Circulation. Cardiovascular Quality and Outcomes最新文献

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Comparison of Hospital Performance in Acute Ischemic Stroke Based on Mortality and Functional Outcome in South Korea. 基于韩国急性缺血性脑卒中死亡率和功能结局的医院表现比较
IF 6.9 2区 医学
Circulation. Cardiovascular Quality and Outcomes Pub Date : 2023-08-01 DOI: 10.1161/CIRCOUTCOMES.122.009653
Bosco Seong Kyu Yang, Minuk Jang, Keon-Joo Lee, Beom Joon Kim, Moon-Ku Han, Joon-Tae Kim, Kang-Ho Choi, Jae-Kwan Cha, Dae-Hyun Kim, Dong-Eog Kim, Wi-Sun Ryu, Jong-Moo Park, Kyusik Kang, Soo Joo Lee, Jae Guk Kim, Mi-Sun Oh, Kyung-Ho Yu, Byung-Chul Lee, Keun-Sik Hong, Yong-Jin Cho, Jay Chol Choi, Tai Hwan Park, Kyung Bok Lee, Jee-Hyun Kwon, Wook-Joo Kim, Sung Il Sohn, Jeong-Ho Hong, Jun Lee, Sang-Hwa Lee, Ji Sung Lee, Juneyoung Lee, Philip B Gorelick, Hee-Joon Bae
{"title":"Comparison of Hospital Performance in Acute Ischemic Stroke Based on Mortality and Functional Outcome in South Korea.","authors":"Bosco Seong Kyu Yang,&nbsp;Minuk Jang,&nbsp;Keon-Joo Lee,&nbsp;Beom Joon Kim,&nbsp;Moon-Ku Han,&nbsp;Joon-Tae Kim,&nbsp;Kang-Ho Choi,&nbsp;Jae-Kwan Cha,&nbsp;Dae-Hyun Kim,&nbsp;Dong-Eog Kim,&nbsp;Wi-Sun Ryu,&nbsp;Jong-Moo Park,&nbsp;Kyusik Kang,&nbsp;Soo Joo Lee,&nbsp;Jae Guk Kim,&nbsp;Mi-Sun Oh,&nbsp;Kyung-Ho Yu,&nbsp;Byung-Chul Lee,&nbsp;Keun-Sik Hong,&nbsp;Yong-Jin Cho,&nbsp;Jay Chol Choi,&nbsp;Tai Hwan Park,&nbsp;Kyung Bok Lee,&nbsp;Jee-Hyun Kwon,&nbsp;Wook-Joo Kim,&nbsp;Sung Il Sohn,&nbsp;Jeong-Ho Hong,&nbsp;Jun Lee,&nbsp;Sang-Hwa Lee,&nbsp;Ji Sung Lee,&nbsp;Juneyoung Lee,&nbsp;Philip B Gorelick,&nbsp;Hee-Joon Bae","doi":"10.1161/CIRCOUTCOMES.122.009653","DOIUrl":"https://doi.org/10.1161/CIRCOUTCOMES.122.009653","url":null,"abstract":"<p><strong>Background: </strong>Recent evidence suggests a correlation between modified Rankin Scale-based measures, an outcome measure commonly used in acute stroke trials, and mortality-based measures used by health agencies in the evaluation of hospital performance. We aimed to examine whether the 2 types of measures are interchangeable in relation to evaluation of hospital performance in acute ischemic stroke.</p><p><strong>Methods: </strong>Five outcome measures, unfavorable functional outcome (3-month modified Rankin Scale score ≥2), death or dependency (3-month modified Rankin Scale score ≥3), 1-month mortality, 3-month mortality, and 1-year mortality, were collected for 8292 individuals who were hospitalized for acute ischemic stroke between January 2014 and May 2015 in 14 hospitals participating in the Clinical Research Collaboration for Stroke in Korea - National Institute of Health registry. Hierarchical regression models were used to calculate per-hospital risk-adjusted outcome rates for each measure. Hospitals were ranked and grouped based on the risk-adjusted outcome rates, and the correlations between the modified Rankin Scale-based and mortality-based ranking and their intermeasure reliability in categorizing hospital performance were analyzed.</p><p><strong>Results: </strong>The comparison between the ranking based on the unfavorable functional outcome and that based on 1-year mortality resulted in a Spearman correlation coefficient of -0.29 and Kendall rank coefficient of -0.23, and the comparison of grouping based on these 2 types of ranks resulted in a weighted kappa of 0.123 for the grouping in the top 33%/middle 33%/bottom 33% and 0.25 for the grouping in the top 20%/middle 60%/bottom 20%, respectively. No significant correlation or similarity in grouping capacities were found between the rankings based on the functional outcome measures and those based on the mortality measures.</p><p><strong>Conclusions: </strong>This study shows that regardless of clinical correlation at an individual patient level, functional outcome-based measures and mortality-based measures are not interchangeable in the evaluation of hospital performance in acute ischemic stroke.</p>","PeriodicalId":10301,"journal":{"name":"Circulation. Cardiovascular Quality and Outcomes","volume":"16 8","pages":"554-565"},"PeriodicalIF":6.9,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10150026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Just a Generator Exchange? 只是一个发电机交换?
