Clinical and experimental rheumatology最新文献_第8页

Application of vascular index based on superb microvascular imaging technique for assessing disease activity in rheumatoid arthritis patients with signal-positive joints. 基于高超微血管成像技术的血管指数在类风湿关节炎信号阳性患者疾病活动性评估中的应用。

IF 3.4 4区医学

Clinical and experimental rheumatology Pub Date : 2025-05-01 DOI: 10.55563/clinexprheumatol/8x1nhn

Yan Song, Jingyi Ma, Tianshu Chu, Ming Wu, Xijun Zhang, Haohui Zhu

{"title":"Application of vascular index based on superb microvascular imaging technique for assessing disease activity in rheumatoid arthritis patients with signal-positive joints.","authors":"Yan Song, Jingyi Ma, Tianshu Chu, Ming Wu, Xijun Zhang, Haohui Zhu","doi":"10.55563/clinexprheumatol/8x1nhn","DOIUrl":"https://doi.org/10.55563/clinexprheumatol/8x1nhn","url":null,"abstract":"Objectives: To explore the value of the vascular index (VI) based on superb microvascular imaging (SMI) technique in assessing rheumatoid arthritis (RA) disease activity.Methods: The study involved 119 RA patients who underwent SMI examinations of 28 joints. Observers obtained the VI values by manually drawing the area of interest and calculating the sum of the VI values for each patient to obtain the VIsum, and then dividing the VIsum by the number of signal-positive joints to obtain the VIstand. Data of patients' 28-joint Disease Activity Score (DAS28) and laboratory tests were also collected. The relationship between VI parameters and clinical indexes as well as the differences of VI parameters among groups with different disease activity were investigated. Moreover, the cut-off values of VI parameters to identify RA patients with DAS28 <2.6/DAS28 ≤3.2 were calculated using the receiver operating characteristic (ROC) curves.Results: VIsum, VIstand correlated with clinical and laboratory indicators, especially with DAS28 (r=0.740, 0.659, respectively, p<0.05). The differences of VIsum and VIstand among the 4 groups of patients were statistically significant (p<0.05). VIsum had higher diagnostic efficacy than VIstand for identifying patients in remission or in low and below activity. With a VIsum cut-off value of 35.5/47.8, the area under the ROC curve for identifying DAS28 <2.6/DAS28 ≤3.2 was 0.872/0.846.Conclusions: As a quantitative indicator to assess synovitis activity of RA patients, SMI-based VI was helpful in assessing RA disease activity.","PeriodicalId":10274,"journal":{"name":"Clinical and experimental rheumatology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143975607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunomodulatory effects of dental pulp stem cells on lymphocytes and monocytes from patients with rheumatoid arthritis. 牙髓干细胞对类风湿关节炎患者淋巴细胞和单核细胞的免疫调节作用。

IF 3.4 4区医学

Clinical and experimental rheumatology Pub Date : 2025-05-01 Epub Date: 2025-05-08 DOI: 10.55563/clinexprheumatol/l64k20

Alessandro Rossi, Giulia Ferrari, Veronica Galli, Martina Bonacini, Gianluca Carnevale, Alessandra Pisciotta, Rosanna Di Tinco, Mariagrazia Catanoso, Fabio Brandolino, Claudio Galluzzo, Alessandro Zerbini, Carlo Salvarani, Stefania Croci

