ChronoPhysiology and Therapy最新文献_第4页

The influence of sex and gonadal hormones on sleep disorders 性激素和性激素对睡眠障碍的影响

ChronoPhysiology and Therapy Pub Date : 2014-06-26 DOI: 10.2147/CPT.S44667

B. Parry, H. Orff, C. Meliska, F. Martinez

{"title":"The influence of sex and gonadal hormones on sleep disorders","authors":"B. Parry, H. Orff, C. Meliska, F. Martinez","doi":"10.2147/CPT.S44667","DOIUrl":"https://doi.org/10.2147/CPT.S44667","url":null,"abstract":"Sleep disorders such as insomnia, sleep-related breathing disorders, circadian rhythm disorders, and sleep-related movement disorders are a significant public health issue, affecting approximately 40 million people in the US each year. Sleep disturbances are observed in both men and women, though prevalence rates often differ between the sexes. In general, research suggests that women more frequently report subjective complaints of insomnia, yet show better sleep than men when evaluated on objective measures of sleep. Men are more likely to be diagnosed with obstructive sleep apnea than women, though rates of obstructive sleep apnea increase after menopause and may be generally underdiagnosed in women. Although circadian rhythm disorders are equally prevalent in men and women, studies find that women typically have earlier bedtimes and exhibit altered temperature and melatonin rhythms relative to men. Lastly, movement disorders appear to be more prevalent in women than men, presumably due to higher rates of anemia and increased risks associated with pregnancy in women. Although gonadal hormones would be expected to play a significant role in the development and/or exacerbation of sleep disturbances, no causal link between these factors has been clearly established. In large part, the impact of hormones on sleep disturbances is significantly confounded by factors such as psychiatric, physical, and lifestyle concerns, which may play an equal or greater role in the development and/or exacerbation of sleep disturbances than do hormonal factors. Current standard of care for persons with sleep disorders includes use of psychological, pharmacologic, and/or medical device supported interventions. Hormonal-based treatments are not typically recommended given the potential for long-term adverse health effects. In sum, there is a sub- stantial need for more comprehensive studies focused on elucidating the impact of hormones on sleep. Such studies should reveal sex-specific differences in sleep, which could lead to enhanced interventions for sex-specific sleep disturbances.","PeriodicalId":10315,"journal":{"name":"ChronoPhysiology and Therapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83748816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

The potential of light therapy in Parkinson's disease 光疗法治疗帕金森病的潜力

ChronoPhysiology and Therapy Pub Date : 2014-02-18 DOI: 10.2147/CPT.S57180

Daniel M. Johnstone, Kristina A. Coleman, C. Moro, N. Torres, J. Eells, G. Baker, K. Ashkan, J. Stone, A. Benabid, J. Mitrofanis

引用次数: 20

Hyperventilation and circadian rhythm of the electrical stability of rat myocardium 换气过度与大鼠心肌电稳定性的昼夜节律

ChronoPhysiology and Therapy Pub Date : 2013-08-30 DOI: 10.2147/CPT.S45307

P. Švorc, A. Marossy

引用次数: 0

Comparison of effects of bright light therapy alone or combined with fluoxetine on severity of depression, circadian rhythms, mood disturbance, and sleep quality, in patients with non-seasonal depression 比较单独或联合氟西汀对非季节性抑郁症患者抑郁严重程度、昼夜节律、情绪障碍和睡眠质量的影响

ChronoPhysiology and Therapy Pub Date : 2013-06-20 DOI: 10.2147/CPT.S46140

M. Ağargün, G. Sayar, Hüseyin Bulut, O. Tan

{"title":"Comparison of effects of bright light therapy alone or combined with fluoxetine on severity of depression, circadian rhythms, mood disturbance, and sleep quality, in patients with non-seasonal depression","authors":"M. Ağargün, G. Sayar, Hüseyin Bulut, O. Tan","doi":"10.2147/CPT.S46140","DOIUrl":"https://doi.org/10.2147/CPT.S46140","url":null,"abstract":"Correspondence: Gokben Hizli Sayar Department of Psychiatry, Uskudar University, Neuropsychiatry Istanbul Hospital, Alemdag Caddesi Site Yolu No 29 Umraniye, Istanbul, Turkey Tel +90 216 633 0649 Fax +90 216 634 1250 Email gokben.hizlisayar@uskudar.edu.tr Purpose: To compare effects of bright light therapy (BLT) alone or combined with the selective serotonin reuptake inhibitor (SSRI) fluoxetine, on severity of depression, circadian rhythms, mood disturbance, and sleep quality, in patients with non-seasonal depression. Patients and methods: Drug-free patients who were administered 10,000 lux of BLT for 30 minutes for 7 days comprised the BLT group (n = 7), while patients who started fluoxetine as an add-on treatment day comprised the SSRI + BLT group (n = 8). The primary outcomes were severity of depression, measured using the Hamilton Depression Rating Scale (HAM-D) and the Beck Depression Inventory (BDI); chronotype, measured using the Morningness Eveningness Questionnaire (MEQ); mood disturbance, measured using the Profile of Mood States (POMS) survey; and sleep quality, measured using the Pittsburgh Sleep Quality Index (PSQI), before and after treatment in both groups. Results: All patients completed the study, and none reported obvious side effects. The mean onset age of depression was 26.1 years ± 5.3 years in the BLT group and 27 years ± 9.5 years in the SSRI + BLT group (P = 0.425). The number of past depressive episodes was 1.29 ± 0.76 in the BLT group, and 1.5 ± 0.8 in the SSRI + BLT group (P = 0.427). The difference between preand posttreatment scores revealed no significant difference between groups for the HAM-D scale, BDI, MEQ, POMS survey, and the PSQI. Conclusion: This study suggests that BLT is effective with respect to the severity of depression, circadian rhythms, mood disturbance, and sleep quality, in non-seasonal depression. However, there was no evidence in favor of adjunctive fluoxetine with BLT in the treatment of non-seasonal depression, for any of the rating scales used in our study.","PeriodicalId":10315,"journal":{"name":"ChronoPhysiology and Therapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75995291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