IF 6.9 2区 医学
Circulation. Cardiovascular Quality and Outcomes Pub Date : 2023-08-01 DOI: 10.1161/CIRCOUTCOMES.123.010266
Stacey J Howell, Eric C Stecker
{"title":"Just a Generator Exchange?","authors":"Stacey J Howell,&nbsp;Eric C Stecker","doi":"10.1161/CIRCOUTCOMES.123.010266","DOIUrl":"https://doi.org/10.1161/CIRCOUTCOMES.123.010266","url":null,"abstract":"","PeriodicalId":10301,"journal":{"name":"Circulation. Cardiovascular Quality and Outcomes","volume":"16 8","pages":"519-520"},"PeriodicalIF":6.9,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10147211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gaps in Guideline-Based Lipid-Lowering Therapy for Secondary Prevention in the United States: A Retrospective Cohort Study of 322 153 Patients. 美国基于指南的二级预防降脂治疗的差距:322例回顾性队列研究 153名患者。
IF 6.9 2区 医学
Circulation. Cardiovascular Quality and Outcomes Pub Date : 2023-08-01 Epub Date: 2023-08-02 DOI: 10.1161/CIRCOUTCOMES.122.009787
Ann Marie Navar, Ahmed A Kolkailah, Anand Gupta, Kristin Khalaf Gillard, Marc K Israel, Yiqing Wang, Eric D Peterson
{"title":"Gaps in Guideline-Based Lipid-Lowering Therapy for Secondary Prevention in the United States: A Retrospective Cohort Study of 322 153 Patients.","authors":"Ann Marie Navar, Ahmed A Kolkailah, Anand Gupta, Kristin Khalaf Gillard, Marc K Israel, Yiqing Wang, Eric D Peterson","doi":"10.1161/CIRCOUTCOMES.122.009787","DOIUrl":"10.1161/CIRCOUTCOMES.122.009787","url":null,"abstract":"<p><strong>Background: </strong>Many patients with atherosclerotic cardiovascular disease (ASCVD) are not on guideline-recommended statin therapy. We evaluated utilization of statins and other lipid-lowering therapy (LLT), and changes in low-density lipoprotein cholesterol (LDL-C), among patients with ASCVD over a 1-year period.</p><p><strong>Methods: </strong>LLT and LDL-C levels at the first outpatient visit (January 1, 2017-December 31, 2018) and 1-year follow-up were evaluated using data from Cerner Real-World Data, an electronic health record-derived data set from 92 US health systems. Logistic regression was used to evaluate factors associated with high-intensity statin use.</p><p><strong>Results: </strong>We identified 322 153 patients with ASCVD (median age 69 years, 58.8% men, 81.8% White). Overall, 76.1% of patients were on statins, with only 39.4% on high-intensity statins. Men were more likely to receive high-intensity statins than women (multivariable-adjusted odds ratio, 1.34 [95% CI, 1.30-1.38]). Increasing age was associated with lower odds of statin use (odds ratio, 0.79 per 5-year increase at 60 years [95% CI, 0.78-0.81]). Patients with peripheral artery disease (odds ratio, 0.40 [95% CI, 0.37-0.42]) and cerebrovascular disease (odds ratio, 0.75 [95% CI, 0.70-0.80]) had lower odds of using high-intensity statins than those with coronary artery disease. At baseline, most patients (61.3%) had elevated LDL-C (≥70 mg/dL), including 59.8% of those on low/moderate-intensity statins and 76.1% on no statin; only 45.3% achieved an LDL-C <70 mg/dL at 1 year. Nonstatin LLT use was low (ezetimibe, 4.4%; proprotein convertase subtilisin/kexin type 9 inhibitors, 0.7%). Among patients on no statin or low/moderate-intensity statin at baseline, 14.8% and 13.4%, respectively, were on high-intensity statins at 1 year.</p><p><strong>Conclusions: </strong>Among patients with ASCVD in routine care, high-intensity statins are underutilized, and uptitration and use of nonstatin therapy are uncommon. Women, older adults, and individuals with noncardiac ASCVD are particularly undertreated. Concerted efforts are needed to address therapeutic inertia for lipid management in patients with ASCVD.</p>","PeriodicalId":10301,"journal":{"name":"Circulation. Cardiovascular Quality and Outcomes","volume":"16 8","pages":"533-543"},"PeriodicalIF":6.9,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10527346/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10149176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Illness Perception and the Impact of a Definitive Diagnosis on Women With Ischemia and No Obstructive Coronary Artery Disease: A Qualitative Study. 疾病感知和明确诊断对女性缺血无阻塞性冠状动脉疾病的影响:一项定性研究。