{"title":"Immunomodulatory effects of dental pulp stem cells on lymphocytes and monocytes from patients with rheumatoid arthritis.","authors":"Alessandro Rossi, Giulia Ferrari, Veronica Galli, Martina Bonacini, Gianluca Carnevale, Alessandra Pisciotta, Rosanna Di Tinco, Mariagrazia Catanoso, Fabio Brandolino, Claudio Galluzzo, Alessandro Zerbini, Carlo Salvarani, Stefania Croci","doi":"10.55563/clinexprheumatol/l64k20","DOIUrl":"https://doi.org/10.55563/clinexprheumatol/l64k20","url":null,"abstract":"Objectives: To investigate the immunomodulatory effects of dental pulp stem cells (DPSCs) on lymphocytes and monocytes from rheumatoid arthritis (RA) patients unresponsive to conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs).Methods: Peripheral blood lymphocytes and monocytes were isolated from 12 RA patients unresponsive to csDMARDs. Lymphocytes were activated using anti-CD3/CD28 beads or with CpG ODN 2006, and monocytes with LPS. After 48 hours of co-culture with DPSCs, the expression of 7 immune checkpoints on DPSCs was analysed by flow-cytometry, and 17 cytokines were quantified in the supernatants.Results: Co-culture of DPSCs with CD3/CD28-activated lymphocytes or LPS-activated monocytes increased the expression of PD-L1, PD-L2, CD155, and Galectin-9 on DPSCs. In contrast, lymphocytes activated with ODN 2006 did not alter immune checkpoint expression. CD80, CD86, and 4-1BBL expression was not induced under any condition. Co-culture with DPSCs reduced levels of sFas-L, IFNγ, sIL-6RA, MIP-1β, TNFα in supernatants of CD3/CD28-activated lymphocytes; and BAFF, sFas-L, IL-1β, sIL-6RA, IL-9, IL-17A, IL-18, IL-23, M-CSF, perforin, TNFα in supernatants of LPS-activated monocytes. IL-6 and IP-10 levels increased in all experimental conditions, while IL-9 increased in ODN 2006- and CD3/CD28-stimulated lymphocyte cultures. DPSCs showed differential effects depending on the activation status of lymphocytes and monocytes.Conclusions: The overexpression of inhibitory immune checkpoints by DPSCs may contribute to their immunomodulatory effects. DPSCs modulated a broader range of cytokines in monocyte supernatants compared to lymphocytes.","PeriodicalId":10274,"journal":{"name":"Clinical and experimental rheumatology","volume":"43 5","pages":"809-814"},"PeriodicalIF":3.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143985975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Psoriatic arthritis phenotype may vary depending on whether the skin or joint domain appears first or whether both appear simultaneously. 银屑病关节炎的表型可能根据皮肤或关节域是否首先出现或两者是否同时出现而有所不同。

IF 3.4 4区医学

Clinical and experimental rheumatology Pub Date : 2025-05-01 Epub Date: 2025-03-05 DOI: 10.55563/clinexprheumatol/8gl4ja

Rubén Queiro, Paula Alvarez, Norma Calleja, Ignacio Braña, Stefanie Burger, Estefanía Pardo, Marta Loredo, Sara Alonso, Valentina Chiminazzo, Mercedes Alperi

{"title":"Psoriatic arthritis phenotype may vary depending on whether the skin or joint domain appears first or whether both appear simultaneously.","authors":"Rubén Queiro, Paula Alvarez, Norma Calleja, Ignacio Braña, Stefanie Burger, Estefanía Pardo, Marta Loredo, Sara Alonso, Valentina Chiminazzo, Mercedes Alperi","doi":"10.55563/clinexprheumatol/8gl4ja","DOIUrl":"10.55563/clinexprheumatol/8gl4ja","url":null,"abstract":"Objectives: We aimed to analyse psoriatic arthritis (PsA) features based on psoriasis-arthritis lag times: simultaneous (S), psoriasis first (PF), arthritis first (AF).Methods: We carried out an inception cohort study involving 340 PsA patients. Phenotypic differences between patients were analysed based on the three disease latency models identified in the study. A post-hoc correction of significant p-values was applied by the Benjamini-Hochberg method.Results: Forty-five (13.2%) patients had S onset, 97 (28.5%) manifested AF, while in 198 (58.2%) psoriasis appeared first. Lag times were markedly different between PF (16.3 ±12.4 years) and AF (5.4 ±2.8 years) groups, p<0.001. The AF group presented less frequently the classic arthritogenic psoriasis pattern: nail (18.8%, p<0.001), scalp (28.1%, p=0.001), folds (10.9%, p=0.009), and ≥3 psoriasis body areas (18.8%, p<0.001), but showed more psoriasis family history (67.6%, p=0.001) and a milder overall joint phenotype. The S group associated a worse cardiometabolic profile and developed more dactylitis (44%, p=0.012) during follow-up. The PF group was younger at psoriasis onset (p<0.001), had more extensive psoriasis (p<0.001), and higher frequency of HLA-Cw6 positivity (43.2%). Within the PF group, patients with axial onset [median 19.0 years (IQR: 10.5-25.5)] had a longer psoriasis-arthritis latency compared to other onset forms [median 14.0 years (IQR: 5-24)].Conclusions: In this study, substantial phenotypic differences were identified based on the three PsA lag time models. In addition, the classic pattern of arthritogenic psoriasis did not prevail in the same way between these groups, which was novel.","PeriodicalId":10274,"journal":{"name":"Clinical and experimental rheumatology","volume":" ","pages":"889-896"},"PeriodicalIF":3.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of TNF-α blockers on reducing the risk of dementia in rheumatoid arthritis: a nationwide cohort study. TNF-α阻滞剂对降低类风湿性关节炎痴呆风险的作用：一项全国性队列研究