The 5-HTP sip tryp: a timely word to the wise 5-羟色胺试验:对智者的及时忠告

ChronoPhysiology and Therapy Pub Date : 2013-05-27 DOI: 10.2147/CPT.S45291

P. Basu, M. Singaravel

引用次数: 0

Variations in circadian heart rate in psychiatric disorders: theoretical and practical implications 精神疾病中昼夜节律心率的变化:理论和实践意义

ChronoPhysiology and Therapy Pub Date : 2013-04-18 DOI: 10.2147/CPT.S43623

H. Stampfer, S. Dimmitt

{"title":"Variations in circadian heart rate in psychiatric disorders: theoretical and practical implications","authors":"H. Stampfer, S. Dimmitt","doi":"10.2147/CPT.S43623","DOIUrl":"https://doi.org/10.2147/CPT.S43623","url":null,"abstract":"Correspondence: Hans G Stampfer School of Psychiatry and Clinical Neurosciences, University of Western Australia, 35 Stirling Highway, Crawley, WA 6009, Australia Tel +618 9346 2140 Email hans.stampfer@uwa.edu.au: Background: Data are presented to demonstrate dimensions of variation in circadian heart rate in patients under treatment for a psychiatric disorder and to comment on their clinical relevance. Method: Serial recordings of 24-hour heart rates were obtained from individuals under treatment for a psychiatric disorder and from healthy volunteers. Results: The mean 24-hour heart rate can vary independently of the circadian rate pattern or “rate architecture.” Sleep and waking heart rate can vary independently. Variations in circadian heart rate are state-dependent: broadly different clinical states are associated with distinctly different patterns of circadian heart rate, particularly during sleep. Conclusion: Different regulatory mechanisms or pathways are involved in mediating different aspects of circadian heart rate. An analysis of circadian heart rate can contribute useful physiological adjunct information to psychiatric assessment and the monitoring of patient response to treatment.","PeriodicalId":10315,"journal":{"name":"ChronoPhysiology and Therapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86300686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Evolution and rupture of vulnerable plaques: a review of mechanical effects 易损斑块的演化和破裂:力学效应的综述

ChronoPhysiology and Therapy Pub Date : 2013-04-11 DOI: 10.2147/CPT.S32050

P. Assemat, K. Hourigan

{"title":"Evolution and rupture of vulnerable plaques: a review of mechanical effects","authors":"P. Assemat, K. Hourigan","doi":"10.2147/CPT.S32050","DOIUrl":"https://doi.org/10.2147/CPT.S32050","url":null,"abstract":"Atherosclerosis occurs as a result of the buildup and infiltration of lipid streaks in artery walls, leading to plaques. Understanding the development of atherosclerosis and plaque vulnerability is of critical importance, since plaque rupture can result in heart attack or stroke. Plaques can be divided into two distinct types: those that rupture (vulnerable) and those that are less likely to rupture (stable). In the last few decades, researchers have been interested in studying the influence of the mechanical effects (blood shear stress, pressure forces, and structural stress) on the plaque formation and rupture processes. In the literature, physiological experimental studies are limited by the complexity of in vivo experiments to study such effects, whereas the numerical approach often uses simplified models compared with realistic conditions, so that no general agreement of the mechanisms responsible for plaque formation has yet been reached. In addition, in a large number of cases, the presence of plaques in arteries is asymptomatic. The prediction of plaque rupture remains a complex question to elucidate, not only because of the interaction of numerous phenomena involved in this process (biological, chemical, and mechanical) but also because of the large time scale on which plaques develop. The purpose of the present article is to review the current mechanical models used to describe the blood flow in arteries in the presence of plaques, as well as reviewing the literature treating the influence of mechanical effects on plaque formation, development, and rupture. Finally, some directions","PeriodicalId":10315,"journal":{"name":"ChronoPhysiology and Therapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90617281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Melatonin and its use in atherosclerosis and dyslipidemia 褪黑素及其在动脉粥样硬化和血脂异常中的应用