IF 6.9 2区 医学
Circulation. Cardiovascular Quality and Outcomes Pub Date : 2023-08-01 DOI: 10.1161/CIRCOUTCOMES.122.009834
Leslie Yingzhijie Tseng, Nükte Göç, Alexandra N Schwann, Emily J Cherlin, Steffne J Kunnirickal, Natalija Odanovic, Leslie A Curry, Samit M Shah, Erica S Spatz
{"title":"Illness Perception and the Impact of a Definitive Diagnosis on Women With Ischemia and No Obstructive Coronary Artery Disease: A Qualitative Study.","authors":"Leslie Yingzhijie Tseng,&nbsp;Nükte Göç,&nbsp;Alexandra N Schwann,&nbsp;Emily J Cherlin,&nbsp;Steffne J Kunnirickal,&nbsp;Natalija Odanovic,&nbsp;Leslie A Curry,&nbsp;Samit M Shah,&nbsp;Erica S Spatz","doi":"10.1161/CIRCOUTCOMES.122.009834","DOIUrl":"https://doi.org/10.1161/CIRCOUTCOMES.122.009834","url":null,"abstract":"<p><strong>Background: </strong>Ischemia and no obstructive coronary artery disease (INOCA) disproportionately impacts women, yet the underlying pathologies are often not distinguished, contributing to adverse health care experiences and poor quality of life. Coronary function testing at the time of invasive coronary angiography allows for improved diagnostic accuracy. Despite increased recognition of INOCA and expanding access to testing, data lack on first-person perspectives and the impact of receiving a diagnosis in women with INOCA.</p><p><strong>Methods: </strong>From 2020 to 2021, we conducted structured telephone interviews with 2 groups of women with INOCA who underwent invasive coronary angiography (n=29) at Yale New Haven Hospital, New Haven, CT: 1 group underwent coronary function testing (n=20, of whom 18 received a mechanism-based diagnosis) and the other group who did not undergo coronary function testing (n=9). The interviews were analyzed using the constant comparison method by a multidisciplinary team.</p><p><strong>Results: </strong>The mean age was 59.7 years, and 79% and 3% were non-Hispanic White and non-Hispanic Black, respectively. Through iterative coding, 4 themes emerged and were further separated into subthemes that highlight disease experience aspects to be addressed in patient care: (1) distress from symptoms of uncertain cause: symptom constellation, struggle for sensemaking, emotional toll, threat to personal and professional identity; (2) a long journey to reach a definitive diagnosis: self-advocacy and fortitude, healthcare interactions brought about further uncertainty and trauma, therapeutic alliance, sources of information; (3) establishing a diagnosis enabled a path forward: relief and validation, empowerment; and (4) commitment to promoting awareness and supporting other women: recognition of sex and racial/ethnic disparities, support for other women.</p><p><strong>Conclusions: </strong>Insights about how women experience the symptoms of INOCA and their interactions with clinicians and the healthcare system hold powerful lessons for more patient-centered care. A coronary function testing-informed diagnosis greatly influences the healthcare experiences, quality of life, and emotional states of women with INOCA.</p>","PeriodicalId":10301,"journal":{"name":"Circulation. Cardiovascular Quality and Outcomes","volume":"16 8","pages":"521-529"},"PeriodicalIF":6.9,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10152095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Patients' Perspectives Regarding Generator Exchanges of Implantable Cardioverter Defibrillators. 患者对植入式心脏复律除颤器发生器更换的看法。