IF 3.4 4区医学

Clinical and experimental rheumatology Pub Date : 2025-05-01 Epub Date: 2025-03-13 DOI: 10.55563/clinexprheumatol/6oto0h

Lung-Fang Chen, Tzu-Min Lin, Yu-Sheng Chang, Hui-Ching Hsu, Yu-Chuan Shen, Sheng-Hong Lin, Wei-Sheng Chen, Li-Fang Hu, Pei-I Kuo, Tzu-Tung Kuo, Shu-Chuan Chen, Jin-Hua Chen, Yu-Kai Lien, Chi-Ching Chang

{"title":"Effect of TNF-α blockers on reducing the risk of dementia in rheumatoid arthritis: a nationwide cohort study.","authors":"Lung-Fang Chen, Tzu-Min Lin, Yu-Sheng Chang, Hui-Ching Hsu, Yu-Chuan Shen, Sheng-Hong Lin, Wei-Sheng Chen, Li-Fang Hu, Pei-I Kuo, Tzu-Tung Kuo, Shu-Chuan Chen, Jin-Hua Chen, Yu-Kai Lien, Chi-Ching Chang","doi":"10.55563/clinexprheumatol/6oto0h","DOIUrl":"10.55563/clinexprheumatol/6oto0h","url":null,"abstract":"Objectives: Rheumatoid arthritis (RA) and Alzheimer's disease (AD) share characteristics of chronic inflammation and immune system dysregulation. RA patients are known to have an increased risk of dementia, yet studies on the association between tumour necrosis factor (TNF)-α blocker use and dementia risk in RA patients are lacking. This population-based cohort study aimed to investigate whether TNF-α blocker use is associated with a reduced risk of dementia in RA patients.Methods: Using Taiwan's National Health Insurance Research Database, we identified RA patients treated with TNF-α blockers (etanercept, adalimumab and golimumab) and matched them 1:4 with RA patients receiving conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs). A stratified Cox proportional hazard model was used to compare dementia risk between these groups.Results: Among 3.987 RA patients using TNF-α blockers and 20,689 RA patients not using TNF-α blockers (comparison group), no significant difference in dementia risk was initially observed. However, upon further analysis stratified by TNF-α blocker exposure, RA patients with long-term (>180 cumulative defined daily dose [cDDD]) TNF-α blocker use had a significantly lower risk of dementia (adjusted hazard ratio [aHR]=0.578, 95% confidence interval [CI]=0.342-0.977), after adjusting for age, sex and comorbidities. Moreover, higher cumulative doses (>1036 cDDD) of TNF-α blockers were associated with a further reduced risk of dementia (aHR=0.387, 95% CI=0.188-0.793).Conclusions: This nationwide cohort study suggests that long-term and higher cumulative doses of TNF-α blockers may be associated with a lower risk of dementia in patients with RA.","PeriodicalId":10274,"journal":{"name":"Clinical and experimental rheumatology","volume":" ","pages":"931-938"},"PeriodicalIF":3.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk factors associated with venous thromboembolism in rheumatoid arthritis in clinical practice. 类风湿关节炎中与静脉血栓栓塞相关的危险因素。

IF 3.4 4区医学

Clinical and experimental rheumatology Pub Date : 2025-04-29 DOI: 10.55563/clinexprheumatol/7r3hxm

Fiona Oudart, Marion Thomas, Alice Combier, Anna Molto, Yannick Allanore, Jérôme Avouac

