International Journal of Advances in Medical Biotechnology - IJAMB最新文献

Baccharis dracunculifolia extract as a promising active for healing chronic wounds 作为一种有望治愈慢性伤口的活性物质的龙胆草提取物

International Journal of Advances in Medical Biotechnology - IJAMB Pub Date : 2023-09-01 DOI: 10.52466/ijamb.v5i2.114

Benedito Domingos Neto, Vitória Maria Medalha Colturato, Daniela Sicci Del Lama, Hernane da Silva Barud, Monica Rosas da Costa Iemma

引用次数: 0

Vesting in biostartups: analysis of new legal framework & fundamental rights 生物初创企业的股权：新法律框架与基本权利分析

International Journal of Advances in Medical Biotechnology - IJAMB Pub Date : 2023-08-25 DOI: 10.52466/ijamb.v5i2.113

Alexandre Eli Alves, Miriam da Costa Claudino, Ricardo Augusto Bonotto Barboza

{"title":"Vesting in biostartups: analysis of new legal framework & fundamental rights","authors":"Alexandre Eli Alves, Miriam da Costa Claudino, Ricardo Augusto Bonotto Barboza","doi":"10.52466/ijamb.v5i2.113","DOIUrl":"https://doi.org/10.52466/ijamb.v5i2.113","url":null,"abstract":"The purpose of this article is to examine the vesting contract in biostartups, with emphasis on the new legal framework from the perspective of the principle of maximum effectiveness of fundamental rights. The vesting contract is analyzed in relation to the effectiveness of these rights, divided into two dimensions. In the subjective dimension, the vesting contract is seen as a way to protect the fundamental rights of startup partners and investors, including the right to contractual freedom. In the objective dimension, the vesting contract is seen as a way to promote the effectiveness of fundamental rights to growth and to innovative entrepreneurship, mitigating labor and tax risks, optimizing the company’s development, and bringing a strong economic and social impact on the development of a nation. The results showed that the vesting contract can generate risk reduction and legal certainty for the partners in a private environment of prior trust. Furthermore, the inclusion of the term “innovation” in Brazilian Federal Constitution reinforces the importance of scientific and technological research for the development of the country. However, the implementation of these fundamental rights is still incipient, especially in the field of biotechnology, where companies are subject to extremely high risks and a very high mortality rate due to innovative projects and the lack of administrative knowledge on the part of managers. Finally, as to the methodology employed, the study has an exploratory and descriptive character, with the conclusions derived from the qualitative analysis of information delimited with a bibliographical and documental review of books, articles, websites, jurisprudence and legislation.","PeriodicalId":103125,"journal":{"name":"International Journal of Advances in Medical Biotechnology - IJAMB","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139349061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Entrepreneurship in biotechnology in Brazil: the path to innovation development 巴西生物技术领域的企业家精神:创新发展之路

International Journal of Advances in Medical Biotechnology - IJAMB Pub Date : 2023-06-29 DOI: 10.52466/ijamb.v5i1.108

Adriana Pagan Tonon, Fernando Luiz Macedo, Creuza Sayuri Tahara Amaral

{"title":"Entrepreneurship in biotechnology in Brazil: the path to innovation development","authors":"Adriana Pagan Tonon, Fernando Luiz Macedo, Creuza Sayuri Tahara Amaral","doi":"10.52466/ijamb.v5i1.108","DOIUrl":"https://doi.org/10.52466/ijamb.v5i1.108","url":null,"abstract":"Studies and debates on entrepreneurship, innovation, and biotechnology have been highlighted on the world stage. Considering this context, it is necessary to evaluate innovation and its consequences for the entrepreneur because innovation is a fundamental requirement for the success of the entrepreneur, especially when it involves the biotechnology area. Innovation has the power to create a new product, a market success, and generate economic benefits for the company. In this context, this work aims to understand through literature research how the insertion of innovation in entrepreneurship can contribute to the biotechnology area. To gain the necessary understanding of the theme, the methodology used was bibliographic research with the purpose of collecting and synthesizing existing knowledge. The results found showed that there are gaps between entrepreneurship and the process of searching for innovation, the selection of ideas, and the challenges facing the changes needed for the entrepreneur's initiatives to be successful. In the biotechnology area, entrepreneurship can assist in innovation processes as well as strengthen the capacity for competitiveness. Therefore, this research puts into debate the relevant aspects of entrepreneurship, the innovation process in the biotechnology area, and its impact on the economy and society.","PeriodicalId":103125,"journal":{"name":"International Journal of Advances in Medical Biotechnology - IJAMB","volume":"62 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114578604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The construction of a performance measurement system for self-evaluation of a graduate biotechnology program 生物技术研究生自我评价绩效评估体系之建构