IF 6.9 2区 医学
Circulation. Cardiovascular Quality and Outcomes Pub Date : 2023-08-01 Epub Date: 2023-07-26 DOI: 10.1161/CIRCOUTCOMES.122.009827
Sarah C Montembeau, Faisal M Merchant, Candace Speight, Daniel B Kramer, Daniel D Matlock, Michal Horný, Neal W Dickert, Birju R Rao
{"title":"Patients' Perspectives Regarding Generator Exchanges of Implantable Cardioverter Defibrillators.","authors":"Sarah C Montembeau, Faisal M Merchant, Candace Speight, Daniel B Kramer, Daniel D Matlock, Michal Horný, Neal W Dickert, Birju R Rao","doi":"10.1161/CIRCOUTCOMES.122.009827","DOIUrl":"10.1161/CIRCOUTCOMES.122.009827","url":null,"abstract":"<p><strong>Background: </strong>Shared decision-making is mandated for patients receiving primary prevention implantable cardioverter defibrillators (ICDs). Less attention has been paid to generator exchange decisions, although at the time of generator exchange, patients' risk of sudden cardiac death, risk of procedural complications, quality of life, or prognosis may have changed. This study was designed to explore how patients make ICD generator exchange decisions.</p><p><strong>Methods: </strong>Emory Healthcare patients with primary prevention ICDs implanted from 2013 to 2021 were recruited to complete in-depth interviews exploring perspectives regarding generator exchanges. Interviews were conducted in 2021. Transcribed interviews were qualitatively coded using multilevel template analytic methods. To investigate benefit thresholds for pursuing generator exchanges, patients were presented standard-gamble type hypothetical scenarios where their ICD battery was depleted but their 5-year risk of sudden cardiac death at that time varied (10%, 5%, and 1%).</p><p><strong>Results: </strong>Fifty patients were interviewed; 18 had a prior generator exchange, 16 had received ICD therapy, and 17 had improved left ventricular ejection fraction. As sudden cardiac death risk decreased from 10% to 5% to 1%, the number of participants willing to undergo a generator exchange decreased from 48 to 42 to 33, respectively. Responses suggest that doctor's recommendations are likely to substantially impact patients' decision-making. Other drivers of decision-making included past experiences with ICD therapy and device implantation, as well as risk aversion. Therapeutic inertia and misconceptions about ICD therapy were common and represent substantive barriers to effective shared decision-making in this context.</p><p><strong>Conclusions: </strong>Strong defaults may exist to continue therapy and exchange ICD generators. Updated risk stratification may facilitate shared decision-making and reduce generator exchanges in very low-risk patients, especially if these interventions are directed toward clinicians. Interventions targeting phenomena such as therapeutic inertia may be more impactful and warrant exploration in randomized trials.</p>","PeriodicalId":10301,"journal":{"name":"Circulation. Cardiovascular Quality and Outcomes","volume":"16 8","pages":"509-518"},"PeriodicalIF":6.9,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10524607/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10147210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Path Less Traveled: Providing Optimal Patient Care on the Road of Diagnostic Uncertainty. 少走的路:在诊断不确定性的道路上提供最佳的患者护理。
IF 6.9 2区 医学
Circulation. Cardiovascular Quality and Outcomes Pub Date : 2023-08-01 Epub Date: 2023-07-21 DOI: 10.1161/CIRCOUTCOMES.123.010318
Shea E Hogan, Prateeti Khazanie