{"title":"Risk factors associated with venous thromboembolism in rheumatoid arthritis in clinical practice.","authors":"Fiona Oudart, Marion Thomas, Alice Combier, Anna Molto, Yannick Allanore, Jérôme Avouac","doi":"10.55563/clinexprheumatol/7r3hxm","DOIUrl":"https://doi.org/10.55563/clinexprheumatol/7r3hxm","url":null,"abstract":"Objectives: To identify classical or disease-related risk factors of venous thromboembolic events (VTE) in rheumatoid arthritis (RA) patients in clinical practice.Methods: Cross-sectional single-centre study conducted on consecutive RA patients over a 24-month period. Electronic medical reports were used to identify the occurrence of VTE after 2018 (JAK inhibitors, JAKi, availability in France) and to collect RA disease characteristics/VTE risk factors. Multivariate logistic regression analysis was performed to identify factors independently associated with VTE.Results: Among 469 RA patients (81% women, mean age 59±14 years), 15 had VTE (3%) after 2018, with a mean interval of 4.5±5.6 months between the occurrence of VTE and the clinical evaluation. The strongest risk factor of VTE was the history of previous VTE with an OR of 44.74 (95% CI 8.83-226.68). We identified hospitalisation up to 3 months before the occurrence of VTE and also diabetes as other factors independently associated with the occurrence VTE, with respective OR of 6.82 (95% CI 1.60-29.11) and 11.23 (95% CI 2.21-57.01). Among RA therapies, JAKi were significantly associated with the occurrence of VTE (OR 5.54, 95% CI 1.03-29.72).Conclusions: In this study of RA patients, history of VTE and recent hospitalisation were identified as strong risk factors of VTE. Moreover, it emphasises the importance of evaluating cardiovascular risk factors, particularly diabetes, for both arterial and venous thromboembolism risks. Finally, JAKi should be used with caution in patients with risk factors for VTE, as recommended by the Pharmacovigilance Risk Assessment Committee and the French Society of Rheumatology.","PeriodicalId":10274,"journal":{"name":"Clinical and experimental rheumatology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143955339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Persistence of ixekizumab in psoriatic arthritis and the influence of gender. ixekizumab治疗银屑病关节炎的持久性及性别的影响。

IF 3.4 4区医学

Clinical and experimental rheumatology Pub Date : 2025-04-29 DOI: 10.55563/clinexprheumatol/re9si5

Evelin Cecilia Cervantes Pérez, Diego Dios Santos, Carlota Iñiguez, María Caeiro Aguado, Carlos García Porrúa, José A Pinto Tasende

引用次数: 0

Soluble TREM-1 ameliorates gouty arthritis by selective inhibition of proinflammatory cytokines and chemokines without affecting TGFβ production. 可溶性TREM-1通过选择性抑制促炎细胞因子和趋化因子改善痛风性关节炎，而不影响TGFβ的产生。

IF 3.4 4区医学

Clinical and experimental rheumatology Pub Date : 2025-04-23 DOI: 10.55563/clinexprheumatol/jv9d10

