidotomy with ethmoidectomy); type III, bilateral, common cavity sphenoidotomy, or \"sphenoid drill-out;\" type IV, transpterygoid approach, to expose the lateral sphenoid sinus recess; and type V, sphenoid nasalization, completely removing the sphenoid sinus floor. By standardizing the nomenclature for these techniques, we aim to enhance consistency in terminology for teaching, surgical planning, clinical research, and interdisciplinary communication in sphenoid sinus surgery.</p>","PeriodicalId":10318,"journal":{"name":"Clinical and Experimental Otorhinolaryngology","volume":" ","pages":"109-122"},"PeriodicalIF":2.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12146609/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}