{"title":"Path Less Traveled: Providing Optimal Patient Care on the Road of Diagnostic Uncertainty.","authors":"Shea E Hogan, Prateeti Khazanie","doi":"10.1161/CIRCOUTCOMES.123.010318","DOIUrl":"10.1161/CIRCOUTCOMES.123.010318","url":null,"abstract":"","PeriodicalId":10301,"journal":{"name":"Circulation. Cardiovascular Quality and Outcomes","volume":"16 8","pages":"530-532"},"PeriodicalIF":6.9,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10530234/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10146736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Disparities in 1-Year-Mortality in Infants With Cyanotic Congenital Heart Disease: Insights From Contemporary National Data. 紫绀型先天性心脏病婴儿1年死亡率的差异:来自当代国家数据的见解
IF 6.9 2区 医学
Circulation. Cardiovascular Quality and Outcomes Pub Date : 2023-07-01 DOI: 10.1161/CIRCOUTCOMES.122.009981
Martina A Steurer, Charles McCulloch, Stephanie Santana, James W Collins, Tonia Branche, John M Costello, Shabnam Peyvandi
{"title":"Disparities in 1-Year-Mortality in Infants With Cyanotic Congenital Heart Disease: Insights From Contemporary National Data.","authors":"Martina A Steurer,&nbsp;Charles McCulloch,&nbsp;Stephanie Santana,&nbsp;James W Collins,&nbsp;Tonia Branche,&nbsp;John M Costello,&nbsp;Shabnam Peyvandi","doi":"10.1161/CIRCOUTCOMES.122.009981","DOIUrl":"https://doi.org/10.1161/CIRCOUTCOMES.122.009981","url":null,"abstract":"<p><strong>Background: </strong>Racial inequities in congenital heart disease (CHD) outcomes are well documented, but contributing factors warrant further investigation. We examined the interplay between race, socioeconomic position, and neonatal variables (prematurity and small for gestational age) on 1-year death in infants with CHD. We hypothesize that socioeconomic position mediates a significant part of observed racial disparities in CHD outcomes.</p><p><strong>Methods: </strong>Linked birth/death files from the Natality database for all liveborn neonates in the United States were examined from 2014 to 2018. Infants with cyanotic CHD were identified. Non-Hispanic Black (NHB) and Hispanic infants were compared with non-Hispanic White (NHW) infants. The primary outcome was 1-year death. Socioeconomic position was defined as maternal education and insurance status. Variables included as mediators were prematurity, small for gestational age, and socioeconomic position. Structural equation modeling was used to calculate the contribution of each mediator to the disparity in 1-year death.</p><p><strong>Results: </strong>We identified 7167 NHW, 1393 NHB, and 1920 Hispanic infants with cyanotic CHD. NHB race and Hispanic ethnicity were associated with increased 1-year death compared to NHW (OR, 1.43 [95% CI, 1.25-1.64] and 1.17 [95% CI, 1.03-1.33], respectively). The effect of socioeconomic position explained 28.2% (CI, 15.1-54.8) of the death disparity between NHB and NHW race and 100% (CI, 42.0-368) of the disparity between Hispanic and NHW. This was mainly driven by maternal education (21.3% [CI, 12.1-43.3] and 82.8% [CI, 33.1-317.8], respectively) while insurance status alone did not explain a significant percentage. The direct effect of race or ethnicity became nonsignificant: NHB versus NHW 43.1% (CI, -0.3 to 63.6) and Hispanic versus NHW -19.0% (CI, -329.4 to 45.3).</p><p><strong>Conclusions: </strong>Less privileged socioeconomic position, especially lower maternal education, explains a large portion of the 1-year death disparity in Black and Hispanic infants with CHD. These findings identify targets for social interventions to decrease racial disparities.</p>","PeriodicalId":10301,"journal":{"name":"Circulation. Cardiovascular Quality and Outcomes","volume":"16 7","pages":"e009981"},"PeriodicalIF":6.9,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9883402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Implications of Social Disadvantage Score in Cardiovascular Outcomes and Risk Assessment: Findings From the Multi-Ethnic Study of Atherosclerosis. 社会弱势评分在心血管结局和风险评估中的意义:来自动脉粥样硬化多民族研究的发现。