Yair Molad, Irina Lagovsky

{"title":"Soluble TREM-1 ameliorates gouty arthritis by selective inhibition of proinflammatory cytokines and chemokines without affecting TGFβ production.","authors":"Yair Molad, Irina Lagovsky","doi":"10.55563/clinexprheumatol/jv9d10","DOIUrl":"https://doi.org/10.55563/clinexprheumatol/jv9d10","url":null,"abstract":"Objectives: TREM-1 is upregulated in MSU crystal-induced activation of myeloid cells in gouty arthritis. The aim of the study was to determine the effect of TREM-1 blockade on proinflammatory cytokines and chemokines production as well as anti-inflammatory TGFβ in gout.Methods: Undifferentiated monocyte THP-1 cells were incubated with an agonist anti-TREM-1 antibody, synthetic peptide LP17 (TREM-1 inhibitor), or isotype-matched control followed by stimulation with MSU crystals, and changes in mRNA levels and protein expression of the relevant cytokines and chemokines were evaluated by RT-PCR and ELISA, respectively. A murine air-pouch model of MSU crystal-induced inflammation with LP17-mediated inhibition of TREM1 was analysed for cytokine level (ELISA) and TREM-1 expression (FACS).Results: MSU crystal-induced THP-1 monocyte activation upregulated mRNA and protein levels of TREM-1, IL-1β, TNFα, IL-8, and CCL3, as well as TGFβ. Co-stimulation with an agonist anti-TREM-1 antibody amplified the effect of MSU crystals on IL-1β, TNFα, IL-8, and CCL3 expression, with no significant effect on TGFβ expression. Blockade of monocyte TREM-1 using LP17 had a significant suppressive effect on the expression of IL-1β, TNFα, IL-8, and CCL3, but not TGFβ. In the in vivo air-pouch murine model, LP17 ameliorated MSU crystal-induced inflammation by diminishing the recruitment of leucocytes and significant reduction of proinflammatory cytokine and chemokine level, with no inhibitory effect on TGFβ level.Conclusions: TREM-1 blockade (LP17) in gouty arthritis selectively inhibits proinflammatory cytokines and chemokines, whereas the level of TGF β remains unaffected. Thus, LP17 induces a shift towards anti-inflammatory cytokine TGFβ that results in spontaneous resolution of the gout attack.","PeriodicalId":10274,"journal":{"name":"Clinical and experimental rheumatology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143980706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reduction of non-classical monocytes that suppress interferon-α in patients with systemic lupus erythematosus. 系统性红斑狼疮患者抑制干扰素-α的非经典单核细胞减少。

IF 3.4 4区医学

Clinical and experimental rheumatology Pub Date : 2025-04-23 DOI: 10.55563/clinexprheumatol/ziktdx

Akina Ishii, Shingo Nakayamada, Naoaki Ohkubo, Yusuke Miyazaki, Shigeru Iwata, Junpei Annan, Naohiro Hashimoto, Kei Sakata, Yoshiya Tanaka

{"title":"Reduction of non-classical monocytes that suppress interferon-α in patients with systemic lupus erythematosus.","authors":"Akina Ishii, Shingo Nakayamada, Naoaki Ohkubo, Yusuke Miyazaki, Shigeru Iwata, Junpei Annan, Naohiro Hashimoto, Kei Sakata, Yoshiya Tanaka","doi":"10.55563/clinexprheumatol/ziktdx","DOIUrl":"https://doi.org/10.55563/clinexprheumatol/ziktdx","url":null,"abstract":"Objectives: Monocytes are known to be involved in both adaptive and innate immune responses, though their roles in the pathogenesis of systemic lupus erythematosus (SLE) are still unclear. Here, we performed phenotypic and functional analyses of each monocyte subset.Methods: Peripheral blood from patients with autoimmune diseases (SLE: n=53, rheumatoid arthritis: n=12, systemic sclerosis: n=36) was analysed using flow cytometry to compare the number of each monocyte subset and the expression levels of the cell surface markers of patients to those of healthy donors (n=28).Results: The number of CD14dimCD16+ non-classical monocytes in peripheral blood from SLE patients was significantly decreased compared with those from healthy donors and patients with other autoimmune diseases. The number of circulating non-classical monocytes was inversely correlated to SLE disease activity. The number of non-classical monocytes was not related to the use of glucocorticoids or to the presence or absence of specific tissue inflammation. The expression levels of cell surface molecules and the survival rate of non-classical monocytes of patients with SLE were similar to those of healthy donors. An in vitro functional assay revealed that non-classical monocytes suppressed IFN-α production from PBMCs or plasmacytoid DCs, and cell-cell contact through ICAM-4 seemed to be important in this process.Conclusions: Our study demonstrated that the number of circulating non-classical monocytes, which has been shown to have the ability to suppress IFN-α production, was decreased in SLE patients, and this might be related to the excess IFN signature in SLE patients.","PeriodicalId":10274,"journal":{"name":"Clinical and experimental rheumatology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143983554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stem cell-derived extracellular vesicles: a functional immunomodulator for cell-free therapy of autoimmune diseases. 干细胞来源的细胞外囊泡：一种用于自身免疫性疾病无细胞治疗的功能性免疫调节剂。

IF 3.4 4区医学

Clinical and experimental rheumatology Pub Date : 2025-04-23 DOI: 10.55563/clinexprheumatol/exbsv0

