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Time of day has no effect on maximal aerobic and peak power 一天中的时间对最大有氧和峰值功率没有影响

ChronoPhysiology and Therapy Pub Date : 2011-08-10 DOI: 10.2147/CPT.S20345

N. Bessot, S. Moussay, B. Dufour, D. Davenne, B. Sesboüé, A. Gauthier

{"title":"Time of day has no effect on maximal aerobic and peak power","authors":"N. Bessot, S. Moussay, B. Dufour, D. Davenne, B. Sesboüé, A. Gauthier","doi":"10.2147/CPT.S20345","DOIUrl":"https://doi.org/10.2147/CPT.S20345","url":null,"abstract":"Correspondence: nicolas Bessot service de Physiologie, ChU Caen, Université de Caen Basse-normandie, Av Côte de nacre, 14033 Caen Cedex, France Tel +332 3106 8130 Fax +332 3106 8132 email bessot-n@phycog.org Background: The aim of this study was to explore the effect of time of day on peak power reached during an exercise test and maximal aerobic power achieved when the subject reached maximal oxygen uptake. Methods: Fifteen male competitive endurance cyclists performed a standardized maximal incremental exercise test at 06:00 hours and 18:00 hours. The test began with a 5-minute warmup period at a workload of 150 W. The work rate was then increased by incremental steps of 30 W per minute until the respiratory exchange ratio reached 1.00. Thereafter, workload was increased in steps of 15 W per minute until exhaustion was reached. Results: No significant diurnal variation was detected in physiological parameters (maximal oxygen uptake and maximal heart rate) or biomechanical parameters (maximal aerobic power, peak power). Conclusion: Circadian variations classically reported in competitive aerobic performances could be due to fluctuations in maximal aerobic endurance and/or improvement in gestural efficiency (pattern of muscle activity, effective force production, and kinematics).","PeriodicalId":10315,"journal":{"name":"ChronoPhysiology and Therapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2011-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73711191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Chronomodulated press-coated pulsatile therapeutic system for aceclofenac: optimization of factors influencing drug release and lag time 乙酰氯芬酸定时压包脉冲治疗系统:影响药物释放和延迟时间的因素优化

ChronoPhysiology and Therapy Pub Date : 2011-02-21 DOI: 10.2147/CPT.S16504

Sumit T. Patil, S. Pund, A. Joshi, C. Shishoo, Aliasgar F. Shahiwala

{"title":"Chronomodulated press-coated pulsatile therapeutic system for aceclofenac: optimization of factors influencing drug release and lag time","authors":"Sumit T. Patil, S. Pund, A. Joshi, C. Shishoo, Aliasgar F. Shahiwala","doi":"10.2147/CPT.S16504","DOIUrl":"https://doi.org/10.2147/CPT.S16504","url":null,"abstract":"DOI: 10.2147/CPT.S16504 Background: The objective of this study was to develop and evaluate a press-coated pulsatile drug delivery system intended for treatment of early morning stiffness and symptomatic relief from pain in patients with rheumatoid arthritis. Methods: The formulation involved press coating of a rupturable coat around a rapidly d isintegrating core tablet of aceclofenac. A three-factor, two-level, full factorial design was used to i nvestigate the influence of amount of glyceryl behenate, amount of sodium chloride in the coating c omposition, and the coating level on the responses, ie, lag time to release and amount of aceclofenac released in 450 minutes. Results: Glyceryl behenate and the coating level had a significant influence on lag time, while sodium chloride helped in the rupture of the coat by acting as a channeling agent. After the coat was ruptured, the core tablet showed a rapid release of aceclofenac due to the presence of Ac-Di-Sol. Graphical analysis of effects by Lenth’s method and Bayesian analysis of coefficients enabled identification of variables active on the selected responses. The optimized formulation comprised 20% w/w glyceryl behenate and 2.2% w/w sodium chloride with a 650 mg coating level, and showed a desired lag time of 358.23 minutes, which mimics the fluctuating symptoms of rheumatoid arthritis, followed by rapid release of aceclofenac.","PeriodicalId":10315,"journal":{"name":"ChronoPhysiology and Therapy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2011-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79350503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

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