International Journal of Advances in Medical Biotechnology - IJAMB最新文献

{"title":"Abstracts of the 1st Meeting of Natural Polymers - EPNAT","authors":"Several Authors","doi":"10.25061/2595-3931/ijamb/2019.v2i2.44","DOIUrl":"https://doi.org/10.25061/2595-3931/ijamb/2019.v2i2.44","url":null,"abstract":"The 1st Meeting of Natural Polymers, the event took place on August 5th and 6th, 2019, in the city of Araraquara - São Paulo, and had as main theme \"Applications and Perspectives\".The objective was to bring together entrepreneurs, undergraduate and graduate students and professors to discuss new research challenges and strategies for different applications of natural polymers.The event was attended by professors from Uniara - Araraquara, USP - Pirassununga, UNESP - Araraquara and Unifesp - Diadema institutions, all located in the State of São Paulo.","PeriodicalId":103125,"journal":{"name":"International Journal of Advances in Medical Biotechnology - IJAMB","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115701342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Industrial Revolution 4.0 and the 3D printing in Biotechnology of tissue regeneration","authors":"Lucas Noboru Fatori Trevizan, Mayté Paredes Zaldivar, A. Massabni","doi":"10.52466/ijamb.v3i1.66","DOIUrl":"https://doi.org/10.52466/ijamb.v3i1.66","url":null,"abstract":"Quando retratada para a sociedade atual, a indústria é considerada parte integrante da sociedade economicamente responsável pelo desenvolvimento e produção de bens de consumo. Os processos de revolução industrial foram marcados pelas fases de aperfeiçoamento e avanços tecnológicos (1ª Revolução Industrial), o uso da energia elétrica (2ª Revolução Industrial) e a disseminação da digitalização da tecnologia (3ª Revolução Industrial). Além disso, hoje em dia tais desenvolvimentos podem ser associados ao uso da internet e à automação de processos por inteligência artificial, chegando assim à 4ª Revolução Industrial. O conceito da Indústria 4.0 está diretamente ligado ao conceito de tecidos inteligentes, a partir de fatores como inovação, o que permite que as empresas tenham modelos de produção complexos, incluindo principalmente caráter sustentável e biotecnologias aplicadas. Além disso, tanto a 4ª Revolução Industrial quanto a biotecnologia podem ser correlacionadas em termos de bioimpressão 3D. Assim, o trabalho mostra um breve histórico das impressoras 3D e seu potencial em aplicações na área de engenharia de tecidos. Revela a necessidade de multidisciplinaridade e de profissionais cada vez mais qualificados diante da nova fase de evolução socioindustrial.","PeriodicalId":103125,"journal":{"name":"International Journal of Advances in Medical Biotechnology - IJAMB","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121160385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The importance of Biotechnology in the health area: historical overview and future perspectives","authors":"A. Massabni, J. Silva","doi":"10.25061/2595-3931/ijamb/2019.v2i2.42","DOIUrl":"https://doi.org/10.25061/2595-3931/ijamb/2019.v2i2.42","url":null,"abstract":"A biotecnologia, em sentido amplo, compreende a manipulação de microrganismos, plantas e animais, com a proposta de obter processos e produtos de interesse da sociedade. Embora o termo tenha surgido no início do século XX, os processos biotecnológicos estão presentes desde os tempos antigos na produção de alimentos e bebidas fermentados. A biotecnologia também está presente desde o início da medicina. A inalação de pó de feridas de varíola humana secas ao sol ou a secreção do úbere de vacas contaminadas com varíola bovina são exemplos de técnicas antigas usadas como métodos de imunização da doença. Nesse sentido, muitos tratamentos surgiram ao longo do tempo, como vacinas, produção de penicilina, o primeiro antibiótico e produção de insulina por DNA recombinante, que revolucionaram a Medicina e possibilitaram uma melhor qualidade de vida para os seres humanos. Muitos produtos e materiais da Biotecnologia ainda estão surgindo, como andaimes em Medicina Regenerativa para recuperação de tecido ósseo, tubos de celulose bacteriana usados como vasos sanguíneos artificiais, células-tronco pluripotentes induzidas e sistemas microfisiológicos, que prometem melhorar ainda mais a medicina moderna e fornecer melhores técnicas e técnicas. terapias para vários tratamentos.","PeriodicalId":103125,"journal":{"name":"International Journal of Advances in Medical Biotechnology - IJAMB","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133364753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Special session in honor of Antonio Carlos Massabni","authors":"V. Constantino, P. Corbi","doi":"10.25061/2595-3931/ijamb/2019.v2i2.52","DOIUrl":"https://doi.org/10.25061/2595-3931/ijamb/2019.v2i2.52","url":null,"abstract":"<jats:p />","PeriodicalId":103125,"journal":{"name":"International Journal of Advances in Medical Biotechnology - IJAMB","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124314733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biotechnology and Industry 4.0: The professionals of the future","authors":"A. Massabni, Gilson José Da Silva","doi":"10.25061/2595-3931/ijamb/2019.v2i2.39","DOIUrl":"https://doi.org/10.25061/2595-3931/ijamb/2019.v2i2.39","url":null,"abstract":"The process of developing technological research is being carried out beyond organizational boundaries, especially organizations that make intensive use of knowledge, such as