Haoxi Ni, Haoting Zhan, Rongrong Wang, Jingdi Zhang, Ye Guo, Yongzhe Li

{"title":"Stem cell-derived extracellular vesicles: a functional immunomodulator for cell-free therapy of autoimmune diseases.","authors":"Haoxi Ni, Haoting Zhan, Rongrong Wang, Jingdi Zhang, Ye Guo, Yongzhe Li","doi":"10.55563/clinexprheumatol/exbsv0","DOIUrl":"https://doi.org/10.55563/clinexprheumatol/exbsv0","url":null,"abstract":"Patients with autoimmune diseases (AIDs) seldom receive efficient clinical management and timely therapy.Although certain immunomodulatory drugs or biologics currently in use have been shown to decelerate AID progression, potential complications and the extended treatment duration affect the prognosis and living quality of patients.Extracellular vesicles (EVs) have attracted significant interest as a cell-free therapeutic approach with reduced side effects. Research has indicated that stem cell-derived EVs (SC-EVs) can modulate the immune response by suppressing hyper-immunity and inflammation. Of note, SC-EVs are anticipated to serve as a potential alternative to traditional cell therapy. The present review explores the effects of different isolation methods on the quality and quantity of EVs derived from various sample sources. It also discusses the mechanisms through which SC-EVs can be used for AID treatment. In addition, the paper summarises the classic preclinical findings of SC-EVs in AID in recent years.Finally, the potential challenges of SC-EVs before receiving approval for clinical application have been elucidated, thereby offering novel insights for future studies on SC-EVs in AIDs.","PeriodicalId":10274,"journal":{"name":"Clinical and experimental rheumatology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143975609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Warm acupuncture for fibromyalgia with increased cold sensitivity: a cross-over randomised controlled trial. 温针治疗冷敏感性增高的纤维肌痛：一项交叉随机对照试验

IF 3.4 4区医学

Clinical and experimental rheumatology Pub Date : 2025-04-22 DOI: 10.55563/clinexprheumatol/r9v8e7

Yang Li, Yi Dan Wang, Zi Hao Li, Shi Ya Wu, Meijuan Long, Juan Jiao

{"title":"Warm acupuncture for fibromyalgia with increased cold sensitivity: a cross-over randomised controlled trial.","authors":"Yang Li, Yi Dan Wang, Zi Hao Li, Shi Ya Wu, Meijuan Long, Juan Jiao","doi":"10.55563/clinexprheumatol/r9v8e7","DOIUrl":"https://doi.org/10.55563/clinexprheumatol/r9v8e7","url":null,"abstract":"Objectives: Although approximately 85% of fibromyalgia patients exhibit increased sensitivity to cold, no therapy is available for this particular subgroup. This exploratory clinical trial to evaluate the effect of warm acupuncture, a traditional and common used acupuncture therapy, in treating fibromyalgia patients with high cold sensitivity.Methods: This randomised, single-blinded, cross-over preliminary study involved an 8-weeks observation and 8-weeks intervention. Thirty-eight patients were assigned to either warm acupuncture group or observation group for 8 weeks randomly, then the assignment switched. The primary outcome was the change in Visual Analogue Scale (VAS) score for cold sensitivity. Secondary outcomes included changes in sensitivity to pain, wind, noise, bright light, and odor assessed by VAS, and series of specialised scales regarding other common fibromyalgia symptoms. A modified intention-to-treat analysis was used to compare differences.Results: The VAS for cold sensitivity decreased by 2.31-cm in the treatment period and by 0.83-cm in the observation period at week 8 (MD, 1.48; 95% CI, 0.28 to 2.67; p=0.019), and the between-group difference became apparent starting at week 4 (MD, 1.16; 95% CI, -0.03 to 2.36; p=0.015). The secondary efficacy measures, including the VAS for pain, wind, and the Polysymptomatic Distress Scale scores, showed greater improvement during the treatment period compared with that in the observation period at week 8. Adverse events were infrequent and minor.Conclusions: Warm acupuncture may reduce the heightened sensitivity to cold, pain and wind, as well as the severity of the fibromyalgia in those patients with cold intolerance.","PeriodicalId":10274,"journal":{"name":"Clinical and experimental rheumatology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143969352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0