IF 6.9 2区 医学
Circulation. Cardiovascular Quality and Outcomes Pub Date : 2023-07-01 Epub Date: 2023-07-05 DOI: 10.1161/CIRCOUTCOMES.122.009304
Aziz Hammoud, Haiying Chen, Alexander Ivanov, Joseph Yeboah, Khurram Nasir, Miguel Cainzos-Achirica, Alain Bertoni, Safi U Khan, Michael Blaha, David Herrington, Michael D Shapiro
{"title":"Implications of Social Disadvantage Score in Cardiovascular Outcomes and Risk Assessment: Findings From the Multi-Ethnic Study of Atherosclerosis.","authors":"Aziz Hammoud, Haiying Chen, Alexander Ivanov, Joseph Yeboah, Khurram Nasir, Miguel Cainzos-Achirica, Alain Bertoni, Safi U Khan, Michael Blaha, David Herrington, Michael D Shapiro","doi":"10.1161/CIRCOUTCOMES.122.009304","DOIUrl":"10.1161/CIRCOUTCOMES.122.009304","url":null,"abstract":"<p><strong>Background: </strong>Social determinants of health contribute to disparate cardiovascular outcomes, yet they have not been operationalized into the current paradigm of cardiovascular risk assessment.</p><p><strong>Methods: </strong>Data from the Multi-Ethnic Study of Atherosclerosis, which includes participants from 6 US field centers, were used to create an index of baseline Social Disadvantage Score (SDS) to explore its association with incident atherosclerotic cardiovascular disease (ASCVD) and all-cause mortality and impact on ASCVD risk prediction. SDS, which ranges from 0 to 4, was calculated by tallying the following social factors: (1) household income less than the federal poverty level; (2) educational attainment less than a high school diploma; (3) single-living status; and (4) experience of lifetime discrimination. Cox models were used to examine the association between SDS and each outcome with adjustment for traditional cardiovascular risk factors. Changes in the discrimination and reclassification of ASCVD risk by incorporating SDS into the pooled cohort equations were examined.</p><p><strong>Results: </strong>A total of 6434 participants (mean age, 61.9±10.2 years; female 52.8%; non-white 60.9%) had available SDS 1733 (26.9%) with SDS 0; 2614 (40.6%) with SDS 1; 1515 (23.5%) with SDS 2; and 572 (8.9%) with SDS ≥3. In total, 775 incident ASCVD events and 1573 deaths were observed over a median follow-up of 17.0 years. Increasing SDS was significantly associated with incident ASCVD and all-cause mortality after adjusting for traditional risk factors (ASCVD: per unit increase in SDS hazard ratio, 1.15 [95% CI, 1.07-1.24]; mortality: per unit increase in SDS hazard ratio, 1.13 [95% CI, 1.08-1.19]). Adding SDS to pooled cohort equations components in a Cox model for 10-year ASCVD risk prediction did not significantly improve discrimination (<i>P</i>=0.208) or reclassification (<i>P</i>=0.112).</p><p><strong>Conclusions: </strong>Although SDS is independently associated with incident ASCVD and all-cause mortality, it does not improve 10-year ASCVD risk prediction beyond pooled cohort equations.</p>","PeriodicalId":10301,"journal":{"name":"Circulation. Cardiovascular Quality and Outcomes","volume":"16 7","pages":"e009304"},"PeriodicalIF":6.9,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10524792/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9889858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Relationship Between In-Hospital Adverse Events and Hospital Performance on 30-Day All-cause Mortality and Readmission for Patients With Heart Failure. 院内不良事件与医院在心衰患者 30 天内全因死亡率和再入院率方面的表现之间的关系。
IF 6.9 2区 医学
Circulation. Cardiovascular Quality and Outcomes Pub Date : 2023-07-01 Epub Date: 2023-07-18 DOI: 10.1161/CIRCOUTCOMES.122.009573
Yun Wang, Noel Eldridge, Mark L Metersky, David Rodrick, Sheila Eckenrode, Jasie Mathew, Deron H Galusha, Andrea A Peterson, David Hunt, Sharon-Lise T Normand, Harlan M Krumholz