International Journal of Advances in Medical Biotechnology - IJAMB Pub Date : 2022-12-06 DOI: 10.52466/ijamb.v5i1.103

Bruna Cristine Scarduelli Pacheco, Claudio Luis Piratelli, André Capaldo Amaral, M. Belderrain, R. V. Françozo

引用次数: 1

Use of high energy milling and porosity insertion in the development of the Mg-Zn system aiming biomedical applications 利用高能铣削和孔隙插入技术开发针对生物医学应用的Mg-Zn系统

International Journal of Advances in Medical Biotechnology - IJAMB Pub Date : 2022-03-01 DOI: 10.52466/ijamb.v5i1.101

Viviane S. Costa, Willian Souza, Pércio M. Pinto, D. Rodrigues Júnior

{"title":"Use of high energy milling and porosity insertion in the development of the Mg-Zn system aiming biomedical applications","authors":"Viviane S. Costa, Willian Souza, Pércio M. Pinto, D. Rodrigues Júnior","doi":"10.52466/ijamb.v5i1.101","DOIUrl":"https://doi.org/10.52466/ijamb.v5i1.101","url":null,"abstract":"The development of metal alloys with porosity controlled by powder metallurgy has shown to be suitable for obtaining biomaterials with the control of mechanical strength and modulus of elasticity, in addition to the possibility of controlling open porosity, which is essential for osseointegration. Magnesium alloys have shown encouraging results when used as tissue engineering scaffolds. Although a considerable number of studies encourage the use of magnesium alloys in bioactive implants for load-bearing in orthopedic applications, a great deal of research effort is still essential to assess in vivo, the long-term capability of such supports. Due to the excellent physical and mechanical properties of magnesium compared to other permanent (non-degradable) elements, porous magnesium alloys have become good candidates to develop biodegradable supports for bone treatments. Porous magnesium alloys could be used in applications where it would be interesting to use a biodegradable metallic material, while maintaining the requirements of mechanical strength, elastic modulus, corrosion resistance and adequate osseointegration. In this work, a new route of processing porous alloys of the MgZn system using high energy milling, via powder metallurgy, will be evaluated.","PeriodicalId":103125,"journal":{"name":"International Journal of Advances in Medical Biotechnology - IJAMB","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125984448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of synthesis temperature on crystallinity, morphology and cell viability of nanostructured hydroxyapatite via wet chemical precipitation method 湿化学沉淀法合成温度对纳米羟基磷灰石结晶度、形态和细胞活力的影响

International Journal of Advances in Medical Biotechnology - IJAMB Pub Date : 2022-03-01 DOI: 10.52466/ijamb.v5i1.110

Andriele L. Rosa, Luana R. Farias, Vinicius P. Dias, Otávio B. Pacheco, F.D.P. Morisso, L. R. Rodrigues Júnior, M. Sagrillo, A. Rossato, L. A. Santos, T. Volkmer

{"title":"Effect of synthesis temperature on crystallinity, morphology and cell viability of nanostructured hydroxyapatite via wet chemical precipitation method","authors":"Andriele L. Rosa, Luana R. Farias, Vinicius P. Dias, Otávio B. Pacheco, F.D.P. Morisso, L. R. Rodrigues Júnior, M. Sagrillo, A. Rossato, L. A. Santos, T. Volkmer","doi":"10.52466/ijamb.v5i1.110","DOIUrl":"https://doi.org/10.52466/ijamb.v5i1.110","url":null,"abstract":"Hydroxyapatite (HA) is the main natural mineral constituent of bones and is a good alternative for biomedical applications because it is osteoconductive, non-allergenic, and non-carcinogenic, which ensures high biocompatibility. A commonly used method for obtaining hydroxyapatite is the wet route, which is simple and low-cost, produces only water as a final residue, and provides HA with a crystallinity comparable to that of bone tissue, which favors its biocompatibility. Therefore, the objective of this work is to synthesize hydroxyapatite via the wet chemical precipitation method at different temperatures (4°C, 30°C, 50°C, or 70°C) to observe the influence of temperature on crystallinity, morphology, and cytotoxicity. The results of X-ray diffraction show that all syntheses resulted in pure hydroxyapatite, while increasing the temperature led to higher crystallinity (10.6% to 56.2%) and the crystal size was slightly affected. The increase in temperature changed the particle shape from irregular to needle-like. Cell viability was tested by PicoGreen® in VERO cells for samples at concentrations of 30 and 300µg/mL, and the samples synthesized at 4°C, with lower crystallinity, caused less DNA damage to cells compared to the negative control. \u0000 ","PeriodicalId":103125,"journal":{"name":"International Journal of Advances in Medical Biotechnology - IJAMB","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124709229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Robotic arm inertial control for recreational child physiotherapy application 机械臂惯性控制在儿童娱乐理疗中的应用