ChronoPhysiology and Therapy Pub Date : 2013-03-16 DOI: 10.2147/CPT.S40209

K. Danilenko, Y. Ragino

{"title":"Melatonin and its use in atherosclerosis and dyslipidemia","authors":"K. Danilenko, Y. Ragino","doi":"10.2147/CPT.S40209","DOIUrl":"https://doi.org/10.2147/CPT.S40209","url":null,"abstract":"Correspondence: Konstantin V Danilenko Institute of Internal Medicine SB RAMS, Bogatkova 175/1, Novosibirsk 630089, Russia Tel +738 3264 2516 Fax +738 3264 2516 Email kvdani@mail.ru Abstract: A review of pineal melatonin synthesis, regulation, and physiological effects indicates that not only does melatonin act as a hormonal signal of darkness, but also that it possesses antioxidant and anti-inflammatory properties. Although oxidation and inflammation play a pivotal role in atherogenesis, no studies have investigated administration of melatonin for human arterial atherosclerosis. However, 13 clinical trials have investigated use of melatonin in dyslipidemia, which is a close correlate of atherosclerosis. The results of these clinical trials, particularly the five that are placebo-controlled, are inconclusive as to whether melatonin can normalize the blood lipid profile. Significant confounders in these studies might be a phase shift of the cholesterol rhythm by melatonin, a posture effect at venipuncture, uncontrolled diet during the course of melatonin intake, and the phenomenon of regression to the mean. Thus, future studies are required, which should also consider use of higher doses of melatonin and/or measurement of oxidized forms of cholesterol-containing particles (which are the most aggressive in relation to atherogenesis) in addition to lipidic fractions.","PeriodicalId":10315,"journal":{"name":"ChronoPhysiology and Therapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74295076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Treatment of attention deficit hyperactivity disorder insomnia with blue wavelength light-blocking glasses 蓝色波长遮光眼镜治疗注意缺陷多动障碍失眠

ChronoPhysiology and Therapy Pub Date : 2013-01-07 DOI: 10.2147/CPT.S37985

R. E. Fargason, Taylor Preston, Emily Hammond, R. May, K. Gamble

{"title":"Treatment of attention deficit hyperactivity disorder insomnia with blue wavelength light-blocking glasses","authors":"R. E. Fargason, Taylor Preston, Emily Hammond, R. May, K. Gamble","doi":"10.2147/CPT.S37985","DOIUrl":"https://doi.org/10.2147/CPT.S37985","url":null,"abstract":"Correspondence: Rachel Fargason 3rd Floor Callahan Eye Foundation Hospital, 1720 University Boulevard, Birmingham, AL 35294, USA Tel +1 205 934 4301 Fax +1 205 975 9600 Email Rfargason@uab.edu Background: The aim of this study was to examine a nonmedical treatment alternative to medication in attention deficit hyperactivity disorder (ADHD) insomnia, in which blue wavelength light-blocking glasses are worn during the evening hours to counteract the phase-delaying effect of light. Outcome measures included sleep quality and midsleep time. The capacity of ADHD subjects to comply with treatment using the glasses was assessed. Methods: Daily bedtime, wake-up time, and compliance diaries were used to assess sleep quality and timing during a baseline observation week and a 2-week intervention period. The Pittsburgh Sleep Quality Index (PSQI) was administered following baseline and intervention. The intervention protocol consisted of use of blue wavelength-blocking glasses and a moderate lighting environment during evening hours. Results: Partial and variable compliance were noted, with only 14 of 22 subjects completing the study due to nonadherence with wearing the glasses and diary completion. Despite the minimum 3-hour recommendation, glasses were worn, on average, for 2.4 hours daily. Lighting was reduced for only 58.7% of the evening. Compared with baseline, the intervention resulted in significant improvement in global PSQI scores, PSQI subcomponent scores, and sleep diary measures of morning refreshment after sleep (P = 0.037) and night-time awakenings (P = 0.015). Global PSQI scores fell from 11.15 to 4.54, dropping below the cut-off score of 5 for clinical insomnia. The more phase-delayed subjects, ie, those with an initial midsleep time after 4:15 am, trended towards an earlier midsleep time by 43.2 minutes following the intervention (P = 0.073). Participants reported less anxiety following the intervention (P = 0.048). Conclusions: Despite only partial compliance with intervention instructions, subjects completing the study showed subjectively reduced anxiety and improved sleep quality on multiple measures. The more sleep-delayed subjects trended toward an earlier sleep period following use of the glasses. Blue-blocking glasses are a potential insomnia treatment for more compliant subjects with ADHD insomnia, especially those with prominent sleep delay. Larger studies of blue light-blocking glasses in more phase-delayed groups could reveal significant advances in chronotherapeutics.","PeriodicalId":10315,"journal":{"name":"ChronoPhysiology and Therapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88279607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Circadian rhythms in cognitive performance: implications for neuropsychological assessment 认知表现中的昼夜节律:对神经心理学评估的影响

ChronoPhysiology and Therapy Pub Date : 2012-12-17 DOI: 10.2147/CPT.S32586

P. Valdez, C. Ramírez, Aída García

引用次数: 77