{"title":"Relationship Between In-Hospital Adverse Events and Hospital Performance on 30-Day All-cause Mortality and Readmission for Patients With Heart Failure.","authors":"Yun Wang, Noel Eldridge, Mark L Metersky, David Rodrick, Sheila Eckenrode, Jasie Mathew, Deron H Galusha, Andrea A Peterson, David Hunt, Sharon-Lise T Normand, Harlan M Krumholz","doi":"10.1161/CIRCOUTCOMES.122.009573","DOIUrl":"10.1161/CIRCOUTCOMES.122.009573","url":null,"abstract":"<p><strong>Background: </strong>Hospitals with high mortality and readmission rates for patients with heart failure (HF) might also perform poorly in other quality concepts. We sought to evaluate the association between hospital performance on mortality and readmission with hospital performance rates of safety adverse events.</p><p><strong>Methods: </strong>This cross-sectional study linked the 2009 to 2019 patient-level adverse events data from the Medicare Patient Safety Monitoring System, a randomly selected medical records-abstracted patient safety database, to the 2005 to 2016 hospital-level HF-specific 30-day all-cause mortality and readmissions data from the United States Centers for Medicare & Medicaid Services. Hospitals were classified to one of 3 performance categories based on their risk-standardized 30-day all-cause mortality and readmission rates: better (both in <25th percentile), worse (both >75th percentile), and average (otherwise). Our main outcome was the occurrence (yes/no) of one or more adverse events during hospitalization. A mixed-effect model was fit to assess the relationship between a patient's risk of having adverse events and hospital performance categories, adjusted for patient and hospital characteristics.</p><p><strong>Results: </strong>The study included 39 597 patients with HF from 3108 hospitals, of which 252 hospitals (8.1%) and 215 (6.9%) were in the better and worse categories, respectively. The rate of patients with one or more adverse events during a hospitalization was 12.5% (95% CI, 12.1-12.8). Compared with patients admitted to better hospitals, patients admitted to worse hospitals had a higher risk of one or more hospital-acquired adverse events (adjusted risk ratio, 1.24 [95% CI, 1.06-1.44]).</p><p><strong>Conclusions: </strong>Patients admitted with HF to hospitals with high 30-day all-cause mortality and readmission rates had a higher risk of in-hospital adverse events. There may be common quality issues among these 3 measure concepts in these hospitals that produce poor performance for patients with HF.</p>","PeriodicalId":10301,"journal":{"name":"Circulation. Cardiovascular Quality and Outcomes","volume":"16 7","pages":"e009573"},"PeriodicalIF":6.9,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10351904/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9883403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From Waveforms to Wisdom: Gleaning More From the ECG About Biological Aging. 从波形到智慧:从心电图中挖掘更多关于生物衰老的信息。
IF 6.9 2区 医学
Circulation. Cardiovascular Quality and Outcomes Pub Date : 2023-07-01 Epub Date: 2023-06-29 DOI: 10.1161/CIRCOUTCOMES.123.010176
Joseph E Ebinger, Susan Cheng
{"title":"From Waveforms to Wisdom: Gleaning More From the ECG About Biological Aging.","authors":"Joseph E Ebinger, Susan Cheng","doi":"10.1161/CIRCOUTCOMES.123.010176","DOIUrl":"10.1161/CIRCOUTCOMES.123.010176","url":null,"abstract":"","PeriodicalId":10301,"journal":{"name":"Circulation. Cardiovascular Quality and Outcomes","volume":"16 7","pages":"e010176"},"PeriodicalIF":6.9,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10524521/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9894626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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