International Journal of Advances in Medical Biotechnology - IJAMB Pub Date : 2022-03-01 DOI: 10.52466/ijamb.v5i1.111

Jean Mendes Nascimento, Caroline Dos Santos Brito, Eric Davi Castro Frazão, Gabriel Augusto Santos Mera, Guilherme Alves Aniceto da Silva, Hugo Guilherme Venceslau de Melo

{"title":"Robotic arm inertial control for recreational child physiotherapy application","authors":"Jean Mendes Nascimento, Caroline Dos Santos Brito, Eric Davi Castro Frazão, Gabriel Augusto Santos Mera, Guilherme Alves Aniceto da Silva, Hugo Guilherme Venceslau de Melo","doi":"10.52466/ijamb.v5i1.111","DOIUrl":"https://doi.org/10.52466/ijamb.v5i1.111","url":null,"abstract":"According to reports from physical therapists, physiotherapy presents a painful and uninteresting process because it distances itself from the ludic, which is a natural essence of the human being, and easily attracts children when applied. In 2021, the “Robotic System for Children's Physiotherapy with Recreational Activities” project was developed, which consisted of a robotic arm to assist in the physiotherapy process of children with Cerebral Palsy. According to the conclusions of the initial project, the developed control was effective in what was proposed but not sufficient for project application in rehabilitation environments In this way, this work present a new control that is safer and that allows its application helping in the rehabilitation of these children. This new control allows the robotic arm to reproduce the movements of the human arm, so that the movement of the forearm, arm and hand are reproduced independently, simultaneously and in real time. Therefore, the prototype control operates reliably and robustly, achieving what was aimed at, a safer and more efficient physiotherapeutic process for users.","PeriodicalId":103125,"journal":{"name":"International Journal of Advances in Medical Biotechnology - IJAMB","volume":"77 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130402484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of the Bioprinting Market in Brazil and its Status in the Global Scenario 巴西生物打印市场分析及其在全球的地位

International Journal of Advances in Medical Biotechnology - IJAMB Pub Date : 2022-03-01 DOI: 10.52466/ijamb.v5i1.109

Isabela De Carvalho Favareto, Márcia Mayumi Omi Simbara

{"title":"Analysis of the Bioprinting Market in Brazil and its Status in the Global Scenario","authors":"Isabela De Carvalho Favareto, Márcia Mayumi Omi Simbara","doi":"10.52466/ijamb.v5i1.109","DOIUrl":"https://doi.org/10.52466/ijamb.v5i1.109","url":null,"abstract":"Additive manufacturing (AM) is a constantly growing manufacturing technique that can be used from the prototyping stage to the final product in several industries. 3D bioprinting is a variant of conventional AM that uses bioinks, i.e., inks with the presence of cells, to manufacture living biological structures. These structures can be used in applications in the medical field and with therapeutic potential, such as the fabrication of tissues and organ models, drug testing, among others. Considering its importance in the global scenario, this work aimed to evaluate the growth related to 3D bioprinting research in Brazil and in the world, and to analyze the Brazilian market compared to the global panorama. For this, qualitative research, literature search in research bases, and the search for patent records were used. The exponential increase of studies in the area was identified, through graphs with trend lines, exposing its enormous potential for development. It was possible to perceive the notable advance in the use of bioprinting worldwide, as well as in Brazil, a leader in research in the area in Latin America, although it is still lagging behind other countries, occupying the twentieth position worldwide in scientific contributions.","PeriodicalId":103125,"journal":{"name":"International Journal of Advances in Medical Biotechnology - IJAMB","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122015739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of heat treatment on microstructure and mechanical properties of Ti30Ta alloy for biomedical applications 热处理对医用Ti30Ta合金组织和力学性能的影响

International Journal of Advances in Medical Biotechnology - IJAMB Pub Date : 2022-03-01 DOI: 10.52466/ijamb.v5i1.106

Celso Bortolini Junior, Reginaldo T. Konatu, Angelo Caporalli Filho, Ana Paula Rosifini Alves Claro

引用次数: 0

Comparison between three decellularization protocol whit SDS in swine esophagus: a future option in veterinary medicine 猪食管三种脱细胞方案与SDS的比较:兽医学的未来选择

International Journal of Advances in Medical Biotechnology - IJAMB Pub Date : 2021-10-10 DOI: 10.52466/ijamb.v4i2.92

Anna Julia Alves dos Santos, Ana Lídia Jacintho Delgado, M. Miglino, Karoline Maia de Souza

引用次数: 0