Biotechnology. Considerable progress has been made in recent years in reducing costs and increasing the ease of gene sequencing and, ultimately, in activating or editing genes. In this context, discussions have been gaining prominence around Industry 4.0, in which new business models and intelligent processes for Biotechnology are evidenced. However, the challenges regarding the training and education of professionals are discussed, emphasizing the importance of a multidisciplinary education, unlike the more traditional nature of education in the areas of biology and sciences. These challenges can be partially transposed by strengthening the partnerships of universities and research centers with companies, in order to materialize in common projects, the demands of industries and the possibilities of transforming research projects into final products available to society. This paper presents a study on the impact of Industry 4.0 technologies on Biotechnology, and also presents the prospect of future professions with the influence of Industry 4.0. The results show that technologies such as artificial intelligence, robotics and 3D printing are promising in the development and advancement of Biotechnology. New automated laboratories are under development. Also, regulatory issues require a great deal of study, and business models will need to be more efficient to generate the results needed for the development of new drugs, food, and research of new products related to health.","PeriodicalId":103125,"journal":{"name":"International Journal of Advances in Medical Biotechnology - IJAMB","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121970399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Fourth Industrial Revolution and the disruptive technologies: implications in work relations","authors":"A. Massabni, Leiraud Hilkner De Souza","doi":"10.25061/2595-3931/ijamb/2019.v2i2.41","DOIUrl":"https://doi.org/10.25061/2595-3931/ijamb/2019.v2i2.41","url":null,"abstract":"This research covers an analysis of the essential aspects involving the Fourth Industrial Revolution, disruptive technologies and their consequences on work relations. Using literature reviews, analysing cases of companies that failed and others that remodeled themselves to survive the yearnings of the technological age, it was possible to obtain important results. The research was conducted in three parts: 1. historical contextualization guiding the reader on the main aspects and peculiarities of the Fourth Industrial Revolution; 2. definition, application and some examples of disruptive technologies; 3. confirmation of the impact of these technologies on work relations. The methods used were: hermeneutics, privileging theoretical studies and analysis of documents and texts and the deductive method, starting from existing laws and theories for the development of a logical reasoning to explain the central problem. Negative impacts of mass unemployment due to the replacement of human labor by highly technological machines cannot be stimated. These machines are part of what has been called disruptive technology, i.e., a product or innovative servant destabilizes competition, overcoming it in such a way that it promotes the rupture of existing models, ruining them. Professionals will be called to fill new jobs, with skills and competencies for Industry 4.0, whose interaction between man and machine will be essential. Use of big data in quality control, robots, fully automated vehicles, 3D printers in production lines, among other activities are examples of work demands.","PeriodicalId":103125,"journal":{"name":"International Journal of Advances in Medical Biotechnology - IJAMB","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128774320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Brazilian sectoral innovation system in the field of Tissue Engineering and Bioprinting: actors, challenges and perspectives","authors":"Pedro Massaguer, Ana L. G. Millás","doi":"10.25061/2595-3931/ijamb/2019.v2i1.25","DOIUrl":"https://doi.org/10.25061/2595-3931/ijamb/2019.v2i1.25","url":null,"abstract":"The objective of this work is to map the main actors within the Brazilian innovation system framework in the field of tissue engineering and bioprinting, and analyze the main conditioners related to entrepreneurship and innovation. While keeping as a backdrop, the history of 3D Biotechnology Solutions startup, its challenges and projects. Tissue engineering is a subcategory of regenerative medicine with the purpose of repairing or substituting, partially or completely, tissues or organs that have been affected by some disease or lesion. The conventional methods used for the production of these biomaterials via tissue engineering do not have the capacity to mimic the reality of native structures in the nano, micro and macro scales, while guaranteeing the reproducibility andscalability ofthematerials. Technologies such as 3D bioprinting or additive manufacturing could change the way that many diseases are treated in the medium term by replacing the damaged tissues with custom bio-similar constructs. Mapping and reflections based on the innovation systems framework contribute to organize stimulus policies, stimulate interaction between actors, identify gaps and technological demands and periodically organize the analysis and expansion of this system in Brazil.","PeriodicalId":103125,"journal":{"name":"International Journal of Advances in Medical Biotechnology - IJAMB","volume":"26 12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129151301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bio-inks for 3D extrusion-based bio-printed scaffolds: Printability assessment","authors":"V. E. Passamai, S. Katz, V. Alvarez, G. R. Castro","doi":"10.25061/2595-3931/ijamb/2019.v2i1.43","DOIUrl":"https://doi.org/10.25061/2595-3931/ijamb/2019.v2i1.43","url":null,"abstract":"Three-dimensional bioprinting is a new technology that should be integrated into several areas, including medical technology. However, before designing and applying it on a large scale, several biophysical parameters and particularly printability need to be established. In the present work, general characteristics of the extrusion method, bioinks, and scaffolds are reviewed. Printability analysis of 3D bioprinting is also included.","PeriodicalId":103125,"journal":{"name":"International Journal of Advances in Medical Biotechnology - IJAMB","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124303944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Approaches to the development of 3d bioprinted skin models: the case of natura cosmetics","authors":"Ana L. G. Millás, J. Lago, L. Vasquez-Pinto, Pedro Massaguer, S. Maria-Engler","doi":"10.25061/2595-3931/ijamb/2019.v2i1.24","DOIUrl":"https://doi.org/10.25061/2595-3931/ijamb/2019.v2i1.24","url":null,"abstract":"We are close to achieving the production of a biomimetic functional skin and this advance is mainly due to the demand that is not limited to the field of regenerative medicine, the need for transplantation of this organ due to the aging of the population, but for ethical reasons related to the tests of safety and efficacy of new formulas in animal models by the cosmetic and pharmaceutical industries. The limitations involved in traditional 2D cell culture approaches and manual techniques for biomimetic generation have driven the use of innovative technologies such as 3D bioprinting. One of the main advantages of the bioprinted skin is the authenticity, scalability and reproducibility of tissues compared to conventional constructs, via precise positioning of multiple cell types and the inclusion of appendages. The models of bioprinted skins will serve as a platform for the development of new formulations, molecule testing, disease simulation, as well as an alternative to chronic wound biocuratives and clinical transplants. This paper reviews the state-of-the-art approaches available for skin model bioprinting, discusses the context of the drug-cosmetic industry in the adoption of these models and presents the characteristics of the project under development at Natura Cosmetics.","PeriodicalId":103125,"journal":{"name":"International Journal of Advances in Medical Biotechnology - IJAMB","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131567249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tissue engineering of different cartilage types: a review of different approaches and recent advances","authors":"K. Boumediene, M. Hammad, J. Dugué, A. Veyssière, C. Baugé","doi":"10.25061/2595-3931/ijamb/2019.v2i1.33","DOIUrl":"https://doi.org/10.25061/2595-3931/ijamb/2019.v2i1.33","url":null,"abstract":"Cartilage is a connective tissue that serves as a structural support for maintaining the shape for specific appendices (nose, ear) and also helps for shock absorption when present in joints. Different types of cartilage coexist in the body: hyaline, elastic and fibrocartilage. Due to their different embryologic origin, they produce distinct extracellular matrix and therefore have specific functions according to their location. Cartilage is frequently subjected to many different lesions. Those include traumatic, metabolic and congenital forms, concerning all regions where this tissue is present: joints, head and neck area, intervertebral disks, etc. Increasing number of cancers also affects cartilage; especially in ear, nose and trachea. Unfortunately, this tissue has a poor regeneration ability. Few therapeutic options exist for cartilaginous lesions and most of them concern articular cartilage. They include micro fracture, autologous chondrocytes implantation, mosaicplasty, allograft and prosthesis. Ear and trachea are also targeted for reconstruction with lesser extent. Therefore, cartilage engineering highly addresses increasing number of pathologies associated to this tissue. In the last two decades, several trials were investigated using both progenitor cells and scaffolds. Even bone marrow derived stem cells were widely used and served as gold standard. Many progenitors from different areas are investigated for their capacity of chondrogenesis. On the other hand, biomaterials, natural and synthetic, are used to induce a 3D environment that allows proper growth and differentiation toward cartilage formation. Their characteristics depend on the location of the expected graft where porosity, biodegradability, ability to support strength and large scale use are the key points. Favorable environments are also needed to achieve appropriate chondrogenesis, including biochemical or mechanical stimuli and low oxygen tension. Bioprinting showed also encouraging outcomes in cartilage reconstruction with the investigation of several scaffolds.","PeriodicalId":103125,"journal":{"name":"International Journal of Advances in Medical Biotechnology - IJAMB","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126260751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}